A laboratory-scale device for the straightforward production of uniform, small sized cell microcapsules with long-term cell viability

Journal of Controlled Release

Volumn 152, Issue 3, 2011, Pages 376-381

  Kontturi, Leena Stiina ^a   Yliperttula, Marjo ^a   Toivanen, Pyry ^b,c   Määttä, Antti ^b   Määttä, Ann Marie ^b   Urtti, Arto ^a  

^a UNIVERSITY OF HELSINKI   (Finland)

^b Finland Ark Therapeutics Oy   (Finland)

^c UNIVERSITY OF EASTERN FINLAND   (Finland)

Author keywords

Alginate; Cell microencapsulation; Cell viability; Device; Recombinant protein

Indexed keywords

ACTIVE PROTEINS; CELL MICROENCAPSULATION; CELL VIABILITY; CO-AXIAL; DEVICE; ENCAPSULATION SYSTEMS; GAS FLOW SYSTEMS; HIGH REPRODUCIBILITY; IN-VITRO; LABORATORY-SCALE DEVICES; LARGE SCALE EXPERIMENTS; MICROCAPSULES; NARROW SIZE DISTRIBUTIONS; RECOMBINANT PROTEIN; REPRODUCIBILITIES; RETINAL PIGMENT EPITHELIAL CELLS; VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR;

ALDEHYDES; ALGINATE; AMINO ACIDS; ENDOTHELIAL CELLS; EXPERIMENTS; GENETIC ENGINEERING; LAMINAR FLOW; PACKAGING; PROTEINS;

ENCAPSULATION;

ALGINATE POLYLYSINE ALGINATE; VASCULOTROPIN RECEPTOR 1;

ARTICLE; CELL VIABILITY; CONTROLLED STUDY; DRUG CAPSULE; EPITHELIUM CELL; GAS FLOW; GENETIC ENGINEERING; HUMAN; HUMAN CELL; MICROCAPSULE; NANODEVICE; NANOENCAPSULATION; PARTICLE SIZE; PIGMENT EPITHELIUM; PRIORITY JOURNAL; PROTEIN SECRETION; REPRODUCIBILITY;

ALGINATES; CELL LINE; CELL SURVIVAL; CYTOLOGICAL TECHNIQUES; DELAYED-ACTION PREPARATIONS; EPITHELIAL CELLS; EUKARYOTIC CELLS; GENETIC ENGINEERING; HUMANS; MICROSCOPY; PARTICLE SIZE; POLYLYSINE; RECOMBINANT PROTEINS; REPRODUCIBILITY OF RESULTS; RETINAL PIGMENT EPITHELIUM; TRANSDUCTION, GENETIC; VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR-1;

EID: 79958228906     PISSN: 01683659     EISSN: 18734995     Source Type: Journal    
DOI: 10.1016/j.jconrel.2011.03.005     Document Type: Article

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