Functional increase of brain histaminergic signaling in Huntington's disease

Brain Pathology

Volumn 21, Issue 4, 2011, Pages 419-427

  Van Wamelen, Daniel J ^a,b   Shan, Ling ^a,c   Aziz, N Ahmad ^b   Anink, Jasper J ^a   Bao, Ai Min ^c   Roos, Raymund A C ^b   Swaab, Dick F ^a  

^a NETHERLANDS INSTITUTE FOR NEUROSCIENCE   (Netherlands)

^b LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

^c ZHEJIANG UNIVERSITY SCHOOL OF MEDICINE   (China)

Author keywords

histamine; histamine receptors; Huntington's disease; hypothalamus; in situ hybridization; post mortem

Indexed keywords

ANTIHISTAMINIC AGENT; HISTAMINE METHYLTRANSFERASE; HISTAMINE RECEPTOR; HISTAMINERGIC RECEPTOR AFFECTING AGENT; HISTIDINE DECARBOXYLASE; MESSENGER RNA;

ADULT; AGED; ARTICLE; BRAIN FUNCTION; CAG REPEAT; CAUDATE NUCLEUS; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; HUMAN; HUMAN TISSUE; HUNTINGTON CHOREA; HYPOTHALAMUS NUCLEUS; INFERIOR FRONTAL GYRUS; MALE; NERVE CELL; NUCLEOTIDE SEQUENCE; ONSET AGE; PROTEIN BLOOD LEVEL; REAL TIME POLYMERASE CHAIN REACTION; TUBEROMAMMILLARY NUCLEUS;

BRAIN; CELL COUNT; FEMALE; HISTAMINE; HISTAMINE N-METHYLTRANSFERASE; HISTIDINE DECARBOXYLASE; HUMANS; HUNTINGTON DISEASE; IN SITU HYBRIDIZATION; MALE; MIDDLE AGED; NEURONS; RECEPTORS, HISTAMINE; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; SIGNAL TRANSDUCTION;

EID: 79958853372     PISSN: 10156305     EISSN: 17503639     Source Type: Journal    
DOI: 10.1111/j.1750-3639.2010.00465.x     Document Type: Article

References (39)

