Endothelial nitric oxide synthase gene variants and primary open-angle glaucoma: Interactions with hypertension, alcohol intake, and cigarette smoking

Archives of Ophthalmology

Volumn 129, Issue 6, 2011, Pages 773-780

  Kang, Jae Hee ^a   Wiggs, Janey L ^b   Rosner, Bernard A ^a,c   Haines, Jonathan ^d   Abdrabou, Wael ^b   Pasquale, Louis R ^b  

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

^c HARVARD SCHOOL OF PUBLIC HEALTH   (United States)

^d VANDERBILT UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ENDOTHELIAL NITRIC OXIDE SYNTHASE;

ADULT; AGED; ALCOHOL CONSUMPTION; ALLELE; ARTICLE; CIGARETTE SMOKING; CONTROLLED STUDY; DIABETES MELLITUS; DISEASE ASSOCIATION; FAMILY HISTORY; FEMALE; FOLLOW UP; GENOTYPE; HETEROZYGOTE; HUMAN; HYPERTENSION; MAJOR CLINICAL STUDY; MALE; OPEN ANGLE GLAUCOMA; PRIORITY JOURNAL; RISK FACTOR; SINGLE NUCLEOTIDE POLYMORPHISM;

ADULT; AGED; ALCOHOL DRINKING; DNA; FEMALE; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; GLAUCOMA, OPEN-ANGLE; HUMANS; HYPERTENSION; INTRAOCULAR PRESSURE; MALE; MIDDLE AGED; NITRIC OXIDE SYNTHASE TYPE III; POLYMORPHISM, SINGLE NUCLEOTIDE; RISK FACTORS; SMOKING;

EID: 79958755361     PISSN: 00039950     EISSN: 15383601     Source Type: Journal    
DOI: 10.1001/archophthalmol.2011.118     Document Type: Article

References (60)

