What drives patent performance of German biotech firms? The impact of R&D subsidies, knowledge networks and their location

Papers in Regional Science

Volumn 90, Issue 2, 2011, Pages 395-418

  Fornahl, Dirk ^a   Broekel, Tom ^b   Boschma, Ron ^b  

^a UNIVERSITY OF BREMEN   (Germany)

^b UTRECHT UNIVERSITY   (Netherlands)

Author keywords

Biotechnology; Clusters; Knowledge networks; R D subsidies; Relatedness

Indexed keywords

BIOTECHNOLOGY; HIGH TECHNOLOGY INDUSTRY; INDUSTRIAL PERFORMANCE; INNOVATION; RESEARCH AND DEVELOPMENT; TECHNOLOGICAL DEVELOPMENT; TECHNOLOGY ADOPTION; TECHNOLOGY TRANSFER;

GERMANY;

EID: 79958128023     PISSN: 10568190     EISSN: 14355957     Source Type: Journal    
DOI: 10.1111/j.1435-5957.2011.00361.x     Document Type: Article

References (61)

1. Ahuja B (2000) Collaboration networks, structural holes and innovation: A longitudinal study. Administrative Science Quarterly 45: 425-455
2. Albino V, Garavelli AC, Schiuma G (1999) Knowledge transfer and inter-firm relationships in industrial districts: The role of the leader firm. Technovation 19: 53-63
3. Audretsch DB, Feldman MP (1996) Innovative clusters and the industry life cycle. Review of Industrial Organization 11: 253-273
4. Baptista R (2000) Do innovations diffuse faster within geographical clusters? International Journal of Industrial Organization 18: 515-535
5. Baptista R, Swann P (1998) Do firms in clusters innovate more? Research Policy 27: 525-540
6. Bathelt H, Malmberg A, Maskell P (2004) Clusters and knowledge: Local buzz, global pipelines and the process of knowledge creation. Progress in Human Geography 28: 31-56
7. Becker W, Dietz J (2004) R&D co-operation and innovation activities of firms - evidence for the German manufacturing industry. Research Policy 33: 209-223
8. BMBF (2008a) Förderbereiche/Förderschwerpunkte und Förderarten. Statistiken des Bundesministeriums für Bildung und Forschung. URL: Last accessed 20 April 2011
9. BMBF (2008b) Merkblatt für Antragsteller/Zuwendungsempfänger zur Zusammenarbeit der Partner von Verbundprojekten. BMBF-Vordruck 0100/10.08. URL: Last accessed 20 April 2011
10. Boschma RA (2005) Proximity and innovation: A critical assessment. Regional Studies 39: 61-74
11. Boschma RA, Frenken K (2010) The spatial evolution of innovation networks. A proximity perspective. In: Boschma RA, Martin R (eds) Handbook of evolutionary economic geography. Edward Elgar, Cheltenham
12. Boschma RA, ter Wal, ALJ (2007) Knowledge networks and innovative performance in an industrial district: The case of a footwear district in the South of Italy. Industry and Innovation 14: 177-199
13. Bowman AW, Azzalini A (1997) Applied smoothing techniques for data analysis - the kernel approach with S-Plus illustrations. Oxford University Press, New York
14. Breschi S, Lissoni F, Malerba F (2003) Knowledge-relatedness in firm technological diversification. Research Policy 32: 69-87
15. Broekel T, Boschma RA (2011) Knowledge networks in the Dutch aviation industry: The proximity paradox. Journal of Economic Geography, doi:10.1093/jeg/lbr010
16. Broekel T, Graf H (2010) Structural properties of co-operation networks in Germany: From basic to applied research. Jena Economic Research Papers 2010-078, Jena
17. Broekel T, Buerger M, Brenner T (2010) An investigation of the relation between co-operation and the innovative success of German regions. Papers in Evolutionary Economic Geography 10.11, Utrecht
18. Brouwer E, Kleinknecht A, Reijnen J (1993) Employment growth and innovation at the firm-level - an empirical study. Journal of Evolutionary Economics 3: 153-159
19. Busom I (1999) An empirical evaluation of the effects of R&D subsidies. Burch Center Working Paper B99/05, University of Califirnia, Berkeley, CA
20. Camagni R (1991) Local milieu, uncertainty and innovation networks: Towards a new dynamic theory of economic space. In: Camagni R (ed) Innovation networks: Spatial perspectives. Belhaven Stress, London
21. Cantner U, Meder A (2007) Technological proximity and the choice of co-operation partner. Journal of Economic Interaction and Coordination 2: 45-65
22. Cantwell J (1999) Innovation as the principal source of growth in the global economy. In: Archibugi D, Howells J (eds) Innovation policy in a global economy. Cambridge University Press, Cambridge
23. Chandy R, Tellis GJ (2000) The incumbent's curse? Incumbency, size, and radical product innovation. Journal of Marketing 64: 1-17
24. Cohen W, Levinthal D (1990) Absorptive capacity: A new perspective on learning and innovation. Administrative Science Quarterly 35: 128-152
25. Cooke P (2001) New economy innovation systems - biotechnology in Europe and the USA. Industry and Innovation 8: 267-289
26. Czarnitzki D, Hussinger K (2004) The link between R&D subsidies, R&D spending and technological performance. ZEW Discussion Papers 04-56, Mannheim
27. Czarnitzki D, Doherr T, Fier A, Licht G, Rammer C (2002) Öffentliche Fördergung der Forschungs- und Innovationsaktivit äten von Unternehmen in Deutschland. Centre for European Economic Research (ZEW), Research Department Industrial Economics and International Management, Mannheim
