Genetic variation in the androgen estrogen conversion pathway in relation to breast cancer prognosticators

Breast Cancer Research and Treatment

Volumn 127, Issue 2, 2011, Pages 503-509

  Darabi, Hatef ^a   Czene, Kamila ^a   Wedrén, Sara ^a   Li, Yuqing ^b   Liu, Jianjun ^b   Hall, Per ^a   Humphreys, Keith ^a  

^a KAROLINSKA INSTITUTE   (Sweden)

^b GENOME INSTITUTE OF SINGAPORE   (Singapore)

Author keywords

Breast cancer; Genetic association; Prognosticators

Indexed keywords

ANDROGEN; ESTROGEN;

ADULT; AGED; AKR1C4 GENE; ARTICLE; BREAST CANCER; CANCER GRADING; CANCER RISK; CONTROLLED STUDY; CYP19A1 GENE; ESTROGEN METABOLISM; FEMALE; GENE CONVERSION; GENE FREQUENCY; GENETIC ASSOCIATION; GENETIC VARIABILITY; HUMAN; LYMPH NODE; MAJOR CLINICAL STUDY; ONCOGENE; PHENOTYPE; PRIORITY JOURNAL; SINGLE NUCLEOTIDE POLYMORPHISM; TUMOR VOLUME; UGT1A1 9 GENE; UGT2B11 GENE; UGT2B4 GENE;

AGED; ANDROGENS; BREAST NEOPLASMS; ESTROGENS; FEMALE; GENETIC VARIATION; HUMANS; MIDDLE AGED; NEOPLASM STAGING; PHENOTYPE; POLYMORPHISM, SINGLE NUCLEOTIDE; PROGNOSIS; TUMOR MARKERS, BIOLOGICAL;

EID: 79958224721     PISSN: 01676806     EISSN: 15737217     Source Type: Journal    
DOI: 10.1007/s10549-010-1218-z     Document Type: Article

References (19)

