Transcutaneous Electrical Nerve Stimulation and Acupuncture

Evidence-Based Chronic Pain Management

Volumn , Issue , 2010, Pages 348-365

  Johnson, Mark I ^a  

^a LEEDS METROPOLITAN UNIVERSITY   (United Kingdom)

Author keywords

Acupuncture for cancer related nonpain symptoms; Acupuncture like TENS (AL TENS) form of hyperstimulation to harness actions of TENS; Complementary therapies for cancer related fatigue; Conventional TENS; International Association for the Study of Pain (IASP); Systematic reviews of TENS for chronic pain; TENS for cancer related nonpain symptoms; TENS for nonmalignant pain; Transcutaneous electrical nerve stimulation and acupuncture

Indexed keywords

EID: 79958126857     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1002/9781444314380.ch27     Document Type: Chapter

References (191)

1. Barlas P, Lundeberg T. Transcutaneous electrical nerve stimulation and acupuncture. In:McMahon S, Koltzenburg M (eds) Melzack and Wall's Textbook of Pain, 5th edn. Elsevier Churchill Livingstone, Philadelphia, 2006:583-590.
2. Filshie J, Thompson J. Acupuncture and TENS. In:Simpson KH, Budd K (eds) Cancer Pain Management. A Comprehensive Approach. Oxford University Press, Oxford, 2000:188-223.
3. Berkovitch M, Waller A. Treating pain with transcutaneous electrical nerve stimulation (TENS). In:Doyle D, Hanks G, Cherny NI, Calman K (eds) Oxford Textbook of Palliative Medicine. Oxford University Press, Oxford, 2005:405-410.
4. Stannard C. Simulation-induced analgesia in cancer pain management. In:Sykes N, Fallon M, Patt R (eds) Textbook of Clinical Pain Management. Hodder Arnold, London, 2002:245-252.
5. Filshie J. The non-drug treatment of neuralgic and neuropathic pain of malignancy. Cancer Surv 1988;7(1):161-193.
6. Cohen AJ, Menter A, Hale L. Acupuncture:role in comprehensive cancer care -a primer for the oncologist and review of the literature. Integrat Cancer Ther 2005;4(2):131-143.
7. Filshie J. Safety aspects of acupuncture in palliative care. Acupunct Med 2001;19(2):117-122.
8. Walsh D. TENS. Clinical Applications and Related Theory. Churchill Livingstone, New York, 1997.
9. Johnson MI. Transcutaneous electrical nerve stimulation. In:Kitchen S (ed) Electrotherapy:Evidence-Based Practice. Churchill Livingstone, Edinburgh, 2002:259-286.
10. Chabal C, Fishbain DA, Weaver M, Heine LW. Long-term transcutaneous electrical nerve stimulation (TENS) use:impact on medication utilization and physical therapy costs. Clin J Pain 1998;14(1):66-73.
11. Johnson MI. Transcutaneous electrical nerve stimulation (TENS) -outcomes. In:Schmidt RF, Willis WD (eds) Encyclopedia of Pain. Springer-Verlag, Berlin, 2007:2511-2514.
12. Charlton JE. Task Force on Professional Education (eds). Stimulation-produced analgesia. In:Core Curriculum for Professional Education in Pain. IASP Press, Seattle, 2005:93-96.
13. Garrison DW, Foreman RD. Decreased activity of spontaneous and noxiously evoked dorsal horn cells during transcutaneous electrical nerve stimulation (TENS). Pain 1994;58(3):309-315.
14. Sluka KA, Walsh D. Transcutaneous electrical nerve stimulation:basic science mechanisms and clinical effectiveness. J Pain 2003;4(3):109-121.
15. Sandkühler J, Chen JG, Cheng G, Randic M. Lowfrequency stimulation of afferent Adelta-fibers induces long-term depression at primary afferent synapses with substantia gelatinosa neurons in the rat. J Neurosci 1997;17(16):6483-6491.
16. Ma YT, Sluka KA. Reduction in inflammation-induced sensitization of dorsal horn neurons by transcutaneous electrical nerve stimulation in anesthetized rats. Exper Brain Res 2001;137(1):94-102.
17. Johnson MI, Ashton CH, Thompson JW. An in-depth study of long-term users of transcutaneous electrical nerve stimulation (TENS). Implications for clinical use of TENS. Pain 1991;44(3):221-229.
18. King EW, Sluka KA. The effect of varying frequency and intensity of transcutaneous electrical nerve stimulation on secondary mechanical hyperalgesia in an animal model of inflammation. J Pain 2001;2(2):128-133.
19. Eriksson M, Sjölund B. Acupuncture-like electroanalgesia in TNS resistant chronic pain. In:Zotterman Y (ed) Sensory Functions of the Skin. Pergamon Press, New York, 1976:575-581.
20. Sandkühler J. Long-lasting analgesia following TENS and acupuncture:Spinal mechanisms beyond gate control. In:Devor M, Rowbotham MC, Wiesenfeld-Hallin Z (eds) Progress In Pain Research And Management, vol 16. IASP Press, Seattle 2000:359-369.
