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Volumn 14, Issue 4, 2011, Pages 431-438

Effects of chronic academic stress on mental state and expression of glucocorticoid receptor α and β isoforms in healthy Japanese medical students

Author keywords

Academic stress; glucocorticoid receptor; medical student; salivary cortisol; Self Rating Depression Scale (SDS); State and Trait Anxiety Inventory (STAI)

Indexed keywords

GLUCOCORTICOID RECEPTOR ALPHA; GLUCOCORTICOID RECEPTOR BETA; HYDROCORTISONE; MESSENGER RNA;

EID: 79958855432     PISSN: 10253890     EISSN: 16078888     Source Type: Journal    
DOI: 10.3109/10253890.2011.555930     Document Type: Article
Times cited : (20)

References (45)
  • 1
    • 0001065189 scopus 로고    scopus 로고
    • Glucocorticoid receptor beta: View II
    • Carlstedt-Duke J. 1999. Glucocorticoid receptor beta: View II. Trends Endocrinol Metab 10:339-342.
    • (1999) Trends Endocrinol Metab , vol.10 , pp. 339-342
    • Carlstedt-Duke, J.1
  • 2
    • 1942536210 scopus 로고    scopus 로고
    • Natural glucocorticoid receptor mutants causing generalized glucocorticoid resistance: Molecular genotype, genetic transmission, and clinical phenotype
    • DOI 10.1210/jc.2003-030450
    • Charmandari E, Kino T, Souvatzoglou E, Vottero A, Bhattacharyya N, Chrousos GP. 2004. Natural glucocorticoid receptor mutants causing generalized glucocorticoid resistance: Molecular genotype, genetic transmission, and clinical phenotype. J Clin Endocrinol Metab 89:1939-1949. (Pubitemid 38514702)
    • (2004) Journal of Clinical Endocrinology and Metabolism , vol.89 , Issue.4 , pp. 1939-1949
    • Charmandari, E.1    Kino, T.2    Souvatzoglou, E.3    Vottero, A.4    Bhattacharyya, N.5    Chrousos, G.P.6
  • 3
    • 20144375590 scopus 로고    scopus 로고
    • Stress and depression among medical students: A cross-sectional study
    • DOI 10.1111/j.1365-2929.2005.02176.x
    • Dahlin M, Joneborg N, Runeson B. 2005. Stress and depression among medical students: A cross-sectional study. Med Educ 39: 594-604. (Pubitemid 40776347)
    • (2005) Medical Education , vol.39 , Issue.6 , pp. 594-604
    • Dahlin, M.1    Joneborg, N.2    Runeson, B.3
  • 5
    • 0242305085 scopus 로고    scopus 로고
    • Anxiety disorders and other psychiatric subgroups in patients complaining of dizziness
    • DOI 10.1016/S0887-6185(02)00226-8, PII S0887618502002268
    • Eckhardt-Henn A, Breuer P, Thomalske C, Hoffmann SO, Hopf HC. 2003. Anxiety disorders and other psychiatric subgroups in patients complaining of dizziness. J Anxiety Disord 17:369-388. (Pubitemid 41123079)
    • (2003) Journal of Anxiety Disorders , vol.17 , Issue.4 , pp. 369-388
    • Eckhardt-Henn, A.1    Breuer, P.2    Thomalske, C.3    Hoffmann, S.O.4    Hopf, H.C.5
  • 6
    • 0024828263 scopus 로고
    • Differential effects of relaxation techniques on trait anxiety: A meta-analysis
    • Eppley KR, Abrams AI, Shear J. 1989. Differential effects of relaxation techniques on trait anxiety: A meta-analysis. J Clin Psychol 45:957-974. (Pubitemid 20061601)
    • (1989) Journal of Clinical Psychology , vol.45 , Issue.6 , pp. 957-974
    • Eppley, K.R.1    Abrams, A.I.2    Shear, J.3
  • 8
