Effect of early clopidogrel discontinuation on rehospitalization in acute coronary syndrome: Results from two distinct patient populations

American Journal of Health-System Pharmacy

Volumn 68, Issue 11, 2011, Pages 1015-1024

  Ernst, Frank R ^a   Johnston, Stephen ^b   Curkendall, Suellen ^c   Mozaffari, Essy ^d   Stemkowski, Stephen ^e  

^a Premier   (United States)

^b Outcomes Research   (United States)

^c THOMSON REUTERS   (United Kingdom)

^d SANOFI   (France)

^e LOVELACE RESPIRATORY RESEARCH INSTITUTE   (United States)

Author keywords

Acute coronary syndrome; Clopidogrel; Drug withdrawal; Hospitals; Myocardial infarction; Platelet aggregation inhibitors; Stents

Indexed keywords

CLOPIDOGREL;

ACUTE CORONARY SYNDROME; ACUTE HEART INFARCTION; ADULT; AGED; ARTICLE; CARDIAC PATIENT; CORONARY STENT; DATA BASE; DISEASE ASSOCIATION; DRUG WITHDRAWAL; FEMALE; HEALTH INSURANCE; HEART MUSCLE REVASCULARIZATION; HOSPITAL DISCHARGE; HOSPITAL PATIENT; HOSPITAL READMISSION; HUMAN; MAJOR CLINICAL STUDY; MALE; OBSERVATIONAL STUDY; OUTPATIENT CARE; PHARMACY; POPULATION; PRIORITY JOURNAL; RETROSPECTIVE STUDY; RISK FACTOR; TREATMENT DURATION;

EID: 79958264154     PISSN: 10792082     EISSN: 15352900     Source Type: Journal    
DOI: 10.2146/ajhp100455     Document Type: Article

References (24)

1. Yusuf S, Zhao F, Mehta SR et al. Clopidogrel in Unstable Angina to Prevent Recurrent Events Trial Investigators. Effects of clopidogrel in addition to aspirin in patients with acute coronary syndromes without ST-segment elevation. N Engl J Med. 2001; 345:494-502.
2. Mehta SR, Yusuf S, Peters RJ et al. Clopidogrel in Unstable angina to prevent Recurrent Events trial (CURE) Investigators. Effects of pretreatment with clopidogrel and aspirin followed by long-term therapy in patients undergoing percutaneous coronary intervention: the PCI-CURE study. Lancet. 2001; 358:527-33.
3. Steinhubl SR, Berger PB, Mann JT III et al. CREDO Investigators. Clopidogrel for the Reduction of Events During Observation. Early and sustained dual oral antiplatelet therapy following percutaneous coronary intervention: a randomized controlled trial. JAMA. 2002; 288:2411-20.
4. Anderson JL, Adams CD, Antman EM et al. American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Writing Committee to Revise the 2002 Guidelines for the Management of Patients With Unstable Angina/Non-ST-Elevation Myocardial Infarction). ACC/AHA 2007 guidelines for the management of patients with unstable angina/non-ST-elevation myocardial infarction: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines. J Am Coll Cardiol. 2007; 50: e1-157.
5. Eisenstein EL, Anstrom KJ, Kong DF et al. Clopidogrel use and long-term clinical outcomes after drug-eluting stent implantation. JAMA. 2007; 297:159-68.
6. Ho PM, Fihn SD, Wang SL et al. Clopidogrel and long-term outcomes after stent implantation for acute coronary syndrome. Am Heart J. 2007; 154:846-51.
7. Ho PM, Peterson ED, Wang L et al. Incidence of death and acute myocardial infarction associated with stopping clopidogrel after acute coronary syndrome. JAMA. 2008; 299:532-9.
8. Wiederkehr D, Berenson K, Casciano R et al. Clinical impact of early clopidogrel discontinuation following acute myocardial infarction hospitalization or stent implantation: analysis in a singleintegrated health network. Curr Med Res Opin. 2009; 25:2317-25.
9. Wiederkehr D, Ogbonnaya A, Casciano R et al. Clinical impact of early clopidogrel discontinuation following acute myocardial infarction hospitalization or stent implantation: analysis in a nationally representative managed-care population. Curr Med Res Opin. 2009; 25:2327-34.
10. Ye X, Gross CR, Schommer J et al. Initiation of statins after hospitalization for coronary heart disease. J Manag Care Pharm. 2007; 3:385-96.
11. Amin A, Stemkowski S, Lin J et al. Thromboprophylaxis rates in US medical centers: success or failure? J Thromb Hemost. 2007; 5:1610-6.
12. Kamal-Bahl SJ, Burke T, Watson W et al. Discontinuation of lipid modifying drugs among commercially insured United States patients in recent clinical practice. Am J Cardiol. 2007; 99:530-4.
13. Premier Research Services. Peer-reviewed publications using Premier/i3 linked data. www.premierinc.com/quality-safety/tools-services/prs/published- research/ index.jsp (accessed 2011 Feb 14).
14. Premier Research Services. Premier Perspective. www.premierinc.com/ quality-safety/tools-services/prs/data/perspective.jsp (accessed 2011 Feb 14).
15. Nguyen-Khoa BA, Goehring EL, Werther W et al. Hospitalized cardiovascular diseases in neovascular age-related macular degeneration. Arch Ophthalmol. 2008; 126:1280-6.
16. A nested case-control study of the association between Coreg IR and Coreg CR and hypersensitivity reactions: anaphylactic reaction/angioedema. http://gsk-clinicalstudyregister.com/files/pdf/23741.pdf (accessed 2010 Feb 4).
17. Shatin D, Rawson NS, Stergasis A. United-Health Group. In: Strom BL, ed. Pharmaco-epidemiology. 4th ed. New York: John Wiley & Sons; 2005:271-80.
18. Averill R, Goldfield N, Hughes J et al. What are APR-DRGs? An introduction to severity of illness and risk of mortality adjustment methodology. http://solutions.3mcom/3MContentRetrievalAPI/BlobServlet?locale=it- IT&lmd=1218718280000&assetId=1180603360910&assetType= MMM-Image&blobAt t r ibute=ImageFile (accessed 2011 Feb 14).
19. Steg PG, Goldberg RJ, Gore JM et al. Baseline characteristics, management practices, and in-hospital outcomes of patients hospitalized with acute coronary syndromes in the Global Registry of Acute Coronary Events (GRACE). Am J Cardiol. 2002; 90:358-63.
20. Yan RT, Yan AT, Tan M et al. Age-related differences in the management and outcome of patients with acute coronary syndromes. Am Heart J. 2006; 151:352-9.
21. Avezum A, Makdisse M, Spencer F et al. Impact of age on management and outcome of acute coronary syndrome: observations from the Global Registry of Acute Coronary Events (GRACE). Am Heart J. 2005; 149:67-73.
22. Ferreira-González I, Marsal JR, Ribera A et al. Background, incidence, and predictors of antiplatelet therapy discontinuation during the first year after drug-eluting stent implantation. Circulation. 2010; 122:1017-25.
23. Fox KA, Dabbous OH, Goldberg RJ et al. Prediction of risk of death and myocardial infarction in the six months after presentation with acute coronary syndrome: prospective multinational observational study (GRACE). Br Med J. 2006; 333:1091-6.
24. Wang PS, Benner JS, Glynn RJ. How well do patients report noncompliance with antihypertensive medications? A comparison of self-report versus filled prescriptions. Pharmacoepidemiol Drug Safe. 2004; 13:11-9.