Soluble CD163: A novel biomarker for the susceptibility to sepsis in severe burn injuries

Indian Journal of Plastic Surgery

Volumn 44, Issue 1, 2011, Pages 118-124

  Piatkowski, Andrzej ^a,c   Grieb, Gerrit ^a   Das, Rittuparna ^b   Bozkurt, Ahmet ^a   Ulrich, Dietmar ^a   Pallua, Norbert ^a  

^a UNIVERSITY HOSPITAL RWTH AACHEN   (Germany)

^b YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c NONE   (Germany)

Author keywords

immune response; Inflammation; organ failure; sepsis; serum marker

Indexed keywords

EID: 79958295959     PISSN: 09700358     EISSN: 1998376X     Source Type: Journal    
DOI: 10.4103/0970-0358.81454     Document Type: Article

References (17)

1. Mosser DM. The many faces of macrophage activation. J Leukoc Biol 2003;73:209-12. (Pubitemid 36158295)
2. Kristiansen M, Graversen JH, Jacobsen C, Sonne O, Hoffman HJ, Law SK, et al. Identification of the haemoglobin scavenger receptor. Nature 2001;409:198-201. (Pubitemid 32144285)
3. Buechler C, Ritter M, Orso E, Langmann T, Klucken J, Schmitz G. Regulation of scavenger receptor CD163 expression in human monocytes and macrophages by pro- and antiinflammatory stimuli. J Leukoc Biol 2000;67:97-103. (Pubitemid 30046823)
4. Moestrup SK, Moller HJ. CD163. A regulated hemoglobin scavenger receptor with a role in the anti-inflammatory response. Ann Med 2004;36:347-54. (Pubitemid 39233102)
5. Droste A, Sorg C, Hogger P. Shedding of CD163, a novel regulatory mechanism for a member of the scavenger receptor cysteinerich family. Biochem Biophys Res Commun 1999;256:110-3. (Pubitemid 29298926)
6. Sulahian TH, Hintz KA, Wardwell K, Guyre PM. Development of an ELISA to measure soluble CD163 in biological fluids. J Immunol Methods 2001;252:25-31. (Pubitemid 32382087)
7. Moller HJ, Peterslund NA, Graversen JH, Moestrup SK. Identification of the hemoglobin scavenger receptor/CD163 as a natural soluble protein in plasma. Blood 2002;99:378-80. (Pubitemid 34533008)
8. Timmermann M, Hogger P. Oxidative stress and 8-isoprostaglandin F(2alpha) induce ectodomain shedding of CD163 and release of tumor necrosis factor-alpha from human monocytes. Free Radic Biol Med 2005;39:98-107. (Pubitemid 40733120)
9. Hintz KA, Rassias AJ, Wardwell K, Moss ML, Morganelli PM, Pioli PA, et al. Endotoxin induces rapid metalloproteinase-mediated shedding followed by up-regulation of the monocyte hemoglobin scavenger receptor CD163. J Leukoc Biol 2002;72:711-7. (Pubitemid 36277842)
10. ACCP/SCCM Consensus Conference Committee. Definition for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis. Crit Care Med 1992;20:864-74.
11. Piatkowski A, Groger A, Pantel M, Bozkurt A, Fuchs PC, Pallua N. The extent of thermal injury affects fractions of mononuclear cells. Burns 2009;35:256-63.
12. Tobiasen J, Hiebert JM, Edlich RF. The abbreviated burn severity index. Ann Emerg Med 1982;11:260-2. (Pubitemid 12068532)
13. Gaini S, Pedersen SS, Koldkaer OG, Pedersen C, Moestrup SK, Moller HJ. New immunological serum markers in bacteraemia: Anti-inflammatory soluble CD163, but not proinflammatory high mobility group-box 1 protein, is related to prognosis. Clin Exp Immunol 2008;151:423-31. (Pubitemid 351160736)
14. Church D, Elsayed S, Reid O, Winston B, Lindsay R. Burn wound infections. Clin Microbiol Rev 2006;19:403-34.
15. Frings W, Dreier J, Sorg C. Only the soluble form of the scavenger receptor CD163 acts inhibitory on phorbol esteractivated T-lymphocytes, whereas membrane-bound protein has no effect. FEBS lett 2002;526:93-6. (Pubitemid 35245699)
16. Hogger P, Sorg C. Soluble CD163 inhibits phorbol ester-induced lymphocyte proliferation. Biochem Biophys Res Commun 2001;288:841-3. (Pubitemid 33140958)
17. Weaver LK, Pioli PA, Wardwell K, Vogel SN, Guyre PM. Upregulation of human monocyte CD163 upon activation of cellsurface Toll-like receptors. J Leukoc Biol 2007;81:663-71. (Pubitemid 46393544)