Risk of window period hepatitis-C infection in high infectious risk donors: Systematic review and meta-analysis

American Journal of Transplantation

Volumn 11, Issue 6, 2011, Pages 1188-1200

  Kucirka, L M ^a   Sarathy, H ^a   Govindan, P ^b   Wolf, J H ^a   Ellison, T A ^a   Hart, L J ^c   Montgomery, R A ^a   Ros, R L ^a   Segev, D L ^a,d  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF CONNECTICUT   (United States)

^c JOHNS HOPKINS UNIVERSITY SCHOOL OF NURSING   (United States)

^d JOHNS HOPKINS UNIVERSITY   (United States)

Author keywords

Deceased donor transplantation; hepatitis C; high risk donor; NAT; organ utilization

Indexed keywords

NUCLEIC ACID; VIRUS ANTIBODY; VIRUS RNA;

BLOOD DONOR; BLOODSTREAM INFECTION; CANADA; DONOR; DRUG USE; ENZYME LINKED IMMUNOSORBENT ASSAY; HEMOPHILIA; HEPATITIS C; HEPATITIS C VIRUS; HIGH RISK POPULATION; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; INFECTION RISK; INTRAVENOUS DRUG ABUSE; MALE HOMOSEXUAL; NUCLEIC ACID ANALYSIS; PRIORITY JOURNAL; REVIEW; RISK ASSESSMENT; SEXUAL BEHAVIOR; SYSTEMATIC REVIEW; UNITED STATES; VIRAL CLEARANCE; VIRUS TRANSMISSION;

DISEASE TRANSMISSION, INFECTIOUS; HEMOPHILIA A; HEPATITIS C; HOMOSEXUALITY, MALE; HUMANS; MALE; ORGAN TRANSPLANTATION; PROSTITUTION; RISK FACTORS; SUBSTANCE ABUSE, INTRAVENOUS; TISSUE DONORS;

EID: 79958838509     PISSN: 16006135     EISSN: 16006143     Source Type: Journal    
DOI: 10.1111/j.1600-6143.2011.03460.x     Document Type: Review

References (76)