1. C Justenhoven U Hamann F Schubert M Zapatka CB Pierl S Rabstein S Selinski T Mueller K Ickstadt M Gilbert YD Ko C Baisch B Pesch V Harth HM Bolt C Vollmert T Illig R Eils J Dippon H Brauch 2008 Breast cancer: a candidate gene approach across the estrogen metabolic pathway Breast Cancer Res Treat 108 137 149 17588204 10.1007/s10549-007-9586-8 1:CAS:528:DC%2BD1cXitVKmtLs%3D (Pubitemid 351623246)
2. C Torresan MM Oliveira GT Torrezan SF de Oliveira CS Abuázar R Losi-Guembarovski RS Lima CA Urban IJ Cavalli EM Ribeiro 2008 Genetic polymorphisms in oestrogen metabolic pathway and breast cancer: a positive association with combined CYP/GST genotypes Clin Exp Med. 8 65 71 18618215 10.1007/s10238-008-0159-x 1:CAS:528:DC%2BD1cXosVequrs%3D (Pubitemid 351999724)
3. CA Haiman L Dossus VW Setiawan DO Stram AM Dunning G Thomas MJ Thun D Albanes D Altshuler E Ardanaz H Boeing J Buring N Burtt EE Calle S Chanock F Clavel-Chapelon GA Colditz DG Cox HS Feigelson SE Hankinson RB Hayes BE Henderson JN Hirschhorn R Hoover DJ Hunter R Kaaks LN Kolonel L Le Marchand P Lenner E Lund S Panico PH Peeters MC Pike E Riboli A Tjonneland R Travis D Trichopoulos S Wacholder RG Ziegler 2007 Genetic variation at the CYP19A1 locus predicts circulating estrogen levels but not breast cancer risk in postmenopausal women Cancer Res 67 1893 1897 17325027 10.1158/0008-5472.CAN-06- 4123 1:CAS:528:DC%2BD2sXit12qtbg%3D (Pubitemid 46424203)
4. YL Low YQ Li K Humphreys A Thalamuthu Y Li H Darabi S Wedren C Bonnard K Czene M Iles T Heikkinen K Aittomäki C Blomqvist H Nevanlinna P Hall ET Liu J Liu 2010 Multi-variant pathway association analysis reveals the importance of genetic determinants of estrogen metabolism in breast and endometrial cancer susceptibility PLoS Genet 6 e1001012 20617168 10.1371/journal.pgen.1001012
5. ER Simpson C Clyne G Rubin WC Boon K Robertson K Britt C Speed M Jones 2002 Aromatase-a brief overview Annu Rev Physiol 64 93 127 11826265 10.1146/annurev.physiol.64.081601.142703 1:CAS:528:DC%2BD38XisFGms7c%3D (Pubitemid 34259227)
6. Entrez Gene Database ( http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene )
7. LU Rosenberg F Granath PW Dickman K Einarsdóttir S Wedrén I Persson P Hall 2008 Menopausal hormone therapy in relation to breast cancer characteristics and prognosis: a cohort study Breast Cancer Res 10 R78 18803850 10.1186/bcr2145
8. Wedrén S (2004) Genetic susceptibility to breast and endometrial cancer. PhD Thesis. ISBN 91-7140-053-2
9. ZS Qin T Niu JS Liu 2002 Partition-ligation-expectation-maximization algorithm for haplotype inference with single-nucleotide polymorphisms Am J Hum Genet 71 1242 1247 12452179 10.1086/344207 1:CAS:528:DC%2BD38XovFOnsrY%3D (Pubitemid 35305248)
10. DO Stram CA Haiman JN Hirschhorn D Altshuler LN Kolonel BE Henderson MC Pike 2003 Choosing haplotype-tagging SNPS based on unphased genotype data using a preliminary sample of unrelated subjects with an example from the Multiethnic Cohort Study Hum Hered 55 27 36 12890923 10.1159/000071807 (Pubitemid 36928743)
11. Y Benjamini Y Hochberg 1995 Controlling the false discovery rate a practical and powerful approach to multiple testing J R Stat Soc Ser B 57 289300
12. JD Storey 2002 A direct approach to false discovery rates J R Stat Soc Ser B 64 479 498 10.1111/1467-9868.00346
13. JD Storey 2003 The positive false discovery rate: a Bayesian interpretation and the q-value Ann Stat 31 2013 2035 10.1214/aos/1074290335 (Pubitemid 38293903)
14. EA Rakha ME El-Sayed S Menon AR Green AH Lee IO Ellis 2008 Histologic grading is an independent prognostic factor in invasive lobular carcinoma of the breast Breast Cancer Res Treat 111 121 127 17929165 10.1007/s10549-007-9768-4 (Pubitemid 352009237)
15. J Tyrer PD Pharoah DF Easton 2006 The admixture maximum likelihood test: a novel experiment-wise test of association between disease and multiple SNPs Genet Epidemiol 30 636 643 16986161 10.1002/gepi.20175 (Pubitemid 44630934)
16. R Project ( http://www-r-project-org/ )
17. EA Rakha ME El-Sayed AH Lee CW Elston MJ Grainge Z Hodi RW Blamey IO Ellis 2008 Prognostic significance of Nottingham histologic grade in invasive breast carcinoma J Clin Oncol 26 3153 3158 18490649 10.1200/JCO.2007.15.5986
18. PA Fasching CR Loehberg PL Strissel MP Lux MR Bani M Schrauder S Geiler K Ringleff S Oeser S Weihbrecht R Schulz-Wendtland A Hartmann MW Beckmann R Strick 2008 Single nucleotide polymorphisms of the aromatase gene (CYP19A1), HER2/neu status, and prognosis in breast cancer patients Breast Cancer Res Treat 112 89 98 18049890 10.1007/s10549-007-9822-2 1:CAS:528:DC%2BD1cXhtFOjtrbE
19. Z Garcia-Casado A Guerrero-Zotano A Llombart-Cussac A Calatrava A Fernandez-Serra A Ruiz-Simon J Gavila MA Climent S Almenar J Cervera-Deval J Campos CV Albaladejo A Llombart-Bosch V Guillem JA Lopez-Guerrero 2010 A polymorphism at the 3′-UTR region of the aromatase gene defines a subgroup of postmenopausal breast cancer patients with poor response to neoadjuvant letrozole BMC Cancer 10 36 20144226 10.1186/1471-2407-10-36