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Volumn 30, Issue 4, 2011, Pages 235-242

Early growth response transcription factors: Key mediators of fibrosis and novel targets for anti-fibrotic therapy

Author keywords

Egr 1; Fibroblast; Fibrosis; Scleroderma (systemic sclerosis); TGF

Indexed keywords

EARLY GROWTH RESPONSE FACTOR 1; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; SMAD2 PROTEIN; SMAD3 PROTEIN; STRESS ACTIVATED PROTEIN KINASE; TRANSFORMING GROWTH FACTOR BETA;

EID: 79958108760     PISSN: 0945053X     EISSN: 15691802     Source Type: Journal    
DOI: 10.1016/j.matbio.2011.03.005     Document Type: Review
Times cited : (100)

References (79)
  • 1
    • 30944446390 scopus 로고    scopus 로고
    • The transcription factor Egr1 is a direct regulator of multiple tumor suppressors including TGFbeta1, PTEN, p53, and fibronectin
    • Baron V., Adamson E.D., Calogero A., Ragona G., Mercola D. The transcription factor Egr1 is a direct regulator of multiple tumor suppressors including TGFbeta1, PTEN, p53, and fibronectin. Cancer Gene Ther. 2006, 13:115-124.
    • (2006) Cancer Gene Ther. , vol.13 , pp. 115-124
    • Baron, V.1    Adamson, E.D.2    Calogero, A.3    Ragona, G.4    Mercola, D.5
  • 2
    • 0038124370 scopus 로고    scopus 로고
    • Simvastatin inhibits expression of tissue factor in advanced atherosclerotic lesions of apolipoprotein E deficient mice independently of lipid lowering: potential role of simvastatin-mediated inhibition of Egr-1 expression and activation
    • Bea F., Blessing E., Shelley M.I., Shultz J.M., Rosenfeld M.E. Simvastatin inhibits expression of tissue factor in advanced atherosclerotic lesions of apolipoprotein E deficient mice independently of lipid lowering: potential role of simvastatin-mediated inhibition of Egr-1 expression and activation. Atherosclerosis 2003, 167:187-194.
    • (2003) Atherosclerosis , vol.167 , pp. 187-194
    • Bea, F.1    Blessing, E.2    Shelley, M.I.3    Shultz, J.M.4    Rosenfeld, M.E.5
  • 3
    • 33645560435 scopus 로고    scopus 로고
    • Insulin-like growth factor-binding protein-5 (IGFBP-5): a critical member of the IGF axis
    • Beattie J., Allan G.J., Lochrie J.D., Flint D.J. Insulin-like growth factor-binding protein-5 (IGFBP-5): a critical member of the IGF axis. Biochem. J. 2006, 395:1-19.
    • (2006) Biochem. J. , vol.395 , pp. 1-19
    • Beattie, J.1    Allan, G.J.2    Lochrie, J.D.3    Flint, D.J.4
  • 6
    • 79958103567 scopus 로고    scopus 로고
    • A non-Smad mechanism of fibroblast activation by transforming growth factor-b via c-Abl and Egr-1: selective modulation by imatinib mesylate
    • Bhattacharyya S., Ishida W., Wu M., Wilkes M., Mori Y., Hinchcliff M., Leof E., Varga J. A non-Smad mechanism of fibroblast activation by transforming growth factor-b via c-Abl and Egr-1: selective modulation by imatinib mesylate. Oncogene 2008, 1-13.
    • (2008) Oncogene , pp. 1-13
    • Bhattacharyya, S.1    Ishida, W.2    Wu, M.3    Wilkes, M.4    Mori, Y.5    Hinchcliff, M.6    Leof, E.7    Varga, J.8
  • 7
    • 70449575813 scopus 로고    scopus 로고
    • The transcriptional cofactor Nab2 is induced by TGF-ß and suppresses fibroblast activation: physiological roles and impaired expression in scleroderma
    • Bhattacharyya S., Wei J., Melichian D.S., Milbrandt J., Takehara K., Varga J. The transcriptional cofactor Nab2 is induced by TGF-ß and suppresses fibroblast activation: physiological roles and impaired expression in scleroderma. PLoS One 2009, 26(4):e7620.
    • (2009) PLoS One , vol.26 , Issue.4
    • Bhattacharyya, S.1    Wei, J.2    Melichian, D.S.3    Milbrandt, J.4    Takehara, K.5    Varga, J.6
  • 10
    • 0348049997 scopus 로고    scopus 로고
    • Ets ternary complex transcription factors
    • Buchwalter G., Gross C., Wasylyk B. Ets ternary complex transcription factors. Gene 2004, 324:1-14.
