Phenotypic and genetic variation in leptin as determinants of weight regain

International Journal of Obesity

Volumn 35, Issue 6, 2011, Pages 785-792

  Erez, G ^a   Tirosh, A ^b,c   Rudich, A ^d   Meiner, V ^e   Schwarzfuchs, D ^f   Sharon, N ^g   Shpitzen, S ^e   Bluher M ^h   Stumvoll, M ^h   Thiery, J ^h   Fiedler, G M ^h   Friedlander, Y ^g   Leiterstdorf, E ^e   Shai, I ^d  

^a Leumit Research Institue   (Israel)

^b BRIGHAM AND WOMEN S HOSPITAL   (United States)

^c SHEBA MEDICAL CENTER   (Israel)

^d BEN GURION UNIVERSITY OF THE NEGEV   (Israel)

^e HADASSAH HEBREW UNIVERSITY MEDICAL CENTER   (Israel)

^f NUCLEAR RESEARCH CENTER NEGEV   (Israel)

^g HEBREW UNIVERSITY OF JERUSALEM   (Israel)

^h UNIVERSITY OF LEIPZIG   (Germany)

Author keywords

genetic polymorphism; leptin; weight maintenance

Indexed keywords

BIOLOGICAL MARKER; LEPTIN;

ADULT; ARTICLE; FEMALE; GENE; GENETIC MARKER; GENETIC VARIABILITY; HORMONE BLOOD LEVEL; HUMAN; MAJOR CLINICAL STUDY; MALE; NUCLEOTIDE SEQUENCE; PHENOTYPIC VARIATION; PREDICTION; PRIORITY JOURNAL; SINGLE NUCLEOTIDE POLYMORPHISM; WEIGHT CHANGE; WEIGHT GAIN;

BIOLOGICAL MARKERS; BODY MASS INDEX; DIET, REDUCING; FEMALE; GENETIC VARIATION; HUMANS; LEPTIN; MALE; MIDDLE AGED; OBESITY; PHENOTYPE; WEIGHT GAIN;

EID: 79958782136     PISSN: 03070565     EISSN: 14765497     Source Type: Journal    
DOI: 10.1038/ijo.2010.217     Document Type: Article

References (38)

