Establishing and sustaining a healthy vaginal environment: Analysis of data from a randomized trial of periodic presumptive treatment for vaginal infections

Journal of Infectious Diseases

Volumn 204, Issue 2, 2011, Pages 323-326

  Balkus, Jennifer E ^a   Richardson, Barbra A ^a   Mandaliya, Kishorchandra ^b   Kiarie, James ^c   Jaoko, Walter ^c   Ndinya Achola, Jeckoniah O ^c   Marrazzo, Jeanne ^a   Farquhar, Carey ^a   McClelland, R Scott ^a,c  

^a UNIVERSITY OF WASHINGTON   (United States)

^b Department of Obstetrics and Gynaecology   (Kenya)

^c UNIVERSITY OF NAIROBI   (Kenya)

Author keywords

[No Author keywords available]

Indexed keywords

CLOTRIMAZOLE; FLUCONAZOLE; METRONIDAZOLE; PLACEBO;

ADULT; ARTICLE; CONTROLLED STUDY; DATA ANALYSIS; FEMALE; HAZARD RATIO; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS 1; INFECTION RISK; MAJOR CLINICAL STUDY; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; RISK FACTOR; RISK REDUCTION; SEXUALLY TRANSMITTED DISEASE; TREATMENT RESPONSE; VAGINA CANDIDIASIS; VAGINA DISCHARGE; VAGINA FLORA; VAGINAL PRURITUS; VAGINITIS;

ADMINISTRATION, ORAL; ADOLESCENT; ADULT; ANTI-INFECTIVE AGENTS; BACTERIA; CANDIDA; CANDIDIASIS, VULVOVAGINAL; CHEMOPREVENTION; FEMALE; HUMANS; MIDDLE AGED; PLACEBOS; TREATMENT OUTCOME; TRICHOMONAS; TRICHOMONAS VAGINITIS; VAGINA; VAGINAL DISEASES; VAGINOSIS, BACTERIAL; YOUNG ADULT;

EID: 79958763763     PISSN: 00221899     EISSN: None     Source Type: Journal    
DOI: 10.1093/infdis/jir241     Document Type: Article

References (16)

1. Van Der Pol B, Kwok C, Pierre-Louis B, et al. Trichomonas vaginalis infection and human immunodeficiency virus acquisition in African women. J Infect Dis 2008; 197:548-54. (Pubitemid 351321532)
2. Atashili J, Poole C, Ndumbe PM, Adimora AA, Smith JS. Bacterial vaginosis and HIV acquisition: A meta-analysis of published studies. AIDS 2008; 22:1493-501.
3. van de Wijgert JH, Morrison CS, Cornelisse PG, et al. Bacterial vaginosis and vaginal yeast, but not vaginal cleansing, increase HIV-1 acquisition in African women. J Acquir Immune Defic Syndr 2008; 48:203-10.
4. Cherpes TL, Meyn LA, Krohn MA, Lurie JG, Hillier SL. Association between acquisition of herpes simplex virus type 2 in women and bacterial vaginosis. Clin Infect Dis 2003; 3:319-25. (Pubitemid 36976487)
5. Schwebke JR, Desmond R. A randomized trial of metronidazole in asymptomatic bacterial vaginosis to prevent the acquisition of sexually transmitted diseases. Am J Obstet Gynecol 2007; 196:517.e1-6.
6. van de Wijgert JH, Morrison CS, Brown J, et al. Disentangling contributions of reproductive tract infections to HIV acquisition in African women. Sex Transm Dis 2009; 36:357-64.
7. Martin HL, Richardson BA, Nyange PM, et al. Vaginal lactobacilli, microbial flora, and risk of human immunodeficiency virus type 1 and sexually transmitted disease acquisition. J Infect Dis 1999; 180:1863-8.
8. McClelland RS, Richardson BA, Hassan WM, et al. Improvement of vaginal health for Kenyan women at risk for acquisition of human immunodeficiency virus type 1: Results of a randomized trial. J Infect Dis 2008; 197:1361-8. (Pubitemid 351706458)
9. Martin HL Jr, Jackson DJ, Mandaliya K, et al. Preparation for AIDS vaccine evaluation in Mombasa, Kenya: Establishment of seronegative cohorts of commercial sex workers and trucking company employees. AIDS Res Hum Retroviruses 1994; 10:S235-7.
10. World Health Organization (WHO). Guideline for the management of sexually transmitted infections. Geneva: WHO, 2003.
11. Nugent RP, Krohn MA, Hillier SL. Reliability of diagnosing bacterial vaginosis is improved by a standardized method of gram stain interpretation. J Clin Microbiol 1991; 29:297-301.
12. Bradshaw CS, Morton AN, Hocking J, et al. High recurrence rates of bacterial vaginosis over the course of 12 months after oral metronidazole therapy and factors associated with recurrence. J Infect Dis 2006; 193:1478-86. (Pubitemid 43794575)
13. McClelland RS, Sangare L, Hassan WM, et al. Infection with Trichomonas vaginalis increases the risk of HIV-1 acquisition. J Infect Dis 2007; 195:698-702.
14. Sobel JD, Ferris D, Schwebke J, et al. Suppressive antibacterial therapy with 0.75% metronidazole vaginal gel to prevent recurrent bacterial vaginosis. Am J Obstet Gynecol 2006; 194:1283-9.
15. Beigi RH, Austin MN, Meyn LA, Krohn MA, Hillier SL. Antimicrobial resistance associated with the treatment of bacterial vaginosis. Am J Obstet Gynecol 2004; 191:1124-9. (Pubitemid 39421560)
16. Abdool Karim Q, Abdool Karim SS, Frohlich JA, et al. Effectiveness and safety of tenofovir gel, an antiretroviral microbicide, for the prevention of HIV infection in women. Science 2010; 329:1168-74.