Teneurin C-terminal associated peptide (TCAP)-1 modulates dendritic morphology in hippocampal neurons and decreases anxiety-like behaviors in rats

Physiology and Behavior

Volumn 104, Issue 2, 2011, Pages 199-204

  Tan, Laura A ^a   Al Chawaf, Arij ^a   Vaccarino, Franco J ^a   Boutros, Paul C ^b   Lovejoy, David A ^a  

^a UNIVERSITY OF TORONTO   (Canada)

^b ONTARIO INSTITUTE FOR CANCER RESEARCH   (Canada)

Author keywords

Amygdala; Anxiety; Dendritic morphology; Hippocampus; Spine density; Teneurin C terminal associated peptide

Indexed keywords

CARBOXY TERMINAL TELOPEPTIDE; TENEURIN C TERMINAL ASSOCIATED PEPTIDE 1; UNCLASSIFIED DRUG;

AMYGDALOID NUCLEUS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANXIETY; ARTICLE; CONTROLLED STUDY; DENDRITIC SPINE; ELEVATED PLUS MAZE; HIPPOCAMPAL CA1 REGION; HIPPOCAMPAL CA3 REGION; MALE; MAZE TEST; NERVE CELL DIFFERENTIATION; NONHUMAN; PRIORITY JOURNAL; RAT;

ANALYSIS OF VARIANCE; ANIMALS; ANXIETY; BEHAVIOR, ANIMAL; DENDRITES; DENDRITIC SPINES; DISEASE MODELS, ANIMAL; HIPPOCAMPUS; INJECTIONS, INTRAVENTRICULAR; MALE; MAZE LEARNING; NERVE TISSUE PROTEINS; NEURONS; RATS; RATS, WISTAR; SILVER STAINING; TENASCIN; TIME FACTORS;

EID: 79958849279     PISSN: 00319384     EISSN: 1873507X     Source Type: Journal    
DOI: 10.1016/j.physbeh.2011.03.015     Document Type: Article

References (33)

