Comparison of salbutamol efficacy in children- via themetered-dose inhaler (MDI) with Volumatic® spacerand via the dry powder inhaler, Easyhaler®, with thenebulizer - in mild to moderate asthma exacerbation: A multicenter, randomized study

Asian Pacific Journal of Allergy and Immunology

Volumn 29, Issue 1, 2011, Pages 25-33

  Direkwatanachai, Chalerat ^a   Teeratakulpisarn, Jamaree ^b   Suntornlohanakul, Somchai ^c   Trakultivakorn, Muthita ^d   Ngamphaiboon, Jarungchit ^e   Wongpitoon, Nares ^f   Vangveeravong, Mukda ^g  

^a MAHIDOL UNIVERSITY   (Thailand)

^b KHON KAEN UNIVERSITY   (Thailand)

^c PRINCE OF SONGKLA UNIVERSITY   (Thailand)

^d Faculty of Medicine Chiang Mai University   (Thailand)

^e CHULALONGKORN UNIVERSITY   (Thailand)

^f POLICE GENERAL HOSPITAL   (Thailand)

^g MINISTRY OF PUBLIC HEALTH   (Thailand)

Author keywords

DPI; Easyhaler; Nebulizer; pMDI; Salbutamol

Indexed keywords

CORTICOSTEROID; PREDNISOLONE; SALBUTAMOL; UNCLASSIFIED DRUG; VENTOLIN RESPIRATORY SOLUTION;

ARTICLE; ASTHMA; BREATHING RATE; CHILD; CONTROLLED STUDY; DISEASE EXACERBATION; DISEASE SEVERITY; DRUG EFFICACY; DRUG RESPONSE; FEMALE; HEART PALPITATION; HUMAN; HYPERTENSION; INTERMETHOD COMPARISON; MAJOR CLINICAL STUDY; MALE; METERED DOSE INHALER; MULTICENTER STUDY; NEBULIZER; OXYGEN SATURATION; POWDER INHALER; RANDOMIZED CONTROLLED TRIAL; TACHYCARDIA; TREATMENT OUTCOME; TREMOR;

ACUTE DISEASE; ADOLESCENT; ALBUTEROL; ASTHMA; BRONCHODILATOR AGENTS; CHILD; CHILD, PRESCHOOL; DRY POWDER INHALERS; ENDPOINT DETERMINATION; FEMALE; HUMANS; INHALATION SPACERS; MALE; NEBULIZERS AND VAPORIZERS; TREATMENT OUTCOME;

EID: 79958266250     PISSN: 0125877X     EISSN: 22288694     Source Type: Journal    
DOI: None     Document Type: Article

References (29)

