Proteasome particle-rich structures are widely present in human epithelial neoplasms: Correlative light, confocal and electron microscopy study

PLoS ONE

Volumn 6, Issue 6, 2011, Pages

  Necchi, Vittorio ^a   Sommi, Patrizia ^a,b   Vanoli, Alessandro ^a   Manca, Rachele ^b   Ricci, Vittorio ^a   Solcia, Enrico ^a,b  

^a UNIVERSITY OF PAVIA   (Italy)

^b FONDAZIONE IRCCS POLICLINICO SAN MATTEO   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIAL PROTEIN; CAGA PROTEIN; CASPASE RECRUITMENT DOMAIN PROTEIN 4; MITOGEN ACTIVATED PROTEIN KINASE; OUTER MEMBRANE PROTEIN; PROTEASOME; PROTEIN TYROSINE PHOSPHATASE SHP 2; UREASE; VACUOLATING TOXIN; TUMOR PROTEIN;

ARTICLE; BACTERIAL VIRULENCE; CARCINOGENESIS; CELL GRANULE; CONFOCAL MICROSCOPY; CONTROLLED STUDY; ELECTRON MICROSCOPY; EPITHELIUM; HELICOBACTER PYLORI; HUMAN; HUMAN TISSUE; IMMUNOREACTIVITY; NEOPLASM; PROTEIN ANALYSIS; PROTEIN STRUCTURE; STOMACH CANCER; UBIQUITINATION; FEMALE; METABOLISM; METHODOLOGY; PATHOLOGY; ULTRASTRUCTURE;

BACTERIA (MICROORGANISMS); HELICOBACTER PYLORI;

FEMALE; HUMANS; MICROSCOPY, CONFOCAL; MICROSCOPY, ELECTRON; NEOPLASM PROTEINS; NEOPLASMS, GLANDULAR AND EPITHELIAL; PROTEASOME ENDOPEPTIDASE COMPLEX; UBIQUITINATION;

EID: 79959242879     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0021317     Document Type: Article

References (25)

