Will stem cell therapies be safe and effective for treating spinal cord injuries?

British Medical Bulletin

Volumn 98, Issue 1, 2011, Pages 127-142

  Thomas, Katharine E ^a   Moon, Lawrence D F ^a  

^a KING'S COLLEGE LONDON   (United Kingdom)

Author keywords

endogenous; Geron; paralysis; spinal cord injury; stem cells; transplant

Indexed keywords

ARTICLE; CELL DIFFERENTIATION; CELL SURVIVAL; CELL TYPE; CLINICAL EFFECTIVENESS; CONVALESCENCE; COST BENEFIT ANALYSIS; DISEASE MODEL; EMBRYONIC STEM CELL; GLIA CELL; GRIP STRENGTH; HEMATOPOIETIC STEM CELL; HUMAN; INJURY SEVERITY; NERVE CELL PLASTICITY; NERVE FIBER; NERVE SPROUTING; NERVOUS SYSTEM DEVELOPMENT; NONHUMAN; OLIGODENDROGLIA; OUTCOME ASSESSMENT; PARAPLEGIA; PATIENT SAFETY; PHASE 1 CLINICAL TRIAL (TOPIC); PHASE 2 CLINICAL TRIAL (TOPIC); PHASE 3 CLINICAL TRIAL (TOPIC); PHYSICAL DISABILITY; PRIORITY JOURNAL; PYRAMIDAL TRACT; QUADRIPLEGIA; REMYELINIZATION; SCHWANN CELL; SPINAL CORD INJURY; STEM CELL TRANSPLANTATION; THORAX INJURY; TISSUE PRESERVATION;

ANIMALS; CLINICAL TRIALS AS TOPIC; DISEASE MODELS, ANIMAL; HUMANS; OLIGODENDROGLIA; PRIMATES; RATS; RECOVERY OF FUNCTION; SPINAL CORD INJURIES; STEM CELL TRANSPLANTATION;

EID: 79958841988     PISSN: 00071420     EISSN: 14718391     Source Type: Journal    
DOI: 10.1093/bmb/ldr013     Document Type: Article

References (37)

