Effects of estrogen on osteoprogenitor cells and cytokines/bone-regulatory factors in postmenopausal women

Bone

Volumn 49, Issue 2, 2011, Pages 202-207

  Mödder, Ulrike I ^a   Roforth, Matthew M ^a   Hoey, Kelley ^a   McCready, Louise K ^a   Peterson, James M ^a   Monroe, David G ^a   Oursler, Merry Jo ^a   Khosla, Sundeep ^a  

^a MAYO CLINIC   (United States)

Author keywords

Cytokines; Estrogen; Osteoporosis; Osteoprogenitor cells; Postmenopausal women

Indexed keywords

ADIPONECTIN; CYCLIN B1; CYCLIN E; CYTOKINE; DICKKOPF 1 PROTEIN; ESTRADIOL; ESTROGEN; INTERLEUKIN 1BETA; INTERLEUKIN 6; MESSENGER RNA; NERVE CELL ADHESION MOLECULE; OSTEOCLAST DIFFERENTIATION FACTOR; OSTEOPROTEGERIN; OXYTOCIN; PROTEIN LYSINE 6 OXIDASE; SCLEROSTIN; SEROTONIN; TRANSCRIPTION FACTOR E2F1; TRANSCRIPTION FACTOR RUNX2; TUMOR NECROSIS FACTOR ALPHA; WNT PROTEIN;

ARTICLE; BONE DEVELOPMENT; BONE MARROW CELL; BONE METABOLISM; CELL LINEAGE; CELL PROLIFERATION; CONTROLLED STUDY; CYTOKINE RELEASE; DOWN REGULATION; ESTROGEN ACTIVITY; GENE EXPRESSION; HUMAN; HUMAN CELL; POSTMENOPAUSE; PROTEIN ANALYSIS; PROTEIN BLOOD LEVEL; PROTEIN FUNCTION; PROTEIN LOCALIZATION; UPREGULATION;

ADIPONECTIN; AGED; BONE AND BONES; BONE MARROW CELLS; BONE MORPHOGENETIC PROTEINS; CELLS, CULTURED; CYTOKINES; ESTRADIOL; ESTROGENS; ESTRONE; FEMALE; GENETIC MARKERS; HUMANS; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; INTERLEUKIN-1; INTERLEUKIN-6; OXYTOCIN; POSTMENOPAUSE; RANK LIGAND; STEM CELLS; TUMOR NECROSIS FACTOR-ALPHA;

EID: 79958770416     PISSN: 87563282     EISSN: 87563282     Source Type: Journal    
DOI: 10.1016/j.bone.2011.04.015     Document Type: Article

References (35)