    • 14944351958 scopus 로고    scopus 로고
    • Stress-induced immune dysfunction: Implications for health
    • DOI 10.1038/nri1571
    • Glaser R, Kiecolt-Glaser JK. 2005. Stress-induced immune dysfunction: Implications for health. Nat Rev Immunol 5: 243-251. (Pubitemid 40364825)
    • (2005) Nature Reviews Immunology , vol.5 , Issue.3 , pp. 243-251
    • Glaser, R.1    Kiecolt-Glaser, J.K.2
  • 10
    • 0035153486 scopus 로고    scopus 로고
    • Stress, hypercortisolism and corticosteroid receptors in depression: Implicatons for therapy
    • DOI 10.1016/S0165-0327(00)00352-9, PII S0165032700003529
    • Holsboer F. 2001. Stress, hypercortisolism and corticosteroid receptors in depression: Implications for therapy. J Affect Disord 62:77-91. (Pubitemid 32126613)
    • (2001) Journal of Affective Disorders , vol.62 , Issue.1-2 , pp. 77-91
    • Holsboer, F.1
  • 11
    • 28444469269 scopus 로고    scopus 로고
    • The effects of sex and hormonal status on the physiological response to acute psychosocial stress
    • DOI 10.1016/j.psyneuen.2005.07.002, PII S0306453005001691
    • Kajantie E, Phillips DI. 2006. The effects of sex and hormonal status on the physiological response to acute psychosocial stress. Psychoneuroendocrinology 31:151-178. (Pubitemid 41740438)
    • (2006) Psychoneuroendocrinology , vol.31 , Issue.2 , pp. 151-178
    • Kajantie, E.1    Phillips, D.I.W.2
  • 12
    • 35348916170 scopus 로고    scopus 로고
    • Gene expression signature in peripheral blood cells from medical students exposed to chronic psychological stress
    • DOI 10.1016/j.biopsycho.2007.07.008, PII S0301051107001172
    • Kawai T, Morita K, Masuda K, Nishida K, Shikishima M, Ohta M, Saito T, Rokutan K. 2007. Gene expression signature in peripheral blood cells from medical students exposed to chronic psychological stress. Biol Psychol 76:147-155. (Pubitemid 47575788)
    • (2007) Biological Psychology , vol.76 , Issue.3 , pp. 147-155
    • Kawai, T.1    Morita, K.2    Masuda, K.3    Nishida, K.4    Shikishima, M.5    Ohta, M.6    Saito, T.7    Rokutan, K.8
  • 14
    • 0034059955 scopus 로고    scopus 로고
    • A prospective study of neuroendocrine and immune alterations associated with the stress of an oral academic examination among graduate students
    • DOI 10.1016/S0306-4530(99)00059-1, PII S0306453099000591
    • Lacey K, Zaharia MD, Griffiths J, Ravindran AV, Merali Z, Anisman H. 2000. A prospective study of neuroendocrine and immune alterations associated with the stress of an oral academic examination among graduate students. Psychoneuroendocrinol-ogy 25:339-356. (Pubitemid 30138009)
    • (2000) Psychoneuroendocrinology , vol.25 , Issue.4 , pp. 339-356
    • Lacey, K.1    Zaharia, M.D.2    Griffiths, J.3    Ravindran, A.V.4    Merali, Z.5    Anisman, H.6
  • 16
    • 34247272941 scopus 로고    scopus 로고
    • Examination stress results in altered cardiovascular responses to acute challenge and lower cortisol
    • DOI 10.1016/j.psyneuen.2007.02.004, PII S0306453007000327
    • Loft P, Thomas MG, Petrie KJ, Booth RJ, MilesJ, Vedhara K.2007. Examination stress results in altered cardiovascular responses to acute challenge and lower cortisol. Psychoneuroendocrinology 32:367-375. (Pubitemid 46621208)