28. Czarnitzki D, Ebersberger B, Fier A (2007) The relationship between R&D collaboration, subsidies and R&D performance: Empirical evidence from Finland and Germany. Journal of Applied Econometrics 22: 1347-1366
29. Dekker R, Kleinknecht AH (2008) The EU framework programs: Are they worth doing? MPRA working papers 8503, Munich
30. Dohse D (2000) Technology policy and the regions - the case of the BioRegio contest. Research Policy 29: 1111-1133
31. Ejermo O (2003) Patent diversity as a predictor of regional innovativeness in Sweden. CESPRI Working Paper 140, Bocconi
32. Fornahl D, Tran CA (2010) The development of local-global linkages in biotechnology districts in Germany: Between local embeddedness and international knowledge sourcing. In: Belussi F, Sammarra A (eds) Business networks in clusters and industrial districts: The governance of the global value chain. Routledge, London and New York
33. Freeman LC (1979) Centrality in social networks. Social Networks 1: 215-239
34. Frenkel A, Schefer D (1998) Local milieu and innovations: Some empirical results. The Annals of Regional Science 32: 185-200
35. Fritsch M, Wein T, Ewers H (2005) Marktversagen und wirtschaftspolitik. Vahlen, München
36. Gertler MS (2003) Tacit knowledge and the economic geography of context, or the undefinable tacitness of being (there). Journal of Economic Geography 3: 75-99
37. Giuliani E, Bell M (2005) The micro-determinants of meso-level learning and innovation: Evidence from a Chilean wine cluster. Research Policy 34: 47-68
38. Görg H, Strobl E (2007) The effect of R&D subsidies on private R&D. Economica 79: 215-234
39. Hassink R (2002) Regional innovation support systems: Recent trends in Germany and East Asia. European Planning Studies A 10: 153-164
40. Haug P (1995) Formation of biotechnology firms in the greater Seattle region: An empirical investigation of entrepreneurial, financial and educational perspectives. Environment and Planning A 27: 249-267
41. Heijs J (2003) Freerider behavior and the public finance of R&D activities in enterprises: The case of the Spanish low interest credits for R&D. Research Policy 32: 445-461
42. Koski H (2008) Public R&D subsidies and employment growth - microeconomic evidence from Finnish firms. Keskusteluaiheita - Discussion Paper 1143, Helsinki
43. McEvily B, Zaheer A (1999) Bridging ties: A source of firm heterogeneity in competitive capabilities. Strategic Management Journal 20: 1133-1158
44. Malmberg A, Maskell P (2006) Localized learning revisited. Growth and Change 37: 1-18
45. Mowery DC, Oxley JE, Silverman BS (1998) Technological overlap and interfirm co-operation: Implications for the resource-based view of the firm. Research Policy 27: 507-523
46. Müller, RH (2003) Biotechnology UFZ Umweltforschungszentrum Leipzig-Halle, Department Umweltmikrobiologie
47. Nooteboom B (2000) Learning and innovation in organizations and economies. Oxford University Press, Oxford
48. Owen-Smith J, Powell WW (2004) Knowledge networks as channels and conduits: The effects of spillovers in the Boston biotechnology community. Organization Science 15: 5-21
49. Peters H (2000) Wirtschaftspolitik. 3. Auflage. Oldenbourg, München
50. Powell W, Koput K, Smith-Doerr L (1996) Interorganizational collaboration and the locus of innovation: Networks of learning in biotechnology. Administrative Science Quarterly 41: 116-145
51. Sammarra A, Biggiero L (2008) Heterogeneity and specificity of inter-firm knowledge flows in innovation networks. Journal of Management Studies 45: 800-829
52. Schwarz M, Peglow F, Fritsch M, Günther J (2010) What determines the innovative success of subsidized collaborative R&D projects? Project-level evidence from Germany. IWH - Discussion Papers 7, Halle
53. Sorenson O, Audia PG (2000) The social structure of entrepreneurial activity: Geographic concentration of footwear production in the United States, 1940-1989. American Journal of Sociology 106: 424-462
54. Sorenson O, Rivkin J, Fleming L (2006) Complexity, networks and knowledge flow. Research Policy 35: 994-1017
55. Sternberg R, Litzenberger T (2004) Regional clusters in Germany - their geography and their relevance for entrepreneurial activities. European Planning Studies 12: 767-791
56. Stuart TE, Ozdemir SZ, Ding WW (2007) Vertical alliance networks: The case of university-biotechnology-pharmaceutical alliance chains. Research Policy 36: 477-498
57. Ter Wal ALJ (2009) The spatial dynamics of the inventor network in German biotechnology, geographical proximity versus triadic closure. Department of Economic Geography, Utrecht
58. Thumm N (2003) Research and patenting in biotechnology - a survey in Switzerland. Swiss Federal Institute of Intellectual Property. URL: Last accessed 16 February 2011
59. Walker G, Kogut B, Shan W (1997) Social capital, structural holes and the formation of an industry network. Organization Science 8: 109-125
60. Wasserman S, Faust K (1994) Centrality in social network analysis: Methods and applications Cambridge University Press, Cambridge
61. Zucker LG, Darby MR (1996) Star scientists and institutional transformation: Patterns of invention and innovation in the formation of the biotechnology industry. Proceedings of the National Academy of Sciences 93: 12709-12716