Saying yes to exercise and no to cardiac injury

Circulation Research

Volumn 108, Issue 12, 2011, Pages 1414-1416

  Bezzerides, Vassilios ^a   Rosenzweig, Anthony ^b,c  

^a BOSTON CHILDREN S HOSPITAL   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

^c BETH ISRAEL DEACONESS MEDICAL CENTER   (United States)

Author keywords

Editorials; endothelial nitric oxide synthase; ischemia; myocardial ischemia; nitric oxide

Indexed keywords

NITRIC OXIDE;

DISEASE ASSOCIATION; EXERCISE; HEART INJURY; HEART MUSCLE INJURY; HEART PROTECTION; HUMAN; NONHUMAN; PRIORITY JOURNAL; REPERFUSION INJURY; REVIEW;

ADOLESCENT; ADULT; ANIMALS; ENZYME ACTIVATION; EXERCISE; HUMANS; MALE; MICE; MICE, KNOCKOUT; MYOCARDIAL REPERFUSION INJURY; NITRIC OXIDE; NITRIC OXIDE SYNTHASE TYPE III; NITRITES; NITROSO COMPOUNDS; PHYSICAL CONDITIONING, ANIMAL; RECEPTORS, ADRENERGIC, BETA-3; TIME FACTORS;

EID: 79958824215     PISSN: 00097330     EISSN: 15244571     Source Type: Journal    
DOI: 10.1161/CIRCRESAHA.111.247122     Document Type: Review

References (25)

