Comparative evaluation of five needleless intravenous connectors

Journal of Advanced Nursing

Volumn 67, Issue 7, 2011, Pages 1601-1613

  Chernecky, Cynthia ^a   Waller, Jennifer ^a  

^a MEDICAL COLLEGE OF GEORGIA   (United States)

Author keywords

Bloodstream; Infection; Intravenous connector; Intravenous technology

Indexed keywords

ANALYSIS OF VARIANCE; ANIMAL; ARTICLE; BACTERIAL COUNT; CATHETER; CATHETER INFECTION; CATHETERIZATION; CATTLE; COMPARATIVE STUDY; EQUIPMENT; EQUIPMENT DESIGN; ESCHERICHIA COLI; EVALUATION; GROWTH, DEVELOPMENT AND AGING; HUMAN; INSTRUMENTATION; INTRAVENOUS DRUG ADMINISTRATION; ISOLATION AND PURIFICATION; MICROBIOLOGY; POSTMARKETING SURVEILLANCE; PSEUDOMONAS AERUGINOSA; STANDARD; STAPHYLOCOCCUS; STATISTICAL MODEL; STATISTICS;

ANALYSIS OF VARIANCE; ANIMALS; CATHETER-RELATED INFECTIONS; CATHETERIZATION; CATHETERS; CATTLE; COLONY COUNT, MICROBIAL; EQUIPMENT CONTAMINATION; EQUIPMENT DESIGN; ESCHERICHIA COLI; HUMANS; INFUSIONS, INTRAVENOUS; MODELS, STATISTICAL; PRODUCT SURVEILLANCE, POSTMARKETING; PSEUDOMONAS AERUGINOSA; STAPHYLOCOCCUS;

EID: 79958755048     PISSN: 03092402     EISSN: 13652648     Source Type: Journal    
DOI: 10.1111/j.1365-2648.2010.05598.x     Document Type: Article

References (34)

