Psychological and neuroendocrinological effects of odor of saffron (Crocus sativus)

Phytomedicine

Volumn 18, Issue 8-9, 2011, Pages 726-730

  Fukui, Hajime ^a   Toyoshima, Kumiko ^a   Komaki, Ryoichi ^b  

^a NARA UNIVERSITY OF EDUCATION   (Japan)

^b KANEBO LTD   (Japan)

Author keywords

Crocus sativa; Hormone; Odor; PMS; Saffron; Stress

Indexed keywords

CROCUS SATIVUS EXTRACT; ESTRADIOL; HYDROCORTISONE; SAFFRON; TESTOSTERONE; UNCLASSIFIED DRUG;

ADULT; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; CROCUS; DYSMENORRHEA; ENZYME IMMUNOASSAY; FEMALE; FOLLICULAR PHASE; HUMAN; LUTEAL PHASE; MENSTRUAL IRREGULARITY; NEUROENDOCRINOLOGY; NONHUMAN; ODOR; PREMENSTRUAL SYNDROME; PRIORITY JOURNAL; PSYCHOLOGIC ASSESSMENT; PSYCHOLOGIC TEST; SALIVA; STATE TRAIT ANXIETY INVENTORY;

ADULT; ANALGESICS; AROMATHERAPY; CROCUS; CYCLOHEXENES; DOUBLE-BLIND METHOD; DYSMENORRHEA; FEMALE; FLOWERS; HUMANS; MEDICINE, EAST ASIAN TRADITIONAL; MENSTRUATION DISTURBANCES; PHYTOTHERAPY; PLANT EXTRACTS; PREMENSTRUAL SYNDROME; TERPENES; YOUNG ADULT;

CROCUS; CROCUS SATIVUS;

EID: 79958119914     PISSN: 09447113     EISSN: 1618095X     Source Type: Journal    
DOI: 10.1016/j.phymed.2010.11.013     Document Type: Article

References (31)

