CERTIFY: Prophylaxis of venous thromboembolism in patients with severe renal insufficiency

Thrombosis and Haemostasis

Volumn 105, Issue 6, 2011, Pages 981-988

  Bauersachs, Rupert ^a   Schellong, Sebastian M ^b   Haas, Sylvia ^c   Tebbe, Ulrich ^d   Gerlach, Horst Eberhard ^e   Abletshauser, Claudia ^f   Sieder, Christian ^f   Melzer, Nima ^f   Bramlage, Peter ^g   Riess, Hanno ^h  

^a KLINIKUM DARMSTADT   (Germany)

^b ACADEMIC TEACHING HOSPITAL DRESDEN FRIEDRICHSTADT   (Germany)

^c TECHNICAL UNIVERSITY OF MUNICH   (Germany)

^d KLINIKUM LIPPE DETMOLD   (Germany)

^e Private Orthodontic Practice   (Germany)

^f NOVARTIS PHARMA GMBH   (Germany)

^g Institute for Cardiovascular Pharmacology and Epidemiology   (Germany)

^h CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

Author keywords

Certoparin; Deep venous thrombosis; Pulmonary embolism; Renal impairment

Indexed keywords

CERTOPARIN; HEPARIN; MONOEMBOLEX;

AGED; ANTICOAGULANT THERAPY; ARTICLE; BLEEDING; BODY MASS; BODY WEIGHT; CONTROLLED STUDY; CREATININE CLEARANCE; DEEP VEIN THROMBOSIS; DISEASE SEVERITY; DOUBLE BLIND PROCEDURE; DRUG EFFICACY; DRUG WITHDRAWAL; FEMALE; GASTROINTESTINAL DISEASE; GLOMERULUS FILTRATION RATE; HEART DISEASE; HUMAN; INFECTION; INFESTATION; KIDNEY FAILURE; LUNG EMBOLISM; MAJOR CLINICAL STUDY; MALE; MORTALITY; NEUROLOGIC DISEASE; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; RESPIRATORY TRACT DISEASE; RISK BENEFIT ANALYSIS; VASCULAR DISEASE; VENOUS THROMBOEMBOLISM;

ACUTE KIDNEY INJURY; AGED; AGED, 80 AND OVER; ANTICOAGULANTS; FEMALE; GERMANY; HEMORRHAGE; HEPARIN; HEPARIN, LOW-MOLECULAR-WEIGHT; HUMANS; INCIDENCE; MALE; RISK ASSESSMENT; VENOUS THROMBOEMBOLISM;

EID: 79958128948     PISSN: 03406245     EISSN: None     Source Type: Journal    
DOI: 10.1160/TH10-09-0614     Document Type: Article

References (28)

