Control of CydB and GltA1 expression by the SenX3 RegX3 two component regulatory system of mycobacterium tuberculosis

PLoS ONE

Volumn 6, Issue 6, 2011, Pages

  Roberts, Gretta ^a,d   Vadrevu, Indumathi S ^b   Madiraju, Murty V ^b   Parish, Tanya ^a,c  

^a QUEEN MARY UNIVERSITY OF LONDON   (United Kingdom)

^b UNIVERSITY OF TEXAS HEALTH CENTER   (United States)

^c INFECTIOUS DISEASE RESEARCH INSTITUTE   (United States)

^d UNIVERSITY OF READING   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIAL PROTEIN; PROTEIN CYDB; PROTEIN GLTA1; PROTEIN REGX3; PROTEIN SENX3; UNCLASSIFIED DRUG; PRIMER DNA; RECOMBINANT PROTEIN;

ARTICLE; BACTERIAL STRAIN; CONTROLLED STUDY; GENE DELETION; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GENE OVEREXPRESSION; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; OPERON; PROMOTER REGION; PROTEIN BINDING; PROTEIN PHOSPHORYLATION; PROTEIN PURIFICATION; QUANTITATIVE ANALYSIS; UPREGULATION; BACTERIAL GENE; GEL MOBILITY SHIFT ASSAY; GENETICS; METABOLISM; NUCLEOTIDE SEQUENCE; PHOSPHORYLATION; PHYSIOLOGY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; VIRULENCE;

MYCOBACTERIUM TUBERCULOSIS;

BACTERIAL PROTEINS; BASE SEQUENCE; DNA PRIMERS; ELECTROPHORETIC MOBILITY SHIFT ASSAY; GENE EXPRESSION PROFILING; GENES, BACTERIAL; MYCOBACTERIUM TUBERCULOSIS; OPERON; PHOSPHORYLATION; PROMOTER REGIONS, GENETIC; RECOMBINANT PROTEINS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; VIRULENCE;

EID: 79959261442     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0021090     Document Type: Article

References (27)

