Effectiveness of anti-inflammatory treatment versus antibiotic therapy and placebo for patients with non-complicated acute bronchitis with purulent sputum. The BAAP Study protocol

BMC Pulmonary Medicine

Volumn 11, Issue , 2011, Pages

  Llor, Carl ^a   Moragas, Ana ^b   Bayona, Carolina ^c   Morros, Rosa ^d   Pera, Helena ^d   Cots, Josep M ^e   Fernández, Yvonne ^b   Miravitlles, Marc ^f   Boada, Albert ^g  

^a UNIVERSITAT ROVIRA I VIRGILI   (Spain)

^b Primary Care Centre Jaume I   (Spain)

^c Primary Healthcare Centre Valls Urbà   (Spain)

^d Fundació d'Investigació d'Atenció Primaria Jordi Gol i Gurina ^*  (Spain)

^e UNIVERSITY OF BARCELONA   (Spain)

^f HOSPITAL CLÍNIC   (Spain)

^g Primary Healthcare Centre (CAP)   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

AMOXICILLIN PLUS CLAVULANIC ACID; C REACTIVE PROTEIN; IBUPROFEN; PLACEBO; AMOXICILLIN; ANTIINFECTIVE AGENT; ANTIINFLAMMATORY AGENT; CLAVULANIC ACID;

ADULT; AGED; ANTIBIOTIC THERAPY; ARTICLE; BRONCHITIS; COUGHING; DISEASE DURATION; DRUG EFFICACY; DYSPNEA; HUMAN; MAJOR CLINICAL STUDY; PATIENT COMPLIANCE; PROTEIN BLOOD LEVEL; PURULENT SPUTUM; RANDOMIZED CONTROLLED TRIAL (TOPIC); SPUTUM; STUDY DESIGN; SUPPURATION; THORAX PAIN; THORAX RADIOGRAPHY; TREATMENT DURATION; WHEEZING; ACUTE DISEASE; ADOLESCENT; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; MIDDLE AGED; OUTCOME ASSESSMENT; PREVALENCE; PROSPECTIVE STUDY; RANDOMIZED CONTROLLED TRIAL; SPAIN; TIME; TREATMENT OUTCOME;

ACUTE DISEASE; ADOLESCENT; ADULT; AGED; AMOXICILLIN; ANTI-BACTERIAL AGENTS; ANTI-INFLAMMATORY AGENTS; BRONCHITIS; CLAVULANIC ACID; COUGH; HUMANS; IBUPROFEN; MIDDLE AGED; OUTCOME ASSESSMENT (HEALTH CARE); PREVALENCE; PROSPECTIVE STUDIES; SPAIN; SPUTUM; TIME FACTORS; TREATMENT OUTCOME; YOUNG ADULT;

EID: 79959257043     PISSN: None     EISSN: 14712466     Source Type: Journal    
DOI: 10.1186/1471-2466-11-38     Document Type: Article

References (24)

