Quantitating glomerular endothelial fenestration: An unbiased stereological approach

American Journal of Nephrology

Volumn 33, Issue SUPPL. 1, 2011, Pages 34-39

  Najafian, Behzad ^a   Mauer, Michael ^b  

^a UNIVERSITY OF WASHINGTON   (United States)

^b UNIVERSITY OF MINNESOTA   (United States)

Author keywords

Contiguity; Endothelium; Fabry disease; Fabry nephropathy; Fenestrae; Fenestration; Glomeruli; Kidney; Morphometry; Stereology

Indexed keywords

ADULT; CAPILLARY ENDOTHELIUM; CLINICAL ARTICLE; CONFERENCE PAPER; CONTROLLED STUDY; ENDOTHELIUM; FABRY DISEASE; FEMALE; GLOMERULUS CAPILLARY; GLOMERULUS FILTRATION; HUMAN; HUMAN TISSUE; KIDNEY BIOPSY; MALE; MEMBRANE TRANSPORT; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; STEREOLOGY;

ADOLESCENT; ADULT; CAPILLARIES; CHILD; CHILD, PRESCHOOL; ENDOTHELIUM, VASCULAR; FABRY DISEASE; FEMALE; HUMANS; KIDNEY GLOMERULUS; MALE; MICROSCOPY, ELECTRON, TRANSMISSION; YOUNG ADULT;

EID: 79958856610     PISSN: 02508095     EISSN: 14219670     Source Type: Journal    
DOI: 10.1159/000327075     Document Type: Conference Paper

References (20)

1. Farquhar MG, Vernier RL, Good RA: An electron microscope study of the glomerulus in nephrosis, glomerulonephritis, and lupus erythematosus. J Exp Med 1957;106:649-660.
2. Kondo H, Ushiki T: Stratified laminae fenestratae (alveolus fenestratus endothelialis) in the glomerular capillaries of the mouse kidney. Arch Histol Jpn 1985;48:117-122. (Pubitemid 15149421)
3. Avasthi PS, Evan AP, Huser JW, Luft FC: Effect of gentamicin on glomerular ultrastructure. J Lab Clin Med 1981;98:444-454. (Pubitemid 11049477)
4. Najafian B, Svarstad E, Bostad L, Gubler MC, Tondel C, Whitley C, Mauer M: Progressive podocyte injury and globotriaosylceramide (GL-3) accumulation in young patients with Fabry disease. Kidney Int 2011;79:663-670.
5. Toyoda M, Najafian B, Kim Y, Caramori ML, Mauer M: Podocyte detachment and reduced glomerular capillary endothelial fenestration in human type 1 diabetic nephropathy. Diabetes 2007;56:2155-2160. (Pubitemid 47195834)
6. Weibel ER: Stereological Methods: Practical Methods for Biological Morphometry. London, Academic Press, 1979.
7. Mattfeldt T, Mall G, Gharehbaghi H, Moller P: Estimation of surface area and length with the orientator. J Microsc 1990;159:301-317. (Pubitemid 20313604)
8. Gokhale AM, Benes VV: Estimation of average particle size from vertical projections. J Microsc 1998;191:195-200. (Pubitemid 28378445)
9. Gokhale AM, Evans RA, Mackes JL, Mouton PR: Design-based estimation of surface area in thick tissue sections of arbitrary orientation using virtual cycloids. J Microsc 2004;216:25-31. (Pubitemid 39312475)
10. Gundersen HJ, Jensen EB: The efficiency of systematic sampling in stereology and its prediction. J Microsc 1987;147:229-263.
11. Satchell SC, Braet F: Glomerular endothelial cell fenestrations: an integral component of the glomerular filtration barrier. Am J Physiol Renal Physiol 2009;296:F947-F956.
12. Kamba T, Tam BY, Hashizume H, Haskell A, Sennino B, Mancuso MR, Norberg SM, O'Brien SM, Davis RB, Gowen LC, Anderson KD, Thurston G, Joho S, Springer ML, Kuo CJ, McDonald DM: VEGF-dependent plasticity of fenestrated capillaries in the normal adult microvasculature. Am J Physiol Heart Circ Physiol 2006;290:H560-H576.
13. Sugimoto H, Hamano Y, Charytan D, Cosgrove D, Kieran M, Sudhakar A, Kalluri R: Neutralization of circulating vascular endothelial growth factor (VEGF) by anti-VEGF antibodies and soluble VEGF receptor 1 (SFLT-1) induces proteinuria. J Biol Chem 2003;278:12605-12608. (Pubitemid 36800018)
14. Foster RR, Satchell SC, Seckley J, Emmett MS, Joory K, Xing CY, Saleem MA, Mathieson PW, Bates DO, Harper SJ: VEGF-C promotes survival in podocytes. Am J Physiol Renal Physiol 2006;291:F196-F207. (Pubitemid 43945950)
15. Foster RR, Slater SC, Seckley J, Kerjaschki D, Bates DO, Mathieson PW, Satchell SC: Vascular endothelial growth factor-C, a potential paracrine regulator of glomerular permeability, increases glomerular endothelial cell monolayer integrity and intracellular calcium. Am J Pathol 2008;173:938-948.
16. Lafayette RA, Druzin M, Sibley R, Derby G, Malik T, Huie P, Polhemus C, Deen WM, Myers BD: Nature of glomerular dysfunction in pre-eclampsia. Kidney Int 1998;54:1240-1249. (Pubitemid 28449911)
17. Stillman IE, Karumanchi SA: The glomerular injury of preeclampsia. J Am Soc Nephrol 2007;18:2281-2284. (Pubitemid 47203843)
18. Baelde HJ, Eikmans M, Lappin DW, Doran PP, Hohenadel D, Brinkkoetter PT, van der Woude FJ, Waldherr R, Rabelink TJ, de Heer E, Bruijn JA: Reduction of VEGF-A and CTGF expression in diabetic nephropathy is associated with podocyte loss. Kidney Int 2007;71:637-645. (Pubitemid 46494557)
19. Moore DF, Krokhin OV, Beavis RC, Ries M, Robinson C, Goldin E, Brady RO, Wilkins JA, Schiffmann R: Proteomics of specific treatment-related alterations in Fabry disease: a strategy to identify biological abnormalities. Proc Natl Acad Sci USA 2007;104:2873-2878. (Pubitemid 46327972)
20. Mauer SM, Fish AJ, Blau EB, Michael AF: The glomerular mesangium. I. Kinetic studies of macromolecular uptake in normal and nephrotic rats. J Clin Invest 1972;51:1092-1101.