3-Bromocyclohexane-1,2-dione as a useful reagent for Hantzsch synthesis of thiazoles and the synthesis of related heterocycles

Tetrahedron Letters

Volumn 52, Issue 28, 2011, Pages 3633-3635

  Guernon, Jason M ^a   Wu, Yong Jin ^a  

^a BRISTOL MYERS SQUIBB   (United States)

Author keywords

3 Bromocyclohexan 1,2 dione; Hantzsch; Thiazole

Indexed keywords

3 BROMOCYCLOHEXANE 1,2 DIONE; CYCLOHEXANE DERIVATIVE; THIAZOLE DERIVATIVE; THIOAMIDE; THIOUREA; UNCLASSIFIED DRUG;

ARTICLE; CHEMICAL REACTION; CHEMICAL STRUCTURE; HANTZSCH SYNTHESIS; PROTON NUCLEAR MAGNETIC RESONANCE; SUBSTITUTION REACTION; SYNTHESIS; TRANSESTERIFICATION;

EID: 79958274006     PISSN: 00404039     EISSN: 18733581     Source Type: Journal    
DOI: 10.1016/j.tetlet.2011.05.028     Document Type: Article

References (11)

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10. 3) δ 191.7, 146.0, 119.4, 35.5, 34.5, 22.9. The carbon data as well as an hmqc experiment which showed no cross peak of a carbon with the 6.43 ppm proton indicate that in solution, the dione 3 exists exclusively in the enol form.
11. 3) δ 190.9, 163.3, 152.7, 150.9, 150.5, 139.7, 120.8, 38.3, 24.6, 23.9.