Association study and expression analysis of CD9 as candidate gene for boar sperm quality and fertility traits

Animal Reproduction Science

Volumn 125, Issue 1-4, 2011, Pages 170-179

  Kaewmala, Kanokwan ^a   Uddin, Muhammad Jasim ^a   Cinar, Mehmet Ulas ^a   Große Brinkhaus, Christine ^a   Jonas, Elisabeth ^a,b   Tesfaye, Dawit ^a   Phatsara, Chirawath ^a,c   Tholen, Ernst ^a   Looft, Christian ^a   Schellander, Karl ^a  

^a UNIVERSITY OF BONN   (Germany)

^b UNIVERSITY OF SYDNEY   (Australia)

^c CHIANG MAI UNIVERSITY   (Thailand)

Author keywords

Immunofluorescence; MRNA expression; Protein expression; Reproductive tissue; Spermatogenesis

Indexed keywords

CD9 ANTIGEN; DNA; LEUKOCYTE ANTIGEN; MEMBRANE PROTEIN;

ANIMAL; ANIMAL DISEASE; ARTICLE; BIOSYNTHESIS; CHEMISTRY; CHI SQUARE DISTRIBUTION; CROSS BREEDING; FERTILITY; FLUORESCENT ANTIBODY TECHNIQUE; GENETICS; GENOTYPE; IMMUNOLOGY; MALE; MALE GENITAL SYSTEM; PHYSIOLOGY; POLYMERASE CHAIN REACTION; RESTRICTION FRAGMENT LENGTH POLYMORPHISM; SEMEN ANALYSIS; SINGLE NUCLEOTIDE POLYMORPHISM; SPERMATOZOON; SPERMATOZOON COUNT; SPERMATOZOON MOTILITY; SWINE; WESTERN BLOTTING;

ANIMALS; ANTIGENS, CD; BLOTTING, WESTERN; CHI-SQUARE DISTRIBUTION; CROSSES, GENETIC; DNA; FERTILITY; FLUORESCENT ANTIBODY TECHNIQUE, INDIRECT; GENITALIA, MALE; GENOTYPE; MALE; MEMBRANE GLYCOPROTEINS; POLYMERASE CHAIN REACTION; POLYMORPHISM, RESTRICTION FRAGMENT LENGTH; POLYMORPHISM, SINGLE NUCLEOTIDE; SEMEN ANALYSIS; SPERM COUNT; SPERM MOTILITY; SPERMATOZOA; SWINE;

ANIMALIA; SUIDAE;

EID: 79958235976     PISSN: 03784320     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.anireprosci.2011.02.017     Document Type: Article

References (43)

