Function and pharmacology of spinally-projecting sympathetic pre-autonomic neurones in the paraventricular nucleus of the hypothalamus

Current Neuropharmacology

Volumn 9, Issue 2, 2011, Pages 262-277

  Nunn, Nicolas ^a   Womack, Matthew ^a   Dart, Caroline ^a   Barrett Jolley, Richard ^a  

^a UNIVERSITY OF LIVERPOOL   (United Kingdom)

Author keywords

Angiotensin; Blood pressure; Cardiovascular; GABA; Hypothalamus; Neuropeptides; Oxytocin; Paraventricular nucleus; Parvocellular mediocellular; Penile erection; Pharmacology; PVN; Substance P; Sympathetic; Tachykinin; Vasopressin

Indexed keywords

2 AMINO 5 PHOSPHONOVALERIC ACID; 4 AMINOBUTYRIC ACID; 4 AMINOBUTYRIC ACID A RECEPTOR; 6 NITRO 7 SULFAMOYLBENZO[F]QUINOXALINE 2,3 DIONE; AMPA RECEPTOR ANTAGONIST; ANGIOTENSIN; ANGIOTENSIN II; ATRIAL NATRIURETIC FACTOR; CORTICOTROPIN RELEASING FACTOR; DOPAMINE; DYNORPHIN; GLUTAMIC ACID; LEPTIN; LEU ENKEPHANLIN; METENDORPHIN; METENKEPHALIN; NEUROPEPTIDE; NEUROTRANSMITTER; NITRIC OXIDE; OXYTOCIN; PITUITARY ADENYLCYCLASE ACTIVATING PEPTIDE; PLASMA PROTEIN; PURINERGIC RECEPTOR; SOMATOSTATIN; SUBSTANCE P; TACHYKININ DERIVATIVE; UNCLASSIFIED DRUG; VASOCTIVE INTESTINAL PEPTIDE; VASOPRESSIN;

ARTICLE; AUTONOMIC NERVE; BLOOD GLUCOSE MONITORING; BLOOD VOLUME; BODY FAT; CARDIOVASCULAR FUNCTION; CAT; CIRCADIAN RHYTHM; DRUG TARGETING; HEART FAILURE; HUMAN; HYPOTHALAMIC PARAVENTRICULAR NUCLEUS; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION; IN VITRO STUDY; IN VIVO STUDY; NERVOUS SYSTEM ELECTROPHYSIOLOGY; NEUROPHARMACOLOGY; NEUROTRANSMISSION; NONHUMAN; PENIS ERECTION; POTASSIUM CONDUCTANCE; PROTEIN EXPRESSION; SPINALLY PROJECTING SYMPATHETIC PREAUTONOMIC NEURON; STRESS; SYMPATHETIC TONE; THERMOREGULATION;

EID: 79958101905     PISSN: 1570159X     EISSN: 18756190     Source Type: Journal    
DOI: 10.2174/157015911795596531     Document Type: Article

References (227)

