Identification of a high molecular weight kininogen fragment as a marker for early gastric cancer by serum proteome analysis

Journal of Gastroenterology

Volumn 46, Issue 5, 2011, Pages 577-585

  Umemura, Hiroshi ^a   Togawa, Akira ^b   Sogawa, Kazuyuki ^a   Satoh, Mamoru ^a   Mogushi, Kaoru ^c   Nishimura, Motoi ^a   Matsushita, Kazuyuki ^a   Tanaka, Hiroshi ^c   Takizawa, Hirotaka ^d   Kodera, Yoshio ^e   Nomura, Fumio ^a  

^a CHIBA UNIVERSITY   (Japan)

^b KIMITSU CHUO HOSPITAL   (Japan)

^c TOKYO MEDICAL AND DENTAL UNIVERSITY   (Japan)

^d Kashiwado Memorial Foundation   (Japan)

^e KITASATO UNIVERSITY   (Japan)

Author keywords

Gastric adenocarcinoma; High molecular weight kininogen; MALDI TOF MS; Proteomics; Serum biomarkers

Indexed keywords

CA 19-9 ANTIGEN; CARCINOEMBRYONIC ANTIGEN; HIGH MOLECULAR WEIGHT KININOGEN;

AGED; ARTICLE; CANCER PATIENT; CANCER STAGING; COHORT ANALYSIS; CONTROLLED STUDY; DIAGNOSTIC VALUE; EARLY CANCER; EARLY DIAGNOSIS; ENZYME ACTIVITY; ENZYME REGULATION; FEMALE; GASTRECTOMY; HUMAN; MAJOR CLINICAL STUDY; MALE; MATRIX ASSISTED LASER DESORPTION IONIZATION TIME OF FLIGHT MASS SPECTROMETRY; MOLECULAR WEIGHT; PREDICTIVE VALUE; PREOPERATIVE EVALUATION; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN BLOOD LEVEL; PROTEIN SYNTHESIS; PROTEOMICS; RECEIVER OPERATING CHARACTERISTIC; SENSITIVITY AND SPECIFICITY; STOMACH ADENOCARCINOMA; STOMACH CANCER; TANDEM MASS SPECTROMETRY;

ADENOCARCINOMA; AGED; AREA UNDER CURVE; CASE-CONTROL STUDIES; EARLY DETECTION OF CANCER; FEMALE; HUMANS; KININOGEN, HIGH-MOLECULAR-WEIGHT; MALE; MASS SPECTROMETRY; MIDDLE AGED; MOLECULAR WEIGHT; NEOPLASM PROTEINS; PROTEOME; PROTEOMICS; ROC CURVE; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION; STOMACH NEOPLASMS; TUMOR MARKERS, BIOLOGICAL;

EID: 79958766040     PISSN: 09441174     EISSN: 14355922     Source Type: Journal    
DOI: 10.1007/s00535-010-0369-3     Document Type: Article

References (34)