    • (2004) Gene , vol.324 , pp. 1-14
    • Buchwalter, G.1    Gross, C.2    Wasylyk, B.3
  • 11
    • 0027182018 scopus 로고
    • Detection and characterization of cellular EGR-1 binding to its recognition site
    • Cao X., Mahendran R., Guy G.R., Tan Y.H. Detection and characterization of cellular EGR-1 binding to its recognition site. J. Biol. Chem. 1993, 268:16949-16957.
    • (1993) J. Biol. Chem. , vol.268 , pp. 16949-16957
    • Cao, X.1    Mahendran, R.2    Guy, G.R.3    Tan, Y.H.4
  • 12
    • 33746374436 scopus 로고    scopus 로고
    • The early-immediate gene EGR-1 is induced by transforming growth factor-beta and mediates stimulation of collagen gene expression
    • Chen S.J., Ning H., Ishida W., Sodin-Semrl S., Takagawa S., Mori Y., Varga J. The early-immediate gene EGR-1 is induced by transforming growth factor-beta and mediates stimulation of collagen gene expression. J. Biol. Chem. 2006, 281:21183-21197.
    • (2006) J. Biol. Chem. , vol.281 , pp. 21183-21197
    • Chen, S.J.1    Ning, H.2    Ishida, W.3    Sodin-Semrl, S.4    Takagawa, S.5    Mori, Y.6    Varga, J.7
  • 13
    • 33646381116 scopus 로고    scopus 로고
    • Role of early growth response-1 (Egr-1) in interleukin-13-induced inflammation and remodeling
    • Cho S.J., Kang M.J., Homer R.J., Kang H.R., Zhang X., Lee P.J., Elias J.A., Lee C.G. Role of early growth response-1 (Egr-1) in interleukin-13-induced inflammation and remodeling. J. Biol. Chem. 2006, 2006(281):8161-8168.
    • (2006) J. Biol. Chem. , vol.2006 , Issue.281 , pp. 8161-8168
    • Cho, S.J.1    Kang, M.J.2    Homer, R.J.3    Kang, H.R.4    Zhang, X.5    Lee, P.J.6    Elias, J.A.7    Lee, C.G.8
  • 15
    • 15244339164 scopus 로고    scopus 로고
    • Imatinib mesylate inhibits the profibrogenic activity of TGF-beta and prevents bleomycin-mediated lung fibrosis
    • Daniels C.E., Wilkes M.C., Edens M., Kottom T.J., Murphy S.J., Limper A.H., et al. Imatinib mesylate inhibits the profibrogenic activity of TGF-beta and prevents bleomycin-mediated lung fibrosis. J. Clin. Invest. 2004, 114:1308-1316.
    • (2004) J. Clin. Invest. , vol.114 , pp. 1308-1316
    • Daniels, C.E.1    Wilkes, M.C.2    Edens, M.3    Kottom, T.J.4    Murphy, S.J.5    Limper, A.H.6
  • 16
    • 77953518507 scopus 로고    scopus 로고
    • The NADPH oxidase subunit NOX4 is a new target gene of the hypoxia-inducible factor-1
    • Diebold I., Petry A., Hess J., Görlach A. The NADPH oxidase subunit NOX4 is a new target gene of the hypoxia-inducible factor-1. Mol. Biol. Cell 2010, 21:2087-2096.
    • (2010) Mol. Biol. Cell , vol.21 , pp. 2087-2096
    • Diebold, I.1    Petry, A.2    Hess, J.3    Görlach, A.4
  • 17
    • 33846209989 scopus 로고    scopus 로고
    • Imatinib mesylate reduces production of extracellular matrix and prevents development of experimental dermal fibrosis
    • Distler J.H., Jungel A., Huber L.C., Schulze-Horsel U., Zwerina J., Gay R.E., et al. Imatinib mesylate reduces production of extracellular matrix and prevents development of experimental dermal fibrosis. Arthritis Rheum. 2007, 56:311-322.
    • (2007) Arthritis Rheum. , vol.56 , pp. 311-322
    • Distler, J.H.1    Jungel, A.2    Huber, L.C.3    Schulze-Horsel, U.4    Zwerina, J.5    Gay, R.E.6
  • 19
    • 0034671736 scopus 로고    scopus 로고
    • Elevated Egr-1 in human atherosclerotic cells transcriptionally represses the transforming growth factor-beta type II receptor
    • Du B., Fu C., Kent K.C., Bush H., Schulick A.H., Kreiger K., Collins T., McCaffrey T.A. Elevated Egr-1 in human atherosclerotic cells transcriptionally represses the transforming growth factor-beta type II receptor. J. Biol. Chem. 2000, 275:39039-39047.