21. Johnson MI. The analgesic effects and clinical use of acupuncture-like TENS (AL-TENS). Phys Ther Rev. 1998;3:73-93.
22. Sjölund B, Terenius L, Eriksson M. Increased cerebrospinal fluid levels of endorphins after electro-acupuncture. Acta Physiol Scand 1977;100(3):382-384.
23. Eriksson MB, Sjölund BH, Nielzen S. Long term results of peripheral conditioning stimulation as an analgesic measure in chronic pain. Pain 1979;6(3):335-347.
24. Eriksson MB, Sjölund BH, Sundbarg G. Pain relief from peripheral conditioning stimulation in patients with chronic facial pain. J Neurosurg 1984;61(1):149-155.
25. Chartered Society of Physiotherapy. Guidance for the Clinical Use of Electrophysical Agents. Chartered Society of Physiotherapy, London, 2006.
26. Zech DF, Grond S, Lynch J, Hertel D, Lehmann KA. Validation of World Health Organization Guidelines for cancer pain relief:a 10-year prospective study. Pain 1995;63(1):65-76.
27. Grond S, Radbruch L, Meuser T, Sabatowski R, Loick G, Lehmann KA. Assessment and treatment of neuropathic cancer pain following WHO guidelines. Pain 1999;79(1):15-20.
28. Hoskin PJ, Hanks GW. The management of symptoms in advanced cancer:experience in a hospital-based continuing care unit. J Roy Soc Med 1988;81(6):341-344.
29. Garrison DW, Foreman RD. Effects of transcutaneous electrical nerve stimulation (TENS) on spontaneous and noxiously evoked dorsal horn cell activity in cats with transected spinal cords. Neurosci Lett 1996;216(2):125-128.
30. Leem J, Park E, Paik K. Electrophysiological evidence for the antinociceptive effect of transcutaneous electrical stimulation on mechanically evoked responsiveness of dorsal horn neurons in neuropathic rats. Neurosci Lett 1995;192(3):197-200.
31. Lee K, Chung J, Willis WD J. Inhibition of primate spinothalamic tract cells by TENS. J Neurosurg 1985;62(2):276-287.
32. Urasaki E, Wada S, Yasukouchi H, Yokota A. Effect of transcutaneous electrical nerve stimulation (TENS) on central nervous system amplification of somatosensory input. J Neurol 1998;245(3):143-148.
33. Ignelzi RJ, Nyquist JK. Excitability changes in peripheral nerve fibers after repetitive electrical stimulation. Implications in pain modulation. J Neurosurg 1979;51(6):824-833.
34. Walsh DM, Lowe AS, McCormack K, Willer JC, Baxter GD, Allen JM. Transcutaneous electrical nerve stimulation:effect on peripheral nerve conduction, mechanical pain threshold, and tactile threshold in humans. Arch Phys Med Rehabil 1998;79(9):1051-1058.
35. Nardone A, Schieppati M. Influences of transcutaneous electrical stimulation of cutaneous and mixed nerves on subcortical and cortical somatosensory evoked potentials. Electroencephalogr Clin Neurophysiol 1989;74(1):24-35.
36. Kalra A, Urban MO, Sluka KA. Blockade of opioid receptors in rostral ventral medulla prevents antihyperalgesia produced by transcutaneous electrical nerve stimulation (TENS). J Pharmacol Exper Therapeut 2001;298(1):257-263.
37. Le Bars D, Dickenson AH, Besson JM. Diffuse noxious inhibitory controls (DNIC). I. Effects on dorsal horn convergent neurones in the rat. Pain 1979;6(3):283-304.
38. Morton CR, Du HJ, Xiao HM, Maisch B, Zimmermann M. Inhibition of nociceptive responses of lumbar dorsal horn neurones by remote noxious afferent stimulation in the cat. Pain 1988;34(1):75-83.
39. Duranti R, Pantaleo T, Bellini F. Increase in muscular pain threshold following low frequency-high intensity peripheral conditioning stimulation in humans. Brain Res 1988;452(1-2):66-72.
40. Radhakrishnan R, Sluka KA. Deep tissue afferents, but not cutaneous afferents, mediate transcutaneous electrical nerve stimulation-Induced antihyperalgesia. J Pain 2005;6(10):673-680.
41. Duggan AW, Foong FW. Bicuculline and spinal inhibition produced by dorsal column stimulation in the cat. Pain 1985;22(3):249-259.
42. Maeda Y, Lisi TL, Vance CG, Sluka KA. Release of GABA and activation of GABA(A) in the spinal cord mediates the effects of TENS in rats. Brain Res 2007;1136(1):43-50.
43. Sjölund BH, Eriksson MB. The influence of naloxone on analgesia produced by peripheral conditioning stimulation. Brain Res 1979;173(2):295-301.
44. Radhakrishnan R, Sluka KA. Spinal muscarinic receptors are activated during low or high frequency TENS-induced antihyperalgesia in rats. Neuropharmacology 2003;45(8):1111-1119.