1. Pollock JS, Förstermann U, Mitchell JA, et al. Purification and characterization of particulate endothelium-derived relaxing factor synthase from cultured and native bovine aortic endothelial cells. Proc Natl Acad Sci U S A. 1991;88(23):10480-10484. (Pubitemid 21915859)
2. Nathanson JA, McKee M. Identification of an extensive system of nitric oxide-producing cells in the ciliary muscle and outflow pathway of the human eye. Invest Ophthalmol Vis Sci. 1995;36(9):1765-1773.
3. Garthwaite G, Bartus K, Malcolm D, et al. Signaling from blood vessels to CNS axons through nitric oxide [published correction appears in J Neurosci. 2006;26(32):1]. J Neurosci. 2006;26(29):7730-7740. (Pubitemid 44315193)
4. Su WW, Cheng ST, Ho WJ, Tsay PK, Wu SC, Chang SH. Glaucoma is associated with peripheral vascular endothelial dysfunction. Ophthalmology. 2008;115(7):1173-1178.
5. Henry E, Newby DE, Webb DJ, O'Brien C. Peripheral endothelial dysfunction in normal pressure glaucoma. Invest Ophthalmol Vis Sci. 1999;40(8):1710-1714. (Pubitemid 29297146)
6. Feke GT, Pasquale LR. Retinal blood flow response to posture change in glaucoma patients compared with healthy subjects. Ophthalmology. 2008;115(2):246-252. (Pubitemid 351163367)
7. Furchgott RF, Zawadzki JV. The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine. Nature. 1980;288(5789):373-376. (Pubitemid 11169009)
8. Ignarro LJ, Buga GM, Byrns RE, Wood KS, Chaudhuri G. Endothelium-derived relaxing factor and nitric oxide possess identical pharmacologic properties as relaxants of bovine arterial and venous smooth muscle. J Pharmacol Exp Ther. 1988;246(1):218-226.
9. Ignarro LJ, Buga GM, Wood KS, Byrns RE, Chaudhuri G. Endothelium-derived relaxing factor produced and released from artery and vein is nitric oxide. Proc Natl Acad Sci U S A. 1987;84(24):9265-9269.
10. Dismuke WM, Ellis DZ. Activation of the BK(Ca) channel increases outflow facility and decreases trabecular meshwork cell volume. J Ocul Pharmacol Ther. 2009;25(4):309-314.
11. Dismuke WM, Mbadugha CC, Ellis DZ. NO-induced regulation of human trabecular meshwork cell volume and aqueous humor outflow facility involve the BKCa ion channel. Am J Physiol Cell Physiol. 2008;294(6):C1378-C1386.
12. Ellis DZ, Dismuke WM, Chokshi BM. Characterization of soluble guanylate cyclase in NO-induced increases in aqueous humor outflow facility and in the trabecular meshwork. Invest Ophthalmol Vis Sci. 2009;50(4):1808-1813.
13. Miyamoto Y, Saito Y, Nakayama M, et al. Replication protein A1 reduces transcription of the endothelial nitric oxide synthase gene containing a -786T - >C mutation associated with coronary spastic angina. Hum Mol Genet. 2000;9(18):2629-2637.
14. Tanus-Santos JE, Desai M, Deak LR, et al. Effects of endothelial nitric oxide synthase gene polymorphisms on platelet function, nitric oxide release, and interactions with estradiol. Pharmacogenetics. 2002;12(5):407-413. (Pubitemid 34816420)
15. Ferrer E, Peinado VI, Díez M, et al. Effects of cigarette smoke on endothelial function of pulmonary arteries in the guinea pig. Respir Res. 2009;10:76.
16. Pinto A, Sorrentino R, Sorrentino P, et al. Endothelial-derived relaxing factor released by endothelial cells of human umbilical vessels and its impairment in pregnancy-induced hypertension. Am J Obstet Gynecol. 1991;164(2):507-513.
17. Lüscher TF. The endothelium in hypertension: bystander, target or mediator? J Hypertens Suppl. 1994;12(10):S105-S116.
18. Kleinhenz DJ, Sutliff RL, Polikandriotis JA, et al. Chronic ethanol ingestion increases aortic endothelial nitric oxide synthase expression and nitric oxide production in the rat. Alcohol Clin Exp Res. 2008;32(1):148-154. (Pubitemid 350293896)
19. Fu W, Conklin BS, Lin PH, Lumsden AB, Yao Q, Chen C. Red wine prevents homocysteine-induced endothelial dysfunction in porcine coronary arteries. J Surg Res. 2003;115(1):82-91. (Pubitemid 37323952)
20. Yang J, Ambrosone CB, Hong CC, et al. Relationships between polymorphisms in NOS3 and MPO genes, cigarette smoking and risk of post-menopausal breast cancer. Carcinogenesis. 2007;28(6):1247-1253.