1. Arnow P.M., Quimosing E.M. & Beach M. (1993) Consequences of intravascular catheter sepsis. Clinical Infectious Diseases 16(6), 778-784.
2. Caillouet B. (2008) The evolution of the injection cap-combining staff safety and patient safety: an M.D. Anderson research study. Presented at the 22nd Annual Association for Vascular Access Conference, September 11, Savannah, GA; 2008.
3. Casella L. & Jarvis E. (2007) Save a patient's line with positive pressure. Acute & Critical Care Special Interest Group Newsletter. Oncology Nursing Society, Pittsburgh, PA, pp. 3-4.
4. Casey A.L., Worthington T., Lambert P.A., Quinn D., Faroqui M.H. & Elliott T.S. (2003) A randomized, prospective clinical trial to assess the potential infection risk associated with the PosiFlow needleless connector. Journal of Hospital Infection 54(4), 288-293.
5. Chernecky C., Macklin D., Casella L. & Jarvis E. (2009) Caring for patients with cancer through nursing knowledge of IV connectors. Clinical Journal of Oncology Nursing 13(6), 630-633.
6. Cook G. & Meyer T. (2007) Luer activated de ice priming volume as a predictor of biofilm formation in an in vitro assay. Poster presentation at the Society for Healthcare Epidemiology of America, Baltimore, MD.
7. De Cicco M., Campisi C. & Matovic M. (2003) Central venous catheter bloodstream infections: pathogenesis factors, new perspectives in prevention and early diagnosis. Journal of Vascular Access 4(3), 83-91.
8. FDA (2010a) Safety. BD Announces Worldwide Voluntary Recall of BD Q-Syte™ Luer Access Devices and BD Nexiva™ Closed IV Catheter Systems. Retrieved from on 3 March 2010.
9. FDA (2010b) Letter to Infection Control Practitioners Regarding Positive Displacement Needleless Connectors. Retrieved from on 15 July 2010.
10. Field K., McFarlane C., Cheng A.C., Hughes P.J., Jacobs E., Styles K., Low J., Stow P., Campbell P. & Athan E. (2007) Incidence of catheter-related bloodstream infection among patients with a needleless, mechanical valve-based intravenous connector in a Australian hematology-oncology unit. Infection Control and Hospital Epidemiology 28(5), 610-613.
11. Garland J.S., Alex C.P., Sevallius J.M., Murphy D.M., Good M.J., Volberding A.M., Hofer L.L., Gordon B.J. & Maki D.G. (2008) Cohort study of the pathogenesis and molecular epidemiology of catheter-related bloodstream infection in neonates with peripherally inserted central venous catheters. Infection Control & Hospital Epidemiology 29(3), 243-249.
12. Hadaway L.C. (2006) Best-practice interventions: keeping central line infection at bay. Nursing 2006 36, 58-63, quiz 63-4.
13. Jacobs B.R., Schilling S., Doellman D., Hutchinson N., Rickey M. & Nelson S. (2004) Central venous catheter occlusion: A prospective, controlled trial examining the impact of a positive-pressure valve device. Jpen: Journal of Parenteral & Enteral Nutrition 28(2), 113-118.
14. Jarvis W.R. (2010) Choosing the best design for intravenous needleless connectors to prevent bloodstream infections. Retrieved from on 15 July 2010.
15. Jarvis W.M., Murphy C., Hall K.K., Fogle P.J., Karchmer T.B., Harrington G., Salgado C., Giannetta E.T., Cameron C. & Sherertz R.J. (2009) Healthcare-associated bloodstream infections associated with negative- or positive-pressure or displacement mechanical valve needleless connectors. Clinical Infectious Diseases 49(12), 1821-1827.
16. Karchmer T.B., Cook E., Palavecino E., Ohl C. & Sherertz R. (2005) Needleless valve ports may be associated with a high rate of catheter-related bloodstream infection [abstract 307]. In Proceedings of the 15th Annual Scientific Meeting of the Society for Healthcare Epidemiology of America. Los Angeles, CA.
17. Lindquist J. (2007) Dilution Plating. Retrieved from on 2 February 2010.
18. Maki D.G., Weise C.E. & Sarafin H.W. (1977) A semiquantitative culture method for identifying intravenous-catheter-related infection. New England Journal Medicine 296(23), 1305-1309.
19. Maragakis L.L., Bradley K.L., Song X., Beers C., Miller M.R., Cosgrove S.E. & Perl T.M. (2006) Increased catheter-related bloodstream infection rates after the introduction of a new mechanical valve intravenous access port. Infection Control & Hospital Epidemiology 27(1), 67-70.
20. Marschall J., Mermel L.A., Classen D., Arias K.M., Podgorny K., Anderson D.J., Burstin H., Calfree D.P., Coffin S.E., Dubberke E.R., Fraser V., Gerding D.N., Griffin F.A., Gross P., Kaye K.S., Klompas M., Lo E., Nicolle L., Pegues D.A., Perl T.M., Saint S., Salgado C.D., Weinstein R.A., Wise R. & Yokoe D.S. (2008) Strategies to prevent central line-associated bloodstream infections in acute care hospitals. Infection Control and Hospital Epidemiology 29(Suppl 1), S22-S30.
21. Menyhay S.Z. & Maki D.G. (2006) Disinfection of needleless catheter connectors and access ports with alcohol may not prevent microbial entry: The promise of a novel antiseptic-barrier cap. Infection Control & Hospital Epidemiology 27(1), 23-27.
22. O'Grady N.P., Alexander M., Dellinger E.P., Gerberding J., Heard S.O., Maki D.G., Masur H., McCormick R.D., Mermel L.A., Pearson M.L., Raad I.I., Randolph A. & Weinstein P.A. (2002) Centers for Disease Control and Preventions (CDC), Hospital Infection Control Practices Advisory Committee. Morbidity & Mortality Weekly Report. Recommendations & Reports 51(RR-10), 1-26.
23. Pittet D., Tarara D. & Wenzel R.P. (1994) Nosocomial bloodstream infections in critically ill patients: Excess length of stay, extra costs and attributable mortality. JAMA: Journal of the American Medical Association 271(20), 1598-1601.
24. Rello J., Ochogavia A., Sabanes E., Roque M., Mariscal D., Reynaga E. & Valles J. (2000) Evaluation of outcome of intravenous catheter-related infections in critically ill patients. American Journal of Respiratory & Critical Care Medicine 162(3 Pt 1), 1027-1030.
25. Rosenthal K. (2006) Do needleless connectors increase bloodstream infection risk? Nursing Management 37, 78-80.
26. Rummel M.A., Donnelly P.J. & Fortenbaugh C.C. (2001) Clinical evaluation of a positive pressure device to prevent central venous catheter occlusion: results of a pilot study. Clinical Journal of Oncology Nursing 5(6), 261-265.
27. Rupp M.E., Sholtz L.A., Jourdan D.R., Marion N.D., Tyner L.K., Fey P.D., Iwen P.C. & Anderson J.R. (2007) Outbreak of bloodstream infection temporally associated with the use of an intravascular needleless valve. Clinical Infectious Diseases 44(11), 1408-1414.
28. Ryder M. (2006). Evidence-based practice in the management of vascular access devices for home parenteral nutrition therapy. Jpen: Journal of Parenteral & Enteral Nutrition 30(1 Suppl), S82-S93, S98-99.
29. Safdar N. & Maki D.G. (2004) The pathogenesis of catheter-related bloodstream infection with noncuffed short-term central venous catheters. Intensive Care Medicine 30(1), 62-67.
30. Schilling S., Doellman D., Hutchinson N. & Jacobs B.R. (2006) The impact of needleless connector device design on central venous catheter occlusion in children: A prospective, controlled trial. Jpen: Journal of Parenteral & Enteral Nutrition 30(2), 85-90.
31. Seymour V.M., Dhallu T.S., Moss H.A., Tebbs S.E. & Elliot T.S. (2000) A prospective clinical study to investigate the microbial contamination of a needleless connector. Journal of Hospital Infection 45(2), 165-168.
32. Shapey I.M., Foster M.A., Whitehouse T., Jumaa P. & Bion J.F. (2009) Central venous catheter-related bloodstream infections; improving post-insertion catheter care. Journal of Hospital Infection 71(2), 117-122.
33. Tacconelli E., Smith G., Hieke K., Lafuma A. & Bastide P. (2009) Epidemiology, medical outcomes and costs of catheter-related bloodstream infections in intensive care units of four European countries: literature- and registry-based estimates. Journal of Hospital Infection 72(2), 97-103.
34. Yébenes J.C., Martinez R., Serra-Prat M., Sauca G., Capdevila A., Balanzo X. & Palomar M. (2003) Resistance to the migration of microorganisms of a needle-free disinfectable connector. American Journal of Infection Control 31(8), 462-464.