1. Provisional Public Health Service inter-agency recommendations for screening donated blood and plasma for antibody to the virus causing acquired immunodeficiency syndrome. 1985 cited 2008 September 12; Available from
2. Rogers MF, Lawton KE, Moseley RR, Jones WK, Guidelines for Preventing Transmission of Human Immunodeficiency Virus Through Transplantation of Human Tissue and Organs. 1994 cited 2008 September 12th; Available from
3. Kucirka LM, Dagher NN, Montgomery RA, Segev DL, Singer AL,. High infectious risk organ donors in kidney transplantation: Risks, benefits, and current practices. Dialysis Transplant 2010; 39: 186-189.
4. Minimum Procurement Standards for an Organ Procurement Organization. 2008 [cited 2010 September 20]; Available from:.
5. Kucirka LM, Singer AL, Ros RL, Montgomery RA, Dagher NN, Segev DL,. Underutilization of hepatitis C-positive kidneys for hepatitis C-positive recipients. Am J Transplant 2010; 10: 1238-1246.
6. Ahn J, Cohen SM,. Transmission of human immunodeficiency virus and hepatitis C virus through liver transplantation. Liver Transpl 2008; 14: 1603-1608.
7. Apperley JF, Rice SJ, Hewitt P, et al,. HIV infection due to a platelet transfusion after allogeneic bone marrow transplantation. Eur J Haematol 1987; 39: 185-189.
8. Calabrese F, Angelini A, Cecchetto A, Valente M, Livi U, Thiene G,. HIV infection in the first heart transplantation in Italy: Fatal outcome. Case report. APMIS 1998; 106: 470-474. (Pubitemid 28252947)
9. Humar A, Morris M, Blumberg E, et al,. Nucleic acid testing (NAT) of organ donors: Is the 'best' test the right test? A consensus conference report. Am J Transplant 2010; 10: 889-899.
10. Tanzi E, Romano L, Zanetti AR,. Hepatitis type C: Modes of transmission and preventive measures. Clin Exp Rheumatol 1995; 13 (Suppl 13): S13-S16.
11. Baggaley RF, Boily MC, White RG, Alary M,. Risk of HIV-1 transmission for parenteral exposure and blood transfusion: A systematic review and meta-analysis. AIDS 2006; 20: 805-812. (Pubitemid 43731561)
12. Dosekun O, Fox J,. An overview of the relative risks of different sexual behaviours on HIV transmission. Curr Opin HIV AIDS 2010; 5: 291-297.
13. Tohme RA, Holmberg SD,. Is sexual contact a major mode of hepatitis C virus transmission? Hepatology 2010; 52: 1497-1505.
14. Vandelli C, Renzo F, Romano L, et al,. Lack of evidence of sexual transmission of hepatitis C among monogamous couples: Results of a 10-year prospective follow-up study. Am J Gastroenterol 2004; 99: 855-859. (Pubitemid 39090213)
15. Marincovich B, Castilla J, del Romero J, et al,. Absence of hepatitis C virus transmission in a prospective cohort of heterosexual serodiscordant couples. Sex Transm Infect 2003; 79: 160-162. (Pubitemid 36469626)
16. Mele A, Tosti ME, Marzolini A, et al,. Prevention of hepatitis C in Italy: Lessons from surveillance of type-specific acute viral hepatitis. SEIEVA collaborating Group. J Viral Hepat 2000; 7: 30-35. (Pubitemid 30139849)
17. Feldman JG, Minkoff H, Landesman S, Dehovitz J,. Heterosexual transmission of hepatitis C, hepatitis B, and HIV-1 in a sample of inner city women. Sex Transm Dis 2000; 27: 338-342. (Pubitemid 30439548)
18. Stroffolini T, Lorenzoni U, Menniti-Ippolito F, Infantolino D, Chiaramonte M,. Hepatitis C virus infection in spouses: Sexual transmission or common exposure to the same risk factors? Am J Gastroenterol 2001; 96: 3138-3141. (Pubitemid 33095353)
19. Busch MP, Lee LL, Satten GA, et al,. Time course of detection of viral and serologic markers preceding human immunodeficiency virus type 1 seroconversion: Implications for screening of blood and tissue donors. Transfusion 1995; 35: 91-97.
20. Rehermann B,. Hepatitis C virus versus innate and adaptive immune responses: A tale of coevolution and coexistence. J Clin Invest 2009; 119: 1745-1754.
