Oxidative damage DNA: 8-oxogua and 8-oxodG as molecular markers of cancer

Medical Science Monitor

Volumn 17, Issue 6, 2011, Pages

  Roszkowski, Krzysztof ^a,b   Jozwicki, Wojciech ^b   Blaszczyk, Piotr ^a   Mucha Malecka, Anna ^c   Siomek, Agnieszka ^b  

^a Regional Oncology Centre Bydgoszcz   (Poland)

^b NICOLAUS COPERNICUS UNIVERSITY   (Poland)

^c INSTITUTE OF ONCOLOGY   (Poland)

Author keywords

8 oxodG; 8 oxoGua; Cancer patients; Damage DNA; Molecular markers

Indexed keywords

8 HYDROXYDEOXYGUANOSINE; 8 HYDROXYGUANINE; DNA;

ARTICLE; BLOOD LEVEL; BREAST CANCER; CANCER PATIENT; CELL DEATH; COLON CANCER; CONTROLLED STUDY; DIGESTIVE SYSTEM CANCER; DISEASE MARKER; DNA ISOLATION; FEMALE; GAS CHROMATOGRAPHY; HEAD AND NECK CANCER; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; ISOTOPE DILUTION ASSAY; LEUKOCYTE; LUNG CANCER; MAJOR CLINICAL STUDY; MALE; MASS SPECTROMETRY; NEOPLASM; OVARY CANCER; OXIDATIVE STRESS; PROSTATE CANCER; TESTIS CANCER; URINE LEVEL; UTERUS CANCER;

EID: 79958711693     PISSN: 12341010     EISSN: 16433750     Source Type: Journal    
DOI: 10.12659/MSM.881805     Document Type: Article

References (35)