45. King EW, Audette K, Athman GA, Nguyen HO, Sluka KA, Fairbanks CA. Transcutaneous electrical nerve stimulation activates peripherally located alpha-2A adrenergic receptors. Pain 2005;115(3):364-373.
46. Sluka KA, Chandran P. Enhanced reduction in hyperalgesia by combined administration of clonidine and TENS. Pain 2002;100(1-2):183-190.
47. Radhakrishnan R, King EW, Dickman JK, et al. Spinal 5-HT(2) and 5-HT(3) receptors mediate low, but not high, frequency TENS-induced antihyperalgesia in rats. Pain 2003;105(1-2):205-213.
48. Carroll D, Tramer M, McQuay H, Nye B, Moore A. Randomization is important in studies with pain outcomes:systematic review of transcutaneous electrical nerve stimulation in acute postoperative pain. Br J Anaesthes 1996;77(6):798-803.
49. Carroll D, Tramer M, McQuay H, Nye B, Moore A. Transcutaneous electrical nerve stimulation in labour pain:a systematic review. Br J Obstet Gynaecol 1997;104(2):169-175.
50. Bjordal JM, Johnson MI, Ljunggreen AE. Transcutaneous electrical nerve stimulation (TENS) can reduce postoperative analgesic consumption. A meta-analysis with assessment of optimal treatment parameters for postoperative pain. Eur J Pain 2003;7(2):181-188.
51. Dowswell T, Bedwell C, Lavender T, Neilson JP. Transcutaneous electrical nerve stimulation (TENS) for pain relief in labour. Cochrane Database of Systematic Reviews 2009, Apr 15;(2):CD007214.
52. Walsh DM, Howe TE, Johnson MI, Sluka KA. Trans cutaneous electrical nerve stimulation for acute pain. Cochrane Database of Systematic Reviews 2009, Apr 15;(2):CD006142.
53. Proctor M, Smith CA, Farquhar CM, Stones W. Transcutaneous electrical nerve stimulation and acupuncture for primary dysmenorrhoea. Cochrane Database of Systematic Reviews 2002, Issue 1. Art. No.:CD002123. DOI:10.1002/14651858.CD002123.
54. Nnoaham KE, Kumbang J. Transcutaneous electrical nerve stimulation (TENS) for chronic pain. Cochrane Database of Systematic Reviews 2008, Jul 16;(3):CD003222.
55. Johnson M, Martinson M. Efficacy of electrical nerve stimulation for chronic musculoskeletal pain:a metaanalysis of randomized controlled trials. Pain 2007;130(1-2):157-165.
56. Bjordal JM, Johnson MI, Lopes-Martins RA, Bogen B, Chow R, Ljunggren AE. Short-term efficacy of physical interventions in osteoarthritic knee pain. A systematic review and meta-analysis of randomized placebo-controlled trials. BMC Musculoskelet Disord 2007;8(1):51.
57. Osiri M, Welch V, Brosseau L, et al. Transcutaneous electrical nerve stimulation for knee osteoarthritis. Cochrane Database of Systematic Reviews 2000, Issue 4. Art. No.:CD002823. DOI:10.1002/14651858.CD002823.
58. Khadilkar A, Milne S, Brosseau L, et al. Transcutaneous electrical nerve stimulation for the treatment of chronic low back pain:a systematic review. Spine 2005;30(23):2657-2666.
59. Brosseau L, Yonge KA, Welch V, et al. Transcutaneous electrical nerve stimulation (TENS) for the treatment of rheumatoid arthritis in the hand. Cochrane Database of Systematic Reviews 2003, Issue 2. Art. No.:CD004377. DOI:10.1002/14651858.CD004377.
60. Kroeling P, Gross AR, Goldsmith CH. A Cochrane review of electrotherapy for mechanical neck disorders. Spine 2005;30(21):641-648.
61. Price CI, Pandyan AD. Electrical stimulation for preventing and treating post-stroke shoulder pain:a systematic Cochrane review. Clin Rehabil 2001;15(1):5-19.
62. Brønfort G, Nilsson N, Haas M, et al. Non-invasive physical treatments for chronic/recurrent headache. Cochrane Database of Systematic Reviews 2004, Issue 3. Art. No.:CD001878. DOI:10.1002/14651858.CD001878.pub2.
63. Pan CX, Morrison RS, Ness J, Fugh-Berman A, Leipzig RM. Complementary and alternative medicine in the management of pain, dyspnoea, and nausea and vomiting near the end of life. A systematic review. J Pain Symptom Manage 2000;20(5):374-387.
64. Gadsby J, Franks A, Jarvis P, Dewhurst F. Acupuncture-like transcutaneous electrical nerve stimulation within palliative care:a pilot study. Complement Ther Med 1997;5(1):13-18.
65. Avellanosa AM, West CR. Experience with transcutaneous electrical nerve stimulation for relief of intractable pain in cancer patients. J Med 1982;13(3):203-213.
66. Ostrowski MJ. Pain control in advanced malignant disease using transcutaneous nerve stimulation. Br J Clin Pract 1979;33(6):157-162.
