Fimbriae of Porphyromonas gingivalis are important for initial invasion of osteoblasts, but not for inhibition of their differentiation and mineralization

Journal of Periodontology

Volumn 82, Issue 6, 2011, Pages 909-916

  Zhang, Wenjian ^a   Ju, Jun ^a   Rigney, Todd ^a   Tribble, Gena D ^a  

^a UNIVERSITY OF TEXAS   (United States)

Author keywords

Fimbriae, bacterial; Osteoblasts; Porphyromonas gingivalis

Indexed keywords

FIMBRIA PROTEIN; FIMBRILLIN;

ANIMAL; ARTICLE; BACTERIUM ADHERENCE; BONE MINERALIZATION; CELL CULTURE; CELL DIFFERENTIATION; CELL PROLIFERATION; FIMBRIA; GENE INACTIVATION; GENETICS; MICROBIOLOGY; MOUSE; MOUSE STRAIN; OSTEOBLAST; PHYSIOLOGY; PORPHYROMONAS GINGIVALIS; SPECIES DIFFERENCE;

ANIMALS; BACTERIAL ADHESION; CALCIFICATION, PHYSIOLOGIC; CELL DIFFERENTIATION; CELL PROLIFERATION; CELLS, CULTURED; FIMBRIAE PROTEINS; FIMBRIAE, BACTERIAL; GENE KNOCKOUT TECHNIQUES; MICE; MICE, INBRED STRAINS; OSTEOBLASTS; PORPHYROMONAS GINGIVALIS; SPECIES SPECIFICITY;

EID: 79958204976     PISSN: 00223492     EISSN: None     Source Type: Journal    
DOI: 10.1902/jop.2010.100501     Document Type: Article

References (35)