1. Airaksinen MS, Reinikainen K, Riekkinen P, Panula P, (1991) Histamine neurons in human hypothalamus: anatomy in normal and Alzheimer diseased brains. Neuroscience 44: 465-481.
2. Altschul SF, Gish W, Miller W, Myers EW, Lipman DJ, (1990) Basic local alignment search tool. J Mol Biol 215: 403-410.
3. André VM, Cepeda C, Levine MS, (2010) Dopamine and glutamate in Huntington's disease: a balancing act. CNS Neurosci Ther 16: 163-178.
4. Anichtchik OV, Rinne JO, Kalimo H, Panula P, (2000) An altered histaminergic innervation of the substantia nigra in Parkinson's disease. Exp Neurol 163: 20-30. (Pubitemid 30314356)
5. Aziz A, Fronczek R, Maat-Schieman M, Unmehopa U, Roelandse F, Overeem S, et al, (2008) Hypocretin and melanin-concentrating hormone in patients with Huntington disease. Brain Pathol 18: 474-483.
6. Aziz NA, Swaab DF, Pijl H, Roos RA, (2007) Hypothalamic dysfunction and neuroendocrine and metabolic alterations in Huntington's disease: clinical consequences and therapeutic implications. Rev Neurosci 18: 223-251.
7. Aziz NA, Pijl H, Frölich M, van der Graaf AW, Roelfsema F, Roos RA, (2009) Increased hypothalamic-pituitary-adrenal axis activity in Huntington's disease. J Clin Endocrinol Metab 94: 1223-1228.
8. Björkqvist M, Petersén A, Nielsen J, Ecker D, Mulder H, Hayden MR, et al, (2006) Cerebrospinal fluid levels of orexin-A are not a clinically useful biomarker for Huntington disease. Clin Genet 70: 78-79. (Pubitemid 44192741)
9. Bossers K, Meerhoff G, Balesar R, van Dongen JW, Kruse CG, Swaab DF, Verhagen J, (2009) Analysis of gene expression in Parkinson's disease: possible involvement of neurotrophic support and axon guidance in dopaminergic cell death. Brain Pathol 19: 91-107.
10. Brown RE, Stevens DR, Haas HL, (2001) The physiology of brain histamine. Prog Neurobiol 63: 637-672. (Pubitemid 32119421)
11. de la Monte SM, Vonsattel JP, Richardsen EP, (1988) Morphometric demonstration of atrophic changes in the cerebral cortex, white matter, and neostriatum in Huntington's disease. J Neuropathol Exp Neurol 47: 516-525.
12. Dere E, Zlomuzica A, De Souza Silva MA, Ruocco LA, Sadile AG, Huston JP, (2010) Neuronal histamine and the interplay of memory, reinforcement and emotions. Behav Brain Res 215: 209-220.
13. Eriksson KS, Sergeeva O, Brown RE, Haas HL, (2001) Orexin/hypocretin excites the histaminergic neurons of the tuberomammillary nucleus. J Neurosci 21: 9273-9279. (Pubitemid 33096871)
14. Fleige S, Pfaffl MW, (2006) RNA integrity and the effect on the real-time qRT-PCR performance. Mol Aspects Med 27: 126-139.
15. Fliers E, Guldenaar SEF, Wiersinga WM, Swaab DF, (1997) Decreased hypothalamic thyrotropin-releasing hormone gene expression in patients with nonthyroidal illness. J Clin Endocrinol Metab 82: 4032-4036. (Pubitemid 27525507)
16. Goncharuk VD, van Heerikhuize J, Swaab DF, Buijs RM, (2002) Paraventricular nucleus of the human hypothalamus in primary hypertension: activation of corticotropin-releasing hormone neurons. J Comp Neurol 443: 321-331. (Pubitemid 34101316)
17. Goodchild RE, Court JA, Hobson I, Piggott MA, Perry RH, Ince P, et al, (1999) Distribution of histamine H3-receptor binding in the normal human basal ganglia: comparison with Huntington's and Parkinson's disease cases. Eur J Neurosci 11: 449-456. (Pubitemid 29050447)
18. Haas HL, Sergeeva OA, Selbach O, (2008) Histamine in the nervous system. Physiol Rev 88: 1183-1241.
19. Heinsen H, Strik M, Bauer M, Luther K, Ulmar G, Gangnus D, et al, (1994) Cortical and striatal neurone number in Huntington's disease. Acta Neuropathol 88: 320-333. (Pubitemid 24309396)
20. Hodges A, Strand AD, Aragaki AK, Kuhn A, Sengstag T, Hughes G, et al, (2006) Regional and cellular gene expression changes in human Huntington's disease brain. Hum Mol Genet 15: 965-977. (Pubitemid 43338237)