67. Wen HL. Cancer pain treated with acupuncture and electrical stimulation. Mod Med Asia 1977;13:12-16.
68. Robb KA, Bennett MI, Johnson MI, Simpson KJ, Oxberry SG. Transcutaneous electric nerve stimulation (TENS) for cancer pain in adults. Cochrane Database of Systematic Reviews 2008, Issue 3. Art. No.:CD006276. DOI:10.1002/14651858.CD006276.pub2.
69. Robb K, Oxberry SG, Bennett MI, Johnson MI, Simpson KH, Searle RD. J Pain Sympt Manage 2009;37(4):746-753.
70. Robb KA, Newham DJ, Williams JE. Transcutaneous electrical nerve stimulation vs. transcutaneous spinal electroanalgesia for chronic pain associated with breast cancer treatments. J Pain Symptom Manage 2007;33(4):410-419.
71. Macdonald ARJ, Coates TW. The discovery of trancutaneous spinal electroanalgesia and its relief of chronic pain. Physiotherapy 1995;81:653-660.
72. Reuss R, Meyer SC. The use of TENS in the management of cancer pain. Clin Manage 1985;5(5):26-28.
73. Ventafridda V, Saganzerla EP, Fochi C, Pozzi G, Cordini G. Transcutaneous nerve stimulation in cancer pain. In:Bonica J, Ventafridda V (eds) Advances in Pain Research and Therapy. Raven Press, New York, 1979:509-515.
74. Rafter J. TENS and Cancer Pain. Acupuncture Foundation of Canada Congress on Acupuncture Techniques, Toronto, Canada, 1986.
75. Librach S, Rapson LM. The use of transcutaneous electrical nerve stimulation (TENS) for the relief of pain in palliative care. Palliat Med 1988;2:15-20.
76. Hidderley M, Weinel E. Clinical practice. Effects of TENS applied to acupuncture points distal to a pain site. Int J Palliat Nurs 1997;3(4):185-191.
77. Hasun R, Marberger M. Transdermal electric pain control in urologic cancer patients. Schmerz Pain Douleur 1988;9(3):234-238.
78. Dil'din AS, Tikhonova GP, Kozlov SV. [Transcutaneous electrostimulation -method leading to a permeation system of electroanalgesia in oncological practice]. Vopr-Onkologia 1985;31(8):33-36.
79. Long DM. External electrical stimulation as a treatment of chronic pain. Minnesota Med 1974;57(3):195-198.
80. Loeser J, Black R, Christman A. Relief of pain by transcutaneous electrical nerve stimulation. J Neurosurg 1975;42:308-314.
81. Hardy RW. Current techniques in the management of pain. Cleveland Clin Q 1974;41(4):177-183.
82. Bates JA, Nathan PW. Transcutaneous electrical nerve stimulation for chronic pain. Anaesthesia 1980;35(8):817-822.
83. Searle RD, Bennett MI, Johnson MI, Callin S, Radford H. Transcutaneous electrical nerve stimulation (TENS) for cancer bone pain. Palliat Med 2008;22(7):878-9.
84. Searle RD, Bennett MI, Johnson MI, Callin S, Radford H. Transcutaneous electrical nerve stimulation (TENS) for cancer bone pain. J Pain Symptom Manage 2009;37(3):424-8.
85. Bennett MI, Johnson MI, Brown SR, Searle RD, Radford H, Brown JM. Feasibility study of Transcutaneous Electrical Nerve Stimulation (TENS) for cancer bone pain. Journal of Pain, in press.
86. Dundee J, Yang J, McMillan C. Non-invasive stimulation of the P6 (Neiguan) antiemetic acupuncture point in cancer chemotherapy. J Roy Soc Med 1991;84(4):210-212.
87. Pearl ML, Fischer M, McCauley DL, Valea FA, Chalas E. Transcutaneous electrical nerve stimulation as an adjunct for controlling chemotherapy-induced nausea and vomiting in gynecologic oncology patients. Cancer Nurs 1999;22(4):307-311.
88. Coloma M, White PF, Ogunnaike BO, et al. Comparison of acustimulation and ondansetron for the treatment of established postoperative nausea and vomiting. Anesthesiology 2002;97(6):1387-1392.
89. Gan TJ, Jiao KR, Zenn M, Georgiade G. A randomized controlled comparison of electro-acupoint stimulation or ondansetron versus placebo for the prevention of postoperative nausea and vomiting. Anesthes Analges 2004;99(4):1070-1075.
90. Zarate E, Mingus M, White PF, et al. The use of transcutaneous acupoint electrical stimulation for preventing nausea and vomiting after laparoscopic surgery. Anesthes Analges 2001;92(3):629-635.
91. Lee A, Done ML. Stimulation of the wrist acupuncture point P6 for preventing postoperative nausea and vomiting. Cochrane Database of Systematic Reviews 2004, Issue 3. Art. No.:CD003281. DOI:10.1002/14651858.CD003281.pub2.
