Global analysis of BRAFV600E target genes in human melanocytes identifies matrix metalloproteinase-1 as a critical mediator of melanoma growth

Journal of Investigative Dermatology

Volumn 131, Issue 7, 2011, Pages 1579-1583

  Ryu, Byungwoo ^a,d   Moriarty, Whei F ^a,b   Stine, Megan J ^a,b   Deluca, Amena ^a   Kim, Dave S ^a   Meeker, Alan K ^a,b   Grills, Landon D ^a   Switzer, Rebecca A ^a   Eller, Mark S ^c   Alani, Rhoda M ^a,b,c  

^a JOHNS HOPKINS UNIVERSITY   (United States)

^b JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d NEVADA CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMPHIREGULIN; B RAF KINASE; COLLAGENASE; EPIDERMAL GROWTH FACTOR; EPITHELIAL DERIVED NEUTROPHIL ACTIVATING FACTOR 78; INTERLEUKIN 8; INTERSTITIAL COLLAGENASE; MESSENGER RNA; SMALL INTERFERING RNA; TRANSIENT RECEPTOR POTENTIAL CHANNEL M2; BRAF PROTEIN, HUMAN; MMP1 PROTEIN, HUMAN;

APOPTOSIS; CANCER GROWTH; CARCINOGENESIS; CELL GROWTH; CELL MEMBRANE; CELL MOTILITY; CELL PROLIFERATION; DOWNSTREAM PROCESSING; ENZYME ACTIVITY; GENE; GENE EXPRESSION; GENE IDENTIFICATION; GENE SILENCING; GENE TARGETING; GENETIC ANALYSIS; HUMAN; LETTER; MELANOCYTE; MELANOMA; METASTASIS; NEVUS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; WILD TYPE; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; MUTATION; PATHOLOGY; PHYSIOLOGY;

CELL PROLIFERATION; GENE EXPRESSION REGULATION, ENZYMOLOGIC; HUMANS; MATRIX METALLOPROTEINASE 1; MELANOCYTES; MELANOMA; MUTATION; PROTO-ONCOGENE PROTEINS B-RAF;

EID: 79958804922     PISSN: 0022202X     EISSN: 15231747     Source Type: Journal    
DOI: 10.1038/jid.2011.65     Document Type: Letter

References (13)

1. Blackburn JS, Liu I, Coon CI et al. (2009) A matrix metalloproteinase-1/ protease activated recep-tor-1 signaling axis promotes melanoma invasion and metastasis. Oncogene 28:4237-48
2. Blackburn JS, Rhodes CH, Coon CI et al. (2007) RNA interference inhibition of matrix metalloproteinase-1 prevents melanoma metastasis by reducing tumor collagenase activity and angiogenesis. Cancer Res 67:10849-58 (Pubitemid 350145914)
3. Boire A, Covic L, Agarwal A et al. (2005) PAR1 is a matrix metalloprotease-1 receptor that promotes invasion and tumorigenesis of breast cancer cells. Cell 120:303-13 (Pubitemid 40222426)
4. Davies H, Bignell GR, Cox C et al. (2002) Mutations of the BRAF gene in human cancer. Nature 417:949-54 (Pubitemid 34716871)
5. Hoek KS, Schlegel NC, Brafford P et al. (2006) Metastatic potential of melanomas defined by specific gene expression profiles with no BRAF signature. Pigment Cell Res 19:290-302 (Pubitemid 44015592)
6. Huntington JT, Shields JM, Der CJ et al. (2004) Overexpression of collagenase 1 (MMP-1) is mediated by the ERK pathway in invasive melanoma cells: role of BRAF mutation and fibroblast growth factor signaling. J Biol Chem 279:33168-76 (Pubitemid 39062961)
7. Lu X, Wang Q, Hu G et al. (2009) ADAMTS1 and MMP1 proteolytically engage EGF-like ligands in an osteolytic signaling cascade for bone metastasis. Genes Dev 23:1882-94
8. Michaloglou C, Vredeveld LC, Soengas MS et al. (2005) BRAFE600-associated senescence-like cell cycle arrest of human naevi. Nature 436:720-4 (Pubitemid 41117276)
9. Pollock PM, Harper UL, Hansen KS et al. (2003) High frequency of BRAF mutations in nevi. Nat Genet 33:19-20 (Pubitemid 36068675)
10. Rodeck U, Melber K, Kath R et al. (1991) Constitutive expression of multiple growth factor genes by melanoma cells but not normal melanocytes. J Invest Dermatol 97:20-6
11. Ryu B, Kim DS, Deluca AM et al. (2007) Comprehensive expression profiling of tumor cell lines identifies molecular signatures of melanoma progression. PloS One 2:e594
12. Woods D, Parry D, Cherwinski H et al. (1997) Raf-induced proliferation or cell cycle arrest is determined by the level of Raf activity with arrest mediated by p21Cip1. Mol Cell Biol 17:5598-611 (Pubitemid 27357656)
13. Zhang Q, Thomas SM, Xi S et al. (2004) SRC family kinases mediate epidermal growth factor receptor ligand cleavage, proliferation, and invasion of head and neck cancer cells. Cancer Res 64:6166-73 (Pubitemid 39129418)