21. Liu CQ, Chen Z, Liu FX, Hu DN, Luo JH, (2007) Involvement of brain endogenous histamine in the degeneration of dopaminergic neurons in 6-hydroxydopamine-lesioned rats. Neuropharmacology 53: 32-41.
22. Liu CQ, Shan L, Balesar R, Luchetti S, van Heerikhuize J, Luo JH, et al, (2010) A quantitative in situ hybridization protocol for formalin-fixed paraffin-embedded archival post-mortem human brain tissue. Methods 52: 359-366.
23. Martínez-Mir I, Herrero J, Estañ L, Morales-Olivas FJ, Rubio E, (1993) Loss of striatal histamine H2 receptors in Huntington's chorea but not in Parkinson's disease: comparison with animal models. Synapse 15: 209-220.
24. Morton AJ, Wood NI, Hastings MH, Hurelbrink C, Barker RA, Maywood ES, (2005) Disintegration of the sleep-wake cycle and circadian timing in Huntington's disease. J Neurosci 25: 157-163. (Pubitemid 40110776)
25. Petersén A, Gil J, Maat-Schieman ML, Björkqvist M, Tanila H, Araujo IM, et al, (2005) Orexin loss in Huntington's disease. Hum Mol Genet 14: 39-47. (Pubitemid 40123461)
26. Phillips W, Shannon KM, Barker RA, (2008) The current clinical management of Huntington's disease. Mov Disord 23: 1491-1504.
27. Politis M, Pavese N, Tai YF, Tabrizi SJ, Barker RA, Piccini P, (2008) Hypothalamic involvement in Huntington's disease: an in vivo PET study. Brain 131 (Pt 11): 2860-2869.
28. Prell GD, Green JP, (1991) Histamine metabolites and pros- methylimidazoleacetic acid in human cerebrospinal fluid. Agents Actions Suppl 33: 343-363.
29. Rinne JO, Anichtchik OV, Eriksson KS, Kaslin J, Tuomisto L, Kalimo H, et al, (2002) Increased brain histamine levels in Parkinson's disease but not in multiple system atrophy. J Neurochem 81: 954-960. (Pubitemid 34811944)
30. Sotrel A, Paskevich PA, Kiely DK, Bird ED, Williams RS, Myers RH, (1991) Morphometric analysis of the prefrontal cortex in Huntington's disease. Neurology 41: 1117-1123.
31. Terao A, Steiniger TL, Morairty SR, Kilduff TS, (2004) Age-related changes in histamine receptor mRNA levels in the mouse brain. Neurosci Lett 355: 81-84. (Pubitemid 38077190)
32. Verwer RW, Raber-Durlacher JE, (1993) Efficient and unbiased estimation of volume and area of tissue components and cell number in gingival biopsies. J Periodontal Res 28: 313-323.
33. Vizuete ML, Merino M, Venero JL, Santiago M, Cano J, Machado A, (2000) Histamine infusion induces a selective dopaminergic neuronal death along with an inflammatory reaction in rat substantia nigra. J Neurochem 75: 540-552. (Pubitemid 30485435)
34. Vonsattel JP, Myers RH, Stevens TJ, Ferrante RJ, Bird ED, Richardson EP Jr, (1985) Neuropathological classification of Huntington's disease. J Neuropathol Exp Neurol 44: 559-577. (Pubitemid 16196286)
35. Wang SS, Kamphuis W, Huitinga I, Zhou JN, Swaab DF, (2008) Gene expression analysis in the human hypothalamus in depression by laser microdissection and real-time PCR: the presence of multiple receptor imbalances. Mol Psychiatry 13: 786-799.
36. Watanabe T, Taguchi Y, Shiosaka S, Tanaka J, Kubota H, Terano Y, et al, (1984) Distribution of the histaminergic neuron system in the central nervous system of rats: a fluorescent immunohistochemical analysis with histidine decarboxylase as a marker. Brain Res 295: 13-25. (Pubitemid 14155851)
37. Whitehouse PJ, Trifiletti RR, Jones BE, Folstein S, Price DL, Snyder SH, Kuhar MJ, (1985) Neurotransmitters receptor alterations in Huntington's disease: autoradiographic and homogenate studies with special reference to benzodiazepine receptor complexes. Ann Neurol 18: 202-210. (Pubitemid 15004891)
38. Yamanaka T, Tosaki A, Miyazaki H, Kurosawa M, Furukawa Y, Yamada M, et al, (2010) Mutant huntingtin fragment selectively suppresses Brn-2 POU domain transcription factor to mediate hypothalamic cell dysfunction. Hum Mol Genet 19: 2099-2112.
39. Zahnow CA, Panula P, Yamatodani A, Millhorn DE, (1998) Glucocorticoid hormones downregulate histidine decarboxylase mRNA and enzyme activity in rat lung. Am J Physiol 275 (2 Pt 1): L407-L413.