21. Nishio K, Suzuki K, Ito Y, et al. Possible interactions of the endothelial constitutive nitric oxide synthase genotype with alcohol drinking and walking time for high serum uric acid levels among Japanese. Metabolism. 2005;54(10):1302-1308. (Pubitemid 41262586)
22. Barton J, Bain C, Hennekens CH, et al. Characteristics of respondents and non-respondents to a mailed questionnaire. Am J Public Health. 1980;70(8):823-825. (Pubitemid 10078239)
23. Rimm EB, Giovannucci EL, Stampfer MJ, Colditz GA, Litin LB, Willett WC. Reproducibility and validity of an expanded self-administered semiquantitative food frequency questionnaire among male health professionals. Am J Epidemiol. 1992;135(10):1114-1136.
24. Avisar R, Avisar E, Weinberger D. Effect of coffee consumption on intraocular pressure. Ann Pharmacother. 2002;36(6):992-995. (Pubitemid 34564381)
25. Barrett JC, Fry B, Maller J, Daly MJ. Haploview: analysis and visualization of LD and haplotype maps. Bioinformatics. 2005;21(2):263-265. (Pubitemid 40202029)
26. Colditz GA, Martin P, Stampfer MJ, et al. Validation of questionnaire information on risk factors and disease outcomes in a prospective cohort study of women. Am J Epidemiol. 1986;123(5):894-900. (Pubitemid 16049247)
27. Ascherio A, Rimm EB, Giovannucci EL, et al. A prospective study of nutritional factors and hypertension among US men. Circulation. 1992;86(5):1475-1484.
28. Giovannucci E, Colditz G, Stampfer MJ, et al. The assessment of alcohol consumption by a simple self-administered questionnaire. Am J Epidemiol. 1991;133(8):810-817.
29. DerSimonian R, Laird N. Meta-analysis in clinical trials. Control Clin Trials. 1986;7(3):177-188. (Pubitemid 17189972)
30. Benjamini Y, Hochberg Y. Controlling the false discovery rate: a practical and powerful approach to multiple testing. J R Statist Soc B. 1995;57(1):289-300.
31. Kang JH, Wiggs JL, Rosner BA, et al. Endothelial nitric oxide synthase gene variants and primary open-angle glaucoma: interactions with sex and postmenopausal hormone use. Invest Ophthalmol Vis Sci. 2010;51(2):971-979.
32. Luna C, Li G, Liton PB, et al. Resveratrol prevents the expression of glaucoma markers induced by chronic oxidative stress in trabecular meshwork cells. Food Chem Toxicol. 2009;47(1):198-204.
33. Garhöfer G, Resch H, Lung S, Weigert G, Schmetterer L. Intravenous administration of L-arginine increases retinal and choroidal blood flow. Am J Ophthalmol. 2005;140(1):69-76.
34. Shareef S, Sawada A, Neufeld AH. Isoforms of nitric oxide synthase in the optic nerves of rat eyes with chronic moderately elevated intraocular pressure. Invest Ophthalmol Vis Sci. 1999;40(12):2884-2891. (Pubitemid 29521601)
35. Nakayama M, Yasue H, Yoshimura M, et al. T-786 - >C mutation in the 5′-flanking region of the endothelial nitric oxide synthase gene is associated with coronary spasm. Circulation. 1999;99(22):2864-2870. (Pubitemid 29258973)
36. Feke GT, Schwartz B, Takamoto T, et al. Optic nerve head circulation in untreated ocular hypertension. Br J Ophthalmol. 1995;79(12):1088-1092. (Pubitemid 26002681)
37. Berisha F, Feke GT, Hirose T, McMeel JW, Pasquale LR. Retinal blood flow and nerve fiber layer measurements in early-stage open-angle glaucoma. Am J Ophthalmol. 2008;146(3):466-472.
38. Araie JC, Iwase A, Tomidokoro A, et al. Clinical relevance of ocular blood flow (OBF) measurements including effects of general medications or specific glaucoma treatment. In: Weinreb RN, Harris A, eds. Ocular Blood Flow in Glaucoma: Consensus Series: 6. Gilsum, NH: Kugler Publications; 2009:157.
39. Tielsch JM, Katz J, Sommer A, Quigley HA, Javitt JC. Hypertension, perfusion pressure, and primary open-angle glaucoma: a population-based assessment. Arch Ophthalmol. 1995;113(2):216-221.
40. Bonomi L, Marchini G, Marraffa M, Bernardi P, Morbio R, Varotto A. Vascular risk factors for primary open angle glaucoma: the Egna-Neumarkt Study. Ophthalmology. 2000;107(7):1287-1293.