1. Swanson, L.W., Sawchenko, P.E., Wiegand, S.J., Price, J.L. Separate neurons in the paraventricular nucleus project to the median-eminence and to the medulla or spinal-cord. Brain Res., 1980, 198, 190-195.
2. Palkovits, M. Interconnections between the neuroendocrine hypothalamus and the central autonomic system. Front. Neuroendocrinol., 1999, 20, 270-295.
3. Swanson, L., Kuypers, H. The paraventricular nucleus of the hypothalamus: Cytoarchitectonic subdivisions and organization of projections to the pituitary, dorsal vagal complex, and spinal cord as demonstrated by retrograde fluorescence double-labeling methods. J. Comp. Neurol., 1980, 194, 555-570.
4. Swanson, L.W., Sawchenko, P.E. Hypothalamic integration-organization of the paraventricular and supraoptic nuclei. Ann. Rev. Neurosci., 1983, 6, 269-324.
5. Herman, J.P., Cullinan, W.E. Neurocircuitry of stress: Central control of the hypothalamo-pituitary-adrenocortical axis. Trends Neurosci., 1997, 20, 78-84.
6. Loewy, A. Forebrain nuclei involved in autonomic control. Prog. Brain Res., 1991, 87, 253.
7. Coote, J.H. Landmarks in understanding the central nervous control of the cardiovascular system. Exp. Physiol., 2007, 92, 3-18.
8. Dampney, R.A. Functional organization of central pathways regulating the cardiovascular system. Physiol. Rev., 1994, 74, 323-364.
9. Spyer, K.M. Annual-review prize lecture-central nervous mechanisms contributing to cardiovascular control. J. Physiol-(London), 1994, 474, 1-19.
10. Hilton, S.M. The defense-arousal system and its relevance for circulatory and respiratory control. J. Exp. Biol., 1982, 100, 159-174.
11. Cannon, W.B. Bodily changes in pain, hunger, fear and rage. 2nd ed Appleton, New York, 1929.
12. Mittleman, M.A., Maclure, M., Tofler, G.H., Sherwood, J.B., Goldberg, R.J., Muller, J.E. Triggering of acute myocardialinfarction by heavy physical exertion-protection against triggering by regular exertion. N. Engl. J. Med., 1993, 329, 1677-1683.
13. Mittleman, M.A., Maclure, M., Sherwood, J.B., Mulry, R.P., Tofler, G.H., Jacobs, S.C., Friedman, R., Benson, H., Muller, J.E. Triggering of acute myocardial-infarction onset by episodes of anger. Circulation, 1995, 92, 1720-1725.
14. Leor, J., Poole, W.K., Kloner, R.A. Sudden cardiac death triggered by an earthquake. New Engl. J.Med., 1996, 334, 413-419.
15. Patel, K.P. Role of paraventricular nucleus in mediating sympathetic outflow in heart failure. Heart Fail.Rev., 2000, V5, 73-86.
16. Woodworth, R., Sherrington, C. A pseudaffective reflex and its spinal path. J. Physiol., 1904, 31, 234.
17. Bard, P. A diencephalic mechanism for the expression of rage with special reference to the sympathetic nervous system. Am. J. Physiol., 1928, 84, 490.
18. Bard, P. Anatomical organization of central nervous system in relation to control of heart and blood vessels. Physiol. Rev., 1961, 40, 3-26.
19. Keller, A.D. Ablation and stimulation of hypothalamus-circulatory effects. Physiol. Rev., 1961, 40, 116-120.
20. Delgado, J. Circulatory effects of cortical stimulation. Physiol. Rev., Suppl., 1960, 4, 146.
21. Kiss, J., Martos, J., Palkovits, M. Hypothalamic paraventricular nucleus: A quantitative analysis of cytoarchitectonic subdivisions in the rat. J. Comp. Neurol., 1991, 313, 563-573.
22. Koutcherov, Y., Mai, J., Ashwell, K., Paxinos, G. Organization of the human paraventricular hypothalamic nucleus. J. Comp. Neurol., 2000, 423, 299-318.
23. Shafton, A., Ryan, A., Badoer, E. Neurons in the hypothalamic paraventricular nucleus send collaterals to the spinal cord and to the rostral ventrolateral medulla in the rat. Brain Res., 1998, 801, 239-243.
24. Lovick, T., Malpas, S., Mahony, M. Renal vasodilatation in response to acute volume load is attenuated following lesions of parvocellular neurones in the paraventricular nucleus in rats. J. Auton. Nerv. Syst., 1993, 43, 247-255.
25. Pyner, S., Coote, J. Identification of branching paraventricular neurons of the hypothalamus that project to the rostroventrolateral medulla and spinal cord. Neuroscience, 2000, 100, 549-556.
