Model-driven design based on sensitivity analysis for a synthetic biology application

Computer Aided Chemical Engineering

Volumn 29, Issue , 2011, Pages 1446-1450

  Anesiadis, Nikolaos ^a   Cluett, William R ^a   Mahadevan, Radhakrishnan ^a,b  

^a UNIVERSITY OF TORONTO   (Canada)

^b UNIVERSITY OF TORONTO   (Canada)

Author keywords

Genetic circuits; Metabolic engineering; Parametric sensitivity

Indexed keywords

EID: 79958780826     PISSN: 15707946     EISSN: None     Source Type: Book Series    
DOI: 10.1016/B978-0-444-54298-4.50068-4     Document Type: Book

References (10)

1. Anesiadis N., Cluett W.R., Mahadevan R. Dynamic metabolic engineering for increasing bioprocess productivity. Metabolic Engineering 2008, 10:255-266.
2. Feng X., Hooshangi S., Chen D., Li G., Weiss R., Rabitz H. Optimizing genetic circuits by global sensitivity analysis. Biophysical Journal 2004, 87:2195-2202.
3. Fung E., Wong W.W., Suen J.K., Butler T., Lee S., Liao J.C. A synthetic gene-metabolic oscillator. Nature 2005, 435:118-122.
4. Gardner T.S., Cantor C.R., Collins J.C. Construction of a genetic toggle switch in Escherichia coli. Nature 2000, 403:339-342.
5. Kiparissides A., Kucherenko S.S., Mantalaris A., Pistikopoulos E.N. Global sensitivity analysis challenges in biological systems modeling. Ind. Eng. Chem. Res. 2009, 48:7168-7180.
6. Purnick P.E.M., Weiss R. The second wave of synthetic biology: from modules to systems. Nature Reviews: Molecular Cell Biology 2009, 10:410-422.
7. Reed J.L., Vo T.D., Schilling C.H., Palsson B.O. An expanded genome-scale model of Escherichia coli K-12 (iJR904 GSM/GPR). Genome Biology 2003, 4:R54.
8. Saltelli A. Making best use of model evaluations to compute sensitivity indices. Computer Physics Communications 2002, 145:280-297.
9. Sobol' I.M. Global sensitivity indices for nonlinear mathematical models and their Monte Carlo estimates. Mathematics and Computers in simulation 2001, 55:271-280.
10. Zheng Y., Rundell A. Comparative study of parameter sensitivity analyses of the TCR-activated Erk-MAPK signalling pathway. IEE Proc. Syst. Biol. 2006, 153(4):201-211.