41. Leske MC, Wu SY, Hennis A, Honkanen R, Nemesure B; BESs Study Group. Risk factors for incident open-angle glaucoma: the Barbados Eye Studies. Ophthalmology. 2008;115(1):85-93. (Pubitemid 350309410)
42. Hulsman CA, Vingerling JR, Hofman A, Witteman JC, de Jong PT. Blood pressure, arterial stiffness, and open-angle glaucoma: the Rotterdam Study. Arch Ophthalmol. 2007;125(6):805-812. (Pubitemid 46919742)
43. Leske MC, Heijl A, Hyman L, Bengtsson B, Dong L, Yang Z; EMGT Group. Predictors of long-term progression in the Early Manifest Glaucoma Trial. Ophthalmology. 2007;114(11):1965-1972. (Pubitemid 350016362)
44. Graham SL, Drance SM, Wijsman K, Douglas GR, Mikelberg FS. Ambulatory blood pressure monitoring in glaucoma: the nocturnal dip. Ophthalmology. 1995;102(1):61-69.
45. Hayreh SS, Zimmerman MB, Podhajsky P, Alward WL. Nocturnal arterial hypotension and its role in optic nerve head and ocular ischemic disorders. Am J Ophthalmol. 1994;117(5):603-624. (Pubitemid 24150730)
46. Dielemans I, Vingerling JR, Algra D, Hofman A, Grobbee DE, de Jong PT. Primary open-angle glaucoma, intraocular pressure, and systemic blood pressure in the general elderly population: the Rotterdam Study. Ophthalmology. 1995;102(1):54-60.
47. Mitchell P, Lee AJ, Rochtchina E, Wang JJ. Open-angle glaucoma and systemic hypertension: the Blue Mountains Eye Study. J Glaucoma. 2004;13(4):319-326. (Pubitemid 38944201)
48. Borissova AM, Tankova T, Kirilov G, Dako vs ka L, Krivoshiev S. The effect of smoking on peripheral insulin sensitivity and plasma endothelin level. Diabetes Metab. 2004;30(2):147-152. (Pubitemid 38715170)
49. Wennmalm A. Effect of cigarette smoking on basal and carbon dioxide stimulated cerebral blood flow in man. Clin Physiol. 1982;2(6):529-535. (Pubitemid 13174127)
50. Robinson F, Petrig BL, Riva CE. The acute effect of cigarette smoking on macular capillary blood flow in humans. Invest Ophthalmol Vis Sci. 1985;26(5):609-613. (Pubitemid 15067801)
51. Tamaki Y, Araie M, Nagahara M, Tomita K. Acute effects of cigarette smoking on tissue circulation in human optic nerve head and choroid-retina. Ophthalmology. 1999;106(3):564-569. (Pubitemid 30191593)
52. Stewart WC, Crinkley CMC, Murrell HP. Cigarette-smoking in normal subjects, ocular hypertensive, and chronic open-angle glaucoma patients. Am J Ophthalmol. 1994;117(2):267-268. (Pubitemid 24053085)
53. Rojanapongpun P, Drance SM. The effects of nicotine on the blood flow of the ophthalmic artery and the finger circulation. Graefes Arch Clin Exp Ophthalmol. 1993;231(7):371-374. (Pubitemid 23258531)
54. Barua RS, Ambrose JA, Eales-Reynolds LJ, DeVoe MC, Zervas JG, Saha DC. Dysfunctional endothelial nitric oxide biosynthesis in healthy smokers with impaired endothelium-dependent vasodilatation. Circulation. 2001;104(16):1905- 1910. (Pubitemid 32983232)
55. Barua RS, Ambrose JA, Srivastava S, DeVoe MC, Eales-Reynolds LJ. Reactive oxygen species are involved in smoking-induced dysfunction of nitric oxide biosynthesis and upregulation of endothelial nitric oxide synthase: an in vitro demonstration in human coronary artery endothelial cells. Circulation. 2003;107(18):2342-2347. (Pubitemid 36578506)
56. Kang JH, Pasquale LR, Rosner BA, et al. Prospective study of cigarette smoking and the risk of primary open-angle glaucoma. Arch Ophthalmol. 2003;121(12):1762-1768. (Pubitemid 37517444)
57. Kang JH, Willett WC, Rosner BA, Hankinson SE, Pasquale LR. Prospective study of alcohol consumption and the risk of primary open-angle glaucoma. Ophthalmic Epidemiol. 2007;14(3):141-147. (Pubitemid 47026986)
58. Abou-Agag LH, Khoo NK, Binsack R, et al. Evidence of cardiovascular protection by moderate alcohol: role of nitric oxide. Free Radic Biol Med. 2005;39(4):540-548. (Pubitemid 41021652)
59. Wallerath T, Deckert G, Ternes T, et al. Resveratrol, a polyphenolic phytoalexin present in red wine, enhances expression and activity of endothelial nitric oxide synthase. Circulation. 2002;106(13):1652-1658.
60. Tielsch JM, Katz J, Singh K, et al. A population-based evaluation of glaucoma screening: the Baltimore Eye Survey. Am J Epidemiol. 1991;134(10):1102-1110.