26. Motawei, K., Pyner, S., Ranson, R.N., Kamel, M., Coote, J.H. Terminals of paraventricular spinal neurones are closely associated with adrenal medullary sympathetic preganglionic neurones: Immunocytochemical evidence for vasopressin as a possible neurotransmitter in this pathway. Exp. Brain Res., 1999, 126, 68-76.
27. Ranson, R.N., Motawei, K., Pyner, S., Coote, J.H. The paraventricular nucleus of the hypothalamus sends efferents to the spinal cord of the rat that closely appose sympathetic preganglionic neurones projecting to the stellate ganglion. Exp. Brain Res., 1998, 120, 164-172.
28. Coote, J.H. Cardiovascular function of the paraventricular nucleus of the hypothalamus. Biol. Signals, 1995, 4, 142-149.
29. Badoer, E. Cardiovascular role of parvocellular neurons in the paraventricular nucleus of the hypothalamus. News Physiol. Sci., 1996, 11, 43-47.
30. Pyner, S. Neurochemistry of the paraventricular nucleus of the hypothalamus: Implications for cardiovascular regulation. J. Chem. Neuroanat., 2009, 38, 197-208.
31. Cui, L.N., Coderre, E., Renaud, L.P. Glutamate and gaba mediate suprachiasmatic nucleus inputs to spinal-projecting paraventricular neurons. Am. J. Physiol-Regul. Integr. Comp. Physiol., 2001, 281, R1283-R1289.
32. Jansen, A.S., Nguyen, X.V., Karpitskiy, V., Mettenleiter, T.C., Loewy, A.D. Central command neurons of the sympathetic nervous system: Basis of the fight-or-flight response. Science, 1995, 270, 644-646.
33. Ferguson, D.W., Berg, W.J., Sanders, J.S. Clinical and hemodynamic correlates of sympathetic-nerve activity in normal humans and patients with heart-failure-evidence from direct microneurographic recordings. J. Am. Coll. Cardiol., 1990, 16, 1125-1134.
34. Vahid-Ansari, F., Leenen, F.H.H. Pattern of neuronal activation in rats with chf after myocardial infarction. Am. J. Physiol. Heart Circ. Physiol., 1998, 44, H2140-H2146.
35. Zhang, K., Li, Y.F., Patel, K.P. Reduced endogenous gabamediated inhibition in the pvn on renal nerve discharge in rats with heart failure. Am. J. Physiol. Regul. Integ. Comp. Physiol., 2002, 282, R1006-R1015.
36. Li, Y.F., Patel, K.P. Paraventricular nucleus of the hypothalamus and elevated sympathetic activity in heart failure: The altered inhibitory mechanisms. Acta Physiol. Scand., 2003, 177, 17-26.
37. Hoffman, N.W., Tasker, J.G., Dudek, F.E. Immunohistochemical differentiation of electrophysiologically defined neuronal populations in the region of the rat hypothalamic paraventricular nucleus. J. Comp. Neurol., 1991, 307, 405-416.
38. Tasker, J.G., Dudek, F.E. Local inhibitory synaptic inputs to neurones of the paraventricular nucleus in slices of rat hypothalamus. J. Physiol. (Lond), 1993, 469, 179-192.
39. Luther, J.A., Halmos, K.C., Tasker, J.G. A slow transient potassium current expressed in a subset of neurosecretory neurons of the hypothalamic paraventricular nucleus. J. Neurophysiol., 2000, 84, 1814-1825.
40. Luther, J.A., Tasker, J.G. Voltage-gated currents distinguish parvocellular from magnocellular neurones in the rat hypothalamic paraventricular nucleus. J. Physiol-London, 2000, 523, 193-209.
41. Stern, J.E. Electrophysiological and morphological properties of pre-autonomic neurones in the rat hypothalamic paraventricular nucleus. J. Physiol-London, 2001, 537, 161-177.
42. Sonner, P.M., Stern, J.E. Role of a-type potassium currents on the excitability and firing activity of rvlm-projecting pvn neurons. FASEB J., 2005, 19, A599-A599.
43. Barrett-Jolley, R., Pyner, S., Coote, J.H. Measurement of voltagegated potassium currents in identified spinally-projecting sympathetic neurones of the paraventricular nucleus. J. Neurosci. Methods, 2000, 102, 25-33.
44. Lewis, R., Mills, A.F., Barrett-Jolley, R. Models of paraventricular nucleus (pvn) sympathetic neurone modulation by glucose and hypoglycaemia. Biophys. J., 2010, 98, 140a-140a.
