Acute panicogenic, anxiogenic and dissociative effects of carbon dioxide inhalation in patients with post-traumatic stress disorder (PTSD)

Journal of Psychiatric Research

Volumn 45, Issue 7, 2011, Pages 989-993

  Muhtz, Christoph ^a   Yassouridis, Alexander ^b   Daneshi, Jasmine ^a   Braun, Miriam ^a   Kellner, Michael ^a  

^a UNIVERSITY MEDICAL CENTER HAMBURG EPPENDORF   (Germany)

^b MAX PLANCK INSTITUTE OF PSYCHIATRY   (Germany)

Author keywords

Carbon dioxide; CO2; Dissociation; Flashback; Panic; Post traumatic stress disorder

Indexed keywords

CARBON DIOXIDE;

ADULT; ANXIETY; ARTICLE; CARBON DIOXIDE BREATHING; CLINICAL ARTICLE; CONTROLLED STUDY; DISSOCIATIVE DISORDER; FEMALE; HUMAN; MALE; PANIC; POSTTRAUMATIC STRESS DISORDER; PRIORITY JOURNAL; VITAL CAPACITY;

ADMINISTRATION, INHALATION; ADULT; ANXIETY; AROUSAL; CARBON DIOXIDE; DISSOCIATIVE DISORDERS; FEMALE; HUMANS; MALE; PANIC; PERSONALITY INVENTORY; PSYCHOMETRICS; REFERENCE VALUES; STRESS DISORDERS, POST-TRAUMATIC;

EID: 79958768006     PISSN: 00223956     EISSN: 18791379     Source Type: Journal    
DOI: 10.1016/j.jpsychires.2011.01.009     Document Type: Article

References (42)