1. Floyd RA, West MS, Eneff KL, Schneider JE: Methylene blue plus light mediates 8-hydroxyguanine formation in DNA. Arch Biochem Biophys, 1989; 273: 106-111
2. Dizdaroglu M: Characterization of free radical-induced damage to DNA by the combined use of enzymatic hydrolysis and gas chromatographymass spectrometry. J Chromatogr, 1986; 367: 357-366
3. Oliński R: DNA damage induced by active oxygen species and its role in the carcinogenesis process. Postepy Hig Med Dosw, 1993; 47: 463-474
4. Dizdaroglu M: Quantitative determination of oxidative base damage in DNA by stable isotope-dilution mass spectrometry. FEBS Lett, 1993; 315: 1-6
5. Demple B, Herman T, Chcn DS: Cloning and expression of APE, the cDNA encoding the major human apurinic endonuclease: definition of a family of DNA repair enzymes. Proc Natl Acad Sci USA, 1991; 88: 11450-1154
6. Bessho T, Roy R, Yamamoto K et al: Repair of 8-hydroxyguanine in DNA by mammalian N-methylpurine-DNA glycosylase. Proc Natl Acad Sci USA, 1993; 90: 8901-8904
7. Nash M, Bruner SD, Scharer GD et al: Cloning of a yeast 8-oxyguanine DNA glycosylase reveals the existence of a base-excision DNA-repair protein superfamily. Curr Biol, 1996; 6: 968-980
8. Bilinska M, Wolszakiewicz J, Duda M et al: Antioxidative activity of sulodexide, a glycosaminoglycan, in patients with stable coronary artery disease: A pilot study. Med Sci Monit, 2009; 15(12): CR618-CR623
9. Misra M, Sarwat M, Bhakuni P et al: Oxidative stress and ischemic myocardial syndromes. Med Sci Monit, 2009; 15(10): RA209-RA219
10. Ueno T, Watanabe H, Fukuda N et al: Influence of genetic polymorphisms in oxidative stress related genes and smoking on plasma MDALDL, soluble CD40 ligand, E-selectin and soluble ICAM1 levels in patients with coronary artery disease. Med Sci Monit, 2009; 15(7): CR341-CR348
11. Cooke MS, Olinski R, Evans MD: Does measurement of oxidative damage to DNA have clinical significance? Clinica Chimica Acta, 2006; 365: 30-49
12. Cooke MS, Evans MD, Herbert KE, Lunec J: Urinary 8-oxo- 2'deoxyguanosine- source, significance and supplements. Free Radic Res, 2000; 32: 381-97
13. Olinski R, Rozalski R, Gackowski D et al: Urinary measurement of 8-OksodG, 8-OksoGua, and 5HMUra: a noninvasive assessment of oxidative damage to DNA. Antioxid Redox Signal, 2006; 8: 1011-19
14. Kuraoka I, Bender C, Romieu A et al: Removal of oxygen freeradicalinduced 5',8-purine cyclodeoxynucleosides from DNA by the nucleotide excision-repair pathway in human cells. Proc Natl Acad Sci USA, 2000; 97: 3832-37
15. Brooks PJ, Wise DS, Berry DA et al: The oxidative DNA lesion 8,5'-(S)-cyclo-2'-deoxyadenosine is repaired by the nucleotide excision repair pathway and blocks gene expression in mammalian cells. J Biol Chem, 2000; 275: 22355-62
16. Mundt JM, Hah SS, Sumbad RA et al: Incorporation of extracellular 8-oxodG into DNA and RNA requires purine nucleoside phosphorylase in MCF-7 cells. Nucleic Acids Res, 2008; 36(1): 228-36
17. Gackowski D, Rozalski R, Roszkowski K et al: 8-Okso-7,8-dihydroguanine and 8-okso-7,8-dihydro-2-deoxyguanosine levels in human urine do not depend on diet. Free Radic Res, 2001; 35: 825-32
18. Cooke MS, Evans MD, Dove R et al: DNA repair is responsible for the presence of oxidatively damaged DNA lesions in urine. Mutat Res, 2005; 574: 58-66
19. Faure H, Mousseau M, Cadet J et al: Urine 8-okso-7,8-dihydro-2-deoxyguanosine vs. 5-(hydroxymethyl) uracil as DNA oxidation marker in adriamycin-treated patients. Free Radic Res, 1998; 28: 377-82
20. Erhola M, Toyokuni S, Okada K et al: Biomarker evidence of DNA oxidation in lung cancer patients: association of urinary 8-hydroxy-2-deoxyguanosine excretion with radiotherapy, chemotherapy, and response to treatment. FEBS Lett, 1997; 409: 287-91
21. Bergman V, Leanderson P, Starkhammar H, Tagesson C: Urinary excretion of 8-hydroxydeoxyguanosine and malondialdehyde after high dose radiochemotherapy preceding stem cell transplantation. Free Radic Biol Med, 2004; 36: 300-6
22. Haghdoost S, Svoboda P, Naslund I et al: Can 8-okso-dG be used as a predictor for individual radiosensitivity? Int J Radiat Oncol Biol Phys, 2001; 50: 405-10
23. Roszkowski K, Gackowski D, Rozalski R et al: Small field radiotherapy of head and neck cancer patients is responsible for oxidatively damaged DNA/oxidative stress on the level of a whole organism. Int J Cancer, 2008; 123: 1964-67
24. Siomek A, Gackowski D, Rozalski R et al: Higher leukocyte 8-oxo-7,8- dihydro-2'-deoxyguanosine and lower plasma ascorbate in aging humans? Antioxid Redox Signal, 2007; 9: 143-50
25. Foksinski M, Bialkowski K, Skiba M et al: Evaluation of 8-oxodeoxyguanosine, typical oxidative DNA damage, in lymphocytes of ozonetreated arteriosclerotic patients. Mutat Res, 1999; 438: 23-27
26. Jaruga P, Speina E, Gackowski D et al: Endogenous oxidative DNA base modifications analysed with repair enzymes and GC/MS technique. Nucleic Acids Res, 2000; 28: e16
27. Escod D, Gedik CM, Collins A: Establishing the background level of base oxidation in human lymphocyte DNA: results of an interlaboratory validation study. FASEB J, 2005; 19: 82-84
28. Collins A, Gedik CM, Olmedilla B et al: Oxidative DNA damage measured in human lymphocytes: large differences between sexes and between countries, and correlations with heart disease mortality rates. FASEB J, 1998; 12: 1397-400
29. Maynard S, Schurman SH, Harboe C et al: Base excision repair of oxidative DNA damage and association with cancer and aging. Carcinogenesis, 2009; 30(1): 2-10
30. Cooke MS, Olinski R, Loft S: Measurement and Meaning of Oxidatively Modified DNA Lesions in Urine. Cancer Epidemiol Biomarkers Prev, 2008; 17(1): 3-14
31. Siomek A, Tujakowski J, Gackowski D et al: Severe oxidatively damaged DNA after cisplatin treatment of cancer patients. Int J Cancer, 2006; 119: 2228-30
32. Gackowski D, Speina E, Zielinska M et al: Products of oxidative DNA damage and repair as possible biomarkers of susceptibility to lung cancer. Cancer Res, 2003; 63: 4899-902
33. Inoue M, Osaki T, Noguchi M et al: Lung Cancer Patients Have Increased 8-Hydroxydeoxyguanosine Levels in Peripheral Lung Tissue DNA. Jpn J Cancer Res, 1998; 89: 691-95
34. Rozalski R, Gackowski D, Roszkowski K et al: The level of 8-hydroxyguanine, a possible repair product of oxidative DNA damage, is higher in urine of cancer patients than in control subjects. Cancer Epid Biom Prev, 2002; 11: 1072-75
35. Cooke MS, Rozalski R, Dove R et al: Evidence for attenuated cellular 8-oxo-7,8-dihydro-29-deoxyguanosine removal in cancer patients. Biol Chem, 2006; 387(4): 393-400