    • (2000) J. Biol. Chem. , vol.275 , pp. 39039-39047
    • Du, B.1    Fu, C.2    Kent, K.C.3    Bush, H.4    Schulick, A.H.5    Kreiger, K.6    Collins, T.7    McCaffrey, T.A.8
  • 20
    • 0034722618 scopus 로고    scopus 로고
    • Modulation of early growth response (EGR) transcription factor-dependent gene expression by using recombinant adenovirus
    • Ehrengruber M.U., Muhlebach S.G., Sohrman S., Leutenegger C.M., Lester H.A., et al. Modulation of early growth response (EGR) transcription factor-dependent gene expression by using recombinant adenovirus. Gene 2000, 258:63-69.
    • (2000) Gene , vol.258 , pp. 63-69
    • Ehrengruber, M.U.1    Muhlebach, S.G.2    Sohrman, S.3    Leutenegger, C.M.4    Lester, H.A.5
  • 21
    • 79958167861 scopus 로고    scopus 로고
    • The early growth response gene Egr-2 (Krox20) is a novel transcriptional target of transforming growth factor-β that is up-regulated in systemic sclerosis and mediates profibrotic responses
    • Fang F., Ooka K., Bhattacharyya S., Wei J., Wu M., Du P., Lin S., Del Galdo F., Feghali-Bostwick C.A., Varga J. The early growth response gene Egr-2 (Krox20) is a novel transcriptional target of transforming growth factor-β that is up-regulated in systemic sclerosis and mediates profibrotic responses. Am. J. Path. 2011, 178:2077-2090.
    • (2011) Am. J. Path. , vol.178 , pp. 2077-2090
    • Fang, F.1    Ooka, K.2    Bhattacharyya, S.3    Wei, J.4    Wu, M.5    Du, P.6    Lin, S.7    Del Galdo, F.8    Feghali-Bostwick, C.A.9    Varga, J.10
  • 22
    • 29144471992 scopus 로고    scopus 로고
    • The effect of anti-inflammatory properties of mycophenolate mofetil on the development of lung reperfusion injury
    • Farivar A.S., MacKinnon-Patterson B., Barnes A.D., Mulligan M.S. The effect of anti-inflammatory properties of mycophenolate mofetil on the development of lung reperfusion injury. J. Heart Lung Transplant. 2005, 24:2235-2242.
    • (2005) J. Heart Lung Transplant. , vol.24 , pp. 2235-2242
    • Farivar, A.S.1    MacKinnon-Patterson, B.2    Barnes, A.D.3    Mulligan, M.S.4
  • 24
    • 57249094020 scopus 로고    scopus 로고
    • IL-13 signaling via IL-13R alpha2 induces major downstream fibrogenic factors mediating fibrosis in chronic TNBS colitis
    • Fichtner-Feigl S., Young C.A., Kitani A., Geissler E.K., Schlitt H.J., Strober W. IL-13 signaling via IL-13R alpha2 induces major downstream fibrogenic factors mediating fibrosis in chronic TNBS colitis. Gastroenterology 2008, 135:2003-2013.
    • (2008) Gastroenterology , vol.135 , pp. 2003-2013
    • Fichtner-Feigl, S.1    Young, C.A.2    Kitani, A.3    Geissler, E.K.4    Schlitt, H.J.5    Strober, W.6
  • 28
    • 0029161198 scopus 로고
    • Early growth response protein 1 (Egr-1): prototype of a zinc-finger family of transcription factors
    • Gashler A., Sukhatme V.P. Early growth response protein 1 (Egr-1): prototype of a zinc-finger family of transcription factors. Prog. Nucleic Acid Res. Mol. Biol. 1995, 50:191-224.
    • (1995) Prog. Nucleic Acid Res. Mol. Biol. , vol.50 , pp. 191-224
    • Gashler, A.1    Sukhatme, V.P.2
  • 29
    • 35848951176 scopus 로고    scopus 로고
    • The transcriptional coactivator and acetyltransferase p300 in fibroblast biology and fibrosis
    • Ghosh A.K., Varga J. The transcriptional coactivator and acetyltransferase p300 in fibroblast biology and fibrosis. J. Cell. Physiol. 2007, 213:663-671.
    • (2007) J. Cell. Physiol. , vol.213 , pp. 663-671
    • Ghosh, A.K.1    Varga, J.2
  • 30
    • 0034691764 scopus 로고    scopus 로고
    • Smad-dependent stimulation of type I collagen gene expression in human skin fibroblasts by TGF-ßeta involves functional cooperation with p300/CBP transcriptional coactivators
    • Ghosh A.K., Yuan W., Mori Y., Varga J. Smad-dependent stimulation of type I collagen gene expression in human skin fibroblasts by TGF-ßeta involves functional cooperation with p300/CBP transcriptional coactivators. Oncogene 2000, 19:3546-3555.