21. Singer AL, Kucirka LM, Namuyinga RHC, Subramanian AK, Segev DL,. The high risk donor: Viral infections in solid organ transplantation. Current Opinion Org Transpl 2008; 13: 400-404.
22. Minimum procurement standards for an organ procurement organization. 2008 cited 2008 September 12; Available from
23. Kucirka LM, Alexander C, Namuyinga R, Hanrahan C, Montgomery RA, Segev DL,. Viral Nucleic Acid Testing (NAT) and OPO-level disposition of high-risk donor organs. Am J Transplant 2009; 9: 620-628.
24. Borst A, Box AT, Fluit AC,. False-positive results and contamination in nucleic acid amplification assays: Suggestions for a prevent and destroy strategy. Eur J Clin Microbiol Infect Dis 2004; 23: 289-299. (Pubitemid 38669939)
25. Botte C, Janot C,. Epidemiology of HCV infection in the general population and in blood transfusion. Nephrol Dial Transplant 1996; 11 (Suppl 4): 19-21. (Pubitemid 26345099)
26. Kucirka LM, Sarathy H, Govindan P, et al,. Risk of window period HIV infection in high risk donors: Systematic review and meta-analysis. Am J Transplant 2010; in press.
27. Mazzeo C, Azzaroli F, Giovanelli S, et al,. Ten year incidence of HCV infection in northern Italy and frequency of spontaneous viral clearance. Gut 2003; 52: 1030-1034. (Pubitemid 36765297)
28. Zou S, Dodd RY, Stramer SL, Strong DM,. Probability of viremia with HBV, HCV, HIV, and HTLV among tissue donors in the United States. N Engl J Med 2004; 351: 751-759. (Pubitemid 39095310)
29. Germain M, Goldman M,. Blood donor selection and screening: Strategies to reduce recipient risk. Am J Ther 2002; 9: 406-410.
30. Cohen DE, Russell CJ, Golub SA, Mayer KH,. Prevalence of hepatitis C virus infection among men who have sex with men at a Boston community health center and its association with markers of high-risk behavior. AIDS Patient Care STDS 2006; 20: 557-564. (Pubitemid 44769203)
31. Dominitz JA, Boyko EJ, Koepsell TD, et al,. Elevated prevalence of hepatitis C infection in users of United States veterans medical centers. Hepatology 2005; 41: 88-96. (Pubitemid 40066386)
32. Hammer GP, Kellogg TA, McFarland WC, et al,. Low incidence and prevalence of hepatitis C virus infection among sexually active non-intravenous drug-using adults, San Francisco, 1997-2000. Sex Transm Dis 2003; 30: 919-924. (Pubitemid 37494356)
33. Hwang LY, Kramer JR, Troisi C, et al,. Relationship of cosmetic procedures and drug use to hepatitis C and hepatitis B virus infections in a low-risk population. Hepatology 2006; 44: 341-351. (Pubitemid 44214873)
34. Rosenberg SD, Goodman LA, Osher FC, et al,. Prevalence of HIV, hepatitis B, and hepatitis C in people with severe mental illness. Am J Public Health 2001; 91: 31-37. (Pubitemid 32049263)
35. Roy E, Haley N, Leclerc P, Boivin JF, Cedras L, Vincelette J,. Risk factors for hepatitis C virus infection among street youths. CMAJ 2001; 165: 557-560. (Pubitemid 32881558)
36. Amon JJ, Garfein RS, Ahdieh-Grant L, et al,. Prevalence of hepatitis C virus infection among injection drug users in the United States, 1994-2004. Clin Infect Dis 2008; 46: 1852-1858.
37. Armstrong GL, Wasley A, Simard EP, McQuillan GM, Kuhnert WL, Alter MJ,. The prevalence of hepatitis C virus infection in the United States, 1999 through 2002. Ann Intern Med 2006; 144: 705-714. (Pubitemid 46780630)
38. Baumbach JP, Foster LN, Mueller M, et al,. Seroprevalence of select bloodborne pathogens and associated risk behaviors among injection drug users in the Paso del Norte region of the United States-Mexico border. Harm Reduct J 2008; 5: 33.
39. Bollepalli S, Mathieson K, Bay C, et al,. Prevalence of risk factors for hepatitis C virus in HIV-infected and HIV/hepatitis C virus-coinfected patients. Sex Transm Dis 2007; 34: 367-370. (Pubitemid 46816782)
40. Briggs ME, Baker C, Hall R, et al,. Prevalence and risk factors for hepatitis C virus infection at an urban Veterans Administration medical center. Hepatology 2001; 34: 1200-1205. (Pubitemid 33096593)
