Steroid therapy may be effective in augmenting hemoglobin levels during hemolytic crises in children with hereditary spherocytosis

Pediatric Blood and Cancer

Volumn 57, Issue 2, 2011, Pages 303-305

  Ballin, Ami ^a,b   Waisbourd Zinman, Orit ^c   Saab, Hitam ^d   Yacobovich, Joanne ^c   Zoldan, Meirah ^c   Barzilai Birenbaum, Shlomit ^c   Yaniv, Isaac ^b,c   Tamary, Hannah ^b,c  

^a WOLFSON MEDICAL CENTER   (Israel)

^b TEL AVIV UNIVERSITY   (Israel)

^c SCHNEIDER CHILDREN S MEDICAL CENTER OF ISRAEL   (Israel)

^d BNAI ZION MEDICAL CENTER   (Israel)

Author keywords

Hereditary spherocytosis; Steroids; Therapy

Indexed keywords

HEMOGLOBIN; PREDNISOLONE;

ARTICLE; CHILD; CHILDHOOD DISEASE; DISEASE SEVERITY; DRUG EFFICACY; DRUG TREATMENT FAILURE; ERYTHROCYTE CONCENTRATE; ERYTHROCYTE TRANSFUSION; FEMALE; HEMOGLOBIN BLOOD LEVEL; HEMOLYSIS; HEREDITARY SPHEROCYTOSIS; HUMAN; IN VITRO STUDY; LOW DRUG DOSE; MAJOR CLINICAL STUDY; MALE; OUTCOME ASSESSMENT; PRESCHOOL CHILD; PRIORITY JOURNAL; STEROID THERAPY; TREATMENT DURATION;

CHILD; CHILD, PRESCHOOL; ERYTHROCYTE TRANSFUSION; ERYTHROPOIETIN; FEMALE; GLUCOCORTICOIDS; HEMOGLOBINS; HUMANS; LOGISTIC MODELS; MALE; MULTIVARIATE ANALYSIS; OSMOTIC FRAGILITY; PREDNISONE; RETROSPECTIVE STUDIES; SPHEROCYTOSIS, HEREDITARY;

EID: 79958839955     PISSN: 15455009     EISSN: 15455017     Source Type: Journal    
DOI: 10.1002/pbc.22844     Document Type: Article

References (8)

1. Grace RF, Lux SE. Disorders of red cell membrane. In: Nathan DG, Orkin SH, Look T, Ginsburg MD, editors. Nathan and Oski's hematology of infancy and childhood, 7th edition. Philadelphia: WB Saunders; 2009. p. 659.
2. Christensen RD, Henry E. Hereditary spherocytosis in neonates with hyperbilirubinemia. Pediatrics 2010; 125(1): 120-125.
3. Schilling RF. Risks and benefits of splenectomy versus no splenectomy for hereditary spherocytosis-A personal view. Br J Haematology 2009; 145(6): 728-732.
4. Coleman DH, Finch CA. The effect of adrenal steroids in hereditary spherocytic anemia. J Lab Clin Med 1956; 47: 602-610.
5. Roper D, Layton M. Investigation of the hereditary haemolytic anemias: Membrane and enzyme abnormalities. In: Lewis SM, Bain BJ, Bates I, editors. Dacie and Lewis practical haematology, 10th edition. London: Churchill Livingstone Elsevier; 2006. p. 206.
6. Duru F, Gurgey A. Effect of corticosteroids in hereditary spherocytosis. Acta Paediatr Jpn 1994; 36: 666-668.
7. Streuli RA, Kanofsky JR, Gunn RB, Yachnin S. Diminished osmotic fragility of human erythrocytes following the membrane insertion of oxygenated sterol compounds. Blood 1981; 58: 317-325.
8. Morley AA. The effect of cortisol on the rate of autohemolysis of red cells incubated in vitro. Br J Haematol 1967; 13: 310-316.