    • (2007) Psychoneuroendocrinology , vol.32 , Issue.4 , pp. 367-375
    • Loft, P.1    Thomas, M.G.2    Petrie, K.J.3    Booth, R.J.4    Miles, J.5    Vedhara, K.6
  • 17
    • 0032521829 scopus 로고    scopus 로고
    • Regulation of serotonin(1A), glucocorticoid, and mineralocorticoid receptor in rat and human hippocampus: Implications for the neurobiology of depression
    • DOI 10.1016/S0006-3223(97)00484-8, PII S0006322397004848
    • Lopez JF, Chalmers DT, Little KY, Watson SJ. 1998. A.E. bennett research award. Regulation of serotonin1A, glucocorticoid, and mineralocorticoid receptor in rat and human hippocampus: Implications for the neurobiology of depression. Biol Psychiatry 43:547-573. (Pubitemid 28198224)
    • (1998) Biological Psychiatry , vol.43 , Issue.8 , pp. 547-573
    • Lopez, J.F.1    Chalmers, D.T.2    Little, K.Y.3    Watson, S.J.4
  • 18
    • 20844437424 scopus 로고    scopus 로고
    • Translational regulatory mechanisms generate N-terminal glucocorticoid receptor isoforms with unique transcriptional target genes
    • DOI 10.1016/j.molcel.2005.03.025, PII S1097276505012189
    • Lu NZ, Cidlowski JA. 2005. Translational regulatory mechanisms generate N-terminal glucocorticoid receptor isoforms with unique transcriptional target genes. Mol Cell 18:331-342. (Pubitemid 41350538)
    • (2005) Molecular Cell , vol.18 , Issue.3 , pp. 331-342
    • Lu, N.Z.1    Cidlowski, J.A.2
  • 19
    • 0036150724 scopus 로고    scopus 로고
    • Hemodynamic and autonomic adjustments to real life stress conditions in humans
    • DOI 10.1161/hy0102.100784
    • Lucini D, Norbiato G, Clerici M, Pagani M. 2002. Hemodynamic and autonomic adjustments to real life stress conditions in humans. Hypertension 39:184-188. (Pubitemid 34098109)
    • (2002) Hypertension , vol.39 , Issue.1 , pp. 184-188
    • Lucini, D.1    Norbiato, G.2    Clerici, M.3    Pagani, M.4
  • 20
    • 67349157695 scopus 로고    scopus 로고
    • Effects of stress throughout the lifespan on the brain, behaviour and cognition
    • Lupien SJ, McEwen BS, Gunnar MR, Heim C. 2009. Effects of stress throughout the lifespan on the brain, behaviour and cognition. Nat Rev Neurosci 10:434-445.
    • (2009) Nat Rev Neurosci , vol.10 , pp. 434-445
    • Lupien, S.J.1    McEwen, B.S.2    Gunnar, M.R.3    Heim, C.4
  • 21
    • 0028989431 scopus 로고
    • Influence of academic stress and season on 24-hour mean concentrations of ACTH, cortisol, and beta-endorphin
    • Malarkey WB, Pearl DK, Demers LM, Kiecolt-Glaser JK, Glaser R. 1995. Influence of academic stress and season on 24-hour mean concentrations of ACTH, cortisol, and beta-endorphin. Psychoneuroendocrinology 20:499-508.
    • (1995) Psychoneuroendocrinology , vol.20 , pp. 499-508
    • Malarkey, W.B.1    Pearl, D.K.2    Demers, L.M.3    Kiecolt-Glaser, J.K.4    Glaser, R.5
  • 22
    • 33645346751 scopus 로고    scopus 로고
    • Reduced glucocorticoid receptor alpha expression in mood disorder patients and first-degree relatives
    • Matsubara T, Funato H, Kobayashi A, Nobumoto M, Watanabe Y. 2006. Reduced glucocorticoid receptor alpha expression in mood disorder patients and first-degree relatives. Biol Psychiatry 59:689-695.
