Zolpidem urine excretion profiles and cross-reactivity with ELISA® kits in subjects using zolpidem or ambien® CR as a prescription sleep aid

Journal of Analytical Toxicology

Volumn 35, Issue 5, 2011, Pages 294-301

  Reidy, L ^a   Nolan, B ^a   Ramos, A R ^a   Walls, H C ^a   Steele, B W ^a  

^a UNIVERSITY OF MIAMI MILLER SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CLOZAPINE; CREATININE; ZOLPIDEM; ZOLPIDEM TARTRATE;

ABSENCE OF SIDE EFFECTS; ADULT; AMNESIA; ARTICLE; DIAGNOSTIC KIT; DROWSINESS; DRUG EXCRETION; DRUG METABOLISM; DRUG URINE LEVEL; ENZYME LINKED IMMUNOSORBENT ASSAY; ENZYME LINKED IMMUNOSORBENT ASSAY KIT; FATIGUE; FEMALE; HUMAN; MALE; MASS FRAGMENTOGRAPHY; SLEEP DISORDER; SLEEP EATING; TREATMENT DURATION; URINALYSIS; WAKEFULNESS;

EID: 79958276493     PISSN: 01464760     EISSN: 01464760     Source Type: Journal    
DOI: 10.1093/anatox/35.5.294     Document Type: Article

References (31)

