MEK-ERK-dependent multiple caspase activation by mitochondrial proapoptotic Bcl-2 family proteins is essential for heavy ion irradiation-induced glioma cell death

Cell Death and Disease

Volumn 1, Issue 7, 2010, Pages

  Tomiyama, A ^a   Tachibana, K ^a   Suzuki, K ^a   Seino, S ^a   Sunayama, J ^a   Matsuda, K I ^a,b   Sato, A ^a,b   Matsumoto, Y ^c   Nomiya, T ^b   Nemoto, K ^b   Yamashita, H ^b,d   Kayama, T ^b,d   Ando, K ^c   Kitanaka, C ^a,d,e  

^a YAMAGATA UNIVERSITY   (Japan)

^b YAMAGATA UNIVERSITY   (Japan)

^c NATIONAL INSTITUTE OF RADIOLOGICAL SCIENCES   (Japan)

^d JAPAN SOCIETY FOR THE PROMOTION OF SCIENCE   (Japan)

^e Oncology Research Center   (Japan)

Author keywords

Apoptosis; Carbon beam; Glioma; Heavy ion radiation; MAPK

Indexed keywords

CASPASE 8; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE KINASE 2; PROTEIN BAK; PROTEIN BAX; PROTEIN BCL 2; CASPASE; MITOGEN ACTIVATED PROTEIN KINASE KINASE; PROTEIN BCL X; SMALL INTERFERING RNA;

APOPTOSIS; ARTICLE; B CELL LYMPHOMA; CANCER CELL CULTURE; CELL DEATH; CONTROLLED STUDY; ENZYME ACTIVATION; GENE SILENCING; GLIOMA CELL; HEAVY ION RADIATION; HUMAN; HUMAN CELL; ION THERAPY; IRRADIATION; MITOCHONDRION; PRIORITY JOURNAL; PROTEIN EXPRESSION; DRUG ANTAGONISM; ENZYMOLOGY; GENETICS; GLIOMA; METABOLISM; RNA INTERFERENCE; TUMOR CELL LINE;

APOPTOSIS; BCL-2 HOMOLOGOUS ANTAGONIST-KILLER PROTEIN; BCL-2-ASSOCIATED X PROTEIN; BCL-X PROTEIN; CASPASE 8; CASPASES; CELL LINE, TUMOR; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; GLIOMA; HUMANS; MITOCHONDRIA; MITOGEN-ACTIVATED PROTEIN KINASE KINASES; PROTO-ONCOGENE PROTEINS C-BCL-2; RNA INTERFERENCE; RNA, SMALL INTERFERING;

EID: 79958701131     PISSN: None     EISSN: 20414889     Source Type: Journal    
DOI: 10.1038/cddis.2010.37     Document Type: Article

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