    • (2006) Biol Psychiatry , vol.59 , pp. 689-695
    • Matsubara, T.1    Funato, H.2    Kobayashi, A.3    Nobumoto, M.4    Watanabe, Y.5
  • 23
    • 34447629382 scopus 로고    scopus 로고
    • Physiology and neurobiology of stress and adaptation: Central role of the brain
    • DOI 10.1152/physrev.00041.2006
    • McEwen BS. 2007. Physiology and neurobiology of stress and adaptation: Central role of the brain. Physiol Rev 87: 873-904. (Pubitemid 47086281)
    • (2007) Physiological Reviews , vol.87 , Issue.3 , pp. 873-904
    • McEwen, B.S.1
  • 24
    • 45549087318 scopus 로고    scopus 로고
    • Impact of stressors in a natural context on release of cortisol in healthy adult humans: A meta-analysis
    • DOI 10.1080/10253890701727874, PII 792011793
    • Michaud K, Matheson K, Kelly O, Anisman H. 2008. Impact of stressors in a natural context on release of cortisol in healthy adult humans: A meta-analysis. Stress 11:177-197. (Pubitemid 351874181)
    • (2008) Stress , vol.11 , Issue.3 , pp. 177-197
    • Michaud, K.1    Matheson, K.2    Kelly, O.3    Anisman, H.4
  • 25
    • 33645757077 scopus 로고    scopus 로고
    • Life stress and diminished expression of genes encoding glucocorticoid receptor and beta2-adrenergic receptor in children with asthma
    • Miller GE, Chen E. 2006. Life stress and diminished expression of genes encoding glucocorticoid receptor and beta2-adrenergic receptor in children with asthma. Proc Natl Acad Sci USA 103: 5496-5501.
    • (2006) Proc Natl Acad Sci USA , vol.103 , pp. 5496-5501
    • Miller, G.E.1    Chen, E.2
  • 27
    • 28344448244 scopus 로고    scopus 로고
    • Salivary biomarkers associated with academic assessment stress among dental undergraduates
    • Ng V, Koh D, Mok BY, Chia SE, Lim LP. 2003. Salivary biomarkers associated with academic assessment stress among dental undergraduates. J Dent Educ 67:1091-1094.
    • (2003) J Dent Educ , vol.67 , pp. 1091-1094
    • Ng, V.1    Koh, D.2    Mok, B.Y.3    Chia, S.E.4    Lim, L.P.5
  • 28
    • 0033600936 scopus 로고    scopus 로고
    • The dominant negative activity of the human glucocorti-coid receptor beta isoform. Specificity and mechanisms of action
    • Oakley RH, Jewell CM, Yudt MR, Bofetiado DM, Cidlowski JA. 1999. The dominant negative activity of the human glucocorti-coid receptor beta isoform. Specificity and mechanisms of action. J Biol Chem 274:27857-27866.
    • (1999) J Biol Chem , vol.274 , pp. 27857-27866
    • Oakley, R.H.1    Jewell, C.M.2    Yudt, M.R.3    Bofetiado, D.M.4    Cidlowski, J.A.5
  • 30
    • 0141431041 scopus 로고    scopus 로고
    • Quantification and glucocorticoid regulation of glucocorticoid receptor transcripts in two human leukemic cell lines
    • DOI 10.1021/bi034651u
    • Pedersen KB, Vedeckis WV. 2003. Quantification and glucocorti-coid regulation of glucocorticoid receptor transcripts in two human leukemic cell lines. Biochemistry 42:10978-10990. (Pubitemid 37174389)
    • (2003) Biochemistry , vol.42 , Issue.37 , pp. 10978-10990
    • Pedersen, K.B.1    Vedeckis, W.V.2
  • 31
    • 77951032927 scopus 로고    scopus 로고
    • The stressed student: Influence of written examinations and oral presentations on salivary cortisol concentrations in university students
    • Preuss D, Schoofs D, Schlotz W, Wolf OT. 2010. The stressed student: Influence of written examinations and oral presentations on salivary cortisol concentrations in university students. Stress 13:221-229.