92. Ezzo J, Streitberger K, Schneider A. Cochrane systematic reviews examine P6 acupuncture-point stimulation for nausea and vomiting. J Altern Complement Med 2006;12(5):489-495.
93. Waller A, Bercovitch M. Treatment of lymphoedema with TENS. In:Lymphoedema. Radcliffe Medical Press, Oxford, 2000:27-184.
94. Filshie J, Hester J. Guidelines for providing acupuncture treatment for cancer patients -a peer-reviewed sample policy document. Acupunct Med 2006;24(4):172-182.
95. Baum M, Ernst E, Lejeune S, Horneber M. Role of complementary and alternative medicine in the care of patients with breast cancer:report of the European Society of Mastology (EUSOMA) Workshop, Florence, Italy, December 2004. Eur J Cancer 2006;42(12):1702-1710.
96. Filshie J, Bolton T, Browne D, Ashley S. Acupuncture and self acupuncture for long-term treatment of vasomotor symptoms in cancer patients -audit and treatment algorithm. Acupunct Med 2005;23(4):171-180.
97. Filshie J, Redman D. Acupuncture and malignant pain problems. Eur J Surg Oncol 1985;11(4):389-394.
98. Filshie J, Penn K, Ashley S, Davis CL. Acupuncture for the relief of cancer-related breathlessness. Palliat Med 1996;10(2):145-150.
99. Cummings M, Reid F. BMAS policy statements in some controversial areas of acupuncture practice. Acupunct Med 2004;22(3):134-136.
100. Mansky PJ, Wallerstedt DB. Complementary medicine in palliative care and cancer symptom management. Cancer J 2006;12(5):425-431.
101. McEachrane-Gross FP, Liebschutz JM, Berlowitz D. Use of selected complementary and alternative medicine (CAM) treatments in veterans with cancer or chronic pain:a crosssectional survey. BMC Complement Altern Med 2006;6:34.
102. Lengacher CA, Bennett MP, Kip KE, et al. Frequency of use of complementary and alternative medicine in women with breast cancer. Oncol Nurs Forum 2002;29(10):1445-1452.
103. Henderson JW, Donatelle RJ. Complementary and alternative medicine use by women after completion of allopathic treatment for breast cancer. Altern Ther Health Med 2004;10(1):52-57.
104. Nahleh Z, Tabbara IA. Complementary and alternative medicine in breast cancer patients. Palliat Support Care 2003;1(3):267-273.
105. Theron EJ, Vermeulen AM. The utilization of transcutaneous electric nerve stimulation in postoperative ileus. South Afr Med J 1983;63(25):971-972.
106. Ernst E, White A. The BBC survey of complementary medicine use in the UK. Complement Ther Med 2000;8(1):32-36.
107. Wells M, Sarna L, Cooley ME, et al. Use of complementary and alternative medicine therapies to control symptoms in women living with lung cancer. Cancer Nurs 2007;30(1):45-55;quiz 56-57.
108. Johnstone PA, Polston GR, Niemtzow RC, Martin PJ. Integration of acupuncture into the oncology clinic. Palliat Med 2002;16(3):235-239.
109. Lund I, Lundeberg T. Are minimal, superficial or sham acupuncture procedures acceptable as inert placebo controls? Acupunct Med 2006;24(1):13-15.
110. Park J, White A, Stevinson C, Ernst E, James M. Validating a new non-penetrating sham acupuncture device:two randomized controlled trials. Acupunct Med 2002;20(4):168-174.
111. White P, Lewith G, Hopwood V, Prescott P. The placebo needle, is it a valid and convincing placebo for use in acupuncture trials? A randomized, single-blind, cross-over pilot trial. Pain 2003;106(3):401-409.
112. Tsukayama H, Yamashita H, Kimura T, Otsuki K. Factors that influence the applicability of sham needle in acupuncture trials:two randomized, single-blind, crossover trials with acupuncture-experienced subjects. Clin J Pain 2006;22(4):346-349.
113. Dincer F, Linde K. Sham interventions in randomized clinical trials of acupuncture -a review. Complement Ther Med 2003;11(4):235-242.
114. Kagitani F, Uchida S, Hotta H, Aikawa Y. Manual acupuncture needle stimulation of the rat hindlimb activates groups I, II, III and IV single afferent nerve fibers in the dorsal spinal roots. Japan J Physiol 2005;55(3):149-155.
115. Wang JQ, Mao L, Han JS. Comparison of the antinociceptive effects induced by electroacupuncture and transcutaneous electrical nerve stimulation in the rat. Int J Neurosci 1992;65(1-4):117-129.
116. Andersson S, Lundeberg T. Acupuncture -from empiricism to science:functional background to acupuncture effects in pain and disease. Med Hypothes 1995;45(3):271-281.
117. Kawakita K, Okada K. Mechanisms of action of acupuncture for chronic pain relief -polymodal receptors are the key candidates. Acupunct Med 2006;24(suppl):S58-66.
118. Li G, Liu HL, Cheung RT, et al. An fMRI study comparing brain activation between word generation and electrical stimulation of language-implicated acupoints. Human Brain Map 2003;18(3):233-238.
