The cutaneous and systemic manifestations of azathioprine hypersensitivity syndrome

Journal of the American Academy of Dermatology

Volumn 65, Issue 1, 2011, Pages 184-191

  Bidinger, Jeffrey J ^a   Sky, Karen ^a   Battafarano, Daniel F ^a   Henning, J Scott ^a  

^a SAN ANTONIO MILITARY MEDICAL CENTER   (United States)

Author keywords

adverse reaction; azathioprine; azathioprine hypersensitivity syndrome; side effects; Sweet's syndrome

Indexed keywords

AZATHIOPRINE; PREDNISONE; THIOPURINE METHYLTRANSFERASE;

ACUTE FEBRILE NEUTROPHILIC DERMATOSIS; ACUTE GENERALIZED EXANTHEMATOUS PUSTULOSIS; ADULT; ARTHRALGIA; ARTICLE; CASE REPORT; CLINICAL FEATURE; CROHN DISEASE; DIARRHEA; DISEASE EXACERBATION; DRUG HYPERSENSITIVITY; DRUG RECHALLENGE; DRUG WITHDRAWAL; ERYTHEMATOUS NODULE; ERYTHEMATOUS PAPULE; FEMALE; FEVER; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; LABORATORY TEST; MALAISE; MALE; PRIORITY JOURNAL; SEPSIS; SKIN BIOPSY; SKIN DISEASE; SMALL VESSEL VASCULITIS; SYSTEMIC LUPUS ERYTHEMATOSUS; VOMITING;

EID: 79958828684     PISSN: 01909622     EISSN: 10976787     Source Type: Journal    
DOI: 10.1016/j.jaad.2010.04.041     Document Type: Review

References (46)

