Interactions between canine RAD51 and full length or truncated BRCA2 BRC repeats

Veterinary Journal

Volumn 190, Issue 2, 2011, Pages 293-295

  Ochiai, K ^a   Yoshikawa, Y ^b   Oonuma, T ^c   Tomioka, Y ^d   Hashizume, K ^e,f   Morimatsu, M ^d  

^a UNIVERSITY OF TOKUSHIMA   (Japan)

^b KITASATO UNIVERSITY   (Japan)

^c EHIME UNIVERSITY   (Japan)

^d HOKKAIDO UNIVERSITY   (Japan)

^e IWATE UNIVERSITY   (Japan)

^f GIFU UNIVERSITY   (Japan)

Author keywords

BRCA2; Canine; RAD51

Indexed keywords

BRCA2 PROTEIN; RAD51 PROTEIN;

ARTICLE; BRC REPEAT; BREAST CANCER; CANCER RISK; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; DNA STRUCTURE; DOG; GENE DELETION; MISSENSE MUTATION; MUTANT; NONHUMAN; PROTEIN BINDING; PROTEIN INTERACTION; SEQUENCE HOMOLOGY; SINGLE NUCLEOTIDE POLYMORPHISM; TUMOR SUPPRESSOR GENE;

ANIMALS; BRCA2 PROTEIN; DOG DISEASES; DOGS; FEMALE; GENES, BRCA2; MAMMARY NEOPLASMS, ANIMAL; MUTATION, MISSENSE; RAD51 RECOMBINASE; TERMINAL REPEAT SEQUENCES;

MAMMALIA;

EID: 79958107701     PISSN: 10900233     EISSN: 15322971     Source Type: Journal    
DOI: 10.1016/j.tvjl.2010.11.001     Document Type: Article

References (10)

1. Arai M., Utsunomiya J., Miki Y. Familial breast and ovarian cancers. International Journal of Clinical Oncology 2004, 9:270-282.
2. Bignell G., Micklem G., Stratton M.R., Ashworth A., Wooster R. The BRC repeats are conserved in mammalian BRCA2 proteins. Human Molecular Genetics 1997, 6:53-58.
3. Hsu W.L., Huang Y.H., Chang T.J., Wong M.L., Chang S.C. Single nucleotide variation in exon 11 of canine BRCA2 in healthy and cancerous mammary tissue. The Veterinary Journal 2010, 184:351-356.
4. Jensen R.B., Carreira A., Kowalczykowski S.C. Purified human BRCA2 stimulates RAD51-mediated recombination. Nature 2010, 467:678-683.
5. Lo T., Pellegrini L., Venkitaraman A.R., Blundell T.L. Sequence fingerprints in BRCA2 and RAD51: implications for DNA repair and cancer. DNA Repair 2003, 2:1015-1028.
6. Moynahan M.E., Jasin M. Mitotic homologous recombination maintains genomic stability and suppresses tumorigenesis. Nature Reviews Molecular Cell Biology 2010, 11:196-207.
7. Ochiai K., Morimatsu M., Tomizawa N., Syuto B. Cloning and sequencing full length of canine Brca2 and Rad51 cDNA. Journal of Veterinary Medical Science 2001, 63:1103-1108.
8. Ochiai K., Morimatsu M., Yoshikawa Y., Syuto B., Hashizume K. Brca2 C-terminus interacts with Rad51 and contributes to nuclear focus formation in double-strand break repair of DNA. Biomedical Research (Tokyo) 2004, 25:269-275.
9. Rivera P., Melin M., Biagi T., Fall T., Haggstrom J., Lindblad-Toh K., von Euler H. Mammary tumor development in dogs is associated with BRCA1 and BRCA2. Cancer Research 2009, 69:8770-8774.
10. Yoshikawa Y., Morimatsu M., Ochiai K., Nagano M., Tomioka Y., Sasaki N., Hashizume K., Iwanaga T. Novel variations and loss of heterozygosity of BRCA2 identified in a dog with mammary tumors. American Journal of Veterinary Research 2008, 69:1323-1328.