119. Guo ZL, Moazzami AR, Longhurst JC. Electroacupuncture induces c-Fos expression in the rostral ventrolateral medulla and periaqueductal gray in cats:relation to opioid containing neurons. Brain Res 2004;1030(1):103-115.
120. de Medeiros MA, Canteras NS, Suchecki D, Mello LE. Analgesia and c-Fos expression in the periaqueductal gray induced by electroacupuncture at the Zusanli point in rats. Brain Res 2003;973(2):196-204.
121. Bing Z, Villanueva L, Le Bars D. Acupuncture and diffuse noxious inhibitory controls:naloxone-reversible depression of activities of trigeminal convergent neurons. Neuroscience 1990;37(3):809-818.
122. Lee JH, Beitz AJ. The distribution of brain-stem and spinal cord nuclei associated with different frequencies of electroacupuncture analgesia. Pain 1993;52(1):11-28.
123. Guo HF, Cui X, Hou Y, Tian J, Wang X, Han J. C-Fos proteins are not involved in the activation of preproenkephalin gene expression in rat brain by peripheral electric stimulation (electroacupuncture). Neurosci Lett 1996;207(3):163-166.
124. Guo HF, Tian J, Wang X, Fang Y, Hou Y, Han J. Brain substrates activated by electroacupuncture (EA) of different frequencies (II):Role of Fos/Jun proteins in EA-induced transcription of preproenkephalin and preprodynorphin genes. Brain Res Molec Brain Res 1996;43(1-2):167-173.
125. Guo HF, Tian J, Wang X, Fang Y, Hou Y, Han J. Brain substrates activated by electroacupuncture of different frequencies (I):Comparative study on the expression of oncogene c-fos and genes coding for three opioid peptides. Brain Res Molec Brain Res 1996;43(1-2):157-166.
126. Ulett GA, Han S, Han JS. Electroacupuncture:mechanisms and clinical application. Biol Psychiat 1998;44(2):129-138.
127. Han JS. Acupuncture:neuropeptide release produced by electrical stimulation of different frequencies. Trends Neurosci 2003;26(1):17-22.
128. Han JS. Acupuncture and endorphins. Neurosci Lett 2004;361(1-3):258-261.
129. Hui KK, Liu J, Marina O, et al. The integrated response of the human cerebro-cerebellar and limbic systems to acupuncture stimulation at ST 36 as evidenced by fMRI. Neuroimage 2005;27(3):479-496.
130. Yoo SS, Teh EK, Blinder RA, Jolesz FA. Modulation of cerebellar activities by acupuncture stimulation:evidence from fMRI study. Neuroimage 2004;22(2):932-940.
131. Wang W, Liu L, Zhi X, et al. Study on the regulatory effect of electro-acupuncture on hegu point (LI4) in cerebral response with functional magnetic resonance imaging. Chin J Integr Med 2007;13(1):10-16.
132. Napadow V, Makris N, Liu J, Kettner NW, Kwong KK, Hui KK. Effects of electroacupuncture versus manual acupuncture on the human brain as measured by fMRI. Human Brain Map 2005;24(3):193-205.
133. Yang C, Li B, Liu TS, Zhao DM, Hu FA. [Effect of electroacupuncture on proliferation of astrocytes after spinal cord injury]. Zhongguo Zhen Jiu (Chinese Acupuncture and Moxibustion) 2005;25(8):569-572.
134. Hui KK, Liu J, Makris N, et al. Acupuncture modulates the limbic system and subcortical gray structures of the human brain:evidence from fMRI studies in normal subjects. Human Brain Map 2000;9(1):13-25.
135. Chen AC, Liu FJ, Wang L, Arendt-Nielsen L. Mode and site of acupuncture modulation in the human brain:3D (124-ch) EEG power spectrum mapping and source imaging. Neuroimage 2006;29(4):1080-1091.
136. Lundeberg T. Some of the effects of acupuncture in the knee may be due to activation of the reward system. Acupunct Med 2006;24(suppl):67-70.
137. Napadow V, Kettner N, Liu J, et al. Hypothalamus and amygdala response to acupuncture stimuli in carpal tunnel syndrome. Pain 2007;130(3):254-266.
138. Sekido R, Ishimaru K, Sakita M. Differences of electroacupuncture-induced analgesic effect in normal and inflammatory conditions in rats. Am J Chin Med 2003;31(6):955-965.
139. Liu S, Zhou W, Ruan X, et al. Activation of the hypothalamus characterizes the response to acupuncture stimulation in heroin addicts. Neurosci Lett 2007;421(3):203-208.
140. Nakagoshi A, Fukunaga M, Umeda M, Mori Y, Higuchi T, Tanaka C. Somatotopic representation of acupoints in human primary somatosensory cortex:an FMRI study. Magnet Reson Med Sci 2005;4(4):187-189.
141. Li G, Huang L, Cheung RT, Liu SR, Ma QY, Yang ES. Cortical activations upon stimulation of the sensorimotor-implicated acupoints. Magnet Reson Imag 2004;22(5):639-644.