1. Khosla S., Melton L.J.I., Riggs B.L. The unitary model for estrogen deficiency and the pathogenesis of osteoporosis: is a revision needed?. J Bone Miner Res 2011, 26:441-451.
2. Gregorio G.B., Yamamoto M., Ali A.A., Abe E., Roberson P., Manolagas S.C., et al. Attenuation of the self-renewal of transit-amplifying osteoblast progenitors in the murine bone marrow by 17beta-estradiol. J Clin Invest 2001, 107:803-812.
3. Manolagas S.C. Birth and death of bone cells: basic regulatory mechanisms and implications for the pathogenesis and treatment of osteoporosis. Endocr Rev 2000, 21:115-137.
4. Dang Z.C., Van Bezooijen R.L., Karperien M., Papapoulos S.E., Lowik C.W.G.M. Exposure of KS483 cells to estrogen enhances osteogenesis and inhibits adipogenesis. J Bone Miner Res 2002, 17:394-405.
5. Saintier D., Burde M.A., Rey J.M., Maudelonde T., de Vernejoul M.C., Cohen-Solal M.E. 17beta-estradiol downregulates beta3-integrin expression in differentiating and mature human osteoclasts. J Cell Physiol 2004, 198:269-276.
6. Shur I., Zemer-Tov E., Socher R., Benayahu D. SVEP1 expression is regulated in estrogen-dependent manner. J Cell Physiol 2007, 210:732-739.
7. Syed F., Khosla S. Mechanisms of sex steroid effects on bone. Biochem Biophys Res Commun 2005, 328:688-696.
8. Simmons P.J., Torok-Storb B. Identification of stromal cell precursors in human bone marrow by novel monoclonal antibody, STRO-1. Blood 1991, 78:55-62.
9. Kolf C.M., Cho E., Tuan R.S. Mesenchymal stromal cells biology of adult mesenchymal stem cells: regulation of niche, self-renewal and differentiation. Arthritis Res Ther 2007, 9:204.
10. Modder U.I., Riggs B.L., Khosla S. The role of the immune system in the development of osteoporosis. Osteoimmunology: interactions of the immune and skeletal systems 2011, 269-299. Elsevier Press. J. Lorenzo, Y. CHoi, M. Horowitz, H. Takayanagi (Eds.).
11. Dafforn A., Chen P., Deng G., Herrler M., Iglehart D., Koritala S., et al. Linear mRNA amplification from as little as 5ng total RNA for global gene expression. Biotechniques 2004, 37:854-857.
12. Nygaard V., Hovig E. Options available for profiling small samples: a review of sample amplification technology when combined with microarray profiling. Nucleic Acids Res 2006, 34:996-1014.
13. Radonic A., Thulke S., Mackay I.M., Landt O., Siegert W., Nitsche A. Guideline to reference gene selection for quantitative real-time PCR. Biochem Biophys Res Commun 2004, 313:856-862.
14. Vandesompele J., De Preter K., Pattyn F., Poppe B., Van Roy N., De Paepe A., et al. Accurate normalization of real-time quantitative RT-PCR data by geometric averaging of multiple internal control genes. Genome Biol 2002, 3. [research0034.1-0-34.11].
15. Zhao S., Fernald R.D. Comprehensive algorithm for quantitative real-time polymerase chain reaction. J Comput Biol 2005, 12:1047-1064.
16. Terpos E., Christoulas D., Katodritou E., Bratengeier C., Linder B., Harmelin S., et al. High serum sclerostin correlates with advanced stage, increased bone resorption, reducted osteoblast function, and poor survival in newly-diagnosed patients with multiple myeloma. Blood 2009, 114. [Abstract 425].
17. Modder U.I.L., Clowes J.A., Hoey K., Peterson J.M., McCready L., Oursler M.J., et al. Regulation of circulating sclerostin levels by sex steroids in women and men. J Bone Miner Res 2011, 26:27-34.
18. Gaudio A., Pennisi P., Bratengeier C., Torrisi V., Lindner B., Mangiafico R.A., et al. Increased sclerostin serum levels associated with bone formation and resorption markers in patients with immobilization-induced bone loss. J Clin Endocrinol Metab 2010, 95:2248-2253.
19. Modder U.I., Hoey K.A., Amin S., McCready L.K., Achenbach S.J., Riggs B.L., et al. Relation of age, gender, and bone mass to circulating sclerostin levels in women and men. J Bone Miner Res 2011, 26:373-379.
20. Subramanian A., Tamayo P., Mootha V.K., Mukherjee S., Ebert B.L., Gillette M.A., et al. Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles. Proc Natl Acad Sci U S A 2005, 102:15545-15550.
21. Efron B., Tibshirani R. On testing the significance of sets of genes. Ann Appl Statist 2007, 1:107-129.
22. O'Brien P.C. Procedures for comparing samples with multiple endpoints. Biometrics 1984, 40:1079-1087.
23. Mirza F.S., Padhi I.D., Raisz L.G., Lorenzo J.A. Serum sclerostin levels negatively correlate with parathyroid hormone levels and free estrogen index in postmenopausal women. J Clin Endocrinol Metab 2010, 95:1991-1997.
24. Khosla S. Update on estrogens and the skeleton. J Clin Endocrinol Metab 2010, 95:3569-3577.
25. Cheng S., Lecanda F., Davidson M.K., Warlow P.M., Zhang S., Zhang L., et al. Human osteoblasts express a repertoire of cadherins, which are critical for BMP-2-induced osteogenic differentiation. J Bone Miner Res 1998, 13:633-644.
26. Liu P., Lin J.H., Zhang B. Differential regulation of cadherin expression by osteotropic hormones and growth factors in vitro in human osteoprogenitor cells. Acta Pharmacol Sin 2005, 26:705-713.
27. Tsutsumimoto T., Kawasaki S., Ebara S., Takaoka K. TNF-alpha and IL-1beta supress N-cadherin expression in MC3T3-E1 cells. J Bone Miner Res 1999, 14:1751-1760.
28. Lai C.F., Cheng S.L., Mbalaviele G., Donsante C., Watkins M., Radice G.L., et al. Accentuated ovariectomy-induced bone loss and altered osteogenesis in heterozygous N-cadherin null mice. J Bone Miner Res 2006, 21:1897-1906.
29. Almeida M., Martin-Millan M., Ambrogini E., Bradsher R.I., Han L., Chen X.-D., et al. Estrogens attenuate oxidative stress and the differentiation and apoptosis of osteoblasts by DNA-binding-independent actions by the ERalpha. J Bone Miner Res 2010, 25:769-781.
30. Gimble J.M., Zvonic S., Floyd Z.E., Kassem M., Nuttall M.E. Playing with bone and fat. J Cell Biochem 2006, 98:251-266.
31. Syed F.A., Oursler M.J., Hefferanm T.E., Peterson J.M., Riggs B.L., Khosla S. Effects of estrogen therapy on bone marrow adipocytes in postmenopausal osteoporotic women. Osteoporos Int 2008, 19:1323-1330.
32. Paszty C., Turner C.H., Robinson M.K. Sclerostin: a gem from the genome leads to bone-building antibodies. J Bone Miner Res 2010, 25:1897-1904.
33. Kearns A.E., Khosla S., Kostenuik P.J. Receptor activator of nuclear factor kappaB ligand and osteoprotegerin regulation of bone remodeling in health and disease. Endocr Rev 2008, 29:155-192.
34. Warden S.J., Robling A.G., Haney E.M., Turner C.H., Bliziotes M.M. The emerging role of serotonin (5-hydroxytryptamine) in the skeleton and its mediation of the skeletal effects of low-density lipoprotein receptor-related protein 5 (LRP5). Bone 2010, 46:4-12.
35. Kontogianni M.D., Dafni U.G., Routsias J.G., Skopouli F.N. Blood leptin and adiponectin as possible mediators of the relation between fat mass and BMD in perimenopausal women. J Bone Miner Res 2004, 19:546-551.