1. Flegal KM, Graubard BI, Williamson DF, Gail MH. Excess deaths associated with underweight, overweight, and obesity. JAMA 2005; 293: 1861-1867. (Pubitemid 40548182)
2. Knowler WC, Barrett-Connor E, Fowler SE, Hamman RF, Lachin JM,Walker EA et al. Reduction of the incidence of type 2 diabetes with lifestyle intervention or metformin. N Engl J Med 2002; 346: 393-403. (Pubitemid 34437694)
3. Wood PD, Stefanick ML, Dreon DM, Frey-Hewitt B, Garay SC, Williams PT et al. Changes in plasma lipids and lipoproteins in overweight men during weight loss through dieting as compared with exercise. N Engl J Med 1988; 319: 1173-1179.
4. Elmer PJ, Grimm Jr R, Laing B, Grandits G, Svendsen K, Van Heel N et al. Lifestyle intervention: results of the Treatment of Mild Hypertension Study (TOMHS). Prev Med 1995; 24: 378-388.
5. Whelton PK, Appel LJ, Espeland MA, Applegate WB, Ettinger Jr WH, Kostis JB et al., on behalf of TONE Collaborative Research Group. Sodium reduction and weight loss in the treatment of hypertension in older persons: a randomized controlled trial of nonpharmacologic interventions in the elderly (TONE). JAMA 1998; 279: 839-846. (Pubitemid 28185548)
6. Stevens VJ, Obarzanek E, Cook NR, Lee IM, Appel LJ, Smith West D et al., Trials for the Hypertension Prevention Research Group. Longterm weight loss and changes in blood pressure: results of the trials of hypertension prevention, phase II. Ann Intern Med 2001; 134: 1-11. (Pubitemid 32037337)
7. Tuomilehto J, Lindstrom J, Eriksson JG, Valle TT, Hämälä inen H, Ilanne-Parikka P et al., on behalf of the Finnish Diabetes Prevention Study Group. Prevention of type 2 diabetes mellitus by changes in lifestyle among subjects with impaired glucose tolerance. N Engl J Med 2001; 344: 1343-1350. (Pubitemid 32378388)
8. Jeffery RW, Drewnowski A, Epstein LH, Stunkard AJ, Wilson GT, Wing RR et al. Long-term maintenance of weight loss: current status. Health Psychol 2000; 19 (Suppl 1): 5-16.
9. Tsai A, Wadden T. Systematic review: an evaluation of major commercial weight loss programs in the United States. Ann Intern Med 2005; 142: 56-66.
10. Dansinger ML, Tatsioni A, Wong JB, Chung M, Balk EA. Metaanalysis: the effect of dietary counseling for weight loss. Ann Intern Med 2007; 147: 41-50. (Pubitemid 351664633)
11. Serdula MK, Mokdad AH,Williamson DF, Galuska DA, Mendlein JM, Heath GW. Prevalence of attempting weight loss and strategies for controlling weight. JAMA 1999; 282: 1353-1358. (Pubitemid 29483193)
12. Leibel R, Rosenbaum M, Hirsch J. Changes in energy expenditure resulting from altered body weight. N Engl J Med 1995; 332: 621-628.
13. Rosenbaum M, Goldsmith R, Bloomfield D, Magnano A, Weimer L, Heymsfield S et al. Low-dose leptin reverses skeletal muscle, autonomic, and neuroendocrine adaptations to maintenance of reduced weight. J Clin Invest 2005; 115: 3579-3586. (Pubitemid 43121846)
14. Uusitupa M. Gene-diet interaction in relation to the prevention of obesity and type 2 diabetes: evidence from the Finnish Diabetes Prevention Study. Nutr Metab Cardiovasc Dis 2005; 15: 225-233. (Pubitemid 40934168)
15. Shai I, Schwarzfuchs D, Henkin Y, Shahar DR, Witkow S, Greenberg I et al., for the Dietary Intervention Randomized Controlled Trial (DIRECT) Group. Weight loss with a lowcarbohydrate, Mediterranean, or low-fat diet. N Engl J Med 2008; 359: 229-241. (Pubitemid 352008438)
16. Hobbs HH, Brown MS, Goldstein JL, Russell DW. Deletion of exon encoding cysteine-rich repeat of LDL receptor alters its binding specificity in a subject with familial hypercholesterolemia. J Biol Chem 1986; 261: 13114-13120. (Pubitemid 17006883)
17. Wigginton JE, Cutler DJ, Abecasis GR. A note on exact tests of Hardy-Weinberg equilibrium. Am J Hum Genet 2005; 76: 887-893. (Pubitemid 40563110)
18. Lake SL, Lyon H, Tantisira K, Silverman EK, Weiss ST, Laird NM et al. Estimation and tests of haplotype-environment interaction when linkage phase is ambiguous. Hum Hered 2003; 55: 56-65. (Pubitemid 36928747)
19. Sinnwell JP, Schaid DJ. Haplo.stats: Statistical analysis of haplotypes with traits and covariates when linkage phase is ambiguous. R package version 1.1.1, April 2004.