41. Brillman JC, Crandall CS, Florence CS, Jacobs JL,. Prevalence and risk factors associated with hepatitis C in ED patients. Am J Emerg Med 2002; 20: 476-480.
42. Choy Y, Gittens-Williams L, Apuzzio J, Skurnick J, Zollicoffer C, McGovern PG,. Risk factors for hepatitis C infection among sexually transmitted disease-infected, inner city obstetric patients. Infect Dis Obstet Gynecol 2003; 11: 191-198. (Pubitemid 38101438)
43. Des Jarlais DC, Diaz T, Perlis T, et al,. Variability in the incidence of human immunodeficiency virus, hepatitis B virus, and hepatitis C virus infection among young injecting drug users in New York City. Am J Epidemiol 2003; 157: 467-471. (Pubitemid 36258602)
44. Firestone Cruz M, Fischer B, Patra J, et al,. Prevalence and associated factors of hepatitis C infection (HCV) in a multi-site Canadian population of illicit opioid and other drug users (OPICAN). Can J Public Health 2007; 98: 130-133.
45. Fuller CM, Ompad DC, Galea S, Wu Y, Koblin B, Vlahov D,. Hepatitis C incidence-a comparison between injection and noninjection drug users in New York City. J Urban Health 2004; 81: 20-24. (Pubitemid 38622996)
46. Gunn RA, Murray PJ, Ackers ML, Hardison WG, Margolis HS,. Screening for chronic hepatitis B and C virus infections in an urban sexually transmitted disease clinic: Rationale for integrating services. Sex Transm Dis 2001; 28: 166-170. (Pubitemid 32194972)
47. Hagan H, Thiede H, Des Jarlais DC,. Hepatitis C virus infection among injection drug users: Survival analysis of time to seroconversion. Epidemiology 2004; 15: 543-549. (Pubitemid 40416907)
48. Hahn JA, Page-Shafer K, Ford J, Paciorek A, Lum PJ,. Traveling young injection drug users at high risk for acquisition and transmission of viral infections. Drug Alcohol Depend 2008; 93: 43-50. (Pubitemid 350236588)
49. Hall CS, Charlebois ED, Hahn JA, Moss AR, Bangsberg DR,. Hepatitis C virus infection in San Francisco's HIV-infected urban poor. J Gen Intern Med 2004; 19: 357-365.
50. Neaigus A, Gyarmathy VA, Miller M, et al,. Injecting and sexual risk correlates of HBV and HCV seroprevalence among new drug injectors. Drug Alcohol Depend 2007; 89: 234-243. (Pubitemid 46754677)
51. Page-Shafer KA, Cahoon-Young B, Klausner JD, et al,. Hepatitis C virus infection in young, low-income women: The role of sexually transmitted infection as a potential cofactor for HCV infection. Am J Public Health 2002; 92: 670-676. (Pubitemid 34246032)
52. Patrick DM, Tyndall MW, Cornelisse PG, et al,. Incidence of hepatitis C virus infection among injection drug users during an outbreak of HIV infection. CMAJ 2001; 165: 889-895. (Pubitemid 34028226)
53. Rifai MA, Moles JK, Lehman LP, Van Der Linden BJ,. Hepatitis C screening and treatment outcomes in patients with substance use/dependence disorders. Psychosomatics 2006; 47: 112-121. (Pubitemid 43346958)
54. Roy E, Alary M, Morissette C, et al,. High hepatitis C virus prevalence and incidence among Canadian intravenous drug users. Int J STD AIDS 2007; 18: 23-27.
55. Sandhu J, Preiksaitis JK, Campbell PM, Carriere KC, Hessel PA,. Hepatitis C prevalence and risk factors in the northern Alberta dialysis population. Am J Epidemiol 1999; 150: 58-66. (Pubitemid 29297270)
56. Shannon K, Rusch M, Morgan R, Oleson M, Kerr T, Tyndall MW,. HIV and HCV prevalence and gender-specific risk profiles of crack cocaine smokers and dual users of injection drugs. Subst Use Misuse 2008; 43: 521-534. (Pubitemid 351448730)
57. Sivapalasingam S, Malak SF, Sullivan JF, Lorch J, Sepkowitz KA,. High prevalence of hepatitis C infection among patients receiving hemodialysis at an urban dialysis center. Infect Control Hosp Epidemiol 2002; 23: 319-324. (Pubitemid 34774361)
58. Spittal PM, Craib KJ, Teegee M, et al,. The Cedar project: Prevalence and correlates of HIV infection among young Aboriginal people who use drugs in two Canadian cities. Int J Circumpolar Health 2007; 66: 226-240.