1. Necchi V, Sommi P, Ricci V, Solcia E, (2010) In vivo accumulation of Helicobacter pylori products, NOD1, uniquitinated proteins and proteasome in a novel cytoplasmic structure. PLoS One 5: e9716.
2. Viala J, Chaput C, IG, Cardona A, Girardin SE, et al. (2004) Nod1 responds to peptidoglycan delivered by the Helicobacter pylori cag pathogenicity island. Nat Immunol 5: 1166-1174.
3. Hatakeyama M, (2004) Oncogenic mechanisms of the Helicobacter pylori CagA protein. Nat Rev Cancer 4: 688-694.
4. Hoeller D, Dikic I, (2009) Targeting the ubiquitin system in cancer therapy. Nature 458: 438-444.
5. Fiocca R, Necchi V, Sommi P, Ricci V, Telford J, et al. (1999) Release of Helicobacter pylori vacuolating cytotoxin by both a specific secretion pathway and budding of outer membrane vesicles. Uptake of released toxin and vesicles by gastric epithelium. J Pathol 188: 220-226.
6. Necchi V, Candusso ME, Tava F, Luinetti O, Ventura U, et al. (2007) Intracellulare, intercellular, and stromal invasion of gastric mucosa, preneopalstic lesions, and cancer by Helicobacter pylori. Gastroenterology 132: 1009-1023.
7. Rivett J, Palmer A, Knecht E, (1992) Electron microscopy localization of the multicatalytic proteinase complex in rat liver and in cultured cells. J Histochem Citochem 40: 1165-1172.
8. Fehling HJ, Swatt W, Laplace C, Kuhn R, Rajewsky K, et al. (1994) MHC class I expression in mice lacking proteasome subunit LMP-7. Science 265: 1234-1237.
9. Seifert U, Bialy LP, Ebstein F, Bech-Otschir D, Voigt A, et al. (2010) Immunoproteasomes preserve protein homeostasis upon interferon-induced oxidative stress. Cell 142: 613-624.
10. Handa O, Naito Y, Yoshikawa T, (2007) CagA protein of Helicobacter pylori: a hijacker of gastric epithelial cell signaling. Biochem Pharmacol 73: 1697-1702.
11. Kopito RR, (2000) Aggresomes, inclusion bodies and protein aggregation. Trends Cell Biol 10: 524-530.
12. Denk H, Stumptner C, Fuchsbichler A, Müller T, Farr GH, et al. (2006) Are the Mallory bodies and intracellular hyaline bodies in neoplastic and non-neoplastic hepatocytes related? J Pathol 208: 653-661.
13. Szeto J, Kaniuk NA, Canadien V, Nisman R, Mizushima N, et al. (2006) ALIS are stress-induced protein storage compartments for substrates of the proteasome and autophagy. Autophagy 2-3: 189-199.
14. Glick D, Barth S, Macleod KF, (2010) Autophagy: cellular and molecular mechanisms. J Pathol 221: 3-12.
15. Bjorkoy G, Lamark T, Brech A, Outzen H, Perander M, et al. (2005) p62/SQSTM1 forms protein aggregates degraded by autophagy and has a protective effect on huntingtin-induced cell death. J Cell Biol 171: 603-614.
16. Meyer-ter-Vehn T, Covacci A, Kist M, Pahl HL, (2000) Helicobacter pylori activates mitogen-activated protein kinase cascades and induces expression of the proto-oncogenes c-fos and c-jun. J Biol Chem 275: 16064-16072.
17. Roberts PJ, Der CJ, (2007) Targeting of Raf-MEK-ERK mitogen-activated protein kinase cascade for the treatment of cancer. Oncogene 26: 3291-3310.
18. Keates S, Keates AC, Katchar K, Peek RM, Kelly CP, (2007) Helicobacter pylori induces up-regulation of the epidermal growth factor receptor in AGS gastric epithelial cells. J Infect Dis 196: 95-103.
19. Kuboki Y, Shiratori K, Hatori T, Fujita I, Kimijima A, et al. (2010) Association of epidermal growth factor receptor and mitogen-activated protein kinase with cystic neoplasms of the pancreas. Mod Pathol 23: 1127-1135.
20. Ito Y, Sasaki Y, Horimoto M, Wada S, Tanaka Y, et al. (1998) Activation of mitogen-activated protein kinases/extracellular signal-regulated kinases in human hepatocellular carcinoma. Hepatology 27: 951-958.
21. Brose MS, Volpe P, Feldman M, Kumar M, Rishi I, et al. (2002) BRAF and RAS mutations in human lung cancers and melanoma. Cancer Res 62: 6997-7000.
22. Kimura ET, Nikiforova MN, Zhu Z, Knauf JA, Nikiforov YE, et al. (2003) High prevalence of BRAF mutations in thyroid cancer: genetic evidence for constitutive activation of the RET/PTC-RAS-BRAF signaling pathway in papillary thyroid carcinoma. Cancer Res 63: 1454-1457.
23. Sieben N, Macropoulos P, Roemen G, Kolkman-Uljee SM, Fleuren GJ, et al. (2004) In ovarian neoplasms, BRAF, but not KRAS, mutations are restricted to low-grade serous tumours. J Pathol 202: 336-340.
24. Schmitz KJ, Wohlschlaeger J, Alakus H, Bohr J, Stauter MA, et al. (2007) Activation of xtracellular regulated kinases (ERK1/2) but not AKT predicts poor prognosis in colorectal carcinoma and is associated with k-ras mutations. Virchows Arch 450: 151-159.
25. Bennett EJ, Bence NF, Jayakumar R, Kopito RR, (2005) Global impairment of the ubiquitin-proteasome system by nuclear or cytoplasmic protein aggregates precedes inclusion body formation. Mol Cell 17: 351-365.