Conformational folding and stability of the HET-C2 glycolipid transfer protein fold: Does a molten globule-like state regulate activity?

Biochemistry

Volumn 50, Issue 23, 2011, Pages 5163-5171

  Kenoth, Roopa ^a   Kamlekar, Ravi Kanth ^a   Simanshu, Dhirendra K ^b   Gao, Yongguang ^a   Malinina, Lucy ^c   Prendergast, Franklyn G ^d   Molotkovsky, Julian G ^e   Patel, Dinshaw J ^b   Venyaminov, Sergei Y ^d   Brown, Rhoderick E ^a  

^a UNIVERSITY OF MINNESOTA   (United States)

^b MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

^c CIC BIOGUNE   (Spain)

^d Mayo Clinic   (United States)

^e SHEMYAKIN OVCHINNIKOV INSTITUTE OF BIOORGANIC CHEMISTRY   (Russian Federation)

Author keywords

[No Author keywords available]

Indexed keywords

ADJACENT CHAINS; CATION INTERACTIONS; CONFORMATIONAL FOLDING; CONFORMATIONAL STATE; CRYSTALLOGRAPHIC STRUCTURE; DISULFIDE BRIDGE; EMISSION WAVELENGTH; FLUORESCENCE PROPERTIES; GLYCO LIPIDS; GLYCOLIPID TRANSFER PROTEINS; HISTIDINE RESIDUES; INTERMEMBRANE TRANSFER; INTRINSIC TRYPTOPHAN FLUORESCENCES; LIPID BINDING; LOCAL POSITIONING; MOLAR ELLIPTICITY; RESONANCE ENERGY TRANSFER; REVERSIBLE INTERACTIONS; SALT BRIDGES; SEQUENCE HOMOLOGY; SIDE-CHAIN INTERACTIONS; SIDE-CHAINS; TRYPTOPHAN RESIDUES;

AMINO ACIDS; COVALENT BONDS; DICHROISM; ENERGY TRANSFER; FLUORESCENCE; PH EFFECTS; PROTEIN FOLDING; PROTEINS;

STABILITY;

DISULFIDE; LIPID TRANSFER PROTEIN; PROTEIN HET C2; TRYPTOPHAN; TYROSINE; UNCLASSIFIED DRUG;

ARTICLE; CIRCULAR DICHROISM; FLUORESCENCE; PH; PODOSPORA ANSERINA; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN CONFORMATION; PROTEIN EXPRESSION; PROTEIN FOLDING; PROTEIN INDUCTION; PROTEIN INTERACTION; PROTEIN STABILITY; PROTEIN STRUCTURE; STATIC ELECTRICITY;

CARRIER PROTEINS; FUNGAL PROTEINS; GLYCOLIPIDS; HUMANS; HYDROGEN-ION CONCENTRATION; PROTEIN FOLDING; TRYPTOPHAN;

PODOSPORA ANSERINA;

EID: 79958852717     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/bi200382c     Document Type: Article

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