1. Goodman KJ, Cockburn M. The role of epidemiology in understanding the health effects of Helicobacter pylori. Epidemiology. 2001;12:266-71. (Pubitemid 32167765)
2. Wobbes T, Thomas CM, Segers MF, Nagengast FM. Evaluation of seven tumor markers (CA 50, CA 19-9, CA 19-9 TruQuant, CA 72-4, CA 195, carcinoembryonic antigen, and tissue polypeptide antigen) in the pretreatment sera of patients with gastric carcinoma. Cancer. 1992;69:2036-41.
3. Fernandez-Fernandez L, Tejero E, Tieso A, Rabadan L, Munoz M, Santos I. Receiver operating characteristic (ROC) curve analysis of the tumor markers CEA, CA 19-9 and CA 72-4 in gastric cancer. Int Surg. 1996;81:400-2.
4. Kochi M, Fujii M, Kanamori N, Kaiga T, Kawakami T, Aizaki K, et al. Evaluation of serum CEA and CA19-9 levels as prognostic factors in patients with gastric cancer. Gastric Cancer. 2000;3:177-86. (Pubitemid 32290724)
5. Wulfkuhle JD, Liotta LA, Petricoin EF. Proteomic applications for the early detection of cancer. Nat Rev Cancer. 2003;3:267-75. (Pubitemid 37328862)
6. Petricoin EF, Belluco C, Araujo RP, Liotta LA. The blood peptidome: a higher dimension of information content for cancer biomarker discovery. Nat Rev Cancer. 2006;6:961-7. (Pubitemid 44862680)
7. Hortin GL. The MALDI-TOF mass spectrometric view of the plasma proteome and peptidome. Clin Chem. 2006;52:1223-37. (Pubitemid 43956011)
8. Davies HA. The ProteinChip System from Ciphergen: a new technique for rapid, micro-scale protein biology. J Mol Med. 2000;78:B29.
9. Kanmura S, Uto H, Sato Y, Kumagai K, Sasaki F, Moriuchi A, et al. The complement component C3a fragment is a potential biomarker for hepatitis C virus-related hepatocellular carcinoma. J Gastroenterol. 2010;45:459-67.
10. Nomura F, Tomonaga T, Sogawa K, Ohashi T, Nezu M, Sunaga M, et al. Identification of novel and downregulated biomarkers for alcoholism by surface enhanced laser desorption/ionization-mass spectrometry. Proteomics. 2004;4:1187-94. (Pubitemid 38445975)
11. Takano S, Yoshitomi H, Togawa A, Sogawa K, Shida T, Kimura F, et al. Apolipoprotein C-1 maintains cell survival by preventing from apoptosis in pancreatic cancer cells. Oncogene. 2008;27:2810-22. (Pubitemid 351620452)
12. Zhang X, Leung SM, Morris CR, Shigenaga MK. Evaluation of a novel, integrated approach using functionalized magnetic beads, bench-top MALDI-TOF-MS with prestructured sample supports, and pattern recognition software for profiling potential biomarkers in human plasma. J Biomol Tech. 2004;15:167-75.
13. Sogawa K, Satoh M, Kodera Y, Tomonaga T, Iyo M, Nomura F. A search for novel markers of alcohol abuse using magnetic beads and MALDI-TOF/TOF mass spectrometry. Proteomics Clin Appl. 2009;3:821-8.
14. Kulasingam V, Diamandis EP. Strategies for discovering novel cancer biomarkers through utilization of emerging technologies. Nat Clin Pract Oncol. 2008;5:588-99.
15. Umemura H, Nezu M, Kodera Y, Satoh M, Kimura A, Tomonaga T, et al. Effects of the time intervals between venipuncture and serum preparation for serum peptidome analysis by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry. Clin Chim Acta. 2009;406:179-80.
16. Umemura H, Kodera Y, Nomura F. Effects of humidity on the dried-droplet sample preparation for MALDI-TOF MS peptide profiling. Clin Chim Acta. 2010;411:2109-11.
17. Ebert MP, Meuer J, Wiemer JC, Schulz HU, Reymond MA, Traugott U, et al. Identification of gastric cancer patients by serum protein profiling. J Proteome Res. 2004;3:1261-6. (Pubitemid 40040381)