1. Yiasemides E, Thom G. Azathioprine hypersensitivity presenting as a neutrophilic dermatosis in a man with ulcerative colitis. Australas J Dermatol 2009;50:48-51.
2. Stapleton M, Panaccione R. Azathioprine induced Sweet's syndrome in a patient with Crohn's disease: a case report. Can J Gastroenterol 2003;17(Suppl A):abstract 255.
3. Treton X, Joly F, Alves A, Panis Y, Bouhnik Y. Azathioprine -induced Sweet's syndrome in Crohn's disease. Inflamm Bowel Dis 2008;14:1757-8.
4. Décisier M, Duhalde V, Faure P, Ammoury A, Gony M, Moreau J, et al. Rapid-onset febrile dermatosis. Gut 2009;58:67, 125.
5. Paoluzi OA, Crispino P, Amantea A, Pica R, Iacopini F, Consolazio A, et al. Diffuse febrile dermatosis in a patient with active ulcerative colitis under treatment with steroids and azathioprine: a case of Sweet's syndrome. Case report and review of literature. Dig Liver Dis 2004;36:361-6. (Pubitemid 41115468)
6. El-Azhary RA, Brunner KL, Gibson LE. Sweet syndrome as a manifestation of azathioprine hypersensitivity. Mayo Clin Proc 2008;83:1026-30.
7. Burrows NP. Sweet's syndrome in association with Crohn's disease. Clin Exp Dermatol 1995;20:279-80.
8. Sarkany RP, Burrows NP, Grant JW, Pye RJ, Norris PG. The pustular eruption of ulcerative colitis: a variant of Sweet's syndrome? Br J Dermatol 1998;138:365-6.
9. De Fonclare AL, Khosrotehrani K, Aractingi S, Duriez P, Cosnes J, Beaugerie L. Erythema nodosum-like eruption as a manifestation of azathioprine hypersensitivity in patients with inflammatory bowel disease. Arch Dermatol 2007;143:744-8. (Pubitemid 46955733)
10. Sinico RA, Sabadini E, Borlandelli S, Cosci P, Di Toma L, Imbasciati E. Azathioprine hypersensitivity: Report of two cases and review of the literature. J Nephrol 2003;16:272-6. (Pubitemid 37304085)
11. Bergman SM, Krane NK, Leonard G, Soto-Aguilar MC, Wallin JD. Azathioprine and hypersensitivity vasculitis. Ann Intern Med 1988;109:83-4.
12. Blanco R, Martínez-Taboada VM, González-Gay MA, Armona J, Fernández-Sueiro JL, González-Vela MC, et al. Acute febrile toxic reaction in patients with refractory rheumatoid arthritis who are receiving combined therapy with methotrexate and azathioprine. Arthritis Rheum 1996;39:1016-20. (Pubitemid 26182070)
13. Appleman M, Wintzen M. Pruritus and leukocytoclastic vasculitis due to azathioprine. Dermatology 2005;210:366. (Pubitemid 40976754)
14. Elston GE, Johnston GA, Mortimer NJ, Harman KE. Acute generalized exanthematous pustulosis associated with azathioprine hypersensitivity. Clin Exp Dermatol 2007;32:52-3. (Pubitemid 46006367)
15. Fields CL, Robinson JW, Roy TM, Ossorio MA, Byrd RP Jr. Hypersensitivity reaction to azathioprine. South Med J 1998; 91:471-4. (Pubitemid 28213391)
16. Garey KW, Streetman DS, Rainish MC. Azathioprine hypersensitivity reaction in a patient with ulcerative colitis. Ann Pharmacother 1998;32:425-8. (Pubitemid 28166608)
17. Rosenthal E. Azathioprine shock. Postgrad Med J 1986;62: 677-8. (Pubitemid 16074402)
18. Sofat N, Houghton J, McHale J, Higgens CS. Azathioprine hypersensitivity. Ann Rheum Dis 2001;60:719-20.
19. Jeurissen ME, Boerbooms AM, van de Putte LB, Kruijsen MW. Azathioprine induced fever, chills, rash, and hepatotoxicity in rheumatoid arthritis. Ann Rheum Dis 1990;49:25-7. (Pubitemid 20035051)
20. Hinrichs R, Schneider LA, Ozdemir C, Staib G, Scharffetter-Kochanek K. Azathioprine hypersensitivity in a patient with peripheral demyelinating polyneuropathy. Br J Dermatol 2003; 148:1076-7. (Pubitemid 36750818)
21. Parnham AP, Dittmer I, Mathieson PW, McIver A, Dudley C. Acute allergic reactions associated with azathioprine. Lancet 1996;348:542-3. (Pubitemid 26279020)
22. Knowles SR, Gupta AK, Shear NH, Sauder D. Azathioprine hypersensitivity-like reactions - a case report and a review of the literature. Clin Exp Dermatol 1995;20:353-6.
23. Corbett M, Schlup M. Azathioprine hypersensitivity mimicking underlying inflammatory bowel disease. Intern Med J 2001;31: 366-7. (Pubitemid 34225192)
