Small molecule Amiloride modulates oncogenic RNA alternative splicing to devitalize human cancer cells

PLoS ONE

Volumn 6, Issue 6, 2011, Pages

  Chang, Jan Gowth ^a,b,c   Yang, Den Mei ^d   Chang, Wen Hsin ^c   Chow, Lu Ping ^e   Chan, Wen Ling ^f   Lin, Hui Hua ^a,b   Huang, Hsien Da ^f   Chang, Ya Sian ^a   Hung, Cheng Hao ^d   Yang, Wen Kuang ^d,g  

^a KAOHSIUNG MEDICAL UNIVERSITY HOSPITAL   (Taiwan)

^b KAOHSIUNG MEDICAL UNIVERSITY   (Taiwan)

^c KAOHSIUNG MEDICAL UNIVERSITY   (Taiwan)

^d CHINA MEDICAL UNIVERSITY HOSPITAL   (Taiwan)

^e NATIONAL TAIWAN UNIVERSITY   (Taiwan)

^f NATIONAL CHIAO TUNG UNIVERSITY   (Taiwan)

^g CHINA MEDICAL UNIVERSITY   (Taiwan)

Author keywords

[No Author keywords available]

Indexed keywords

AMILORIDE; CELL DNA; CELL PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE P38; PROTEIN KINASE B; PROTEIN SF2; RIBONUCLEOPROTEIN; RIBONUCLEOPROTEIN 20; STRESS ACTIVATED PROTEIN KINASE; UNCLASSIFIED DRUG; ISOPROTEIN; MESSENGER RNA; NUCLEAR PROTEIN; PHOSPHOPROTEIN PHOSPHATASE 1; RNA; RNA BINDING PROTEIN; SERINE ARGININE RICH SPLICING PROTEINS; SERINE-ARGININE-RICH SPLICING PROTEINS; TUMOR PROTEIN;

ALTERNATIVE RNA SPLICING; ARTICLE; CANCER CELL; CANCER INVASION; CELL CYCLE; CELL DAMAGE; CELL MIGRATION; CONTROLLED STUDY; CYTOKINESIS; CYTOSKELETON; DNA DEGRADATION; DOWN REGULATION; DRUG MECHANISM; ENZYME INDUCTION; ENZYME PHOSPHORYLATION; ENZYME REGULATION; EXON; EXTRACELLULAR MATRIX; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; HUMAN GENOME; ION TRANSPORT; ONCOGENE; PROTEOMICS; APOPTOSIS; CELL NUCLEUS; CHEMISTRY; DNA FRAGMENTATION; DNA REPAIR; DRUG EFFECT; ENZYME ACTIVATION; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; MITOSIS; NEOPLASM; PATHOLOGY; PHOSPHORYLATION; TUMOR CELL LINE; TUMOR GENE;

ALTERNATIVE SPLICING; AMILORIDE; APOPTOSIS; CELL LINE, TUMOR; CELL NUCLEUS; CYTOKINESIS; CYTOSKELETON; DNA FRAGMENTATION; DNA REPAIR; ENZYME ACTIVATION; EXONS; GENE EXPRESSION REGULATION, NEOPLASTIC; GENES, NEOPLASM; GENOME, HUMAN; HUMANS; MITOSIS; NEOPLASM INVASIVENESS; NEOPLASM PROTEINS; NEOPLASMS; NUCLEAR PROTEINS; PHOSPHORYLATION; PROTEIN ISOFORMS; PROTEIN PHOSPHATASE 1; PROTEOMICS; PROTO-ONCOGENE PROTEINS C-AKT; RNA, MESSENGER; RNA, NEOPLASM; RNA-BINDING PROTEINS;

EID: 79958294217     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0018643     Document Type: Article

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