20. Barrett JC, Fry B, Maller J, Daly MJ. Haploview: analysis and visualization of LD and haplotype maps. Bioinformatics 2005; 21: 263-265. (Pubitemid 40202029)
21. Benjamini Y, Hochberg Y. Controlling the false discovery rate: a practical and powerful approach to multiple testing. J R Stat Soc 1995; 57: 289-300.
22. Martin SS, Qasim A, Reilly MP. Leptin resistance: a possible interface of inflammation and metabolism in obesity-related cardiovascular disease. J Am Coll Cardiol 2008; 52: 1201-1210.
23. MacLean PS, Higgins JA, Jackman MR, Johnson GC, Felming- Elder BK, Wyatt HR et al. Peripheral metabolic responses to prolonged weight reduction that promote rapid, efficient regain in obesity-prone rats. Am J Physiol Regul Integr Comp Physiol 2006; 290: R1577-R1588. (Pubitemid 43830823)
24. Rosenbaum M, Vandenborne K, Goldsmith R, Simoneau JA, Heymsfield S, Joanisse DR et al. Effects of weight change on skeletal muscle work efficiency in human subjects. Am J Physiol Regul Integr Comp Physiol 2003; 285: R183-R192. (Pubitemid 36736517)
25. Scarpace PJ, Matheny M, Zhang Y, Shek EW, Prima V, Zolotukhin S et al. Leptin-induced leptin resistance reveals separate roles for the anorexic and thermogenic responses in weight maintenance. Endocrinology 2002; 143: 3026-3035. (Pubitemid 34809876)
26. Filozof CM, Murúa C, Sanchez MP, Brailovsky C, Perman M, Gonzalez CD et al. Low plasma leptin concentration and low rates of fat oxidation in weight-stable post-obese subjects. Obes Res 2000; 8: 205-210.
27. Rosenbaum M, Sy M, Pavlovich K, Leibel RL, Hirsch J. Leptin reverses weight loss-induced changes in regional neural activity responses to visual food stimuli. J Clin Invest 2008; 118: 2583-2591. (Pubitemid 351949785)
28. Vogels N, Westerterp-Plantenga MS. Successful long-term weight maintenance: a 2-year follow-up. Obesity 2007; 15: 1258-1566.
29. Mavri A, Stegnar M, Sabovic M. Do baseline serum leptin levels predict weight regain after dieting in obese women? Diabetes Obes Metab 2001; 3: 293-296. (Pubitemid 32785340)
30. Montague CT, Farooqi IS, Whitehead JP, Soos MA, Rau H, Wareham NJ et al. Congenital leptin deficiency is associated with severe early-onset obesity in humans. Nature 1997; 387: 903-908. (Pubitemid 27289591)
31. Strobel A, Issad T, Camoin L, Ozata M, Strosberg AD. A leptin missense mutation associated with hypogonadism and morbid obesity. Nat Genet 1998; 18: 213-215.
32. Le Stunff C, Le Bihan C, Schork NJ, Bougneres P. A common promoter variant of the leptin gene is associated with changes in the relationship between serum leptin and fat mass in obese girls. Diabetes 2000; 49: 2196-2200.
33. Li WD, Reed DR, Lee JH, Xu W, Kilker RL, Sodam BR et al. Sequence variants in the 50 flanking region of the leptin gene are associated with obesity in women. Ann Hum Genet 1999; 63: 227-234. (Pubitemid 29471966)
34. Mammes O, Betoulle D, Aubert R, Herbeth B, Siest G, Fumeron F. Association of the G-2548A polymorphism in the 50 region of the LEP gene with overweight. Ann Hum Genet 2000; 64: 391-394. (Pubitemid 32055730)
35. Jiang Y, Wilk JB, Borecki I, Williamson S, DeStefano AL, Xu G et al. Common variants in the 50 region of the leptin gene are associated with body mass index in men from the National Heart, Lung, and Blood Institute Family Heart Study. Am J Hum Genet 2004; 75: 220-230. (Pubitemid 38943865)
36. Karvonen MK, Pesonen U, Heinonen P, Laakso M, Rissanen A, Naukkarinen H et al. Identification of new sequence variants in the leptin gene. J Clin Endocr Metab 1998; 83: 3239-3242. (Pubitemid 28500966)
37. Gaukrodger N, Mayosi BM, Imrie H, Avery P, Baker M, Connell JM et al. A rare variant of the leptin gene has large effects on blood pressure and carotid intima-medial thickness: a study of 1428 individuals in 248 families. J Med Genet 2005; 42: 474-478. (Pubitemid 40847234)
38. Peltonen L, McKusick VA. Genomics and medicine: dissecting human disease in the postgenomic era. Science 2001; 291: 1224-1229. (Pubitemid 32173078)