    • (2000) Oncogene , vol.19 , pp. 3546-3555
    • Ghosh, A.K.1    Yuan, W.2    Mori, Y.3    Varga, J.4
  • 32
    • 33747625686 scopus 로고    scopus 로고
    • Hepatocyte growth factor induces cell scattering through MAPK/Egr-1-mediated upregulation of Snail
    • Grotegut S., von Schweinitz D., Christofori G., Lehembre F. Hepatocyte growth factor induces cell scattering through MAPK/Egr-1-mediated upregulation of Snail. EMBO J. 2006, 25:3534-3545.
    • (2006) EMBO J. , vol.25 , pp. 3534-3545
    • Grotegut, S.1    von Schweinitz, D.2    Christofori, G.3    Lehembre, F.4
  • 33
    • 0035469890 scopus 로고    scopus 로고
    • Lipopolysaccharide activation of the MEK-ERK1/2 pathway in human monocytic cells mediates tissue factor and tumor necrosis factor alpha expression by inducing Elk-1 phosphorylation and Egr-1 expression
    • Guha M., O'Connell M.A., Pawlinski R., Hollis A., McGovern P., Yan S.F., Stern D., Mackman N. Lipopolysaccharide activation of the MEK-ERK1/2 pathway in human monocytic cells mediates tissue factor and tumor necrosis factor alpha expression by inducing Elk-1 phosphorylation and Egr-1 expression. Blood 2001, 98:1429-1439.
    • (2001) Blood , vol.98 , pp. 1429-1439
    • Guha, M.1    O'Connell, M.A.2    Pawlinski, R.3    Hollis, A.4    McGovern, P.5    Yan, S.F.6    Stern, D.7    Mackman, N.8
  • 34
    • 41349104073 scopus 로고    scopus 로고
    • Oxidant and redox signaling in vascular oxygen sensing: implications for systemic and pulmonary hypertension
    • Gupte S.A., Wolin M.S. Oxidant and redox signaling in vascular oxygen sensing: implications for systemic and pulmonary hypertension. Antioxid. Redox Signal. 2008, 10:1137-1152.
    • (2008) Antioxid. Redox Signal. , vol.10 , pp. 1137-1152
    • Gupte, S.A.1    Wolin, M.S.2
  • 35
    • 37849018402 scopus 로고    scopus 로고
    • Hemin Upregulates Egr-1 Expression in Vascular Smooth Muscle Cells via ROS ERK-1/2 Elk-1 and NF-{kappa}B
    • Hasan R.N., Schafer A.I. Hemin Upregulates Egr-1 Expression in Vascular Smooth Muscle Cells via ROS ERK-1/2 Elk-1 and NF-{kappa}B. Circ. Res. 2008, 102:42-50.
    • (2008) Circ. Res. , vol.102 , pp. 42-50
    • Hasan, R.N.1    Schafer, A.I.2
  • 38
    • 67651005404 scopus 로고    scopus 로고
    • EMT: when epithelial cells decide to become mesenchymal-like cells
    • Kalluri R. EMT: when epithelial cells decide to become mesenchymal-like cells. J. Clin. Invest. 2009, 119:1417-1419.
    • (2009) J. Clin. Invest. , vol.119 , pp. 1417-1419
    • Kalluri, R.1
  • 39
    • 0036212895 scopus 로고    scopus 로고
    • Epidermal growth factor and thrombininduced proliferation of immortalized human keratinocytes is coupled to the synthesis of Egr-1, a zinc finger transcriptional regulator
    • Kaufmann K., Thiel G. Epidermal growth factor and thrombininduced proliferation of immortalized human keratinocytes is coupled to the synthesis of Egr-1, a zinc finger transcriptional regulator. J. Cell. Biochem. 2002, 85:381-391.
    • (2002) J. Cell. Biochem. , vol.85 , pp. 381-391
    • Kaufmann, K.1    Thiel, G.2
  • 40
    • 33644850380 scopus 로고    scopus 로고
    • Early growth response-1 in cardiovascular pathobiology
    • Khachigian L.M. Early growth response-1 in cardiovascular pathobiology. Circ. Res. 2006, 98:186-191.
    • (2006) Circ. Res. , vol.98 , pp. 186-191
    • Khachigian, L.M.1
  • 41
    • 0031831112 scopus 로고    scopus 로고
    • Early growth response factor 1: a pleiotropic mediator of inducible gene expression
    • Khachigian L.M., Collins T. Early growth response factor 1: a pleiotropic mediator of inducible gene expression. J. Mol. Med. 1998, 76:613-616.
