Carcinoembryonic antigen level can be overestimated in metabolic syndrome

Journal of Korean Medical Science

Volumn 26, Issue 6, 2011, Pages 759-764

  Kim, Kyu Nam ^a   Joo, Nam Seok ^a   Je, Sang Yeon ^a   Kim, Kwang Min ^a   Kim, Bom Taeck ^a   Park, Sat Byul ^a   Cho, Doo Yeoun ^a   Park, Rae Woong ^a   Lee, Duck Joo ^a  

^a Ajou University School of Medicine   (South Korea)

Author keywords

Carcinoembryonic antigen; Metabolic syndrome; Smoking

Indexed keywords

CARCINOEMBRYONIC ANTIGEN; LOW DENSITY LIPOPROTEIN CHOLESTEROL;

ADOLESCENT; ADULT; AGED; ARTICLE; BLOOD; BLOOD PRESSURE; CHILD; FEMALE; HUMAN; MALE; METABOLIC SYNDROME X; MIDDLE AGED; OCCULT BLOOD; PATHOLOGY; PREVALENCE; RISK; SMOKING;

ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; BLOOD PRESSURE; CARCINOEMBRYONIC ANTIGEN; CHILD; CHOLESTEROL, LDL; FEMALE; HUMANS; MALE; METABOLIC SYNDROME X; MIDDLE AGED; OCCULT BLOOD; ODDS RATIO; PREVALENCE; SMOKING;

EID: 79958294575     PISSN: 10118934     EISSN: 15986357     Source Type: Journal    
DOI: 10.3346/jkms.2011.26.6.759     Document Type: Article

References (25)

