Venous thromboembolism in coagulopathic surgical intensive care unit patients: Is there a benefit from chemical prophylaxis?

Journal of Trauma - Injury, Infection and Critical Care

Volumn 70, Issue 6, 2011, Pages 1398-1400

  Edwards, Meghan ^a   Felder, Seth ^a   Ley, Eric ^a   Srour, Marissa ^a   Mirocha, James ^a   Margulies, Daniel R ^a   Salim, Ali ^a  

^a CEDARS SINAI MEDICAL CENTER   (United States)

Author keywords

Coagulopathy; Intensive care unit; Prophylaxis; Venous thromboembolism

Indexed keywords

ANTICOAGULANT AGENT; HEPARIN; LOW MOLECULAR WEIGHT HEPARIN; WARFARIN;

AGED; ARTICLE; BLOOD CLOTTING DISORDER; CRITICALLY ILL PATIENT; FEMALE; HOSPITAL ADMISSION; HUMAN; INTENSIVE CARE UNIT; LUNG EMBOLISM; MAJOR CLINICAL STUDY; MALE; MEDICAL RECORD REVIEW; PRIORITY JOURNAL; RETROSPECTIVE STUDY; RISK ASSESSMENT; THROMBOCYTE COUNT; VENOUS THROMBOEMBOLISM;

AGE FACTORS; AGED; APACHE; BLOOD COAGULATION DISORDERS; CHI-SQUARE DISTRIBUTION; CRITICAL ILLNESS; FEMALE; HOSPITAL MORTALITY; HUMANS; INCIDENCE; INTENSIVE CARE UNITS; INTERNATIONAL NORMALIZED RATIO; LENGTH OF STAY; LOS ANGELES; MALE; RETROSPECTIVE STUDIES; RISK FACTORS; SEX FACTORS; STATISTICS, NONPARAMETRIC; VENOUS THROMBOEMBOLISM;

EID: 79958782250     PISSN: 00225282     EISSN: 15298809     Source Type: Journal    
DOI: 10.1097/TA.0b013e318217868d     Document Type: Article

References (14)

1. Clagett GP, Reisch JS. Prevention of venous thromboembolism in general surgical patients. Results of meta-analysis. Ann Surg. 1988;208: 227-240.
2. Cade JF. High risk of the critically ill for venous thromboembolism. Crit Care Med. 1982;10:448-450.
3. Geerts WH, Bergzvist D, Pineo GF, et al. Prevention of venous thromboembolism: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines (8th edition). Chest. 2008;133(6 suppl): 381S-453S.
4. Geerts W, Selby R. Prevention of venous thromboembolism in the ICU. Chest. 2003;124 (6 suppl):357S-363S.
5. Walsh TS, Stanworth SJ, Prescott RJ, Lee RJ, Watson DM, Wyncoll D; Writing Committee of the Intensive Care Study of Coagulopathy Investigators. Prevalence, management, and outcomes of critically ill patients with prothrombin time prolongation in United Kingdom intensive care units. Crit Care Med. 2010;38:1939-1946.
6. Andrews L, Maini B, Marik PE. The incidence of deep venous thrombosis in ICU patients. Chest. 1997;111:661-644.
7. Cook D, Crowther M, Meade M, et al. Deep venous thrombosis in medical-surgical critically ill patients: prevalence, incidence, and risk factors. Crit Care Med. 2005;7:1565-1571. (Pubitemid 40980613)
8. Major KM, Wilson M, Nishi GK, et al. The incidence of thromboembolism in the surgical intensive care unit. Am Surg. 2003;69:10: 857-861.
9. Rice TW, Wheeler AP. Coagulopathy in critically ill patients. I. platelet disorders. Chest. 2009;136:1622-1630.
10. Cook D, Douketis J, Meade M, et al; Canadian Critical Care Trials Group. Venous thromboembolism and bleeding in critically ill patients with severe renal insufficiency receiving dalteparin thromboprophylaxis: prevalence, incidence and risk factors. Crit Care. 2008;12:R32.
11. Northup PG, McMahon MM, Ruhl AP, et al. Coagulopathy does not fully protect hospitalized cirrhosis patients from peripheral venous thromboembolism. Am J Gastroenterol. 2006;101:1524-1528. (Pubitemid 43980626)
12. Gulley D, Teal E, Suvannasankha A, Chalasani N, Liangpunsakul S. Deep vein thrombosis and pulmonary embolism in cirrhosis patients. Dig Dis Sci. 2008;53:3012-3017.
13. Senzolo M, Sartori MT, Lisman T. Should we give thromboprophylaxis to patients with liver cirrhosis and coagulopathy? HPB (Oxford). 2009; 11:459-464.
14. Salottolo K, Offner P, Levy AS, Mains CW, Slone DS, Bar-Or D. Interrupted pharmocologic thromboprophylaxis increases venous thromboembolism in traumatic brain injury. J Trauma. 2011;70:19-24; discussion 25-26.