24. Mayo JM, Colmenarejo MB, Vaquerizo PJ, Gutierrez MV. Hypersensitivity reaction to azathioprine in a patient with ulcerative colitis. Infrequent manifestations. Inflamm Bowel Dis 2004;10:700. (Pubitemid 39276483)
25. Craner MJ, Zajicek JP. Immunosuppressive treatments in MS - side effects from azathioprine. J Neurol 2001;248:625-6. (Pubitemid 32695808)
26. Stetter M, Schmidl M, Krapf R. Azathioprine hypersensitivity mimicking Goodpasture's syndrome. Am J Kidney Dis 1994;23: 874-7. (Pubitemid 24173574)
27. Watts GF, Corston R. Hypersensitivity to azathioprine in myasthenia gravis. Postgrad Med J 1984;60:362-3. (Pubitemid 14137764)
28. Demirtasx-Ertan G, Rowshani AT, ten Berge IJ. Azathioprine -induced shock in a patient suffering from undifferentiated erosive oligoarthritis. Neth J Med 2006;64:124-6.
29. Stratton JD, Farrington K. Relapse of vasculitis, sepsis, or azathioprine allergy? Nephrol Dial Transplant 1998;13:2927-8.
30. Reinhold-Keller E, Schmin WH, Gross WL. Azathioprine toxicity mimicking a relapse of Wegner's granulomatosis. Rheumatology 2001;40:831-2. (Pubitemid 32707788)
31. Caramaschi P, Biasi D, Carletto A, Bambara LM. Azathioprine hypersensitivity in a patient affected by systemic lupus erythematosus. Lupus 1997;6:616-7. (Pubitemid 27406167)
32. Collison DW, Dahlberg PJ, Hogan JD. Azathioprine hypersensitivity in bullous pemphigoid. J Am Acad Dermatol 1990;23: 125-7. (Pubitemid 20219230)
33. Saway PA, Heck LW, Bonner JR, Kirklin JK. Azathioprine hypersensitivity. Case report and review of the literature. Am J Med 1988;84:960-4.
34. Meys E, Devogelaer JP, Geubel A, Rahier J. Nagant de Deuxchaisnes C. Fever, hepatitis and acute interstitial nephritis in a patient with rheumatoid arthritis. Concurrent manifestations of azathioprine hypersensitivity. J Rheumatol 1992;19:807-9.
35. Smak G, van Saase JLCM, Weimar W, Kramer P. Fever and rigor as sole symptoms of azathioprine hypersensitivity. Neth J Med 1995;47:288-90. (Pubitemid 26015258)
36. Refabert L, Sinnassamy P, Leroy B, Fauroux B, de Blic J, Bensman A. Azathioprine -induced pulmonary haemorrhage in a child after renal transplantation. Pediatr Nephrol 1995;9: 470-3.
37. Walker DC, Cohen PR. Trimethoprim-Sulfamethoxazole-associated acute febrile neutrophilic dermatosis: case report and review of drug-induced Sweet's syndrome. J Am Acad Dermatol 1996;34:918-23. (Pubitemid 26143882)
38. Patel AA, Swerlick RA, McCall CO. Azathioprine in dermatology: the past, the present, and the future. J Am Acad Dermatol 2006;55:369-89. (Pubitemid 44189574)
39. Krynetski EY, Evans WE. Pharmacogenetics as a molecular basis for individualized drug therapy: the thiopurine S-methyltransferase paradigm. Pharm Res 1999;16:342-9. (Pubitemid 29162090)
40. Bajaj JS, Saeian K, Varma RR, Franco J, Knox JF, Podoll J, et al. Increased rates of early adverse reaction to azathioprine in patients with Crohn's disease compared to autoimmune hepatitis: a tertiary referral center experience. Am J Gastroenterol 2005;100:1121-5. (Pubitemid 40769051)
41. Mann CL, Davies MB, Boggild MD, Alldersea J, Fryer AA, Jones PW, et al. Glutathione S-transferase polymorphisms in MS: their relationship to disability. Neurology 2000;54:552-7. (Pubitemid 30082917)
42. Davis M, Eddleston AL, Williams R. Hypersensitivity and jaundice due to azathioprine. Postgrad Med J 1980;56:274-5. (Pubitemid 10147321)
43. Lemann M, Bouhnek Y, Kmieciak-Le Corguille M, et al. Treatment of Crohn's disease with 6-mercaptopurine in patients intolerant to azathioprine. Gastroenterology 1997; 112:A1025.
44. Marinaki AM, Ansari A, Duley JA, Arenas M, Sumi S, Lewis CM, et al. Adverse drug reactions to azathioprine therapy are associated with polymorphism in the gene encoding inosine triphosphate pyrophosphatase (ITPase). Pharmacogenetics 2004;14:181-7. (Pubitemid 38373112)
45. Zaltzman M, Kalleback J, Shapiro T, et al. Life threatening hypotension associated with azathioprine therapy. S Afr Med J 1984;65:306. (Pubitemid 14173371)
46. Cohen PR, Kurzrock R. Sweet's syndrome revisited: a review of disease concepts. Int J Dermatol 2003;42:761-78. (Pubitemid 37304040)