1. Franco OH, de Laet C, Peeters A, Jonker J, Mackenbach J, Nusselder W. Effects of physical activity on life expectancy with cardiovascular disease. Arch Intern Med. 2005;165:2355-2360. (Pubitemid 41640847)
2. Flynn KE, Pina IL, Whellan DJ, Lin L, Blumenthal JA, Ellis SJ, Fine LJ, Howlett JG, Keteyian SJ, Kitzman DW, Kraus WE, Miller NH, Schulman KA, Spertus JA, O'Connor CM, Weinfurt KP. Effects of exercise training on health status in patients with chronic heart failure: HF-action randomized controlled trial. JAMA. 2009;301:1451-1459.
3. O'Connor CM, Whellan DJ, Lee KL, Keteyian SJ, Cooper LS, Ellis SJ, Leifer ES, Kraus WE, Kitzman DW, Blumenthal JA, Rendall DS, Miller NH, Fleg JL, Schulman KA, McKelvie RS, Zannad F, Pina IL. Efficacy and safety of exercise training in patients with chronic heart failure: HF-action randomized controlled trial. JAMA. 2009;301:1439-1450.
4. Bostrom P, Mann N, Wu J, Quintero PA, Plovie ER, Kova DP, Gupta RK, Xiao C, MacRae CA, Rosenzweig A, Spiegelman BM. C/ebpb controls exercise-induced cardiac growth and protects against pathological cardiac remodeling. Cell. 2010;143:1072-1083.
5. Demirel HA, Powers SK, Zergeroglu MA, Shanely RA, Hamilton K, Coombes J, Naito H. Short-term exercise improves myocardial tolerance to in vivo ischemia-reperfusion in the rat. J Appl Physiol. 2001;91: 2205-2212. (Pubitemid 33015075)
6. Lennon SL, Quindry JC, French JP, Kim S, Mehta JL, Powers SK. Exercise and myocardial tolerance to ischaemia-reperfusion. Acta Physiol Scand. 2004;182:161-169. (Pubitemid 39371863)
7. Calvert JW, Elston M, Pablo Aragón J, Nicholson CK, Moody BF, Hood RL, Sindler A, Gundewar S, Seals DR, Barouch LA, Lefer DJ. Exercise protects against myocardial ischemia-reperfusion injury via stimulation of 3-adrenergic receptors and increased nitric oxide signaling: role of nitrite and nitrosothiols. Circ Res. 2011;108:1448-1458.
8. Marber MS. Stress proteins and myocardial protection. Clin Sci (Lond). 1994;86:375-381. (Pubitemid 24137309)
9. Martin JL, Mestril R, Hilal-Dandan R, Brunton LL, Dillmann WH. Small heat shock proteins and protection against ischemic injury in cardiac myocytes. Circulation. 1997;96:4343-4348. (Pubitemid 28007464)
10. Staib JL, Quindry JC, French JP, Criswell DS, Powers SK. Increased temperature, not cardiac load, activates heat shock transcription factor 1 and heat shock protein 72 expression in the heart. Am J Physiol Regul Integr Comp Physiol. 2007;292:R432-R439. (Pubitemid 46089858)
11. Powers SK, Quindry JC, Kavazis AN. Exercise-induced cardioprotection against myocardial ischemia-reperfusion injury. Free Radic Biol Med. 2008;44:193-201.
12. McMullen JR, Shioi T, Zhang L, Tarnavski O, Sherwood MC, Kang PM, Izumo S. Phosphoinositide 3-kinase(p110alpha) plays a critical role for the induction of physiological, but not pathological, cardiac hypertrophy. Proc Natl Acad Sci USA. 2003;100:12355-12360. (Pubitemid 37271564)
13. DeBosch B, Treskov I, Lupu TS, Weinheimer C, Kovacs A, Courtois M, Muslin AJ. Akt1 is required for physiological cardiac growth. Circulation. 2006;113:2097-2104.
14. Matsui T, Li L, del Monte F, Fukui Y, Franke T, Hajjar R, Rosenzweig A. Adenoviral gene transfer of activated PI 3-kinase and akt inhibits apoptosis of hypoxic cardiomyocytes in vitro. Circulation. 1999;100: 2373-2379.
15. Matsui T, Tao J, del Monte F, Lee K-H, Li L, Picard M, Force TL, Franke TF, Hajjar RJ, Rosenzweig A. Akt activation preserves cardiac function and prevents injury after transient cardiac ischemia in vivo. Circulation. 2001;104:330-335. (Pubitemid 32666956)
16. Webb A, Bond R, McLean P, Uppal R, Benjamin N, Ahluwalia A. Reduction of nitrite to nitric oxide during ischemia protects against myocardial ischemia-reperfusion damage. Proc Natl Acad Sci USA. 2004;101:13683-13688. (Pubitemid 39238463)
17. Schulz R, Kelm M, Heusch G. Nitric oxide in myocardial ischemia/ reperfusion injury. Cardiovasc Res. 2004;61:402-413. (Pubitemid 38210147)
18. Duranski MR, Greer JJ, Dejam A, Jaganmohan S, Hogg N, Langston W, Patel RP, Yet SF, Wang X, Kevil CG, Gladwin MT, Lefer DJ. Cytoprotective effects of nitrite during in vivo ischemia-reperfusion of the heart and liver. J Clin Invest. 2005;115:1232-1240. (Pubitemid 40629041)
19. Bryan NS, Calvert JW, Elrod JW, Gundewar S, Ji SY, Lefer DJ. Dietary nitrite supplementation protects against myocardial ischemia-reperfusion injury. Proc Natl Acad Sci USA. 2007;104:19144-19149.
20. Bryan NS, Fernandez BO, Bauer SM, Garcia-Saura MF, Milsom AB, Rassaf T, Maloney RE, Bharti A, Rodriguez J, Feelisch M. Nitrite is a signaling molecule and regulator of gene expression in mammalian tissues. Nat Chem Biol. 2005;1:290-297.
21. Goh KP, Sum CF. Connecting the dots: molecular and epigenetic mechanisms in type 2 diabetes. Curr Diabetes Rev. 2010;6:255-265.
22. Tavernier B, Li JM, El-Omar MM, Lanone S, Yang ZK, Trayer IP, Mebazaa A, Shah AM. Cardiac contractile impairment associated with increased phosphorylation of troponin I in endotoxemic rats. FASEB J. 2001;15:294-296.
23. Dimmeler S, Fleming I, Fisslthaler B, Hermann C, Busse R, Zeiher AM. Activation of nitric oxide synthase in endothelial cells by akt-dependent phosphorylation. Nature. 1999;399:601-605.
24. Fulton D, Gratton JP, McCabe TJ, Fontana J, Fujio Y, Walsh K, Franke TF, Papapetropoulos A, Sessa WC. Regulation of endothelium-derived nitric oxide production by the protein kinase akt. Nature. 1999;399: 597-601.
25. Lewis GD, Farrell L, Wood MJ, Martinovic M, Arany Z, Rowe GC, Souza A, Cheng S, McCabe EL, Yang E, Shi X, Deo R, Roth FP, Asnani A, Rhee EP, Systrom DM, Semigran MJ, Vasan RS, Carr SA, Wang TJ, Sabatine MS, Clish CB, Gerszten RE. Metabolic signatures of exercise in human plasma. Sci Transl Med. 2:33-37.