1. Boucheix C., Duc G.H.T., Jasmin C., Rubinstein E. Tetraspanins and malignancy. Expert Rev. Mol. Med. 2001, 3:1-17.
2. Capon F., Allen M.H., Ameen M., Burden A.D., Tillman D., Barker J.N. A synonymous SNP of the corneodesmosin gene leads to increased mRNA stability and demonstrates association with psoriasis across diverse ethnic groups. Hum. Mol. Genet. 2004, 13(20):2361-2368.
3. Chuan Y., Pang S.T., Bergh A., Norstedt G., Pousette A. Androgens induce CD-9 in human prostate tissue. Int. J. Androl. 2005, 28:291-296.
4. Corpet F. Multiple sequence alignment with hierarchical clustering. Nucleic Acids Res. 1988, 16:10881-10890.
5. Daghigh-Kia, H., 2007. Identification and SNP detection for preimplantation active genes and their association with embryo development and male fertility in cattle. Thesis, (PhD), Institute of Animal Science, Animal Breeding and Husbandry Group, University of Bonn, Bonn, Germany, p. 135.
6. Falconer D.S., Mackay T.F.C. Introduction to Quantitative Genetics 1996, Longmans Green, Harlow, Essex, UK. fourth ed.
7. Hemler M.E. Specific tetraspanin functions. J. Cell Biol. 2001, 155:1103-1108.
8. Horejsi V., Vlcek C. Novel structurally distinct family of leucocyte surface glycoproteins including CD9, CD37, CD53 and CD63. FEBS Lett. 1991, 288:1-4.
9. Inoue N., Ikawa M., Isotani A., Okabe M. The immunoglobulin superfamily protein Izumo is required for sperm to fuse with eggs. Nature 2005, 434:234-238.
10. Iwamoto R., Senoh H., Okada Y., Uchida T., Mekada E. An antibody that inhibits the binding of diphtheria toxin to cells revealed the association of a 27-kDa membrane protein with the diphtheria toxin receptor. J. Biol. Chem. 1991, 266:20463-20469.
11. Jae Ho L., Wolfgang E., Karim N. Stem cell protein Piwil2 modulates expression of murine spermatogonial stem cell expressed genes. Mol. Reprod. Dev. 2006, 73:173-179.
12. Jiang Z., Cote J., Kwon J.M., Goate A.M., Wu J.Y. Aberrant splicing of tau pre-mRNA caused by intronic mutations associated with the inherited dementia frontotemporal dementia with parkinsonism linked to chromosome 17. Mol. Cell Biol. 2000, 20:4036-4048.
13. Kaji K., Kudo A. The mechanism of sperm-oocyte fusion in mammals. Reproduction 2004, 127:423-429.
14. Kaji K., Oda S., Shikano T., Ohnuki T., Uematsu Y., Sakagami J., Tada N., Miyazaki S., Kudo A. The gamete fusion process is defective in eggs of CD9-deficient mice. Nat. Genet. 2000, 24:279-282.
15. Kanatsu-Shinohara M., Inoue K., Lee J., Yoshimoto M., Ogonuki N., Miki H., Baba S., Kato T., Kazuki Y., Toyokuni S., Toyoshima M., Niwa O., Oshimura M., Heike T., Nakahata T., Ishino F., Ogura A., Shinohara T. Generation of pluripotent stem cells from neonatal mouse testis. Cell 2004, 119:1001-1012.
16. Kanatsu-Shinohara M., Toyokuni S., Shinohara T. CD9 is a surface marker on mouse and rat male germline stem cells. Biol. Reprod. 2004, 70:70-75.
17. Klassen H., Schwartz M.R., Bailey A.H., Young M.J. Surface markers expressed by multipotent human and mouse neural progenitor cells include tetraspanins and non-protein epitopes. Neurosci. Lett. 2001, 312:180-182.
18. Laura L.T., Abraham L.K. The ADAM-integrin-tetraspanin complex in fetal and postnatal testicular cords. Birth Defects Res. C: Embryo Today: Rev. 2005, 75:130-141.
19. Le H.H., Nott A., Moore M. How introns influence and enhance eukaryotic gene expression. Trends Biochem. Sci. 2003, 28:215-220.
20. Le Naour F., Rubinstein E., Jasmin C., Prenant M., Boucheix C. Severely reduced female fertility in CD9-deficient mice. Science 2000, 287:319-321.
21. Levy S., Shoham T. Protein-protein interactions in the tetraspanin web. Physiology 2005, 20:218-224.
22. Li Y.-H., Hou Y., Ma W., Yuan J.-X., Zhang D., Sun Q.-Y., Wang W.-H. Localization of CD9 in pig oocytes and its effects on sperm-egg interaction. Reproduction 2004, 127:151-157.