1. Abdullaev, F.I., 1993. Biological effects of saffron. Biofactors 4 (2), 83-86. (Pubitemid 23218839)
2. Abdullaev, F.I., 2002. Cancer chemopreventive and tumoricidal properties of saffron (Crocus sativus L.). Exp. Biol. Med. (Maywood) 227 (1), 20-25.
3. Abe, K., Saito, H., 2000. Effects of saffron extract and its constituent crocin on learning behaviour and long-term potentiation. Phytother. Res. 14 (3), 149-152.
4. Abe, K., Sugiura, M., Yamaguchi, S., Shoyama, Y., Saito, H., 1999. Saffron extract prevents acetaldehyde-induced inhibition of long-term potentiation in the rat dentate gyrus in vivo. Brain Res. 851 (1-2), 287-289. (Pubitemid 30038160)
5. Agha-Hosseini, M., Kashani, L., Aleyaseen, A., Ghoreishi, A., Rahmanpour, H., Zarrinara, A.R., Akhondzadeh, S., 2008. Crocus sativus L. (saffron) in the treatment of premenstrual syndrome: a double-blind, randomised and placebo-controlled trial. BJOG 115 (4), 515-519.
6. Akhondzadeh, S., Fallah-Pour, H., Afkham, K., Jamshidi, A.H., Khalighi-Cigaroudi, F., 2004. Comparison of Crocus sativus L. and imipramine in the treatment of mild to moderate depression: a pilot double-blind randomized trial. BMC Complement Altern. Med. 4, 12.
7. Akhondzadeh, S., Tahmacebi-Pour, N., Noorbala, A.A., Amini, H., Fallah-Pour, H., Jamshidi, A.H., Khani, M., 2005. Crocus sativus L. in the treatment of mild to moderate depression: a double-blind, randomized and placebo-controlled trial. Phytother. Res. 19 (2), 148-151.
8. Aung, H.H., Wang, C.Z., Ni, M., Fishbein, A., Mehendale, S.R., Xie, J.T., Shoyama, C.Y., Yuan, C.S., 2007. Crocin from Crocus sativus possesses significant anti-proliferation effects on human colorectal cancer cells. Exp. Oncol. 29 (3), 175-180.
9. Chang, A.S., Chang, S.M., 1999. Nongenomic steroidal modulation of high-affinity serotonin transport. Biochim. Biophys. Acta 1417 (1), 157-166.
10. Chryssanthi, D.G., Lamari, F.N., Iatrou, G., Pylara, A., Karamanos, N.K., Cordopatis, P., 2007. Inhibition of breast cancer cell proliferation by style constituents of different Crocus species. Anticancer Res. 27 (1A), 357-362. (Pubitemid 46363354)
11. Escribano, J., Alonso, G.L., Coca-Prados, M., Fernandez, J.A., 1996. Crocin, safranal and picrocrocin from saffron (Crocus sativus L.) inhibit the growth of human cancer cells in vitro. Cancer Lett. 100 (1-2), 23-30. (Pubitemid 26056388)
12. Farage, M.A., Osborn, T.W., MacLean, A.B., 2008. Cognitive, sensory, and emotional changes associated with the menstrual cycle: a review. Arch. Gynecol. Obstet. 278 (4), 299-307.
13. Fukui, H., Yamashita, M., 2003. The effects of music and visual stress on testosterone and cortisol in men and women. Neuro. Endocrinol. Lett. 24, 173-180.
14. Hellhammer, D.H., Wüst, S., Kudielka, B.M., 2009. Salivary cortisol as a biomarker in stress research. Psychoneuroendocrinology 34 (2), 163-171.
15. Hosseinzadeh, H., Karimi, G.H., Niapoor, M., 2004. Antidepressant effects of Crocus sativus stigma extracts and its constituents, crocin and safranal, in mice. Acta Hort. 650, 435-445.
16. Hosseinzadeh, H., Khosravan, V., 2002. Anticonvulsant effects aqueous and ethanolic extracts of Crocus sativus L. stigmas in mice. Arch. Arch. Irn. Med. 5 (1), 44-47.
17. Hosseinzadeh, H., Younesi, H.M., 2002. Antinociceptive and anti-inflammatory effects of Crocus sativus L. stigma and petal extracts in mice. BMC Pharmacol. 2, 7.
18. Karimi, G., Hosseinzadeh, H., Khaleghpanah, P., 2001. Study of antidepressant effect of aqueous and ethanolic of Crocus sativus in mice. Iran. J. Basic Med. Sci. 4, 11-15.
19. Kirschbaum, C., Hellhammer, D.H., 1994. Salivary cortisol in psycho-neuroendocrine research: recent developments and applications. Psychoneuroendocrinology 19, 313-333. (Pubitemid 24150545)
20. Madan, C.L., Kapur, B.M., Gupta, U.S., 1966. Saffron. Econ. Bot. 20, 377.
21. Maki, P.M., Dumas, J., 2009. Mechanisms of action of estrogen in the brain: insights from human neuroimaging and psychopharmacologic studies. Semin. Reprod. Med. 27 (3), 250-259.
22. Moshiri, E., Basti, A.A., Noorbala, A.A., Jamshidi, A.H., Hesameddin Abbasi, S., Akhondzadeh, S., 2006. Crocus sativus L. (petal) in the treatment of mild-to-moderate depression: a double-blind, randomized and placebo-controlled trial. Phytomedicine 13 (9-10), 607-611.
23. Mousavi, S.H., Tavakkol-Afshari, J., Brook, A., Jafari-Anarkooli, I., 2009. Role of caspases and Bax protein in saffron-induced apoptosis in MCF-7 cells. Food Chem. Toxicol. 47 (8), 1909-1913.
24. Nair, S.C., Kurumboor, S.K., Hasegawa, J.H., 1995. Saffron chemoprevention in biology and medicine: a review. Cancer Biother. 10 (4), 257-264.
25. Noorbala, A.A., Akhondzadeh, S., Tahmacebi-Pour, N., Jamshidi, A.H., 2005. Hydro-alcoholic extract of Crocus sativus L. versus fluoxetine in the treatment of mild to moderate depression: a double-blind, randomized pilot trial. J. Ethnopharmacol. 97 (2), 281-284. (Pubitemid 40222030)
26. Odber, J., Cawood, E.H., Bancroft, J., 1998. Salivary cortisol in women with and without perimenstrual mood changes. J. Psychosom. Res. 45 (6), 557-568.
27. Premkumar, K., Abraham, S.K., Santhiya, S.T., Ramesh, A., 2003. Protective effects of saffron (Crocus sativus Linn.) on genotoxins-induced oxidative stress in Swiss albino mice. Phytother. Res. 17 (6), 614-617.
28. Ríos, J.L., Recio, M.C., Giner, R.M., Máñez, S., 1996. An update review of saffron and its active constituents. Phytother. Res. 10 (3), 189-193.
29. Shah, N.R., Jones, J.B., Aperi, J., Shemtov, R., Karne, A., Borenstein, J., 2008. Selective serotonin reuptake inhibitors for premenstrual syndrome and premenstrual dysphoric disorder: a meta-analysis. Obstet. Gynecol. 111 (5), 1175-1182.
30. Wihlbäck, A.C., Sundström Poromaa, I., Bixo, M., Allard, P., Mjörndal, T., Spigset, O., 2004. Influence of menstrual cycle on platelet serotonin uptake site and serotonin2A receptor binding. Psychoneuroendocrinology 29 (6), 757-766. (Pubitemid 38521238)
31. Zhang, Y., Shoyama, Y., Sugiura, M., Saito, H., 1994. Effects of Crocus sativus L. on the ethanol-induced impairment of passive avoidance performances in mice. Biol. Pharm. Bull. 17 (2), 217-221.