1. Stock AM, Guhaniyogi G, (2006) A new perspective on response regulator activation. J Bacteriol 188: 7328-7330.
2. Ewann F, Jackson M, Pethe K, Cooper A, Mielcarek N, et al. (2002) Transient requirement of the PrrA-PrrB two-component system for early intracellular multiplication of Mycobacterium tuberculosis. Infect Immun 70: 2256-2263.
3. Malhotra V, Sharma D, Ramanathan VD, Shakila H, Saini DK, et al. (2004) Disruption of response regulator gene, devR, leads to attenuation in virulence of Mycobacterium tuberculosis. FEMS Microbiol Lett 231: 237-245.
4. Parish T, Smith DA, Kendall S, Casali N, Bancroft GJ, et al. (2003) Deletion of two-component regulatory systems increases the virulence of Mycobacterium tuberculosis. Infect Immun 71: 1134-1140.
5. Parish T, Smith DA, Roberts G, Betts J, Stoker NG, (2003) The senX3-regX3 two-component regulatory system of Mycobacterium tuberculosis is required for virulence. Microbiology 149: 1423-1435.
6. Perez E, Samper S, Bordas T, Guilhot C, Gicquel B, et al. (2001) An essential role for phoP in Mycobacterium tuberculosis virulence. Molec Microbiol 41: 179-187.
7. Rickman L, Saldanha JW, Hunt DM, Hoar DN, Colston MJ, et al. (2004) A two-component signal transduction system with a PAS domain- containing sensor is required for virulence of Mycobacterium tuberculosis in mice. Biochem Biophys Res Comm 314: 259-267.
8. Wren BW, Colby SW, Cubberley RR, Pallen MJ, (1992) Degenerate PCR primers for the amplification of fragments from genes encoding response regulators from a range of pathogenic bacteria. FEMS Microbiol Lett 99: 287-292.
9. Himpens S, Locht C, Supply P, (2000) Molecular characterization of the mycobacterial SenX3-RegX3 two-component system: evidence for autoregulation. Microbiology 146: 3091-3098.
10. Glover RT, Kriakov J, Garforth SJ, Baughn AD, Jacobs WR, (2007) The two-component regulatory system senX3-regX3 regulates phosphate-dependent gene expression in Mycobacterium smegmatis. J Bacteriol 189: 5495-5503.
11. Rifat D, Bishai WR, Karakousis PC, (2009) Phosphate depletion: a novel trigger for Mycobacterium tuberculosis persistence. J Infect Dis 200: 1126-1135.
12. Muttucumaru DGN, Roberts G, Hinds J, Stabler RA, Parish T, (2004) Gene expression profile of Mycobacterium tuberculosis in a non- replicating state. Tuberculosis 84: 239-246.
13. Wayne LG, (2001) In vitro model of hypoxically induced nonreplicating persistence of Mycobacterium tuberculosis. In: Parish T, Stoker NG, editors. Mycobacterium tuberculosis protocols Humana Press.
14. Mahenthiralingam E, Draper P, Davis EO, Colston MJ, (1993) Cloning and sequencing of the gene which encodes the highly inducible acetamidase of Mycobacterium smegmatis. J Gen Microbiol 139: 575-583.
15. Parish T, Mahenthiralingam E, Draper P, Davis EO, Colston MJ, (1997) Regulation of the inducible acetamidase gene of Mycobacterium smegmatis. Microbiology 143: 2267-2276.
16. Betts JC, Lukey PT, Robb LC, McAdam RA, Duncan K, (2002) Evaluation of a nutrient starvation model of Mycobacterium tuberculosis persistence by gene and protein expression profiling. Molec Microbiol 43: 717-731.
17. Kendall SL, Movahedzadeh F, Rison SCG, Wernisch L, Parish T, et al. (2004) The Mycobacterium tuberculosis dosRS two-component system is induced by multiple stresses. Tuberculosis 84: 247-255.
18. Sherman DR, Voskuil M, Schnappinger D, Liao R, Harrell MI, et al. (2001) Regulation of the Mycobacterium tuberculosis hypoxic response gene encoding alpha-crystallin. Proc Natl Acad Sci USA 98: 7534-7539.
19. Voskuil MI, Schnappinger D, Visconti KC, Harrell MI, Dolganov GM, et al. (2003) Inhibition of respiration by nitric oxide induces a Mycobacterium tuberculosis dormancy program. J Exp Med 198: 705-713.
20. Fen ZY, Caceres NE, Sarath G, Barletta RG, (2002) Mycobacterium smegmatis L-alanine dehydrogenase (Ald) is required for proficient utilization of alanine as a sole nitrogen source and sustained anaerobic growth. J Bacteriol 184: 5001-5010.
21. Kana BD, Weinstein EA, Avarbock D, Dawes SS, Rubin H, et al. (2001) Characterization of the cydAB-encoded cytochrome bd oxidase from Mycobacterium smegmatis. J Bacteriol 183: 7076-7086.
22. Fol M, Chauhan A, Nair NK, Maloney E, Moomey M, et al. (2006) Modulation of Mycobacterium tuberculosis proliferation by MtrA, an essential two-component response regulator. Molec Microbiol 60: 643-657.
23. Rajagopalan M, Dziedzic R, Al Zayer M, Stankowska D, Ouimet MC, et al. (2010) Mycobacterium tuberculosis origin of replication and the promoter for immunodominant secreted antigen 85B are the targets of MtrA, the essential response regulator. J Biol Chem 285: 15816-15827.
24. Shi LB, Sohaskey CD, Kana BD, Dawes S, North RJ, et al. (2005) Changes in energy metabolism of Mycobacterium tuberculosis in mouse lung and under in vitro conditions affecting aerobic respiration. Proc Natl Acad Sci USA 102: 15629-15634.
25. Sassetti C, Rubin EJ, (2003) Genetic requirements for mycobacterial survival during infection. Proc Natl Acad Sci USA 100: 12989-12994.
26. Sassetti CM, Boyd DH, Rubin EJ, (2003) Genes required for mycobacterial growth defined by high density mutagenesis. Molec Microbiol 48: 77-84.
27. Fisher MA, Plikaytis BB, Shinnick TM, (2002) Microarray analysis of the Mycobacterium tuberculosis transcriptional response to the acidic conditions found in phagosomes. J Bacteriol 184: 4025-4032.