23. Lin C.L., Ponsuksili S., Tholen E., Jennen D.G.J., Schellander K., Wimmers K. Candidate gene markers for sperm quality and fertility of boar. Anim. Reprod. Sci. 2006, 92:349-363.
24. Liu G., Jennen D.G., Tholen E., Juengst H., Kleinwachter T., Holker M. A genome scan reveals QTL for growth, fatness, leanness and meat quality in a Duroc-Pietrain resource population. Anim. Genet. 2007, 38:241-252.
25. Mattioli M., Gloria A., Mauro A., Gioia L., Barboni B. Fusion as the result of sperm-somatic cell interaction. Reproduction 2009, 138:679-687.
26. Miyado K., Yoshida K., Yamagata K., Sakakibara K., Okabe M., Wang X., Miyamoto K., Akutsu H., Kondo T., Takahashi Y., Ban T., Ito C., Toshimori K., Nakamura A., Ito M., Miyado M., Mekada E., Umezawa A. The fusing ability of sperm is bestowed by CD9-containing vesicles released from eggs in mice. PNAS 2008, 105:12921-12926.
27. Oka M., Tagoku K., Russell T.L., Nakano Y., Hamazaki T., Meyer E.M., Yokota T., Terada N. CD9 is associated with leukemia inhibitory factor-mediated maintenance of embryonic stem cells. Mol. Biol. Cell 2002, 13:1274-1281.
28. Oritani K., Wu X., Medina K., Hudson J., Miyake K., Gimble J.M., Burstein S.A., Kincade P.W. Antibody ligation of CD9 modifies production of myeloid cells in long-term cultures. Blood 1996, 87:2252-2261.
29. Pagani F., Baralle F. Genomic variants in exons and introns: identifying the splicing spoilers. Nat. Rev. Genet. 2004, 5:389-396.
30. Primakoff P., Myles D.G. Penetration, adhesion, and fusion in mammalian sperm-egg interaction. Science 2002, 296:2183-2185.
31. Ren D.R., Ren J., Xing Y.Y., Guo Y.M., Wu Y.B., Yang G.C., Mao H.R., Huang L.S. A genome scan for quantitative trait loci affecting male reproductive traits in a White Duroc×Chinese Erhualian resource population. J. Anim. Sci. 2009, 87:17-23.
32. Rothschild M.F., Ruvinsky A. The Genetics of the Pig 1998, University Press, CABI, Cambridge, UK, p. 640. first ed.
33. Rozen S., Skaletsky H. Primer3 on the WWW for general users and for biologist programmers. Methods Mol. Biol. 2000, 132:365-386.
34. Schultz N., Hamra F.K., Garbers D.L. A multitude of genes expressed solely in meiotic or postmeiotic spermatogenic cells offers a myriad of contraceptive targets. PNAS 2003, 100:12201-12206.
35. Schwark H.J., Zebrowski Z., Ovsjannikov V.N. Internationals Handbuch der Tierproduction 1975, Schweine, VEB Deutscher Landwirtschaftsverlag, Berlin.
36. See M.T. Selection for AI Stud traits. Proceedings of National Swine Improvement Federation, vol. 25 2000.
37. Stein K.K., Primakoff P., Myles D. Sperm-egg fusion: events at the plasma membrane. J. Cell Sci. 2004, 117:6269-6274.
38. Virts E.L., Raschke W.C. The role of intron sequences in high level expression from CD45 cDNA constructs. J. Biol. Chem. 2001, 276:19913-19920.
39. Wang J.-C., Bégin L.R., Bérubé N.G., Chevalier S., Aprikian A.G., Gourdeau H., Chevrette M. Down-regulation of CD9 expression during prostate carcinoma progression is associated with CD9 mRNA modifications. Clin. Cancer Res. 2007, 13:2354-2361.
40. Wimmers K., Lin C.L., Tholen E., Jennen D.G.J., Schellander K., Ponsuksili S. Polymorphisms in candidate genes as markers for sperm quality and boar fertility. Anim. Genet. 2005, 36:152-155.
41. Wimmers K., Murani E., Schellander K., Ponsuksili S. QTL for traits related to humoral immune response estimated from data of a porcine F2 resource population. Int. J. Immunogenet. 2009, 36:141-151.
42. Yubero N., Jiménez-Marín A., Lucena C., Barbancho M., Garrido J.J. Immunohistochemical distribution of the tetraspanin CD9 in normal porcine tissues. Mol. Biol. Rep. 2010, 10.1007/s11033-010-0198-8.
43. Yuberoa N., Jiménez-Marína A., Yerleb M., Moreraa L., Barbanchoa M.J., Llanesa D., Garridoa J.J. Molecular cloning, expression pattern and chromosomal mapping of pig CD9 antigen. Cytogenet. Genome Res. 2003, 101:143-146.