1. Pihlstrom BL, Michalowicz BS, Johnson NW. Periodontal diseases. Lancet 2005;366:1809-1820. (Pubitemid 41642647)
2. Williams RC. Periodontal disease. N Engl J Med 1990;322:373-382. (Pubitemid 20042743)
3. Haffajee AD, Socransky SS. Microbial etiological agents of destructive periodontal diseases. Periodontol 2000 1994;5:78-111.
4. Potempa J, Banbula A, Travis J. Role of bacterial proteinases in matrix destruction and modulation of host responses. Periodontol 2000 2000;24:153-192.
5. Sandros J, Karlsson C, Lappin DF, Madianos PN, Kinane DF, Papapanou PN. Cytokine responses of oral epithelial cells to Porphyromonas gingivalis infection. J Dent Res 2000;79:1808-1814. (Pubitemid 32489424)
6. Frank RM, Voegel JC. Bacterial bone resorption in advanced cases of human periodontitis. J Periodontal Res 1978;13:251-261. (Pubitemid 8321709)
7. Katz J, Sambandam V, Wu JH, Michalek SM, Balkovetz DF. Characterization of Porphyromonas gingivalisinduced degradation of epithelial cell junctional complexes. Infect Immun 2000;68:1441-1449. (Pubitemid 30108542)
8. Lamont RJ, Chan A, Belton CM, Izutsu KT, Vasel D, Weinberg A. Porphyromonas gingivalis invasion of gingival epithelial cells. Infect Immun 1995;63:3878-3885.
9. Lamont RJ, Jenkinson HF. Subgingival colonization by Porphyromonas gingivalis. Oral Microbiol Immunol 2000;15:341-349.
10. Tribble GD, Lamont RJ. Bacterial invasion of epithelial cells and spreading in periodontal tissue. Periodontol 2000 2010;52:68-83.
11. Tsuda K, Furuta N, Inaba H, et al. Functional analysis of alpha5beta1 integrin and lipid rafts in invasion of epithelial cells by Porphyromonas gingivalis using fluorescent beads coated with bacterial membrane vesicles. Cell Struct Funct 2008;33:123-132.
12. Yilmaz O, Verbeke P, Lamont RJ, Ojcius DM. Intercellular spreading of Porphyromonas gingivalis infection in primary gingival epithelial cells. Infect Immun 2006;74:703-710. (Pubitemid 43023126)
13. Lamont RJ, Jenkinson HF. Life below the gum line: Pathogenic mechanisms of Porphyromonas gingivalis. Microbiol Mol Biol Rev 1998;62:1244-1263. (Pubitemid 28558298)
14. Holt SC, Kesavalu L, Walker S, Genco CA. Virulence factors of Porphyromonas gingivalis. Periodontol 2000 1999;20:168-238.
15. Amano A, Nakagawa I, Okahashi N, Hamada N. Variations of Porphyromonas gingivalis fimbriae in relation to microbial pathogenesis. J Periodontal Res 2004;39:136-142. (Pubitemid 39090095)
16. Hamada S, Amano A, Kimura S, Nakagawa I, Kawabata S, Morisaki I. The importance of fimbriae in the virulence and ecology of some oral bacteria. Oral Microbiol Immunol 1998;13:129-138. (Pubitemid 28286363)
17. Yilmaz O, Watanabe K, Lamont RJ. Involvement of integrins in fimbriae-mediated binding and invasion by Porphyromonas gingivalis. Cell Microbiol 2002;4:305-314. (Pubitemid 34567598)
18. Michel C. Ultrastructural study of the alveolar bone in parodontolysis (in French). Parodontologie 1969;23:191-210.
19. Okahashi N, Inaba H, Nakagawa I, et al. Porphyromonas gingivalis induces receptor activator of NF-kappaB ligand expression in osteoblasts through the activator protein 1 pathway. Infect Immun 2004;72:1706-1714. (Pubitemid 38263795)
20. Love RM, McMillan MD, Park Y, Jenkinson HF. Coinvasion of dentinal tubules by Porphyromonas gingivalis and Streptococcus gordonii depends upon binding specificity of streptococcal antigen I/II adhesin. Infect Immun 2000;68:1359-1365. (Pubitemid 30108532)
21. Zhang W, Swearingen EB, Ju J, Rigney T, Tribble GD. Porphyromonas gingivalis invades osteoblasts and inhibits bone formation. Microbes and Infection/Institut Pasteur 2010;12:838-845.
22. Xie H, Chung WO, Park Y, Lamont RJ. Regulation of the Porphyromonas gingivalis fimA (Fimbrillin) gene. Infect Immun 2000;68:6574-6579. (Pubitemid 32463356)
23. Wong GL, Cohn DV. Target cells in bone for parathormone and calcitonin are different: Enrichment for each cell type by sequential digestion of mouse calvaria and selective adhesion to polymeric surfaces. Proc Natl Acad Sci U S A 1975;72:3167-3171.
24. Parfitt AM. Osteonal and hemi-osteonal remodeling: The spatial and temporal framework for signal traffic in adult human bone. J Cell Biochem 1994;55:273-286. (Pubitemid 24218802)
25. Jilka RL. Biology of the basic multicellular unit and the pathophysiology of osteoporosis. Med Pediatr Oncol 2003;41:182-185. (Pubitemid 36910125)
26. Aubin JE, Turksen K. Monoclonal antibodies as tools for studying the osteoblast lineage. Microsc Res Tech 1996;33:128-140.
27. Elkaim R, Obrecht-Pflumio S, Tenenbaum H. Paxillin phosphorylation and integrin expression in osteoblasts infected by Porphyromonas gingivalis. Arch Oral Biol 2006;51:761-768. (Pubitemid 44233476)
28. Kadono H, Kido J, Kataoka M, Yamauchi N, Nagata T. Inhibition of osteoblastic cell differentiation by lipopolysaccharide extract from Porphyromonas gingivalis. Infect Immun 1999;67:2841-2846. (Pubitemid 29244698)
29. Kato T, Tsuda T, Inaba H, et al. Porphyromonas gingivalis gingipains cause G (1) arrest in osteoblastic/stromal cells. Oral Microbiol Immunol 2008;23:158-164. (Pubitemid 351248612)
30. Loomer PM, Sigusch B, Sukhu B, Ellen RP, Tenenbaum HC. Direct effects of metabolic products and sonicated extracts of Porphyromonas gingivalis 2561 on osteogenesis in vitro. Infect Immun 1994;62:1289-1297. (Pubitemid 24110822)
31. Roberts HC, Moseley R, Sloan AJ, Youde SJ, Waddington RJ. Lipopolysaccharide alters decorin and biglycan synthesis in rat alveolar bone osteoblasts: Consequences for bone repair during periodontal disease. Eur J Oral Sci 2008;116:207-216.
32. Njoroge T, Genco RJ, Sojar HT, Hamada N, Genco CA. A role for fimbriae in Porphyromonas gingivalis invasion of oral epithelial cells. Infect Immun 1997;65:1980-1984. (Pubitemid 27193632)
33. Weinberg A, Belton CM, Park Y, Lamont RJ. Role of fimbriae in Porphyromonas gingivalis invasion of gingival epithelial cells. Infect Immun 1997;65:313-316. (Pubitemid 27008940)
34. Xia Q, Wang T, Taub F, et al. Quantitative proteomics of intracellular Porphyromonas gingivalis. Proteomics 2007;7:4323-4337. (Pubitemid 350250477)
35. Ohno T, Okahashi N, Kawai S, et al. Proinflammatory gene expression in mouse ST2 cell line in response to infection by Porphyromonas gingivalis. Microbes and Infection/Institut Pasteur 2006;8:1025-1034.