18. Ebert MP, Lamer S, Meuer J, Malfertheiner P, Reymond M, Buschmann T, et al. Identification of the thrombin light chain a as the single best mass for differentiation of gastric cancer patients from individuals with dyspepsia by proteome analysis. J Proteome Res. 2005;4:586-90. (Pubitemid 40548167)
19. Ebert MP, Niemeyer D, Deininger SO, Wex T, Knippig C, Hoffmann J, et al. Identification and confirmation of increased fibrinopeptide a serum protein levels in gastric cancer sera by magnet bead assisted MALDI-TOF mass spectrometry. J Proteome Res. 2006;5:2152-8. (Pubitemid 44330807)
20. Su Y, Shen J, Qian H, Ma H, Ji J, Ma H, et al. Diagnosis of gastric cancer using decision tree classification of mass spectral data. Cancer Sci. 2007;98:37-43. (Pubitemid 44803918)
21. Inoue M, Tsugane S. Epidemiology of gastric cancer in Japan. Postgrad Med J. 2005;81:419-24. (Pubitemid 41002579)
22. Hatakeyama M. Helicobacter pylori and gastric carcinogenesis. J Gastroenterol. 2009;44:239-48.
23. Ohata H, Kitauchi S, Yoshimura N, Mugitani K, Iwane M, Nakamura H, et al. Progression of chronic atrophic gastritis associated with Helicobacter pylori infection increases risk of gastric cancer. Int J Cancer. 2004;109:138-43. (Pubitemid 38160674)
24. Mukoubayashi C, Yanaoka K, Ohata H, Arii K, Tamai H, Oka M, et al. Serum pepsinogen and gastric cancer screening. Intern Med. 2007;46:261-6. (Pubitemid 46488392)
25. Villanueva J, Shaffer DR, Philip J, Chaparro CA, Erdjument-Bromage H, Olshen AB, et al. Differential exoprotease activities confer tumor-specific serum peptidome patterns. J Clin Invest. 2006;116:271-84. (Pubitemid 43121812)
26. Schaub NP, Jones KJ, Nyalwidhe JO, Cazares LH, Karbassi ID, Semmes OJ, et al. Serum proteomic biomarker discovery reflective of stage and obesity in breast cancer patients. J Am Coll Surg. 2009;208:970-8.
27. Roeise O, Sivertsen S, Ruud TE, Bouma BN, Stadaas JO, Aasen AO. Studies on components of the contact phase system in patients with advanced gastrointestinal cancer. Cancer. 1990;65:1355-9. (Pubitemid 20097162)
28. Colman RW, Jameson BA, Lin Y, Johnson D, Mousa SA. Domain 5 of high molecular weight kininogen (kininostatin) down-regulates endothelial cell proliferation and migration and inhibits angiogenesis. Blood. 2000;95:543-50. (Pubitemid 30041667)
29. Zhang JC, Donate F, Qi X, Ziats NP, Juarez JC, Mazar AP, et al. The antiangiogenic activity of cleaved high molecular weight kininogen is mediated through binding to endothelial cell tropomyosin. Proc Natl Acad Sci USA. 2002;99:12224-9.
30. Asakura S, Hurley RW, Skorstengaard K, Ohkubo I, Mosher DF. Inhibition of cell adhesion by high molecular weight kininogen. J Cell Biol. 1992;116:465-76.
31. Kawasaki M, Maeda T, Hanasawa K, Ohkubo I, Tani T. Effect of His-Gly-Lys motif derived from domain 5 of high molecular weight kininogen on suppression of cancer metastasis both in vitro and in vivo. J Biol Chem. 2003;278:49301-7.
32. Liu Y, Pixley R, Fusaro M, Godoy G, Kim E, Bromberg ME, et al. Cleaved high-molecular-weight kininogen and its domain 5 inhibit migration and invasion of human prostate cancer cells through the epidermal growth factor receptor pathway. Oncogene. 2009;28:2756-65.
33. Fortin T, Salvador A, Charrier JP, Lenz C, Bettsworth F, Lacoux X, et al. Multiple reaction monitoring cubed for protein quantification at the low nanogram/milliliter level in nondepleted human serum. Anal Chem. 2009;81:9343-52.
34. Baechle D, Sparbier K, Dihazi H, Blaschke S, Mueller GA, et al. Towards stable diagnostic setups in clinical proteomics: absolute quantitation of peptide biomarkers using MALDI-TOF-MS. Proteomics Clin Appl. 2007;1:1280-4.