Pharmacodynamic interaction study of Allium sativum (garlic) with cilostazol in patients with type II diabetes mellitus

Indian Journal of Pharmacology

Volumn 43, Issue 3, 2011, Pages 270-274

  Mateen, A A ^a   Rani, P Usha ^a   Naidu, M U R ^a   Chandrashekar, E ^a  

^a NIZAM'S INSTITUTE OF MEDICAL SCIENCES   (India)

Author keywords

Cilostazol; garlic; platelet aggregation

Indexed keywords

ANTIDIABETIC AGENT; CILOSTAZOL; GARLIC EXTRACT; PLACEBO;

ADULT; ARTICLE; BLEEDING TIME; BLOOD CLOTTING TIME; CLINICAL ARTICLE; CONTROLLED STUDY; CROSSOVER PROCEDURE; DRUG ACTIVITY; DRUG POTENTIATION; HUMAN; NON INSULIN DEPENDENT DIABETES MELLITUS; RANDOMIZED CONTROLLED TRIAL; SINGLE DRUG DOSE; THROMBOCYTE AGGREGATION; THROMBOCYTE AGGREGATION INHIBITION;

EID: 79958279664     PISSN: 02537613     EISSN: 19983751     Source Type: Journal    
DOI: 10.4103/0253-7613.81514     Document Type: Article

References (17)

1. Abebe W. Herbal medication: Potential for adverse interactions with analgesic drugs. J Clin Pharm Ther 2002;27:391-401. (Pubitemid 35469171)
2. Beebe HG, Dawson DL, Cutler BS, Herd JA, Strandness DE Jr, Bortey EB, et al. A new pharmacological treatment for intermittent claudication: Results of a randomized, multicenter trial. Arch Intern Med 1999;159:2041-50. (Pubitemid 29453592)
3. Legnani C, Frascaro M, Guazzaloca G, Ludovici S, Cesarano G, Coccheri S. Effects of a dried garlic preparation on fi brinolysis and platelet aggregation in healthy subjects. Arzneimittelforschung 1993;43:119-22. (Pubitemid 23060784)
4. Kiesewetter H, Jung F, Jung EM, Mroweitz C, Koscielny J, Wenzel E. Effect of garlic on platelet aggregation in patients with increased risk of juvenile ischaemic attack. Eur J Clin Pharmacol 1993;45:333-6. (Pubitemid 23338541)
5. Bordia A, Verma SK, Srivastava KC. Effect of garlic on platelet aggregation in humans: A study in healthy subjects and patients with coronary artery disease. Prostaglandins Leukot Essent Fatty Acids 1996;55:201-5. (Pubitemid 26366840)
6. Lawson LD, Ransom DK, Hughes BG. Inhibition of whole blood plateletaggregation by compounds in garlic clove extracts and commercial garlic products. Thromb Res 1992;65:141-56.
7. Steiner M, Lin RS. Changes in platelet function and susceptibility of lipoproteins to oxidation associated with administration of aged garlic extract. J Cardiovasc Pharmacol 1998;31:904-8. (Pubitemid 28265300)
8. Rahman K, Billington D. Dietary supplementation with aged garlic extract inhibits ADP-induced platelet aggregation in humans. J Nutr 2000;130:2662-5.
9. Apitz-Castro R, Cabrera S, Cruz MR, Ledezma E, Jain MK. Effects of garlic extract and of three pure components isolated from it on human platelet aggregation, arachidonate metabolism, release reaction and platelet ultrastructure. Thromb Res 1983;32:155-69. (Pubitemid 14238545)
10. Apitz-Castro R, Escalante J, Vargas R, Jain MK. Ajoene, the antiplatelet principle of garlic, synergistically potentiates the antiaggregatory action of prostacyclin, forskolin, indomethacin and dypiridamole on human platelets. Thromb Res 1986;42:303-11. (Pubitemid 16035630)
11. Mohammad SF, Woodward SC. Characterization of a potent inhibitor of platelet aggregation and release reaction isolated from allium sativum (garlic). Thromb Res 1986;44:793-806. (Pubitemid 17228881)
12. Bordia A. Effect of garlic on human platelet aggregation in vitro. Atherosclerosis 1978;30:355-60. (Pubitemid 9008939)
13. Boullin DJ. Garlic as a platelet inhibitor. Lancet 1981;1:776-7. (Pubitemid 11154025)
14. Makheia AN, Vanderhoek JY, Bailey JM. Inhibition of platelet aggregation and thromboxane synthesis by onion and garlic. Lancet 1979;1:781. (Pubitemid 9160677)
15. Vanderhoek JY, Makheja AN, Bailey JM. Inhibition of fatty acid oxygenases by onion and garlic oils. Evidence for the mechanism by which these oils inhibit platelet aggregation. Biochem Pharmacol 1980;29:3169-73. (Pubitemid 11240869)
16. Apitz-Castro R, Jain MK, Bartoli F, Ledezma E, Ruiz MC, Salas R. Evidence for direct coupling of primary agonist-receptor interaction to the exposure of functional IIb-IIIa complexes in human blood platelets. Results from studies with the antiplatelet compound ajoene. Biochim Biophys Acta 1991;1094:269-80.
17. Aruna D, Naidu MU. Pharmacodynamic interaction studies of Ginkgo biloba with cilostazol and clopidogrel in healthy human subjects. Br J Clin Pharmacol 2007;63:333-8.