    • (1998) J. Mol. Med. , vol.76 , pp. 613-616
    • Khachigian, L.M.1    Collins, T.2
  • 42
    • 0029098225 scopus 로고
    • Activation of the c-Abl tyrosine kinase in the stress response to DNA-damaging agents
    • Kharbanda S.R., Ren P., Pandey T.D., Shafman S.M., Feller R.R., Weichselbaum, et al. Activation of the c-Abl tyrosine kinase in the stress response to DNA-damaging agents. Nature 1995, 376:785-788.
    • (1995) Nature , vol.376 , pp. 785-788
    • Kharbanda, S.R.1    Ren, P.2    Pandey, T.D.3    Shafman, S.M.4    Feller, R.R.5    Weichselbaum6
  • 45
    • 77957174189 scopus 로고    scopus 로고
    • EGR1, EGR2, and EGR3 activate the expression of their coregulator NAB2 establishing a negative feedback loop in cells of neuroectodermal and epithelial origin
    • Kumbrink J., Kirsch K.H., Johnson J.P. EGR1, EGR2, and EGR3 activate the expression of their coregulator NAB2 establishing a negative feedback loop in cells of neuroectodermal and epithelial origin. J. Cell. Biochem. 2010, 111:207-217.
    • (2010) J. Cell. Biochem. , vol.111 , pp. 207-217
    • Kumbrink, J.1    Kirsch, K.H.2    Johnson, J.P.3
  • 46
    • 14044266360 scopus 로고    scopus 로고
    • Analysis of congenital hypomyelinating Egr2Lo/Lo nerves identifies Sox2 as an inhibitor of Schwann cell differentiation and myelination
    • Le N., Nagarajan R., Wang J.Y., Araki T., Schmidt R.E., Milbrandt J. Analysis of congenital hypomyelinating Egr2Lo/Lo nerves identifies Sox2 as an inhibitor of Schwann cell differentiation and myelination. Proc. Natl. Acad. Sci. USA. 2005, 102:2596-2601.
    • (2005) Proc. Natl. Acad. Sci. USA. , vol.102 , pp. 2596-2601
    • Le, N.1    Nagarajan, R.2    Wang, J.Y.3    Araki, T.4    Schmidt, R.E.5    Milbrandt, J.6
  • 47
    • 0029812609 scopus 로고    scopus 로고
    • Luteinizing hormone deficiency and female infertility in mice lacking the transcription factor NGFI-A (Egr-1)
    • Lee S.L., Sadovsky Y., Swirnoff A.H., Polish J.A., Goda P., Gavrilina G., Milbrandt J. Luteinizing hormone deficiency and female infertility in mice lacking the transcription factor NGFI-A (Egr-1). Science. 1996, 273:1219-1221.
    • (1996) Science. , vol.273 , pp. 1219-1221
    • Lee, S.L.1    Sadovsky, Y.2    Swirnoff, A.H.3    Polish, J.A.4    Goda, P.5    Gavrilina, G.6    Milbrandt, J.7
  • 50
    • 76249103099 scopus 로고    scopus 로고
    • Early growth response protein-1 (Egr-1) is preferentially expressed in T helper type 2 (Th2) cells and is involved in acute transcription of the Th2 cytokine interleukin-4
    • Lohoff M., Giaisi M., Köhler R., Casper B., Krammer P.H., Li-Weber M. Early growth response protein-1 (Egr-1) is preferentially expressed in T helper type 2 (Th2) cells and is involved in acute transcription of the Th2 cytokine interleukin-4. J. Biol. Chem. 2010, 285:1643-1652.
    • (2010) J. Biol. Chem. , vol.285 , pp. 1643-1652
    • Lohoff, M.1    Giaisi, M.2    Köhler, R.3    Casper, B.4    Krammer, P.H.5    Li-Weber, M.6
  • 51
    • 0025348013 scopus 로고
    • Tyrosine kinase activity and transformation potency of bcr-abl oncogene products
    • Lugo T.G., Pendergast A.M., Muller A.J., Witte O.N. Tyrosine kinase activity and transformation potency of bcr-abl oncogene products. Science 1990, 247:1079-1082.
    • (1990) Science , vol.247 , pp. 1079-1082
    • Lugo, T.G.1    Pendergast, A.M.2    Muller, A.J.3    Witte, O.N.4
  • 52
    • 4644362064 scopus 로고    scopus 로고
    • Fibroblast growth factor-2 induction of platelet-derived growth factor-C chain transcription in vascular smooth muscle cells is ERK-dependent but not JNK-dependent and mediated by Egr-1
    • Midgley V.C., Levon M. Fibroblast growth factor-2 induction of platelet-derived growth factor-C chain transcription in vascular smooth muscle cells is ERK-dependent but not JNK-dependent and mediated by Egr-1. J. Biol. Chem. 2004, 279:40289-40295.