1. Steeves JD, Fawcett JW, Tuszynski MH et al. Experimental treatments for spinal cord injury: what you should know if you are considering participation in a clinical trial, 2007. www. spinalresearch.org/downloads/Experimental- treatment-for-SCI.pdf (1 May 2011, date last accessed.)
2. Thuret S, Moon LD, Gage FH. Therapeutic interventions after spinal cord injury. Nat Rev Neurosci 2006;7:628-43. (Pubitemid 44106745)
3. Fawcett JW, Curt A, Steeves JD et al. Guidelines for the conduct of clinical trials for spinal cord injury as developed by the ICCP panel: spontaneous recovery after spinal cord injury and statistical power needed for therapeutic clinical trials. Spinal Cord 2007;45:190-205. (Pubitemid 46340848)
4. Crowe MJ, Bresnahan JC, Shuman SL et al. Apoptosis and delayed degeneration after spinal cord injury in rats and monkeys. Nat Med 1997;3:73-76. (Pubitemid 27019144)
5. Hooshmand MJ, Sontag CJ, Uchida N et al. Analysis of host-mediated repair mechanisms after human CNS-stem cell transplantation for spinal cord injury: correlation of engraftment with recovery. PLoS ONE 2009;4:e5871.
6. Guest JD, Hiester ED, Bunge RP. Demyelination and Schwann cell responses adjacent to injury epicenter cavities following chronic human spinal cord injury. Exp Neurol 2005;192:384-93. (Pubitemid 40341683)
7. Totoiu MO, Keirstead HS. Spinal cord injury is accompanied by chronic progressive demyelination. J Comp Neurol 2005;486:373-83. (Pubitemid 40605041)
8. Kim K, Doi A, Wen B et al. Epigenetic memory in induced pluripotent stem cells. Nature 2010;467:285-90.
9. Amariglio N, Hirshberg A, Scheithauer BW et al. Donor-derived brain tumor following neural stem cell transplantation in an ataxia telangiectasia patient. PLoS Med 2009;6:e1000029.
10. Miura K, Okada Y, Aoi T et al. Variation in the safety of induced pluripotent stem cell lines. Nat Biotechnol 2009;27:743-5.
11. Tsuji O, Miura K, Okada Y et al. Therapeutic potential of appropriately evaluated safeinduced pluripotent stem cells for spinal cord injury. Proc Natl Acad Sci USA 2010;107:12704-9.
12. Hofstetter CP, Holmstrom NA, Lilja JA et al. Allodynia limits the usefulness of intraspinal neural stem cell grafts; directed differentiation improves outcome. Nat Neurosci 2005;8:346-53. (Pubitemid 40300192)
13. Keirstead HS, Nistor G, Bernal G et al. Human embryonic stem cell-derived oligodendrocyte progenitor cell transplants remyelinate and restore locomotion after spinal cord injury. J Neurosci 2005;25:4694-705. (Pubitemid 40664118)
14. Salazar DL, Uchida N, Hamers FP et al. Human neural stem cells differentiate and promote locomotor recovery in an early chronic spinal cord injury NOD-scid mouse model. PLoS ONE 2010;5:e12272.
15. Sharp K, Flanagan L, Yee KM et al. A re-assessment of a combinatorial treatment involving Schwann cell transplants and elevation of cyclic AMP on recovery of motor function following thoracic spinal cord injury in rats. Exp Neurol 2010. 10.1016/j.expneurol.2010.12.020.
16. Steward O, Sharp K, Yee KM et al. A re-assessment of the effects of a Nogo-66 receptor antagonist on regenerative growth of axons and locomotor recovery after spinal cord injury in mice. Exp Neurol 2008;209:446-68.
17. Steward O, Sharp K, Selvan G et al. A re-assessment of the consequences of delayed transplantation of olfactory lamina propria following complete spinal cord transection in rats. Exp Neurol 2006;198:483-99.
18. Pinzon A, Marcillo A, Quintana A et al. A re-assessment of minocycline as a neuroprotective agent in a rat spinal cord contusion model. Brain Res 2008;1243:146-51.
19. Pinzon A, Marcillo A, Pabon D et al. A re-assessment of erythropoietin as a neuroprotective agent following rat spinal cord compression or contusion injury. Exp Neurol 2008;213:129-36.
20. Kilkenny C, Browne WJ, Cuthill IC et al. Improving bioscience research reporting: the ARRIVE guidelines for reporting animal research. PLoS Biol 2010;8:e1000412.
21. Kilkenny C, Parsons N, Kadyszewski E et al. Survey of the quality of experimental design, statistical analysis and reporting of research using animals. PLoS ONE 2009;4:e7824.
22. Cummings BJ, Uchida N, Tamaki SJ et al. Human neural stem cells differentiate and promote locomotor recovery in spinal cord-injured mice. Proc Natl Acad Sci USA 2005;102:14069-74. (Pubitemid 41377704)
23. Hill CE, Moon LD, Wood PM et al. Labeled Schwann cell transplantation: cell loss, host Schwann cell replacement, and strategies to enhance survival. Glia 2006;53:338-43. (Pubitemid 43221355)
24. Lemon RN. Descending pathways in motor control. Ann Rev Neurosci 2008;31:195-218.
25. Rosenzweig ES, Courtine G, Jindrich DL et al. Extensive spontaneous plasticity of corticospinal projections after primate spinal cord injury. Nat Neurosci 2010;13:1505-10.
26. Wolf DP. Nonhuman primate embryonic stem cells: an underutilized resource. Regen Med 2008;3:129-31. (Pubitemid 351546455)
27. Iwanami A, Kaneko S, Nakamura M et al. Transplantation of human neural stem cells for spinal cord injury in primates. J Neurosci Res 2005;80:182-90. (Pubitemid 40676302)
28. Yamane J, Nakamura M, Iwanami A et al. Transplantation of galectin-1-expressing human neural stem cells into the injured spinal cord of adult common marmosets. J Neurosci Res 2010;88:1394-405.
29. Hyun JK, Kim HW. Clinical and experimental advances in regeneration of spinal cord injury. J Tissue Eng 2010;2010:650857.
30. Wirth ED III, Reier PJ, Fessler RG et al. Feasibility and safety of neural tissue transplantation in patients with syringomyelia. J Neurotrauma 2001;18:911-29. (Pubitemid 32852892)
31. Dobkin BH, Curt A, Guest J. Cellular transplants in China: observational study from the largest human experiment in chronic spinal cord injury. Neurorehabil Neural Repair 2006;20:5-13. (Pubitemid 43214453)
32. Cyranoski D. Chinese network to start trials of spinal surgery. Nature 2007;446:476-7. (Pubitemid 46514701)
33. Cyranoski D. Stem-cell therapy faces more scrutiny in China. Nature 2009;459:146-7.
34. Cloutier F, Siegenthaler MM, Nistor G et al. Transplantation of human embryonic stem cellderived oligodendrocyte progenitors into rat spinal cord injuries does not cause harm. Regen Med 2006;1:469-79.
35. Sharp J, Frame J, Siegenthaler M et al. Human embryonic stem cell-derived oligodendrocyte progenitor cell transplants improve recovery after cervical spinal cord injury. Stem Cells 2010;28:152-63.
36. Baker M. Tumours spark stem-cell review. Nature 2009;457:941.
37. Cummings BJ, Uchida N, Tamaki SJ et al. Human neural stem cell differentiation following transplantation into spinal cord injured mice: association with recovery of locomotor function. Neurol Res 2006;28:474-81. (Pubitemid 44141313)