Animal models of addiction: Fat and sugar

Current Pharmaceutical Design

Volumn 17, Issue 12, 2011, Pages 1168-1172

  Morgan, Drake ^a   Sizemore, Glen M ^a  

^a UNIVERSITY OF FLORIDA COLLEGE OF MEDICINE   (United States)

Author keywords

Animal models; Fat; Food addiction; Obesity; Self administration; Sugar

Indexed keywords

FAT; SUGAR;

ADDICTION; ARTICLE; DRUG DEPENDENCE; FAT INTAKE; FOOD ADDICTION; GENETIC MANIPULATION; MOTIVATION; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; REINFORCEMENT; RELAPSE; SUGAR INTAKE;

EID: 79958216712     PISSN: 13816128     EISSN: 18734286     Source Type: Journal    
DOI: 10.2174/138161211795656747     Document Type: Article

References (66)

1. Clark JT, Kalra PS, Crowley WR, et al., Neuropeptide-Y and humanpancreatic-polypeptide stimulate feeding-behavior in rats. Endocrinology 1984; 115: 427-9.
2. Nakazato M, Murakami N, Date Y, et al. A role for ghrelin in thecentral regulation of feeding. Nature 2001; 409: 194-8.
3. Fan W, Boston BA, Kesterson RA, et al. Role of melanocortinergicneurons in feeding and the agouti obesity syndrome. Nature 1997;385: 165-8.
4. Qu DQ, Ludwig DS, Gammeltoft S, et al. A role for melaninconcentratinghormone in the central regulation of feeding behaviour. Nature 1996; 380: 243-7.
5. Turton MD, OShea D, Gunn I, et al. A role for glucagon-like peptide-1 in the central regulation of feeding. Nature 1996; 379: 69-72.
6. Sakurai T, Amemiya A, Ishii M, et al. Orexins and orexin receptors:A family of hypothalamic neuropeptides and G proteincoupledreceptors that regulate feeding behavior. Cell 1998; 92: 573-85.
7. Madsen AN, Hansen G, Paulsen SJ, Lykkegaard K, Tang-Christensen M, Hansen HS, Levin BE, Larsen PJ, Knudsen LB, Fosgerau K, Vrang N. Long-term characterization of the dietinducedobese and diet-resistant rat model: a polygenetic rat modelmimicking the human obesity syndrome. J Endocrinol 2010; 206:287-96.
8. Rothwell NJ, Stock MJ. The development of obesity in animals: therole of dietary factors. Clin Endocrinol Metab 1984; 13: 437-49.
9. Irani BG, Dunn-Meynell AA, Levin BE. Altered hypothalamicleptin, insulin, and melanocortin binding associated with moderatefatdiet and predisposition to obesity. Endocrinology 2007; 148:310-6.
10. Jarosz PA, Kessler JT, Sekhon P, Coscina DV. Conditioned placepreferences (CPPs) to high-caloric snack foods in rat strains geneticallyprone vs. resistant to diet-induced obesity: resistance tonaltrexone blockade. Pharmacol Biochem Behav 2007; 86: 699-704.
11. Saper CB, Chou TC, Elmquest JK. The need to feed: homeostaticand hedonic control of eating. Neuron 2002; 36: 199-211.
12. Pérez-Echarri N, Pérez-Matute P, Martínez JA, Marti A, Moreno-Aliaga MJ. Serum and gene expression levels of leptin and adiponectinin rats susceptible or resistant to diet-induced obesity. JPhysiol Biochem 2005; 61: 333-42.
13. Madsen AN, Hansen G, Paulsen SJ, Lykkegaard K, Tang-Christensen M, Hansen HS, Levin BE, Larsen PJ, Knudsen LB, Fosgerau K, Vrang N. Long-term characterization of the dietinducedobese and diet-resistant rat model: a polygenetic rat modelmimicking the human obesity syndrome. J Endocrinol 2010; 206:287-96.
14. Flatt JP. The difference in the storage capacities for carbohydrateand for fat, and its implications in the regulation of body weight. Ann N Y Acad Sci 1987; 499:104-23.
15. Kanarek RB, Marks-Kaufman R. Factors influencing the effects ofnutritive and non-nutritive sweeteners on energy intake and bodyweight in rats. Appetite 1988;11: 16-9.
16. Harris RB. Role of set-point theory in regulation of body weight. FASEB J 1990; 4: 3310-8.
17. Miller WC. Diet composition, energy intake, and nutritional statusin relation to obesity in men and women. Med Sci Sports Exerc 1991; 23: 280-4.
18. Rolls BJ, Shide DJ. The influence of dietary fat on food intake andbody weight. Nutr Rev 1992; 50: 283-90.
19. A. Dietary composition, substrate balances and body fat insubjects with a predisposition to obesity. Int J Obes Relat MetabDisord 1993; 17: S32-6.
