Rational design, fabrication, characterization and in vitro testing of biodegradable microparticles that generate targeted and sustained transgene expression in HepG2 liver cells

Journal of Drug Targeting

Volumn 19, Issue 6, 2011, Pages 393-408

  Intra, Janjira ^a   Salem, Aliasger K ^a  

^a UNIVERSITY OF IOWA   (United States)

Author keywords

complexes; formulation; galactose; HepG2; liver; luciferase; Microparticle; non viral gene delivery; plasmid DNA; Poly(lactide co glycolide) (PLGA); Polyethylenimine (PEI); polyplexes; PVA; targeting ligands

Indexed keywords

APOLIPOPROTEIN E; GALACTOSE; PLASMID DNA; POLYETHYLENEIMINE; POLYGLACTIN; SURFACTANT;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DRUG EFFICACY; DRUG FORMULATION; DRUG RELEASE; FIBROBLAST; GENE EXPRESSION; GENE TARGETING; HUMAN; HUMAN CELL; IN VITRO STUDY; KIDNEY CELL; LIVER CELL; NONHUMAN; NONVIRAL GENE DELIVERY SYSTEM; PARTICLE SIZE; PRIORITY JOURNAL; SCANNING ELECTRON MICROSCOPY; SURFACE PROPERTY; ZETA POTENTIAL;

ANIMALS; APOLIPOPROTEINS E; BIOCOMPATIBLE MATERIALS; CELL SURVIVAL; CERCOPITHECUS AETHIOPS; COS CELLS; DNA; DRUG CARRIERS; DRUG COMPOUNDING; DRUG DESIGN; GALACTOSE; GENE TRANSFER TECHNIQUES; HEK293 CELLS; HEP G2 CELLS; HUMANS; IMINES; LACTIC ACID; MICROSCOPY, ELECTRON, SCANNING; MICROSCOPY, ELECTRON, TRANSMISSION; MICROSPHERES; MOLECULAR STRUCTURE; PARTICLE SIZE; PLASMIDS; POLYETHYLENES; POLYGLYCOLIC ACID; SURFACE PROPERTIES; TRANSFECTION; TRANSGENES;

EID: 79958834800     PISSN: 1061186X     EISSN: 10292330     Source Type: Journal    
DOI: 10.3109/1061186X.2010.504263     Document Type: Article

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