1. W. Weiten. Psychology: Themes and Variations, 8th ed., Wadsworth Publishing, Belmont, CA, 2008, pp 199-201.
2. T. Swainston Harrison and G.M. Keating. Zolpidem: a review of its use in the management of insomnia. CNS Drugs 19: 65-89 (2005).
3. Ambien.com (2008) Information about a Short-term Treatment for Insomnia - Ambien.com Home Page for Health-care Professionals. Sanofi-Synthelabo, Inc. (accessed March 2010).
4. W.B. Mendelson. Sleepwalking associated with zolpidem. J. Clin. Psychopharmacol. 14: 150 (1994).
5. M.J. Mattila, J. Vanakoski, H. Kalska, and T. Seppälä. Effects of alcohol, zolpidem and some other sedatives and hypnotics on human performance and memory. Pharmacol. Biochem. Behav. 59: 917-923 (1998).
6. P. Denis and M.L. Bocca. Effects of zolpidem 10 mg, zopiclone 7.5 mg and flunitrazepam 1 mg on nighttime motor activity. Eur. Neuropsychopharmacol. 13: 111-115 (2003).
7. I. Hindermarch, A. Patat, N. Stanley, I. Paty, and U. Rigney. Residual effects of zaleplon and zolpidem following middle of the night administration five hours to one hour before awakening. Hum. Psychopharmacol. 16: 159-167 (2001).
8. J.C. Verster, E.R. Volkerts, A.H. Schreuder, E.J. Eijken, J.H. Van Heuckelum, D.S. Veldhuijzen, M.N. Verbaten, I. Paty, M. Darwish, P. Danjou, and A. Patat. Residual effects of middle-of-the-night administration of zaleplon and zolpidem on driving ability, memory functions and psychomotor performance. J. Clin. Psychopharmacol. 22: 576-583 (2002).
9. C.J. Wilkinson. The acute effects of zolpidem, administered alone and with alcohol, on cognitive and psychomotor function. J. Clin. Psychiatry 56: 309-318 (1995).
10. M. Partinen, K. Hirvonen, C. Hublin, M. Halavaara, and H. Hiltunen. Effects of after-midnight intake of zolpidem and temazepam on driving ability in women with non-organic insomnia. Sleep Med. 4: 553-561 (2003).
11. D.R. Drover. Comparative pharmacokinetics and pharmacodynamics of short acting hypnosedatives zaleplon, zolpidem and zopiclone. Clin. Pharmacokinet. 43: 227-238 (2004).
12. S. Vajta, J.P. Thenot, F. de Maack, G. Devant, and M. Lesieur. Thermospray liquid chromatography tandem mass spectrometry: application to the elucidation of zolpidem metabolism. Biomed. Environ. Mass Spectrom. 15: 223-228 (1988).
13. L.L. Von Moltke, D.J. Greenblatt, B.W. Granda, S.X. Duan, J.M. Grassi, K. Venkatakrishnan, J.S. Marmatz, and R.I. Shader. Zolpidem metabolism in vitro: responsible cytochromes, chemical inhibitors, and in vivo correlations. Br. J. Clin. Pharmacol. 48: 89-97 (1999).
14. L.L. Von Moltke, J.L. Weemhoff, M.D. Perloff, L.M. Hesse, J.S. Harmatz, B.F. Roth-Schechter, and D.J. Greenblatt. Effect of zolpidem on human cytochrome P450 activity and on transport mediated by P-glycoprotein. Biopharm. Drug Dispos. 23: 361-367 (2002).
15. T.P. Rohrig and C.M. Moore. Zolpidem. Forensic aspects for the toxicologist and pathologist. Forensic Sci. Med. Pathol. 1: 81-90 (2005).
16. A.A. Piergies, S. Sainati, and B. Roth-Schechter. Lack of cross reactivity of Ambien (zolpidem) with drugs in standard urine drug screen. Arch. Pathol. Lab. Med. 121: 392-394 (1997).
17. Zolpidem direct ELISA kit (package insert). Immunalysis Corporation, Pomona, CA, 2009.
18. Neogen direct ELISA kit (package insert). Neogen Corporation, Lexington, KY. 2009.
19. L. Reidy, W. Gennero, B.W. Steele, and H.C. Walls. The incidence of zolpidem use in suspected DUI drivers in Miami-Dade Florida: a comparative study using Immunalysis Zolpidem ELISA kit and gas chromatographic-mass spectrometric screening. J. Anal. Toxicol. 32: 688-694 (2008).
20. E.H. Foerster, D. Hatchett, and J.C. Garriott. A rapid, comprehensive screening procedure for basic drugs in blood or tissues by gas chromatography. J. Anal. Toxicol. 2: 50-55 (1978).
21. R.L Barkin. Zolpidem extended-release: a single insomnia treatment option for sleep induction and sleep maintenance symptoms. Am. J. Ther. 14: 299-305 (2007).
22. M.L. Pujol, V. Cirimele, P.J. Tritsch, M. Villain, and P. Kintz. Evaluation of the IDS One-Step ELISA kits for the detection of illicit drugs in hair. Forensic Sci. Int. 170: 189-192 (2007).
23. J.H. Lewis and J.H. Vine. A simple and rapid method for the identification of zolpidem carboxylic acid in urine. J. Anal. Toxicol. 31: 195-199 (2007).
24. V. Ascalone, L. Flaminio, P. Guinebault, J.P. Thénot, and P.L. Morselli. Determination of zolpidem, a new sleep-inducing agent, and its metabolites in biological fluids: pharmacokinetics, drug metabolism and overdosing investigations in humans. J. Chromatogr. 581: 237-250 (1992).
25. P. Salva and J. Costa. Clinical pharmokinetics and pharmacodynamics of zolpidem. Therapeutic implications. Clin. Pharmacokinet. 29: 142-153 (1995).
26. K. Huynh, G. Wang, C. Moore, R. Barhate, C. Coulter, W. Rodrigues, P. Catbagan, and J. Soares. Development of a homogeneous immunoassay for the detection of zolpidem in urine. J. Anal. Toxicol. 33: 486-490 (2009).
27. G. Hempel and G. Blaschke. Direct determination of zolpidem and its main metabolites in urine using capillary electrophoresis with laser-induced fluorescence detection. J. Chromatogr. B Biomed. Appl. 675: 131-137 (1996).
28. J.P. Thénot, P. Hermann, A. Durand, J.T. Burke, J. Allen, D. Garrigou, S. Vajta, H. Albin, J.J. Thébault, G. Olive, and S.J. Warrington. Pharmacokinetics and metabolism of zolpidem in various animal species and in humans. In Imidazopyridines in Sleep Disorders, J.P. Sauvanet, S.Z. Langer, and P.L. Morselli, Eds. Raven Press, New York, NY, 1988, pp 139-153.
29. M. Villain, M. Cheze, A. Tracqui, B. Ludes, and P. Kintz. Windows of detection of zolpidem in urine and hair; application to two drug facilitated sexual assaults. Forensic Sci. Int. 143: 157-161 (2004).
30. T. Keller, A. Schneider, and E. Tutsch-Bauer. GC/MS determination of zolpidem in postmortem specimen in a voluntary intoxication. Forensic Sci. Int. 106: 103-108 (1999).
31. L.M. Hesse, L.L. von Moltke, and D.J. Greenblatt. Clinically important drug interactions with zopiclone, zolpidem and zaleplon. CNS Drugs 17: 513-532 (2003).