    • (2004) J. Biol. Chem. , vol.279 , pp. 40289-40295
    • Midgley, V.C.1    Levon, M.2
  • 54
    • 0036901274 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor-gamma (PPAR-gamma) activation suppresses ischemic induction of Egr-1 and its inflammatory gene targets
    • Okada M., Wen F., Yan S.F. Peroxisome proliferator-activated receptor-gamma (PPAR-gamma) activation suppresses ischemic induction of Egr-1 and its inflammatory gene targets. FASEB J. 2002, 16:1861-1868.
    • (2002) FASEB J. , vol.16 , pp. 1861-1868
    • Okada, M.1    Wen, F.2    Yan, S.F.3
  • 55
    • 77956266529 scopus 로고    scopus 로고
    • Early growth response-1 attenuates liver injury and promotes hepatoprotection after carbon tetrachloride exposure in mice
    • Pritchard M.T., Cohen J.I., Roychowdhury S., Pratt B.T., Nagy L.E. Early growth response-1 attenuates liver injury and promotes hepatoprotection after carbon tetrachloride exposure in mice. J. Hepatol. 2010, 53:655-662.
    • (2010) J. Hepatol. , vol.53 , pp. 655-662
    • Pritchard, M.T.1    Cohen, J.I.2    Roychowdhury, S.3    Pratt, B.T.4    Nagy, L.E.5
  • 56
    • 35048875855 scopus 로고    scopus 로고
    • TGF-beta signaling: a tale of two responses
    • Rahimi R.A., Leof E.B. TGF-beta signaling: a tale of two responses. J. Cell. Biochem. 2007, 102:593-608.
    • (2007) J. Cell. Biochem. , vol.102 , pp. 593-608
    • Rahimi, R.A.1    Leof, E.B.2
  • 57
    • 66449105548 scopus 로고    scopus 로고
    • Thrombin induces Egr-1 expression in fibroblasts involving elevation of the intracellular Ca2+ concentration, phosphorylation of ERK and activation of ternary complex factor
    • Rössler O.G., Thiel G. Thrombin induces Egr-1 expression in fibroblasts involving elevation of the intracellular Ca2+ concentration, phosphorylation of ERK and activation of ternary complex factor. BMC Mol. Biol. 2009, 10:40.
    • (2009) BMC Mol. Biol. , vol.10 , pp. 40
    • Rössler, O.G.1    Thiel, G.2
  • 58
    • 0015694748 scopus 로고
    • Letter: A new consistent chromosomal abnormality in chronic myelogenous leukaemia identified by quinacrinefluorescence and Giemsa staining
    • Rowley J.D. Letter: A new consistent chromosomal abnormality in chronic myelogenous leukaemia identified by quinacrinefluorescence and Giemsa staining. Nature 1973, 243:290-293.
    • (1973) Nature , vol.243 , pp. 290-293
    • Rowley, J.D.1
  • 59
    • 0029092509 scopus 로고
    • Identification of NAB1, a repressor of NGFI-A- and Krox20-mediated transcription
    • Russo M.W., Sevetson B.R., Milbrandt J. Identification of NAB1, a repressor of NGFI-A- and Krox20-mediated transcription. Proc. Natl. Acad. Sci. USA. 1995, 92:6873-6877.
    • (1995) Proc. Natl. Acad. Sci. USA. , vol.92 , pp. 6873-6877
    • Russo, M.W.1    Sevetson, B.R.2    Milbrandt, J.3
  • 60
    • 0034023246 scopus 로고    scopus 로고
    • Altered molecular response to adrenoreceptor-induced cardiac hypertrophy in Egr-1-deficient mice
    • Saadane N., Alpert L., Chalifour L.E. Altered molecular response to adrenoreceptor-induced cardiac hypertrophy in Egr-1-deficient mice. Am. J. Physiol. Heart Circ. Physiol. 2000, 278:H796-H805.
    • (2000) Am. J. Physiol. Heart Circ. Physiol. , vol.278
    • Saadane, N.1    Alpert, L.2    Chalifour, L.E.3
  • 61
    • 76649115304 scopus 로고    scopus 로고
    • A TGFβ-responsive Gene Signature is Associated with a subset of diffuse Scleroderma with increased disease severity
    • Sargent J.L., Milano A., Bhattacharyya S., Varga J., Connolly M.K., Chang H.W., Whitfield M.L. A TGFβ-responsive Gene Signature is Associated with a subset of diffuse Scleroderma with increased disease severity. J. Inves. Derm. 2009, 2009(130):694-705.