    • (2010) Stress , vol.13 , pp. 221-229
    • Preuss, D.1    Schoofs, D.2    Schlotz, W.3    Wolf, O.T.4
  • 32
    • 4644292447 scopus 로고    scopus 로고
    • Stress, depression, the immune system, and cancer
    • DOI 10.1016/S1470-2045(04)01597-9, PII S1470204504015979
    • Reiche EM, Nunes SO, Morimoto HK. 2004. Stress, depression, the immune system, and cancer. Lancet Oncol 5:617-625. (Pubitemid 39303129)
    • (2004) Lancet Oncology , vol.5 , Issue.10 , pp. 617-625
    • Reiche, E.M.V.1    Nunes, S.O.V.2    Morimoto, H.K.3
  • 33
    • 30644459622 scopus 로고    scopus 로고
    • Stress and depression-induced immune dysfunction: Implications for the development and progression of cancer
    • DOI 10.1080/02646830500382102, PII Q22W0X191W5654N1
    • Reiche EM, Morimoto HK, Nunes SM. 2005. Stress and depression-induced immune dysfunction: Implications for the development and progression of cancer. Int Rev Psychiatry 17: 515-527. (Pubitemid 43086678)
    • (2005) International Review of Psychiatry , vol.17 , Issue.6 , pp. 515-527
    • Reiche, E.M.V.1    Morimoto, H.K.2    Nunes, S.O.V.3
  • 34
    • 0034454682 scopus 로고    scopus 로고
    • How do glucocorticoids influence stress responses? Integrating permissive, suppressive, stimulatory, and preparative actions
    • DOI 10.1210/er.21.1.55
    • Sapolsky RM, Romero LM, Munck AU. 2000. How do glucocorticoids influence stress responses? Integrating permissive, suppressive, stimulatory, and preparative actions. Endocr Rev 21:55-89. (Pubitemid 32266068)
    • (2000) Endocrine Reviews , vol.21 , Issue.1 , pp. 55-89
    • Sapolsky, R.M.1    Romero, L.M.2    Munck, A.U.3
  • 35
    • 37848999958 scopus 로고    scopus 로고
    • Neuroendocrine stress responses to an oral academic examination: No strong influence of sex, repeated participation and personality traits
    • Schoofs D, Hartmann R, Wolf OT. 2008. Neuroendocrine stress responses to an oral academic examination: No strong influence of sex, repeated participation and personality traits. Stress 11: 52-61.
    • (2008) Stress , vol.11 , pp. 52-61
    • Schoofs, D.1    Hartmann, R.2    Wolf, O.T.3
  • 36
    • 3042776968 scopus 로고    scopus 로고
    • Psychological stress and the human immune system: A meta-analytic study of 30 years of inquiry
    • DOI 10.1037/0033-2909.130.4.601
    • Segerstrom SC, Miller GE. 2004. Psychological stress and the human immune system: A meta-analytic study of 30 years of inquiry. Psychol Bull 130:601-630. (Pubitemid 38882638)
    • (2004) Psychological Bulletin , vol.130 , Issue.4 , pp. 601-630
    • Segerstrom, S.C.1    Miller, G.E.2
  • 40
    • 0346726016 scopus 로고    scopus 로고
    • Use and abuse of academic examinations in stress research
    • DOI 10.1097/01.PSY.0000097349.84109.1F
    • Stowell JR. 2003. Use and abuse of academic examinations in stress research. Psychosom Med 65:1055-1057. (Pubitemid 38057807)
    • (2003) Psychosomatic Medicine , vol.65 , Issue.6 , pp. 1055-1057
    • Stowell, J.R.1
  • 44
    • 33845775157 scopus 로고    scopus 로고
    • Examination stress as an ecological inducer of cortisol and psychological responses to stress in undergraduate students
    • DOI 10.1080/10253890601029751, PII U0152N7165728730
    • Weekes N, Lewis R, Patel F, Garrison-Jakel J, Berger DE, Lupien SJ. 2006. Examination stress as an ecological inducer of cortisol and psychological responses to stress in undergraduate students. Stress 9:199-206. (Pubitemid 46005631)
    • (2006) Stress , vol.9 , Issue.4 , pp. 199-206
    • Weekes, N.1    Lewis, R.2    Patel, F.3    Garrison-Jakel, J.4    Berger, D.E.5    Lupien, S.J.6
  • 45
    • 76549189227 scopus 로고
    • A self-rating depression scale
    • Zung WWK. 1965. A self-rating depression scale. Arch Gen Psychiatry 12:63-70.
    • (1965) Arch Gen Psychiatry , vol.12 , pp. 63-70
    • Zung, W.W.K.1


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