20. Volkow ND, Wise RA. How can drug addiction help us understandobesity? Nat Neurosci 2005; 8: 555-60.
21. Corwin RL. Bingeing rats: a model of intermittent excessive behavior? Appetite 2006; 46:11-5.
22. Grant JE, Brewer JA, Potenza MN. The neurobiology of substanceand behavioral addictions. CNS Spectr 2006; 11: 924-30.
23. Dagher A. The neurobiology of appetite: hunger as addiction. Int JObes 2009; 33: S30-3.
24. Blumenthal DM, Gold MS. Neurobiology of food addiction. CurrOpin Clin Nutr Metab Care 2010; 13: 359-65.
25. Randolph TG (1956). The descriptive features of food addiction -addictive eating and drinking. Quarterly Journal of Studies on Alcohol 1956; 17: 198-224.
26. Ahmed SH, Koob GF. Transition from moderate to excessive drugintake: change in hedonic set point. Science 1998; 282: 298-300.
27. Grimm JW, Hope BT, Wise RA, Shaham Y. Neuroadaptation.Incubation of cocaine craving after withdrawal. Nature 2001; 412:141-2.
28. Deroche-Gamonet V, Belin D, Piazza PV. Evidence for addictionlikebehavior in the rat. Science 2004; 305: 1014-7.
29. Vanderschuren LJ, Everitt BJ. Drug seeking becomes compulsiveafter prolonged cocaine self-administration. Science 2004; 305:1017-9.
30. Morgan D, Smith MA, Roberts DC. Binge self-administration anddeprivation produces sensitization to the reinforcing effects of cocainein rats. Psychopharmacology 2005; 178: 309-16.
31. Avena NM. Examining the addictive-like properties of binge eatingusing an animal model of sugar dependence. Exp Clin Psychopharmacol 2007; 15: 481-91.
32. Avena NM, Rada P, Hoebel BG. Evidence for sugar addiction:behavioral and neurochemical effects of intermittent, excessivesugar intake. Neurosci Biobehav Rev 2008; 32: 20-39.
33. Avena NM, Rada P, Hoebel BG. Sugar and fat bingeing have notabledifferences in addictive-like behavior. J Nutr 2009; 139: 623-8.
34. Avena NM. The study of food addiction using animal models ofbinge eating. Appetite 2010; 55: 734-7.
35. Wojnicki FH, Roberts DC, Corwin RL. Effects of baclofen onoperant performance for food pellets and vegetable shortening aftera history of binge-type behavior in non-food deprived rats. PharmacolBiochem Behav 2006; 84: 197-206.
36. Corwin RL, Wojnicki FH. Baclofen, raclopride, and naltrexonedifferentially affect intake of fat and sucrose under limited accessconditions. Behav Pharmacol 2009; 20: 537-48.
37. Berner LA, Avena NM, Hoebel BG. Bingeing, self-restriction, andincreased body weight in rats with limited access to a sweet-fatdiet. Obesity (Silver Spring) 2008; 16: 1998-2002.
38. Berner LA, Bocarsly ME, Hoebel BG, Avena NM. Baclofen suppressesbinge eating of pure fat but not a sugar-rich or sweet-fatdiet. Behav Pharmacol 2009; 20: 631-4.
39. Wong KJ, Wojnicki FH, Corwin RL. Baclofen, raclopride, andnaltrexone differentially affect intake of fat/sucrose mixtures underlimited access conditions. Pharmacol Biochem Behav 2009; 92:528-36.
40. Morgan D, Liu Y, Roberts DC. Rapid and persistent sensitizationto the reinforcing effects of cocaine. Neuropsychopharmacology 2006; 31: 121-8.
41. Roberts DC, Morgan D, Liu Y. How to make a rat addicted tococaine. Prog Neuropsychopharmacol Biol Psychiatry. 2007; 31:1614-24.
42. Lenoir M, Serre F, Cantin L, Ahmed SH. Intense sweetness surpassescocaine reward. PLoS One 2007; 2: e698.
43. Cantin L, Lenoir M, Augier E, Vanhille N, Dubreucq S, Serre F,Vouillac C, Ahmed SH. Cocaine is low on the value ladder of rats:possible evidence for resilience to addiction. PLoS One 2010; 5:e11592.
44. Freed DE, Green L. A behavioral economic analysis of fat appetitein rats. Appetite 1998; 31: 333-49.
45. Smethells JR, Ewan EE, Hursh SR. Tests of behavioral-economicassessments of relative reinforcer efficacy: economic substitutes. JExp Anal Behav 2007; 87: 219-40.
46. Ward SJ, Dykstra LA. The role of CB1 receptors in sweet versus fatreinforcement: effect of DB1 receptor deletion, CB1 receptor anatagonism(SR141716A) and CB1 receptor agonism (CP-55940). Behavioural Pharmacology 2005; 16: 381-8.