    • (2009) J. Inves. Derm. , vol.2009 , Issue.130 , pp. 694-705
    • Sargent, J.L.1    Milano, A.2    Bhattacharyya, S.3    Varga, J.4    Connolly, M.K.5    Chang, H.W.6    Whitfield, M.L.7
  • 62
    • 40749118892 scopus 로고    scopus 로고
    • A peptide that ameliorates lupus up-regulates the diminished expression of early growth response factors 2 and 3
    • Sela U., Dayan M., Hershkoviz R., Lider O., Mozes E. A peptide that ameliorates lupus up-regulates the diminished expression of early growth response factors 2 and 3. J. Immunol. 2008, 180:1584-1591.
    • (2008) J. Immunol. , vol.180 , pp. 1584-1591
    • Sela, U.1    Dayan, M.2    Hershkoviz, R.3    Lider, O.4    Mozes, E.5
  • 63
    • 33744955345 scopus 로고    scopus 로고
    • NAB2 represses transcription by interacting with the CHD4 subunit of the nucleosome remodeling and deacetylase (NuRD) complex
    • Srinivasan R., Mager G.M., Ward R.M., Mayer J., Svaren J. NAB2 represses transcription by interacting with the CHD4 subunit of the nucleosome remodeling and deacetylase (NuRD) complex. J. Biol. Chem. 2006, 281:15129-15137.
    • (2006) J. Biol. Chem. , vol.281 , pp. 15129-15137
    • Srinivasan, R.1    Mager, G.M.2    Ward, R.M.3    Mayer, J.4    Svaren, J.5
  • 65
    • 0029891229 scopus 로고    scopus 로고
    • NAB2, a corepressor of NGFI-A (Egr-1) and Krox20, is induced by proliferative and differentiative stimuli
    • Svaren J., Sevetson B.R., Apel E.D., Zimonjic D.B., Popescu N.C., Milbrandt J. NAB2, a corepressor of NGFI-A (Egr-1) and Krox20, is induced by proliferative and differentiative stimuli. Mol. Cell. Biol. 1996, 16:3545-3553.
    • (1996) Mol. Cell. Biol. , vol.16 , pp. 3545-3553
    • Svaren, J.1    Sevetson, B.R.2    Apel, E.D.3    Zimonjic, D.B.4    Popescu, N.C.5    Milbrandt, J.6
  • 67
    • 42549130381 scopus 로고    scopus 로고
    • Transcription factor early growth response-1 induction mediates inflammatory gene expression and brain damage following transient focal ischemia
    • Tureyen K., Brooks N., Bowen K., Svaren J., Vemuganti R. Transcription factor early growth response-1 induction mediates inflammatory gene expression and brain damage following transient focal ischemia. J. Neurochem. 2008, 105:1313-1324.
    • (2008) J. Neurochem. , vol.105 , pp. 1313-1324
    • Tureyen, K.1    Brooks, N.2    Bowen, K.3    Svaren, J.4    Vemuganti, R.5
  • 68
    • 11244292291 scopus 로고    scopus 로고
    • Imatinib mesylate blocks a non-Smad TGF-beta pathway and reduces renal fibrogenesis in vivo
    • Wang S., Wilkes M.C., Leof E.B., Hirschberg R. Imatinib mesylate blocks a non-Smad TGF-beta pathway and reduces renal fibrogenesis in vivo. FASEB J. 2005, 19:1-11.
    • (2005) FASEB J. , vol.19 , pp. 1-11
    • Wang, S.1    Wilkes, M.C.2    Leof, E.B.3    Hirschberg, R.4
  • 69
    • 79952037889 scopus 로고    scopus 로고
    • Fibrosis in systemic sclerosis: Emerging concepts and implications for targeted therapy
    • Wei J., Bhattacharyya S., Tourtellotte W.G., Varga J. Fibrosis in systemic sclerosis: Emerging concepts and implications for targeted therapy. Autoimmun. Rev. 2011, 10:267-275.
    • (2011) Autoimmun. Rev. , vol.10 , pp. 267-275
    • Wei, J.1    Bhattacharyya, S.2    Tourtellotte, W.G.3    Varga, J.4
  • 70
    • 33748760321 scopus 로고    scopus 로고
    • Transforming growth factor beta activation of c-Abl is independent of receptor internalization and regulated by phosphatidylinositol 3-kinase and PAK2 in mesenchymal cultures
    • Wilkes M.C., Leof E.B. Transforming growth factor beta activation of c-Abl is independent of receptor internalization and regulated by phosphatidylinositol 3-kinase and PAK2 in mesenchymal cultures. J. Biol. Chem. 2006, 281:27846-27854.
    • (2006) J. Biol. Chem. , vol.281 , pp. 27846-27854
    • Wilkes, M.C.1    Leof, E.B.2
  • 71
    • 51449089944 scopus 로고    scopus 로고
    • In perspective: murine models of scleroderma
    • Wu M., Varga J. In perspective: murine models of scleroderma. Curr. Rheumatol. Rep. 2008, 10:173-182.
