IgE-sensitization to the cough suppressant pholcodine and the effects of its withdrawal from the Norwegian market

Allergy: European Journal of Allergy and Clinical Immunology

Volumn 66, Issue 7, 2011, Pages 955-960

  Florvaag, E ^a,b   Johansson, S G O ^c   Irgens, A ^a   De Pater, G H ^a  

^a HAUKELAND UNIVERSITY HOSPITAL   (Norway)

^b UNIVERSITY OF BERGEN   (Norway)

^c KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

Author keywords

anaphylaxis; IgE antibodies; neuromuscular blocking agents; pholcodine withdrawal

Indexed keywords

IMMUNOGLOBULIN E; IMMUNOGLOBULIN E ANTIBODY; MORPHINE; PHOLCODINE; SUXAMETHONIUM;

ANAPHYLAXIS; ARTICLE; DRUG EXPOSURE; DRUG HYPERSENSITIVITY; DRUG MARKETING; DRUG MONITORING; DRUG SENSITIZATION; DRUG WITHDRAWAL; HUMAN; INCIDENCE; NORWAY; PREVALENCE; PRIORITY JOURNAL;

ANAPHYLAXIS; ANTITUSSIVE AGENTS; CODEINE; DRUG HYPERSENSITIVITY; HUMANS; IMMUNOGLOBULIN E; MORPHOLINES; NEUROMUSCULAR BLOCKING AGENTS; NORWAY; SAFETY-BASED DRUG WITHDRAWALS;

EID: 79958176388     PISSN: 01054538     EISSN: 13989995     Source Type: Journal    
DOI: 10.1111/j.1398-9995.2010.02518.x     Document Type: Article

References (20)

1. Mertes PM, Laxenaire MC,. Adverse reactions to neuromuscular blocking agents. Curr Allergy Asthma Rep 2004; 4: 7-17.
2. Dewachter P, Mouton-Faivre C, Emala CW,. Anaphylaxis and anesthesia: controversies and new insights. Anesthesiology 2009; 111: 1141-1150.
3. Mertes PM, Aimone-Gastin I, Guéant-Rodriguez RM, Mouton-Faivre C, Audibert G, O'Brien J, et al., Hypersensitivity reactions to neuromuscular blocking agents. Curr Pharm Des 2008; 14: 2809-2825.
4. Kroigaard M, Garvey LH, Gillberg L, Johansson SGO, Mosbech H, Florvaag E, et al., Scandinavian Clinical Practice Guidelines on the diagnosis, management and follow-up of anaphylaxis during anaesthesia. Acta Anaesthesiol Scand, 2007; 51: 655-670. (Pubitemid 46918542)
5. Laake JH, Rottingen JA,. Rocuronium and anaphylaxis-a statistical challenge. Acta Anaesthesiol Scand, 2001; 45: 1196-1203. (Pubitemid 33063402)
6. Fisher MM, Baldo BA,. Immunoassays for the diagnosis of anaphylaxis to neuromuscular blocking drugs: the value of morphine for the detection of IgE antibodies in allergic subjects. Anaesth Intensive Care 2000; 28: 167-170. (Pubitemid 30201232)
7. Florvaag E, Johansson SGO, Ãman H, Venemalm L, Degerbeck F, Dybendal T, et al., Prevalence of IgE antibodies to morphine. Relation to the high and low incidence of NMBA anaphylaxis in Norway and Sweden, respectively. Acta Anaesthesiol Scand 2005; 49: 437-444. (Pubitemid 40488565)
8. Baldo BA, Fisher MM,. Substituted ammonium ions as allergenic determinants in drug allergy. Nature 1983; 306: 262-264. (Pubitemid 14232353)
9. Florvaag E, Johansson SGO, Ãman H, Harboe T, Nopp A,. Pholcodine stimulates a dramatic increase of IgE in IgE-sensitized individuals. A pilot study. Allergy 2006; 61: 49-55. (Pubitemid 43381191)
10. Harboe T, Johansson SGO, Florvaag E, Ãman H,. Pholcodine exposure raises serum IgE in patients with previous anaphylaxis to neuromuscular blocking agents. Allergy 2007; 62: 1445-1450. (Pubitemid 350045601)
11. Florvaag E, Johansson SGO,. The pholcodine story. Immunol Allergy Clin North Am 2009; 29: 419-427.
12. Johansson SGO, Ãman H, Nopp A, Florvaag E,. Pholcodine caused anaphylaxis in Sweden 30-years ago. Allergy 2009; 64: 820-821.
13. Florvaag E,. Anaphylactic reactions during general anaesthesia. New Horiz 2005; 2: 1-6.
14. Johansson SGO, Florvaag E, Ãman H, Poulsen LK, Mertes PM, Harper NJ, et al., National pholcodine consumption and prevalence of IgE-sensitization; a multicentre study. Allergy 2010; 65: 498-502.
15. Harboe T, Guttormsen AB, Irgens Ã, Dybendal T, Florvaag E,. Anaphylaxis during anaesthesia in Norway. A six-year single centre study. Anesthesiology 2005; 102: 897-903.
16. Harper NJ, Dixon T, Dugué P, Edgar DM, Fay A, Gooi HC, et al., Suspected Anaphylactic reactions associated with anaesthesia. Anaesthesia 2009; 64: 199-211.
17. Johansson SGO, Nopp A, Ãman H, Stahl-Skov P, Hunting AS, Guttormsen AB,. Anaphylaxis to Patent Blue V. II. A unique IgE-mediated reaction. Allergy 2010; 65: 124-129.
18. Moneret-Vautrin DA, Kanny G, Guéant JL, Widmer S, Laxenaire MC,. Prevention by monovalent haptens of IgE-dependent leucocyte histamine release to muscle relaxants. Int Arch Allergy Immunol 1995; 107: 172-175.
19. Elsayed S, Dybendal T, Aasen T,. IgE antibodies against pholcodine in serum from a patient experiencing anaphylactic reaction after intake of cough suppressant mixture. Proceedings of the XVI European Congress of Allergology and Clinical Immunology, Madrid, Spain (Eds. Basomba A, Hernandez de Rojas F.) 1995: 811-816.
20. Codrenu F, Morisset M, Kanny G, Moneret-Vautrin DA,. Allergy to pholcodine: first case documented by oral challenge. Allergy 2005; 60: 544-545. (Pubitemid 40332992)