142. Zhang WT, Jin Z, Luo F, Zhang L, Zeng YW, Han JS. Evidence from brain imaging with fMRI supporting functional specificity of acupoints in humans. Neurosci Lett 2004;354(1):50-53.
143. Yan B, Li K, Xu J, et al. Acupoint-specific fMRI patterns in human brain. Neurosci Lett 2005;383(3):236-240.
144. Li K, Shan B, Xu J, et al. Changes in FMRI in the human brain related to different durations of manual acupuncture needling. J Altern Complement Med 2006;12(7):615-623.
145. Han JS, Xuan YT. A mesolimbic neuronal loop of analgesia:I. Activation by morphine of a serotonergic pathway from periaqueductal gray to nucleus accumbens. Int J Neurosci 1986;29(1-2):109-117.
146. Kong J, Ma L, Gollub RL, et al. A pilot study of functional magnetic resonance imaging of the brain during manual and electroacupuncture stimulation of acupuncture point (LI-4 Hegu) in normal subjects reveals differential brain activation between methods. J Altern Complement Med 2002;8(4):411-419.
147. Wu MT, Sheen JM, Chuang KH, et al. Neuronal specificity of acupuncture response:a fMRI study with electroacupuncture. Neuroimage 2002;16(4):1028-1037.
148. Zhang WT, Jin Z, Cui GH, et al. Relations between brain network activation and analgesic effect induced by low vs. high frequency electrical acupoint stimulation in different subjects:a functional magnetic resonance imaging study. Brain Res 2003;982(2):168-178.
149. Kong J, Gollub RL, Webb JM, Kong JT, Vangel MG, Kwong K. Test-retest study of fMRI signal change evoked by electroacupuncture stimulation. Neuroimage 2007;34(3):1171-1181.
150. Lewith GT, White PJ, Pariente J. Investigating acupuncture using brain imaging techniques:the current state of play. Evidence-based Complement Altern Med 2005;2(3):315-319.
151. Campbell A. Point specificity of acupuncture in the light of recent clinical and imaging studies. Acupunct Med 2006;24(3):118-122.
152. Ahn AC, Wu J, Badger GJ, Hammerschlag R, Langevin HM. Electrical impedance along connective tissue planes associated with acupuncture meridians. BMC Complement Altern Med 2005;5:10.
153. Lee MS, Jeong SY, Lee YH, Jeong DM, Eo YG, Ko SB. Differences in electrical conduction properties between meridians and non-meridians. Am J Chin Med 2005;33(5):723-728.
154. Langevin HM, Churchill DL, Wu J, et al. Evidence of connective tissue involvement in acupuncture. Fed Am Soc Exper Biol J 2002;16(8):872-874.
155. Melzack R, Stillwell DM, Fox EJ. Trigger points and acupuncture points for pain:correlations and implications. Pain 1977;3(1):3-23.
156. Moncayo R, Rudisch A, Kremser C, Moncayo H. 3D-MRI rendering of the anatomical structures related to acupuncture points of the Dai mai, Yin qiao mai and Yang qiao mai meridians within the context of the WOMED concept of lateral tension:implications for musculoskeletal disease. BMC Musculoskelet Disord 2007;8:33.
157. Moncayo R, Rudisch A, Diemling M, Kremser C. In-vivo visualisation of the anatomical structures related to the acupuncture points Dai mai and Shen mai by MRI:a single -case pilot study. BMC Med Imag 2007;7:4.
158. Derry CJ, Derry S, McQuay HJ, Moore RA. Systematic review of systematic reviews of acupuncture published 1996-2005. Clin Med 2006;6(4):381-386.
159. National Health Service Centre for Reviews and Dissemination Acupuncture. Effect Health Care Bull 2001;7(2):1-12.
160. Ernst E. Acupuncture -a critical analysis. J Intern Med 2006;259(2):125-137.
161. White A, Foster NE, Cummings M, Barlas P. Acupuncture treatment for chronic knee pain:a systematic review. Rheumatology 2007;46(3):384-390.
162. Manheimer E, Linde K, Lao L, Bouter LM, Berman BM. Meta-analysis:acupuncture for osteoarthritis of the knee. Ann Intern Med 2007;146(12):868-877.
163. Ezzo J, Berman B, Hadhazy VA, Jadad AR, Lao L, Singh BB. Is acupuncture effective for the treatment of chronic pain? A systematic review. Pain 2000;86(3):217-225.
164. White P, Lewith G, Berman B, Birch S. Reviews of acupuncture for chronic neck pain:pitfalls in conducting systematic reviews. Rheumatology 2002;41(11):1224-1231.
165. Linde C, Isacsson G, Jonsson B. Outcome of 6-week treatment with transcutaneous electric nerve stimulation compared with splint on symptomatic temporomandibular joint disk displacement without reduction. Acta Odontol Scand 1995;53(2):92-98.
166. Johnson MI. The clinical effectiveness of acupuncture for pain relief -you can be certain of uncertainty. Acupunct Med 2006;24(2):71-79.