1. Qian X., Barsyte-Lovejoy D., Wang L., Chewpoy B., Gautum N., Al Chawaf A., et al. Cloning and characterization of teneurin C-terminus associated peptide (TCAP)-3 from the hypothalamus of an adult rainbow trout (Oncorhynchus mykiss). Gen Comp Endocrinol 2004, 137:205-216.
2. Wang L., Rotzinger S., Al Chawaf A., Elias C.F., Barsyte-Lovejoy D., Qian X., et al. Teneurin proteins possess a carboxy terminal sequence with neuromodulatory activity. Brain Res Mol Brain Res 2005, 133:253-265.
3. Trubiani G., Al Chawaf A., Belsham D.D., Barsyte-Lovejoy D., Lovejoy D.A. Teneurin carboxy (C)-terminal associated peptide-1 inhibits alkalosis-associated necrotic neuronal death by stimulating superoxide dismutase and catalase activity in immortalized mouse hypothalamic cells. Brain Res 2007, 1176:27-36.
4. Tan L.A., Xu K., Vaccarino F.J., Lovejoy D.A., Rotzinger S. Teneurin C-terminal associated peptide (TCAP)-1 attenuates corticotropin-releasing factor (CRF)-induced c-Fos expression in the limbic system and modulates anxiety behavior in male Wistar rats. Behav Brain Res 2009, 201:198-206.
5. Tan L.A., Xu K., Vaccarino F.J., Lovejoy D.A., Rotzinger S. Repeated intracerebral teneurin C-terminal associated peptide (TCAP)-1 injections produce enduring changes in behavioral responses to corticotropin-releasing factor (CRF) in rat models of anxiety. Behav Brain Res 2008, 188:195-200.
6. Kupferschmidt D.A., Lovejoy D.A., Rotzinger S., Erb S. Teneurin C-terminal associated peptide (TCAP)-1 blocks the effects of corticotropin-releasing factor on reinstatement of cocaine seeking and on cocaine-induced behavioural sensitization. Br J Pharmacol 2011, 162:574-583.
7. Al Chawaf A., Xu K., Tan L., Vaccarino F.J., Lovejoy D.A., Rotzinger S. Corticotropin-releasing factor (CRF)-induced behaviors are modulated by intravenous administration of teneurin C-terminal associated peptide-1 (TCAP-1). Peptides 2007, 28:1406-1415.
8. Jacobson L., Sapolsky R. The role of the hippocampus in feedback regulation of the hypothalamic-pituitary-adrenocortical axis. Endocr Rev 1991, 12:118-134.
9. Herman J.P., Figueiredo H., Mueller N.K., Ulrich-Lai Y., Ostrander M.M., Choi D.C., et al. Central mechanisms of stress integration: hierarchical circuitry controlling hypothalamo-pituitary-adrenocortical responsiveness. Front Neuroendocrinol 2003, 24:151-180.
10. Herman J.P., Ostrander M.M., Mueller N.K., Figueiredo H. Limbic system mechanisms of stress regulation: hypothalamo-pituitary-adrenocortical axis. Prog Neuropsychopharmacol Biol Psychiatry 2005, 29:1201-1213.
11. Watanabe Y., Gould E., McEwen B.S. Stress induces atrophy of apical dendrites of hippocampal CA3 pyramidal neurons. Brain Res 1992, 588:341-345.
12. Magarinos A.M., McEwen B.S., Flugge G., Fuchs E. Chronic psychosocial stress causes apical dendritic atrophy of hippocampal CA3 pyramidal neurons in subordinate tree shrews. J Neurosci 1996, 16:3534-3540.
13. Mahajan D.S., Desiraju T. Alterations of dendritic branching and spine densities of hippocampal CA3 pyramidal neurons induced by operant conditioning in the phase of brain growth spurt. Exp Neurol 1988, 100:1-15.
14. Dalla C., Whetstone A.S., Hodes G.E., Shors T.J. Stressful experience has opposite effects on dendritic spines in the hippocampus of cycling versus masculinized females. Neurosci Lett 2009, 449:52-56.
15. Shors T.J., Chua C., Falduto J. Sex differences and opposite effects of stress on dendritic spine density in the male versus female hippocampus. J Neurosci 2001, 21:6292-6297.
16. Mitra R., Jadhav S., McEwen B.S., Vyas A., Chattarji S. Stress duration modulates the spatiotemporal patterns of spine formation in the basolateral amygdala. Proc Natl Acad Sci U S A 2005, 102:9371-9376.
17. Vyas A., Jadhav S., Chattarji S. Prolonged behavioral stress enhances synaptic connectivity in the basolateral amygdala. Neuroscience 2006, 143:387-393.
18. Tada T., Sheng M. Molecular mechanisms of dendritic spine morphogenesis. Curr Opin Neurobiol 2006, 16:95-101.
19. Gu J., Firestein B.L., Zheng J.Q. Microtubules in dendritic spine development. J Neurosci 2008, 28:12120-12124.
20. Al Chawaf A., St Amant K., Belsham D., Lovejoy D.A. Regulation of neurite growth in immortalized mouse hypothalamic neurons and rat hippocampal primary cultures by teneurin C-terminal-associated peptide-1. Neuroscience 2007, 144:1241-1254.
21. Paxinos G., Watson C. The rat brain in stereotaxic coordinates 1998, Academic Press, Toronto. 4th ed.
22. Sholl D.A. Dendritic organization in the neurons of the visual and motor cortices of the cat. J Anat 1953, 87:387-406.
23. Amaral D.G., Lavenex P. Hippocampal Neuroanatomy. The hippocampus book 2007, 37-114. Oxford University Press, New York. P. Anderson, R. Morris, D.G. Amaral, T. Bliss, J. O'Keefe (Eds.).
24. Knowles W.D. Normal anatomy and neurophysiology of the hippocampal formation. J Clin Neurophysiol 1992, 9:252-263.
25. Radley J.J., Morrison J.H. Repeated stress and structural plasticity in the brain. Ageing Res Rev 2005, 4:271-287.
26. Bourne J.N., Harris K.M. Balancing structure and function at hippocampal dendritic spines. Annu Rev Neurosci 2008, 31:47-67.
27. Hotulainen P., Hoogenraad C.C. Actin in dendritic spines: connecting dynamics to function. J Cell Biol 2010, 189:619-629.
28. Soetanto A., Wilson R.S., Talbot K., Un A., Schneider J.A., Sobiesk M., Kelly J., Leurgans S., Bennett D.A., Arnold S.E. Association of anxiety and depression with microtubule-associated protein 2- and synaptopodin-immunolabeled dendrite and spine densities in hippocampal CA3 of older humans. Arch Gen Psychiatry 2010, 67:448-457.
29. Xu H., He J., Richardson J.S., Li X.M. The response of synaptophysin and microtubule-associated protein 1 to restraint stress in rat hippocampus and its modulation by venlafaxine. J Neurochem 2004, 91:1380-1388.
30. Treit D., Menard J., Royan C. Anxiogenic stimuli in the elevated plus-maze. Pharmacol Biochem Behav 1993, 44:463-469.
31. Pellow S., File S.E. Anxiolytic and anxiogenic drug effects on exploratory activity in an elevated plus-maze: a novel test of anxiety in the rat. Pharmacol Biochem Behav 1986, 24:525-529.
32. Rodgers R.J., Dalvi A. Anxiety, defence and the elevated plus-maze. Neurosci Biobehav Rev 1997, 21:801-810.
33. Hajszan T., Szigeti-Buck K., Sallam N.L., Bober J., Parducz A., Maclusky N.J., et al. Effects of estradiol on learned helplessness and associated remodeling of hippocampal spine synapses in female rats. Biol Psychiatry 2010, 67:168-174.