1. Crowther M, Lim W. Low molecular weight heparin and bleeding in patients with chronic renal failure. Curr Opin Pulm Med 2007; 13: 409-413.
2. Clark NP. Low-molecular-weight heparin use in the obese, elderly, and in renal insufficiency. Thromb Res 2008; 123 (Suppl 1): S58-61.
3. Schmid P, AG Fischer, Wuillemin WA. Low-molecular-weight heparin in patients with renal insufficiency. Swiss Med Wkly 2009; 139: 438-452.
4. Nutescu EA, SA Spinler, Wittkowsky A, et al. Low-molecular-weight heparins in renal impairment and obesity: available evidence and clinical practice recom-mendations across medical and surgical settings. Ann Pharmacother 2009; 43: 1064-1083.
5. Lim W, Dentali F, Eikelboom JW, et al. Meta-analysis: low-molecular-weight heparin and bleeding in patients with severe renal insufficiency. Ann Intern Med 2006; 144: 673-684.
6. Monreal M, Falga C, Valle R, et al. Venous thromboembolism in patients with renal insufficiency: findings from the RIETE Registry. Am J Med 2006; 119: 1073-1079.
7. Geerts WH, Bergqvist D, Pineo GF, et al. Prevention of venous thromboembolism: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines (8th Edition). Chest 2008; 133: 381S-453S.
8. Riess H, Haas S, Tebbe U, et al. A randomized, double-blind, multicenter study of certoparin versus UFH to prevent venous thromboembolic events in acutely ill, non-surgical patients; The CERTIFY Study. J Thromb Haemost 2010; 8: 1209-1215.
9. Cockcroft DW, Gault MH. Prediction of creatinine clearance from serum creatinine. Nephron 1976; 16: 31-41.
10. Schwarz T, Schmidt B, Schellong SM. Interobserver agreement of complete compression ultrasound for clinically suspected deep vein thrombosis. Clin Appl Thromb Hemost 2002; 8: 45-49.
11. Schellong SM. Complete compression ultrasound for the diagnosis of venous thromboembolism. Curr Opin Pulm Med 2004; 10: 350-355.
12. Schellong SM, Beyer J, Kakkar AK, et al. Ultrasound screening for asymptomatic deep vein thrombosis after major orthopaedic surgery: the VENUS study. J Thromb Haemost 2007; 5: 1431-1437.
13. Collet JP, Montalescot G, Agnelli G, et al. Non-ST-segment elevation acute coronary syndrome in patients with renal dysfunction: benefit of low-molecular-weight heparin alone or with glycoprotein IIb/IIIa inhibitors on outcomes. The Global Registry of Acute Coronary Events. Eur Heart J 2005; 26: 2285-2293.
14. Reddan DN, Szczech L, Bhapkar MV, et al. Renal function, concomitant medication use and outcomes following acute coronary syndromes. Nephrol Dial Transplant 2005; 20: 2105-2112.
15. Spinler SA, Inverso SM, Cohen M, et al. Safety and efficacy of unfractionated heparin versus enoxaparin in patients who are obese and patients with severe renal impairment: analysis from the ESSENCE and TIMI 11B studies. Am Heart J 2003; 146: 33-41.
16. Anavekar NS, McMurray JJ, Velazquez EJ, et al. Relation between renal dysfunction and cardiovascular outcomes after myocardial infarction. N Engl J Med 2004; 351: 1285-1295.
17. Go AS, Chertow GM, Fan D, et al. Chronic kidney disease and the risks of death, cardiovascular events, and hospitalization. N Engl J Med 2004; 351: 1296-1305.
18. Thorevska N, Amoateng-Adjepong Y, Sabahi R, et al. Anticoagulation in hospitalized patients with renal insufficiency: a comparison of bleeding rates with unfractionated heparin vs enoxaparin. Chest 2004; 125: 856-863.
19. Jochberger S, Mayr V, Luckner G, et al. Antifactor Xa activity in critically ill patients receiving antithrombotic prophylaxis with standard dosages of certoparin: a prospective, clinical study. Crit Care 2005; 9: R541-548.
20. Hirsh J, Bauer KA, Donati MB, et al. Parenteral anticoagulants: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines (8th Edition). Chest 2008; 133: 141S-159S.
21. Mahe I, Aghassarian M, Drouet L, et al. Tinzaparin and enoxaparin given at prophylactic dose for eight days in medical elderly patients with impaired renal function: a comparative pharmacokinetic study. Thromb Haemost 2007; 97: 581-586.
22. Falga C, Capdevila JA, Soler S, et al. Clinical outcome of patients with venous thromboembolism and renal insufficiency. Findings from the RIETE registry. Thromb Haemost 2007; 98: 771-776.
23. Cohen AT, Tapson VF, Bergmann JF, et al. Venous thromboembolism risk and prophylaxis in the acute hospital care setting (ENDORSE study): a multinational cross-sectional study. Lancet 2008; 371: 387-394.
24. Duarte CG, Preuss HG. Assessment of renal function--glomerular and tubular. Clin Lab Med 1993; 13: 33-52.
25. Douville P, Martel AR, Talbot J, et al. Impact of age on glomerular filtration estimates. Nephrol Dial Transplant 2009; 24: 97-103.
26. Glassock RJ, Winearls C. An epidemic of chronic kidney disease: fact or fiction? Nephrol Dial Transplant 2008; 23: 1117-1121.
27. Baglin T. Venous thromboembolism in hospitalised patients: a public health crisis? Br J Haematol 2008; 141: 764-770.
28. Goldhaber SZ. Preventing pulmonary embolism and deep vein thrombosis: a 'call to action' for vascular medicine specialists. J Thromb Haemost 2007; 5: 1607-1609.