1. Fukuda I, Yamakado M, Kiyose H. Influence of smoking on serum carcinoembryonic antigen levels in subjects who underwent multiphasic health testing and services. J Med Syst 1998; 22: 89-93.
2. Amino N, Kuro R, Yabu Y, Takai SI, Kawashima M, Morimoto S, Ichihara K, Miyai K, Kumahara Y. Elevated levels of circulating carcinoembryonic antigen in hypothyroidism. J Clin Endocrinol Metab 1981; 52: 457-62.
3. Bulut I, Arbak P, Coskun A, Balbay O, Annakkaya AN, Yavuz O, Gülcan E. Comparison of serum CA 19.9, CA 125 and CEA levels with severity of chronic obstructive pulmonary disease. Med Princ Pract 2009; 18: 289-93.
4. Witherspoon LR, Shuler SE, Alyea K, Husserl FE. Carcinoembryonic antigen: assay following heat compared with perchloric acid extraction in patients with colon cancer, non-neoplastic gastrointestinal diseases, or chronic renal failure. J Nucl Med 1983; 24: 916-21.
5. Herbeth B, Bagrel A. A study of factors influencing plasma CEA levels in an unselected population. Oncodev Biol Med 1980; 1: 191-8.
6. Reaven GM. Banting lecture 1988. Role of insulin resistance in human disease. Diabetes 1988; 37: 1595-607.
7. Laaksonen DE, Lakka HM, Niskanen LK, Kaplan GA, Salonen JT, Lakka TA. Metabolic syndrome and development of diabetes mellitus: application and validation of recently suggested definitions of the metabolic syndrome in a prospective cohort study. Am J Epidemiol 2002; 156: 1070-7.
8. Furberg AS, Veierød MB, Wilsgaard T, Bernstein L, Thune I. Serum high-density lipoprotein cholesterol, metabolic profile, and breast cancer risk. J Natl Cancer Inst 2004; 96: 1152-60.
9. Colangelo LA, Gapstur SM, Gann PH, Dyer AR, Liu K. Colorectal cancer mortality and factors related to the insulin resistance syndrome. Cancer Epidemiol Biomarkers Prev 2002; 11: 385-91.
10. Michaud DS, Liu S, Giovannucci E, Willett WC, Colditz GA, Fuchs CS. Dietary sugar, glycemic load, and pancreatic cancer risk in a prospective study. J Natl Cancer Inst 2002; 94: 1293-300.
11. Park JS, Choi GS, Jang YS, Jun SH, Kang H. Influence of obesity on the serum carcinoembryonic antigen value in patients with colorectal cancer. Cancer Epidemiol Biomarkers Prev 2010; 19: 2461-8.
12. Grundy SM, Cleeman JI, Daniels SR, Donato KA, Eckel RH, Franklin BA, Gordon DJ, Krauss RM, Savage PJ, Smith SC Jr, Spertus JA, Costa F; American Heart Association; National Heart, Lung, and Blood Institute. Diagnosis and management of the metabolic syndrome: an American Heart Association/National Heart, Lung, and Blood Institute Scientific Statement. Circulation 2005; 112: 2735-52.
13. Lee SY, Park HS, Kim DJ, Han JH, Kim SM, Cho GJ, Kim DY, Kwon HS, Kim SR, Lee CB, Oh SJ, Park CY, Yoo HJ. Appropriate waist circumference cutoff points for central obesity in Korean adults. Diabetes Res Clin Pract 2007; 75: 72-80.
14. Kim MH, Kim MK, Choi BY, Shin YJ. Prevalence of the metabolic syndrome and its association with cardiovascular diseases in Korea. J Korean Med Sci 2004; 19: 195-201.
15. Ryu SY, Kweon SS, Park HC, Shin JH, Rhee JA. Obesity and the metabolic syndrome in Korean adolescents. J Korean Med Sci 2007; 22: 513-7.
16. Wolk A, Gridley G, Svensson M, Nyrén O, McLaughlin JK, Fraumeni JF, Adam HO. A prospective study of obesity and cancer risk (Sweden). Cancer Causes Control 2001; 12: 13-21.
17. Schoen RE, Tangen CM, Kuller LH, Burke GL, Cushman M, Tracy RP, Dobs A, Savage PJ. Increased blood glucose and insulin, body size, and incident colorectal cancer. J Natl Cancer Inst 1999; 91: 1147-54.
18. Ahmed RL, Schmitz KH, Anderson KE, Rosamond WD, Folsom AR. The metabolic syndrome and risk of incident colorectal cancer. Cancer 2006; 107: 28-36.
19. Trevisan M, Liu J, Muti P, Misciagna G, Menotti A, Fucci F; Risk Factors and Life Expectancy Research Group. Markers of insulin resistance and colorectal cancer mortality. Cancer Epidemiol Biomarkers Prev 2001; 10: 937-41.
20. Ishizaka N, Ishizaka Y, Toda E, Koike K, Yamakado M, Nagai R. Are serum carcinoembryonic antigen levels associated with carotid atherosclerosis in Japanese men? Arterioscler Thromb Vasc Biol 2008; 28: 160-5.
21. Vassalle C, Pratali L, Ndreu R, Battaglia D, Andreassi MG. Carcinoembryonic antigen concentrations in patients with acute coronary syndrome. Clin Chem Lab Med 2010; 48: 1339-43.
22. Zhang L, Li SN, Wang XN. CEA and AFP expression in human hepatoma cells transfected with antisense IGF-I gene. World J Gastroenterol 1998; 4: 30-2.
23. Cowey S, Hardy RW. The metabolic syndrome: a high-risk state for cancer? Am J Pathol 2006; 169: 1505-22.
24. Boos CJ, Lip GY. Is hypertension an inflammatory process? Curr Pharm Des 2006; 12: 1623-35.
25. Cea-Calvo L, Lozano JV, Fernández-Pérez C, Llisterri JL, Martí-Canales JC, Aznar J, Gil-Guillén V, Redón J; Investigators of PREV-ICTUS study. Prevalence of low HDL cholesterol, and relationship between serum HDL and cardiovascular disease in elderly Spanish population: the PREV-ICTUS study. Int J Clin Pract 2009; 63: 71-81.