1. Global Initiative for Asthma. Global Strategy for Asthma Management and Prevention. Updated 2008.
2. Bunyarittipong P, Tuchinda M, Balankura K, Visitsunthorn N, Vanaprapar N. Prevalence of allergic diseases in Thai children. J Pediatr Soc Thai. 1990;29: 24-32.
3. Vichyanond P, Jirapongsananurak O, Visitsunthorn N, Tuchinda M. Prevalence of asthma, rhinitis and eczema in children from Bangkok areausing ISAAC (International Study of Asthma and Allergies in Children)questionnaires. J Med Assoc Thai. 1998; 81: 175-84.
4. Trakultivakorn M, Sangsupawanich S, Vichyanond P. Time trends of theprevalence of asthma, rhinitis and eczema in Thai children-ISAAC(International Study of Asthma and Allergies in Childhood) Phase Three. JAsthma. 2007; 44: 609-11.
5. Boonsawat W, Charoenphan P, Kiatboonsri S, Wongtim S, Viriyachaiyo V, Pothirat C, et al. Survey of asthma control in Thailand. Respirology. 2004; 9:373-8.
6. British Thoracic Society and others. Guidelines on the management ofasthma: management of acute asthma. Thorax. 2003; 58(suppl): i32-50.
7. Mitchell EA. Consensus on acute asthma management in children: Ad Hoc Pediatric Group. N Z Med J 1992; 105: 353-5.
8. Todd Loffer D, Ikle D, Nelson HS. A comparison of commercial jet nebulizers. Chest. 1994; 106: 1788-93.
9. Cates C. Spacers and nebulisers for the delivery of beta-agonists in non-lifethreateningacute asthma. Respir Med. 2003; 97: 762-9.
10. Cates CJ, Crilly JA, Rowe BH. Holding chamber versus nebulisers for β2 agonist treatment for acute asthma. Cochrane Database Syst Rev. 2006;Issue 2: CD000052.
11. Haahtela T, Vidgren M, Nyberg A, Korhonen P, Laurikainen K, Silvasti M.A. novel multiple dose powder inhaler. Salbutamol powder and aerosol giveequal bronchodilatation with equal doses. Annals Allergy. 1994; 72: 178-82.
12. Koskela T, Malmstrom K, Sairanen U, Peltola S, Keski-Karhu J, Silvasti M. Efficacy of salbutamol via Easyhaler unaffected by low inspiratory flow. Respir Med. 2000; 94: 1229-33.
13. Chong Neto HJ, Chong-Silva DC, Marani DM, Kuroda F, Olandosky M, deNoronha L. Different inhaler devices in acute asthma attacks: arandomnized, double-blind, placebo-controlled study. J Pediatr (Rio J).2005; 81: 298-304.
14. Wood DW, Downes JJ, Lecks HI. A clinical scoring system for thediagnosis of respiratory failure. Am J Dis Child. 1972; 123: 227-8.
15. The Fourth Report on the Diagnosis, Evaluation, and Treatment of High Blood Pressure in Children and Adolescents. U.S. Department of Health and Human Services. National Institute of Health. National Heart, Lung and Blood Institute. NIH Publication No 05-5267. Revised May 2005.
16. Pocock SJ. Clinical trials: a practical approach. John Wiley&Sons:Chichester; 1983. p. 129-130.
17. Castro-Rodriguez JA, Rodrigo GJ. B-agonist through metered-dose inhalerwith valved holding chamber versus nebulizer for acute exacerbation ofwheezing or asthma in children under 5 years of age: a systemic review withmeta-analysis. J Pediatr. 2004; 145: 172-7.
18. Drblik S, Lapierre G, Thivierge R, Turgeon J, Gaudreault P, Cummins-McManus B, et al. Comparative efficacy of terbutaline sulphate delivered byTurbuhaler dry powder inhaler or pressurised metered dose inhaler withNebuhaler spacer in children during an acute asthmatic episode. Arch DisChild. 2003; 88: 319-23.
19. Robertson CF, Norden MA, Fitzgerald DA, Connor FL, Van Asperen PP, Cooper PJ, et al. Treatment of acute asthma: salbutamol via jet nebuliser vsspacer and metered dose inhaler. J Paediatr Child Health 1998; 34: 142-6.
20. Schuh S, Johnson DW, Stephens D, Callahan S, Winders P, Canny GJ. Comparison of albuterol delivered by a metered dose inhaler with spacerversus a nebulizer in children with mild acute asthma. J Pediatr. 1999; 135:22-7.
21. Leversha AM, Campanella SG, Aickin RP, Asher MI. Costs andeffectiveness of spacer versus nebulizer in young children with moderate andsevere acute asthma. J Pediatr. 2000; 136: 497-502.
22. Delgado A, Chou KJ, Silver EJ, Crain EF. Nebulizers vs metered-doseinhalers with spacers for bronchodilator therapy to treat wheezing in childrenaged 2-24 months in a pediatric emergency department. Arch PediatrAdolesc Med. 2003; 157: 76-80.
23. Geller DE. Comparing clinical features of the nebulizer, metered-doseinhaler, and dry powder inhaler. Respir Care. 2005; 50: 1313-21.
24. Pedersen JZ, Bungaard A. Comparative efficacy of different methods ofnebulizing terbutaline. Eur J Clin Pharmacol. 1983; 25: 739-42.
25. Madsen EB, Bundgaard A, Hidinger KG. Cumulative dose-response studycomparing terbutaline pressurized aerosol administered via a pearshapedspacer and terbutaline in a nebulized solution. Eur J Clin Pharmacol. 1982;23: 27-30.
26. Blake KV, Hoppe M, Harman E, Hendeles L. Relative amount of albuteroldelivered to lung receptors from a metered-dose inhaler and nebulizersolution. Bioassay by histamine bronchoprovocation. Chest. 1992; 101: 309-15.
27. Amirav I, Newhouse MT. Metered=dose inhaler accessory devices in acuteasthma. Efficacy and comparison with nebulizers: a literature review. Arch Pediatr Adolesc Med. 1997; 151: 876-82.
28. Kerem E, Levison H, Schuh S, O'Brodovich H, Reisman J, Bentur L, et al. Efficacy of albuterol administered by nebulizer versus spacer device inchildren with asthma. J Pediatr. 1993; 123: 313-7.
29. Vangveeravong M. A comparative study of efficacy of salbutamol viametered dose inhaler with Volumetric spacer and via dry powder inhaler,Easyhaler, to nebulization in mild to moderate severity acute asthmaexacerbation in childhood. J Med Assoc Thai. 2008; 91(suppl3): S115-23.