167. Lee H, Schmidt K, Ernst E. Acupuncture for the relief of cancer-related pain -a systematic review. Eur J Pain 2005;9(4):437-444.
168. Xia YQ, Zhang D, Yang CX, Xu HL, Li Y, Ma LT. An approach to the effect on tumors of acupuncture in combination with radiotherapy or chemotherapy. J Trad Chin Med 1986;6(1):23-26.
169. Dang W, Yang J. Clinical study on acupuncture treatment of stomach carcinoma pain. J Trad Chin Med 1998;18(1):31-38.
170. Alimi D, Rubino C, Pichard-Leandri E, Fermand-Brule S, Dubreuil-Lemaire ML, Hill C. Analgesic effect of auricular acupuncture for cancer pain:a randomized, blinded, controlled trial. J Clin Oncol 2003;21(22):4120-4126.
171. Alimi D, Rubino C, Leandri EP, Brule SF. Analgesic effects of auricular acupuncture for cancer pain. J Pain Symptom Manage 2000;19(2):81-82.
172. Xu S, Liu Z, Xu M. Treatment of cancerous abdominal pain by acupuncture on zusanli (ST 36) -a report of 92 cases. J Trad Chin Med 1995;15(3):189-191.
173. Rico RC, Trudnowski RJ. Studies with electro-acupuncture. J Med 1982;13(3):247-251.
174. Mehling WE, Jacobs B, Acree M, et al. Symptom management with massage and acupuncture in postoperative cancer patients:a randomized controlled trial. J Pain Symptom Manage 2007;33(3):258-266.
175. Wong R, Sagar S. Acupuncture treatment for chemotherapy-induced peripheral neuropathy -a case series. Acupunct Med 2006;24(2):87-91.
176. Minton O, Higginson IJ. Electroacupuncture as an adjunctive treatment to control neuropathic pain in patients with cancer. J Pain Symptom Manage 2007;33(2):115-117.
177. Bardia A, Barton DL, Prokop LJ, Bauer BA, Moynihan TJ. Efficacy of complementary and alternative medicine therapies in relieving cancer pain:a systematic review. J Clin Oncol 2006;24(34):5457-5464.
178. Ezzo J, Vickers A, Richardson MA, et al. Acupuncturepoint stimulation for chemotherapy-induced nausea and vomiting. J Clin Oncol 2005;23(28):7188-7198.
179. Jobst K, Chen JH, McPherson K, et al. Controlled trial of acupuncture for disabling breathlessness. Lancet 1986;2(8521-22):1416-1419.
180. Wu HS, Wu SC, Lin JG, Lin LC. Effectiveness of acupressure in improving dyspnoea in chronic obstructive pulmonary disease. J Adv Nurs 2004;45(3):252-259.
181. Maa SH, Gauthier D, Turner M. Acupressure as an adjunct to a pulmonary rehabilitation program. J Cardiopulmon Rehabil 1997;17(4):268-276.
182. Lewith GT, Prescott P, Davis CL. Can a standardized acupuncture technique palliate disabling breathlessness:a single-blind, placebo-controlled crossover study. Chest 2004;125(5):1783-1790.
183. Vickers AJ, Feinstein MB, Deng GE, Cassileth BR. Acupuncture for dyspnoea in advanced cancer:a randomized, placebo-controlled pilot trial [ISRCTN89462491]. BMC Palliat Care 2005;4:5.
184. Sood A, Barton DL, Bauer BA, Loprinzi CL. A critical review of complementary therapies for cancer-related fatigue. Integrat Cancer Ther 2007;6(1):8-13.
185. Vickers AJ, Straus DJ, Fearon B, Cassileth BR. Acupuncture for postchemotherapy fatigue:a phase II study. J Clin Oncol 2004;22(9):1731-1735.
186. Jedel E. Acupuncture in xerostomia -a systematic review. J Oral Rehabil 2005;32(6):392-396.
187. Blom M, Dawidson I, Fernberg JO, Johnson G, Angmar-Mansson B. Acupuncture treatment of patients with radiation-induced xerostomia. Eur J Cancer B Oral Oncol 1996;32B(3):182-190.
188. Blom M, Dawidson I, Angmar-Mansson B. The effect of acupuncture on salivary flow rates in patients with xerostomia. Oral Surg Oral Med Oral Pathol 1992;73(3):293-298.
189. List T, Lundeberg T, Lundstrom I, Lindstrom F, Ravald N. The effect of acupuncture in the treatment of patients with primary Sjogren's syndrome. A controlled study. Acta Odontol Scand 1998;56(2):95-99.
190. Wymenga AN, Sleijfer DT. Management of hot flushes in breast cancer patients. Acta Oncol 2002;41(3):269-275.
191. Nedstrand E, Wyon Y, Hammar M, Wijma K. Psychological well-being improves in women with breast cancer after treatment with applied relaxation or electro-acupuncture for vasomotor symptoms. J Psychosom Obstet Gynaecol 2006;27(4):193-199.