1. Bailey J.E., Argyropoulos S.V., Lightman S.L., Nutt D.J. Does the brain noradrenaline network mediate the effects of the CO2 challenge?. Journal of Psychopharmacology 2003, 17:252-259.
2. Bandelow B., Hajak G., Holzrichter S., Kunert H.J., Ruther E. Assessing the efficacy of treatments for panic disorder and agoraphobia. I. Methodological problems. International Clinical Psychopharmacology 1995, 10:83-93.
3. Blechert J., Michael T., Grossman P., Lajtman M., Wilhelm F.H. Autonomic and respiratory characteristics of posttraumatic stress disorder and panic disorder. Psychosomatic Medicine 2007, 69:935-943.
4. Brown T.A., McNiff J. Specificity of autonomic arousal to DSM-IV panic disorder and posttraumatic stress disorder. Behaviour Research and Therapy 2009, 47:487-493.
5. Colasanti A., Salamon E., Schruers K., van Diest R., van Duinen M., Griez E.J. Carbon dioxide-induced emotion and respiratory symptoms in healthy volunteers. Neuropsychopharmacology 2008, 33:3103-3110.
6. Cougle J.R., Feldner M.T., Keough M.E., Hawkins K.A., Fitch K.E. Comorbid panic attacks among individuals with posttraumatic stress disorder: associations with traumatic event exposure history, symptoms, and impairment. Journal of Anxiety Disorders 2010, 24:183-188.
7. Coupland N.J., Lillywhite A., Bell C.E., Potokar J.P., Nutt D.J. A pilot controlled study of the effects of flumazenil in posttraumatic stress disorder. Biological Psychiatry 1997, 41:988-990.
8. Dillon D.J., Gorman J.M., Liebowitz M.R., Fyer A.J., Klein D.F. Measurement of lactate-induced panic and anxiety. Psychiatry Research 1987, 20:97-105.
9. Esquivel G., Schruers K.R., Maddock R.J., Colasanti A., Griez E.J. Acids in the brain: a factor in panic?. Journal of Psychopharmacology 2010, 24:639-647.
10. Fishman S.M., Carr D.B., Becket A., Rosenbaum J.F. Hypercapneic ventilatory response in patients with panic disorder before and after alprazolam treatment and in pre- and postmenstrual women. Journal of Psychiatric Research 1994, 28:165-170.
11. Foa E.B., Cashman L., Jaycox L., Perry K. The validation of a self-report measure of posttraumatic stress disorder: the posttraumatic diagnostic scale. Psychological Assessment 1997, 4:445-451.
12. Gorman J.M., Kent J.M., Sullivan G.M., Coplan J.D. Neuroanatomical hypothesis of panic disorder, revised. American Journal of Psychiatry 2000, 157:493-505.
13. Gorman J.M., Kent J., Martinez J., Browne S., Coplan J., Papp L.A. Physiological changes during carbon dioxide inhalation in patients with panic disorder, major depression, and premenstrual dysphoric disorder: evidence for a central fear mechanism. Archives of General Psychiatry 2001, 58:125-131.
14. Griez E.J., Colasanti A., van Diest R., Salamon E., Schruers K. Carbon dioxide inhalation induces dose-dependent and age related negative affectivity. PLoS One 2007, 2:e987.
15. Jensen C.F., Keller T.W., Peskind E.R., McFall M.E., Veith R.C., Martin D., et al. Behavioral and neuroendocrine responses to sodium lactate infusion in subjects with posttraumatic stress disorder. American Journal of Psychiatry 1997, 154:266-268.
16. Kellner M., Levengood R., Yehuda R., Wiedemann K. Provocation of a posttraumatic flashback by cholecystokinin tetrapeptide?. American Journal of Psychiatry 1998, 155:1299.
17. Kellner M., Wiedemann K., Yassouridis A., Levengood R., Guo L.S., Holsboer F., et al. Behavioral and endocrine response to cholecystokinin tetrapeptide in patients with posttraumatic stress disorder. Biological Psychiatry 2000, 47:107-111.
18. Kellner M., Yassouridis A., Hua Y., Wendrich M., Naber D., Wiedemann K. Trait dissociation affects the behavioral response to cholecystokinin tetrapeptide in healthy man. Psychiatry Research 2002, 111:93-96.
19. Kelly M.M., Forsyth J.P., Karekla M. Sex differences in response to a panicogenic challenge procedure: an experimental evaluation of panic vulnerability in a non-clinical sample. Behaviour Research and Therapy 2006, 44:1421-1430.
20. Klein D.F. False suffocation alarms, spontaneous panics, and related conditions. An integrative hypothesis. Archives of General Psychiatry 1993, 50:306-317.
21. Leonard K.N., Telch J.M., Harrington P.J. Dissociation in the laboratory: a comparison of strategies. Behaviour Research and Therapy 1999, 37:49-61.
22. Mellman T.A., Davis G.C. Combat-related flashbacks in posttraumatic stress disorder: phenomenology and similarity to panic attacks. Journal of Clinical Psychiatry 1985, 46:379-382.
23. Muhtz C., Wester M., Yassouridis A., Wiedemann K., Kellner M. A combined dexamethasone/corticotropin-releasing hormone test in patients with chronic PTSD-first preliminary results. Journal of Psychiatric Research 2008, 42:689-693.
24. Muhtz C., Braun M., Daneshi J., Kellner M. Carbon-dioxide induced panic and flashbacks in a patient with chronic PTSD before and after successful combined psycho- and pharmacotherapy. German Journal of Psychiatry 2010, 12:9.
25. Nixon R.D., Bryant R.A. Induced arousal and reexperiencing in acute stress disorder. Journal of Anxiety Disorders 2005, 19:587-594.
26. Ogliari A., Tambs K., Harris J.R., Scaini S., Maffei C., Reichborn-Kjennerud T., et al. The relationships between adverse events, early antecedents, and carbon dioxide reactivity as an intermediate phenotype of panic disorder: a general population study. Psychotherapy and Psychosomatics 2010, 79:48-55.
27. Rainey J.M., Aleem A., Ortiz A., Yeragani V., Pohl R., Berchou R. A laboratory procedure for the induction of flashbacks. American Journal of Psychiatry 1987, 144:1317-1319.
28. Randall P.K., Bremner J.D., Krystal J.H., Nagy L.M., Heninger G.R., Nicolaou A.L., et al. Effects of the benzodiazepine antagonist flumazenil in PTSD. Biological Psychiatry 1995, 38:319-324.
29. Rassovsky Y., Kushner M.G. Carbon dioxide in the study of panic disorder: issues of definition, methodology, and outcome. Journal of Anxiety Disorders 2003, 17:1-32.
30. Rassovsky Y., Abrams K., Kushner M.G. Suffocation and respiratory responses to carbon dioxide and breath holding challenges in individuals with panic disorder. Journal of Psychosomatic Research 2006, 60:291-298.
31. Rosen S.D., King J.C., Nixon P.G. Hyperventilation in patients who have sustained myocardial infarction after a work injury. Journal of the Royal Society of Medicine 1994, 87:268-271.
32. Schmidt N.B., Richey J.A. Social anxiety symptoms uniquely predict fear responding to 35% CO(2) challenge. Journal of Psychiatric Research 2008, 42:851-857.
33. Schruers K., Esquivel G., van Duinen M., Wichers M., Kenis G., Colasanti A., et al. Genetic moderation of CO2- induced fear by 5-HTTPLPR genotype. Journal of Psychopharmacology 2010, 24:639-647.
34. Shipherd J.C., Beck J.G., Ohtake P.J. Relationships between the anxiety sensitivity index, the suffocation fear scale, and responses to CO2 inhalation. Journal of Anxiety Disorders 2001, 15:247-258.
35. Southwick S.M., Krystal J.H., Bremner J.D., Morgan C.A., Nicolaou A.L., Nagy L.M., et al. Noradrenergic and serotonergic function in posttraumatic stress disorder. Archives of General of Psychiatry 1997, 54:749-758.
36. Southwick S.M., Krystal J.H., Morgan C.A., Johnson D., Nagy L.M., Nicolaou A., et al. Abnormal noradrenergic function in posttraumatic stress disorder. Archives of General Psychiatry 1993, 50:266-274.
37. Strohle A. Increased response to a putative panicogenic nocebo administration in female patients with panic disorder. Journal of Psychiatric Research 2000, 34:439-442.
38. Talesnik B., Berzak E., Ben-Zion I., Kaplan Z., Benjamin J. Sensitivity to carbon dioxide in drug-naive subjects with post-traumatic stress disorder. Journal of Psychiatric Research 2007, 41:451-454.
39. Verburg K., Pols H., de Leeuw M., Griez E. Reliability of the 35% carbon dioxide panic provocation challenge. Psychiatry Research 1998, 78:207-214.
40. Verburg K., Klaassen T., Pols H., Griez E. Comorbid depressive disorder increases vulnerability to the 35% carbon dioxide (CO2) challenge in panic disorder patients. Journal of Affective Disorders 1998, 49:195-201.
41. Wittchen H.U., Wunderlich U., Gruschwitz, Zaudig M. SKID-I. Strukturiertes Klinisches Interview für DSM-IV. Achse I: Psychische Störungen 1997, Göttingen (Germany).
42. Ziemann A.E., Allen J.E., Dahdaleh N.S., Drebot, Coryell M.W., Wunsch A.M., et al. The amygdala is a chemosensor that detects carbon dioxide and acidosis to elicit fear behavior. Cell 2009, 139:1012-1021.