59. Strasfeld L, Lo Y, Netski D, Thomas DL, Klein RS,. The association of hepatitis C prevalence, activity, and genotype with HIV infection in a cohort of New York City drug users. J Acquir Immune Defic Syndr 2003; 33: 356-364. (Pubitemid 36859062)
60. Tabibian JH, Wirshing DA, Pierre JM, et al,. Hepatitis B and C among veterans on a psychiatric ward. Dig Dis Sci 2008; 53: 1693-1698. (Pubitemid 351624423)
61. Thorpe LE, Ouellet LJ, Levy JR, Williams IT, Monterroso ER,. Hepatitis C virus infection: Prevalence, risk factors, and prevention opportunities among young injection drug users in Chicago, 1997-1999. J Infect Dis 2000; 182: 1588-1594.
62. Tortu S, Neaigus A, McMahon J, Hagen D,. Hepatitis C among noninjecting drug users: A report. Subst Use Misuse 2001; 36: 523-534. (Pubitemid 32411076)
63. Weisbord JS, Trepka MJ, Zhang G, Smith IP, Brewer T,. Prevalence of and risk factors for hepatitis C virus infection among STD clinic clientele in Miami, Florida. Sex Transm Infect 2003; 79: E1.
64. Wylie JL, Shah L, Jolly AM,. Demographic, risk behaviour and personal network variables associated with prevalent hepatitis C, hepatitis B, and HIV infection in injection drug users in Winnipeg, Canada. BMC Public Health 2006; 6: 229.
65. Zule WA, Bobashev G,. High dead-space syringes and the risk of HIV and HCV infection among injecting drug users. Drug Alcohol Depend 2009; 100: 204-213.
66. Augenbraun M, Goedert JJ, Thomas D, et al,. Incident hepatitis C virus in women with human immunodeficiency virus infection. Clin Infect Dis 2003; 37: 1357-1364. (Pubitemid 37433633)
67. Hahn JA, Page-Shafer K, Lum PJ, et al,. Hepatitis C virus seroconversion among young injection drug users: Relationships and risks. J Infect Dis 2002; 186: 1558-1564. (Pubitemid 35379631)
68. Thorpe LE, Ouellet LJ, Hershow R, et al,. Risk of hepatitis C virus infection among young adult injection drug users who share injection equipment. Am J Epidemiol 2002; 155: 645-653. (Pubitemid 34246097)
69. Dodd RY, Notari EPt, Stramer SL,. Current prevalence and incidence of infectious disease markers and estimated window-period risk in the American Red Cross blood donor population. Transfusion 2002; 42: 975-979.
70. O'Brien SF, Yi QL, Fan W, Scalia V, Kleinman SH, Vamvakas EC,. Current incidence and estimated residual risk of transfusion-transmitted infections in donations made to Canadian Blood Services. Transfusion 2007; 47: 316-325. (Pubitemid 46150983)
71. De Carli G, Puro V, Ippolito G,. Risk of hepatitis C virus transmission following percutaneous exposure in healthcare workers. Infection 2003; 31 (Suppl 2): 22-27. (Pubitemid 38186792)
72. Holland CA, Ma Y, Moscicki B, Durako SJ, Levin L, Wilson CM,. Seroprevalence and risk factors of hepatitis B, hepatitis C, and human cytomegalovirus among HIV-infected and high-risk uninfected adolescents: Findings of the REACH Study. Adolescent medicine HIV/AIDS research network. Sex Transm Dis 2000; 27: 296-303. (Pubitemid 30252424)
73. Kim JH, Psevdos G, Suh J, Sharp VL,. Co-infection of hepatitis B and hepatitis C virus in human immunodeficiency virus-infected patients in New York City, United States. World J Gastroenterol 2008; 14: 6689-6693.
74. Macalino GE, Vlahov D, Sanford-Colby S, et al,. Prevalence and incidence of HIV, hepatitis B virus, and hepatitis C virus infections among males in Rhode Island prisons. Am J Public Health 2004; 94: 1218-1223. (Pubitemid 38857326)
75. Conry-Cantilena C, VanRaden M, Gibble J, et al,. Routes of infection, viremia, and liver disease in blood donors found to have hepatitis C virus infection. N Engl J Med 1996; 334: 1691-1696. (Pubitemid 26193620)
76. Haley RW, Fischer RP,. Commercial tattooing as a potentially important source of hepatitis C infection. Clinical epidemiology of 626 consecutive patients unaware of their hepatitis C serologic status. Medicine (Baltimore) 2001; 80: 134-151. (Pubitemid 32285210)