Nanomechanical analysis of insulinoma cells after glucose and capsaicin stimulation using atomic force microscopy

Acta Pharmacologica Sinica

Volumn 32, Issue 6, 2011, Pages 853-860

  Yang, Rui Guo ^a   Xi, Ning ^a   Lai, King Wai Chiu ^a   Zhong, Bei Hua ^b,c   Fung, Carmen Kar Man ^a   Qu, Chen Geng ^a   Wang, Donna H ^b,d  

^a Michigan State University   (United States)

^b MICHIGAN STATE UNIVERSITY   (United States)

^c GUANGZHOU MEDICAL UNIVERSITY   (China)

^d MICHIGAN STATE UNIVERSITY   (United States)

Author keywords

AFM nanoindentation; capsaicin; cellular height; cellular stiffness; glucose; insulin secretion

Indexed keywords

CAPSAICIN; GLUCOSE; INSULIN; ION CHANNEL; VANILLOID RECEPTOR 1;

ANIMAL CELL; ATOMIC FORCE MICROSCOPY; BIOLOGICAL ACTIVITY; CELL LINE; CELL MEMBRANE POTENTIAL; CELL SIZE; CELL STIFFNESS; CELL STIMULATION; CELL STRAIN ATCC; CELL STRUCTURE; CELLULAR PARAMETERS; CONFERENCE PAPER; CONTROLLED STUDY; DOSE RESPONSE; DRUG MECHANISM; INSULIN RELEASE; INSULINOMA; MOLECULAR MECHANICS; NONHUMAN; PANCREAS ISLET BETA CELL; RAT; STIMULUS SECRETION COUPLING;

ANIMALS; BIOMECHANICS; CAPSAICIN; CELL LINE, TUMOR; CELL MEMBRANE; CELL SIZE; CYTOSKELETON; DOSE-RESPONSE RELATIONSHIP, DRUG; GLUCOSE; INSULIN-SECRETING CELLS; MEMBRANE POTENTIALS; MICROSCOPY, ATOMIC FORCE; TRPV CATION CHANNELS;

EID: 79958102435     PISSN: 16714083     EISSN: 17457254     Source Type: Journal    
DOI: 10.1038/aps.2011.56     Document Type: Conference Paper

References (21)

1. Leung YM, Ahmed I, Sheu L, Tsushima RG, Diamant NE, Hara M, et al. Electrophysiological characterization of pancreatic islet cells in the mouse insulin promoter-green fluorescent protein mouse. Endocrinology 2005;146:4766-75. (Pubitemid 41446614)
2. 2+ signals and insulin secretion in pancreatic beta-cell. Cell Calcium 2006;39:155-62. (Pubitemid 43013847)
3. Nilius B, Owsianik G, Voets T, Peters JA. Transient receptor potential cation channels in disease. Physiol Rev 2007;87:165-217. (Pubitemid 46207713)
4. Karlsson S, Scheurink AJ, Steffens AB, Ahren B. Involvement of capsaicin-sensitive nerves in regulation of insulin secretion and glucose tolerance in conscious mice. Am J Physiol 1994;267: R1071-7.
5. Akiba Y, Kato S, Katsube K, Nakamura M, Takeuchi K, Ishii H, et al. Transient receptor potential vanilloid subfamily 1 expressed in pancreatic islet beta cells modulates insulin secretion in rats. Biochem Biophys Res Commun 2004;321:219-25. (Pubitemid 39055627)
6. Lundbaek JA, Birn P, Girshman J, Hansen AJ, Andersen OS. Membrane stiffness and channel function. Biochemistry 1996;35:3825-30. (Pubitemid 26102173)
7. + channel regulation. Kidney Int 1995;48:970-84.
8. Lundbaek JA, Andersen OS. Spring constants for channel-induced lipid bilayer deformations estimates using gramicidin channels. Biophys J 1999;76:889-95. (Pubitemid 29264568)
9. Lim CT, Zhou EH, Quek ST. Mechanical models for living cells - A review. J Biomech 2006;39:195-216. (Pubitemid 41728994)
10. Touhami A, Nysten B, Dufrene YF. Nanoscale mapping of the elasticity of microbial cells by atomic force microscopy. Langmuir 2003;19:4539-43.
11. Pelling AE, Veraitch FS, Chu CP, Mason C, Horton MA. Mechanical dynamics of single cells during early apoptosis. Cell Motil Cytoskeleton 2009;66:409-22.
12. Cross SE, Jin YS, Rao J, Gimzewski JK. Nanomechanical analysis of cells from cancer patients. Nat Nanotechnol 2007;2:780-3. (Pubitemid 350223349)
13. Fung C K M, Seiffert-Sinha K, Lai K W C, Yang RG, Panyard D, Zhang JB, et al. Investigation of human keratinocyte cell adhesion using atomic force microscopy. Nanomedicine 2010;6:191-200.
14. Hammerick KE, Huang Z, Sun N, Lam MT, Prinz FB, Wu JC, et al. Elastic properties of induced pluripotent stem cells. Tissue Eng Part A 2011;17:495-502.
15. Henquin JC. Triggering and amplifying pathways of regulation of insulin secretion by glucose. Diabetes 2000;49:1751-60.
16. Malaisse WJ, Sener A, Koser M, Ravazzola M, Malaisse-Lagae F. The stimulus-secretion coupling of glucose-induced insulin release due to glycogenolysis in glucose-deprived islets. Biochem J 1977;164:447-54. (Pubitemid 8105683)
17. Henquin JC, Meissner HP. Significance of ionic fluxes and changes in membrane potential for stimulus-secretion coupling in pancreatic B-cells. Experientia 1984;40:1043-52. (Pubitemid 15147090)
18. Schmidt PT, Tornoe K, Poulsen SS, Rasmussen TN, Holst JJ. Tachykinins in the porcine pancreas: potent exocrine and endocrine effects via NK-1 receptors. Pancreas 2000;20:241-7. (Pubitemid 30171776)
19. Kilpatrick DL. Ion channels and membrane potential in stimulussecretion coupling in adrenal paraneurons. Can J Physiol Pharmacol 1984;62:477-83. (Pubitemid 14083677)
20. Ammala C, Kane C, Cosgrove KE, Chapman JC, Aynsley-Green A, Lindley KJ, et al. Characterization of ion channels in stimulussecretion coupling in pancreatic islets. Digestion 1997;58:81-5. (Pubitemid 27315654)
21. Petersen OH. Stimulus-secretion coupling: cytoplasmic calcium signals and the control of ion channels in exocrine acinar cells. J Physiol 1992;448:1-51.