Bromination of 3-substituted benzo[b]thiophenes: Access to Raloxifen intermediate

Tetrahedron Letters

Volumn 52, Issue 29, 2011, Pages 3736-3739

  Liger, François ^a   Pellet Rostaing, Stéphane ^a   Popowycz, Florence ^a   Lemaire, Marc ^a  

^a UNIVERSITÉ LYON 1   (France)

Author keywords

Benzo b thiophene; Bromination; Electrophilic aromatic substitution; Raloxifen

Indexed keywords

BENZOTHIOPHENE DERIVATIVE; RALOXIFENE;

ARTICLE; BROMINATION; CONTROLLED STUDY; DRUG ISOLATION; DRUG STRUCTURE; DRUG SYNTHESIS; PROCESS OPTIMIZATION;

EID: 79959221504     PISSN: 00404039     EISSN: 18733581     Source Type: Journal    
DOI: 10.1016/j.tetlet.2011.05.043     Document Type: Article

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20. 2, cyclohexane/EtOAc 93:7) to afford the pure desired product.
21. 3): δ = 107.2 (C), 113.9 (C), 120.5 (C), 123.7 (CH), 125.5 (CH), 129.7 (CH), 136.1 (C), 138.0 (CH), 140.0 (C) ppm.
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23. 6) δ = 107.0 (C), 108.8 (CH), 115.0 (C), 117.2 (CH), 123.5 (CH), 131.2 (C), 136.5 (CH), 141.3 (C), 157.4 (C) ppm.
24. 3), 105.1 (CH), 106.8 (C), 114.6 (C), 116.3 (CH), 123.2 (CH), 131.3 (C), 135.0 (CH), 140.3 (C), 158.8 (C) ppm.
25. 3), 100.3 (C), 105.0 (CH), 114.8 (2 CH), 115.7 (C), 115.9 (CH), 123.1 (CH), 124.3 (C), 129.5 (2 CH), 133.2 (C), 138.5 (C), 152.6 (C), 158.5 (C), 161.2 (C) ppm.