47. Naef L, Moquin L, Dal Bo G, Giros B, Gratton A, Walker CD. Maternal high-fat intake alters presynaptic regulation of dopaminein the nucleus accumbens and increases motivation for fat rewardsin the offspring. Neuroscience 2011, doi:10/1016/j.neuroscience.2010.12.037
48. Ghitza UE, Gray SM, Epstein DH, Rice KC, Shaham Y. The anxiogenicdrug yohimbine reinstates palatable food seeking in a ratrelapse model: a role of CRF1 receptors. Nuropsychopharm 2006;31: 2188-96.
49. Nair SG, Gray SM, Ghitza UE. Role of food type in yohimbineandpellet-riming-induced reinstatement of food seeking. PhysioBehav 2006; 88: 559-66.
50. Alsiö J, Pickering C, Roman E, Hulting A-L, Lindblom J, Schiöth HB. Motivation for sucrose in sated rats is predicted by low anxiety-like behavior. Neurosci Letters 2009; 454: 193-7.
51. Ghitza UE, Nair SG, Golden SA, et al. Peptide YY3-36 decreasesreinstatement of high-fat food seeking during dieting in a rat relapsemodel. J Neurosci 2007; 27: 11522-32.
52. Ward SJ, Walker EA, Dykstra LA. Effect of cannabinoid CB1receptor antagonist SR141716A and CB1 receptor knockout oncue-induced reinstatement of Ensure and corn-oil seeking in mice. Neuropsychopharmacol 2007; 32: 2592-2600.
53. Nair SG, Golden SA, Shaham Y. Differential effects of thehypocretin 1 receptor antagonist SB 334867 on high-fat food selfadministrationand reinstatement of food seeking in rats. Brit JPharmacol 2008; 154: 406-16.
54. Tracy AL, Clegg DJ, Johnson JD, Davidson TL, Benoit SC. Themelanocortin antagonist AgRP (83-132) increases appetitive respondingfor a fat, but not a carbohydrate, reinforcer. PharmacolBiochem Behav 2008; 89: 263-71.
55. Borgland SL, Chang S-J, Bowers MS, et al. Orexin A/hypocretin-1selectively promotes motivation for positive reinforcers. J Neurosci 2009; 29: 11215-25.
56. Nair SG, Adams-Deutsch T, Pickens CL, Smith DG, Shaham Y. effects of the MCH1 receptor anatagonist SNAP 94847 on high-fatfood-reinforced operant responding and reinstatement of food seekingin rats. Psychopharmacology 2009; 205: 129-40.
57. Perello M, Sakata I, Birnbaum S, et al. Ghrelin increases the rewardingvalue of high-fat diet in an orexin-dependent manner. BiolPsychiatry 2010; 67: 880-6.
58. Thanos PK, Cho J, Kim R, et al. Bromocriptine increased operantresponding for high fat food but decreased chow intake in bothobesity-prone and resistant rats. Behavioural Brain Research 2010;217: 165-70.
59. Nair SG, Navarre BM, Cifani C, Pickens CL, Bossert JM, Shaham Y. role of dorsal medial prefrontal cortex dopamine D1-family receptorsin relapse to ghih-fat food seeking induced by the anxiogenicdrug yohimbine. Neuropsychopharmacol 211; 36; 497-510.
60. Hayward MD, Pintar JE, Low MJ. Selective reward deficit in micelacking β-endorphine and enkephalin. J Neurosci 2002; 22: 8251-8.
61. Finger BC, Dinan TG, Cryan JF. Progressive ratio responding in anobese mouse model: effects of fenfluramine. Neuropharmacology 2010; 59: 619-26.
62. Barbano MF, Castañé A, Martin-García E, Maldonado R. Delta-9-tetrahydrocannabinol enhances food reinforcement in a mouse operantconflict test. Psychopharmacol 2009; 205: 475-87.
63. Lu L, Grimm JW, Hope BT, Shaham Y. Incubation of cocainecraving after withdrawal: a review of preclinical data. Neuropharmacology 2004; 47: 214-26.
64. Wojnicki FH, Babbs RK, Corwin RL. Reinforcing efficacy of fat,as assessed by progressive ratio responding, depends upon availabilitynot amount consumed. Physiol Behav 2010; 100: 316-21.
65. Rowland NE, Nasrallah N, Robertson KL. Accurate caloric compensationin rats for electively consumed ethanol-beer or ethanolpolycosemixtures. Pharmacol Biochem Behav 2005; 80: 109-14.
66. Peris J, Zharikova A, Li Z, Lingis M, MacNeill M, Wu MT, Rowland NE. Brain ethanol levels in rats after voluntary ethanol consumptionusing a sweetened gelatin vehicle. Pharmacol BiochemBehav 2006; 85: 562-8.