1. Macfarlane J, Holmes W, Gard P, Macfarlane R, Rose D, Weston V, et al. Prospective study of the incidence, aetiology and outcome of adult lower respiratory tract illness in the community. Thorax 2001, 56:109-14. 10.1136/thorax.56.2.109, 1746009, 11209098.
2. Llor C, Hernández S. Infectious disease in primary care: 1-year prospective study. Enferm Infecc Microbiol Clin 2010, 28:222-6. 10.1016/j.eimc.2009.03.014, 19720435.
3. Boivin G, Abed Y, Pelletier G, Ruel L, Moisan D, Côté S, Peret TC, Erdman DD, Anderson LJ. Virological features and clinical manifestations associated with human metapneumovirus: a new paramyxovirus responsible for acute respiratory-tract infections in all age groups. J Infect Dis 2002, 186:1330-4. 10.1086/344319, 12402203.
4. Bastien N, Ward D, Van Caeseele P, Brandt K, Lee SH, McNabb G, et al. Human metapneumovirus infection in the Canadian population. J Clin Microbiol 2003, 41:4642-6. 10.1128/JCM.41.10.4642-4646.2003, 254302, 14532196.
5. Ward JI, Cherry JD, Chang SJ, Partridge S, Lee H, Treanor J, Greenberg DP, Keitel W, Barenkamp S, Bernstein DI, Edelman R, Edwards K, . APERT Study Group Efficacy of an acellular pertussis vaccine among adolescents and adults. N Engl J Med 2005, 353:1555-63. 10.1056/NEJMoa050824, 16221778, APERT Study Group.
6. Kicska G, Zhuang H, Alavi A. Acute bronchitis imaged with F-18 FDG positron emission tomography. Clin Nucl Med 2003, 28:511-2.
7. Williamson HA. Pulmonary function tests in acute bronchitis: evidence for reversible airway obstruction. J Fam Pract 1987, 25:251-6.
8. Chodosh S. Acute bacterial exacerbations in bronchitis and asthma. Am J Med 1987, 82(4A):154-63.
9. Gonzales R, Sande MA. Uncomplicated acute bronchitis. Ann Intern Med 2000, 133:981-91.
10. Linder JA, Singer DE. Health-related quality of life of adults with upper respiratory tract infections. J Gen Intern Med 2003, 18:802-7. 10.1046/j.1525-1497.2003.21246.x, 1494925, 14521642.
11. Picazo JJ, Pérez-Cecilia E, Herreras A, . Grupo DIRA en Atención Primaria [Respiratory infections outside the hospital. DIRA study]. Enferm Infecc Microbiol Clin 2003, 21:410-6. 10.1157/13051905, 14525706, Grupo DIRA en Atención Primaria.
12. Romero J, Rubio M, Corral O, Pacheco S, Agudo E, Picazo JJ. [Community-acquired respiratory infections]. Enferm Infecc Microbiol Clin 1997, 15:289-98.
13. Gonzales R, Steiner JF, Sande MA. Antibiotic prescribing for colds, upper respiratory tract infections, and bronchitis by ambulatory care physicians. JAMA 1997, 278:901-4. 10.1001/jama.278.11.901, 9302241.
14. Mainous AG, Zoorob RH, Hueston WJ. Current management of acute bronchitis in ambulatory care: the use of antibiotics and bronchodilators. Arch Fam Med 1996, 5:79-83. 10.1001/archfami.5.2.79, 8601212.
15. Bent S, Saint S, Vittinghoff E, Grady D. Antibiotics in acute bronchitis: a meta-analysis. Am J Med 1999, 107:62-67.
16. Evans AT, Husain S, Durairaj L, Sadowski LS, Charles-Damte M, Wang Y. Azithromycin for acute bronchitis: a randomised double-blind, controlled trial. Lancet 2002, 359:1648-1654. 10.1016/S0140-6736(02)08597-5, 12020525.
17. Smucny J, Fahey T, Becker L, Glazier R. Antibiotics for acute bronchitis. Cochrane Database Syst Rev 2004, 4:CD000245.
18. Stott NC, West RR. Randomised controlled trial of antibiotics in patients with cough and purulent sputum. Br Med J 1976, 2:556-9. 10.1136/bmj.2.6035.556, 1688091, 786428.
19. Llor C, Cots JM, Bjerrum L, Cid M, Guerra G, Arranz X, Gómez M, Monedero MJ, Alcántara Jde D, Pérez C, García G, Ortega J, Cigüenza ML, Pineda V, Paredes J, Burgazzoli JL, Hernández S, . grupo de estudio Happy Audit España Antibiotic prescribing in respiratory tract infections and predictive factors for their use. Aten Primaria 2010, 42:28-35. 10.1016/j.aprim.2009.04.018, 19713006, grupo de estudio Happy Audit España.
20. Llor C, Bayona C. Spanish primary healthcare physicians' knowledge of resistance of respiratory germs and antimicrobial treatment in acute bronchitis. Eur J Gen Pract 2004, 10:88-92. 10.3109/13814780409044541, 15534572.
21. Wenzel RP, Fowler AA. Acute bronchitis. N Engl J Med 2006, 355:2125-30. 10.1056/NEJMcp061493, 17108344.
22. Nduba VN, Mwachari CW, Magaret AS, Park DR, Kigo A, Hooton TM, et al. Placebo found equivalent to amoxicillin for treatment of acute bronchitis in Nairobi, Kenya: a triple blind, randomised, equivalence trial. Thorax 2008, 63:999-1005. 10.1136/thx.2008.097311, 18559367.
23. Butler CC, Rollnick S, Kinnersley P, Tapper-Jones L, Houston H. Communicating about expected course and re-consultation for respiratory tract infections in children: an exploratory study. Br J Gen Pract 2004, 54:536-8. 1324807, 15239917.
24. Knutson D. Diagnosis and management of acute bronchitis. Am Fam Physician 2002, 65:2039-44.