    • (2008) Curr. Rheumatol. Rep. , vol.10 , pp. 173-182
    • Wu, M.1    Varga, J.2
  • 72
    • 59649085854 scopus 로고    scopus 로고
    • Rosiglitazone abrogates bleomycin-induced scleroderma and blocks profibrotic responses through peroxisome proliferator-activated receptor-gamma
    • Wu M., Melichian D.S., Chang E., Warner-Blankenship M., Ghosh A.K., Varga J. Rosiglitazone abrogates bleomycin-induced scleroderma and blocks profibrotic responses through peroxisome proliferator-activated receptor-gamma. Am. J. Pathol. 2009, 174:519-533.
    • (2009) Am. J. Pathol. , vol.174 , pp. 519-533
    • Wu, M.1    Melichian, D.S.2    Chang, E.3    Warner-Blankenship, M.4    Ghosh, A.K.5    Varga, J.6
  • 74
    • 77952234615 scopus 로고    scopus 로고
    • Fibrosis under arrest
    • Wynn T.A. Fibrosis under arrest. Nat. Med. 2010, 16:523-525.
    • (2010) Nat. Med. , vol.16 , pp. 523-525
    • Wynn, T.A.1
  • 75
    • 0034533374 scopus 로고    scopus 로고
    • Egr-1, a master switch coordinating upregulation of divergent gene families underlying ischemic stress
    • Yan S.F., Fujita T., Lu J., Okada K., Shan Zou Y., Mackman N., Pinsky D.J., Stern D.M. Egr-1, a master switch coordinating upregulation of divergent gene families underlying ischemic stress. Nat. Med. 2000, 6:1355-1361.
    • (2000) Nat. Med. , vol.6 , pp. 1355-1361
    • Yan, S.F.1    Fujita, T.2    Lu, J.3    Okada, K.4    Shan, Z.Y.5    Mackman, N.6    Pinsky, D.J.7    Stern, D.M.8
  • 76
    • 68449084140 scopus 로고    scopus 로고
    • The fibrotic phenotype induced by IGFBP-5 is regulated by MAPK activation and egr-1-dependent and -independent mechanisms
    • Yasuoka H., Hsu E., Ruiz X.D., Steinman R.A., Choi A.M., Feghali-Bostwick C.A. The fibrotic phenotype induced by IGFBP-5 is regulated by MAPK activation and egr-1-dependent and -independent mechanisms. Am. J. Pathol. 2009, 175:605-615.
    • (2009) Am. J. Pathol. , vol.175 , pp. 605-615
    • Yasuoka, H.1    Hsu, E.2    Ruiz, X.D.3    Steinman, R.A.4    Choi, A.M.5    Feghali-Bostwick, C.A.6
  • 77
    • 3042801241 scopus 로고    scopus 로고
    • Coactivating factors p300 and CBP are transcriptionally crossregulated by Egr1 in prostate cells, leading to divergent responses
    • Yu J., de Belle I., Liang H., Adamson E.D. Coactivating factors p300 and CBP are transcriptionally crossregulated by Egr1 in prostate cells, leading to divergent responses. Mol. Cell 2004, 15:83-94.
    • (2004) Mol. Cell , vol.15 , pp. 83-94
    • Yu, J.1    de Belle, I.2    Liang, H.3    Adamson, E.D.4
  • 78
    • 77952742328 scopus 로고    scopus 로고
    • Positive regulation of the Egr-1/osteopontin positive feedback loop in rat vascular smooth muscle cells by TGF-beta, ERK, JNK, and p38 MAPK signaling
    • Yu H.W., Liu Q.F., Liu G.N. Positive regulation of the Egr-1/osteopontin positive feedback loop in rat vascular smooth muscle cells by TGF-beta, ERK, JNK, and p38 MAPK signaling. Biochem. Biophys. Res. Commun. 2010, 396:451-456.
    • (2010) Biochem. Biophys. Res. Commun. , vol.396 , pp. 451-456
    • Yu, H.W.1    Liu, Q.F.2    Liu, G.N.3
  • 79
    • 53349145748 scopus 로고    scopus 로고
    • Early growth response gene 2 (Egr-2) controls the self-tolerance of T cells and prevents the development of lupuslike autoimmune disease
    • Zhu B., Symonds A.L., Martin J.E., Kioussis D., Wraith D.C., Li S., Wang P. Early growth response gene 2 (Egr-2) controls the self-tolerance of T cells and prevents the development of lupuslike autoimmune disease. J. Exp. Med. 2008, 205:2295-2307.
    • (2008) J. Exp. Med. , vol.205 , pp. 2295-2307
    • Zhu, B.1    Symonds, A.L.2    Martin, J.E.3    Kioussis, D.4    Wraith, D.C.5    Li, S.6    Wang, P.7


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