45. Li, D.P., Chen, S.R., Pan, H.L. Adenosine inhibits paraventricular pre-sympathetic neurons through atp-dependent potassium channels. J. Neurochem., 2010, 113, 530-542.
46. Lesage, F. Pharmacology of neuronal background potassium channels. Neuropharmacology, 2003, 44, 1-7.
47. Kirsch, G.E., Narahashi, T. 3, 4-diaminopyridine-potent new potassium channel blocker. Biophys. J., 1978, 22, 507-512.
48. Jan, L.Y., Jan, Y.N. Annual review prize lecture-voltage-gated and inwardly rectifying potassium channels. J. Physiol-London, 1997, 505, 267-282.
49. Garcia, M.L., Galvez, A., Garciacalvo, M., King, V.F., Vazquez, J., Kaczorowski, G.J. Use of toxins to study potassium channels. J. Bioenerg. Biomembr., 1991, 23, 615-646.
50. Edwards, G., Weston, A.H. The pharmacology of atp-sensitive potassium channels. Ann. Rev. Pharmacol. Toxicol., 1993, 33, 597-637.
51. Choi, K.L., Aldrich, R.W., Yellen, G. Tetraethylammonium blockade distinguishes 2 inactivation mechanisms in voltageactivated k+ channels. Proc. Natl. Acad. Sci. USA, 1991, 88, 5092-5095.
52. Candia, S., Garcia, M.L., Latorre, R. Mode of action of iberiotoxin, a potent blocker of the large conductance ca-2+-activated k+ channel. Biophys. J., 1992, 63, 583-590.
53. Barrett-Jolley, R., Dart, C., Standen, N.B. Direct block of native and cloned (kir2.1) inward rectifier k+ channels by chloroethylclonidine. Br. J. Pharmacol., 1999, 128, 760-766.
54. Womack, M.D., Morris, R., Gent, T.C., Barrett-Jolley, R. Substance p targets sympathetic control neurons in the paraventricular nucleus. Circ. Res., 2007, 100, 1650-1658.
55. Badoer, E., Ng, C.W., De Matteo, R. Tonic sympathoinhibition arising from the hypothalamic pvn in the conscious rabbit. Brain Res., 2002, 947, 17-24.
56. Martin, D., Haywood, J. Hemodynamic responses to paraventricular nucleus disinhibition with bicuculline in conscious rats. Am. J. Physiol. Heart Circ. Physiol., 1993, 265, H1727.
57. Martin, D.S., Segura, T., Haywood, J.R. Cardiovascular responses to bicuculline in the paraventricular nucleus of the rat. Hypertension, 1991, 18, 48-55.
58. Park, J.B., Stern, J.E. A tonic, gabaa receptor-mediated inhibitory postsynaptic current restrains firing activity in preautonomic and magnocellular neuroendocrine neurons of the paraventricular nucleus of the hypothalamus (pvn). FASEB J., 2005, 19, A599-A599.
59. Hallbeck, M., Blomqvist, A. Spinal cord-projecting vasopressinergic neurons in the rat paraventricular hypothalamus. J. Comp. Neurol., 1999, 411, 201-211.
60. Hallbeck, M., Larhammar, D., Blomqvist, A. Neuropeptide expression in rat paraventricular hypothalamic neurons that project to the spinal cord. J. Comp. Neurol., 2001, 433, 222-238.
61. Hallbeck, M. Dynorphin mrna-expressing neurons in the rat paraventricular hypothalamic nucleus project to the spinal cord. Neurosci. Lett., 2000, 285, 161-164.
62. Cechetto, D.F., Saper, C.B. Neurochemical organization of the hypothalamic projection to the spinal-cord in the rat. J. Comp. Neurol., 1988, 272, 579-604.
63. Jansen, A.S.P., Wessendorf, M.W., Loewy, A.D. Transneuronal labeling of cns neuropeptide and monoamine neurons after pseudorabies virus injections into the stellate ganglion. Brain Res., 1995, 683, 1-24.
64. Sawchenko, P.E., Swanson, L.W. Immunohistochemical identification of neurons in the paraventricular nucleus of the hypothalamus that project to the medulla or to the spinal-cord in the rat. J. Comp. Neurol., 1982, 205, 260-272.
65. Strack, A.M., Sawyer, W.B., Platt, K.B., Loewy, A.D. Cns cell groups regulating the sympathetic outflow to adrenal-gland as revealed by trans-neuronal cell body labeling with pseudorabies virus. Brain Res., 1989, 491, 274-296.
66. Xi, D., Kusano, K., Gainer, H. Quantitative analysis of oxytocin and vasopressin messenger ribonucleic acids in single magnocellular neurons isolated from supraoptic nucleus of rat hypothalamus. Endocrinology, 1999, 140, 4677-4682.
67. Malpas, S.C., Coote, J.H. Role of vasopressin in sympathetic response to paraventricular nucleus stimulation in anesthetized rats. Am. J. Physiol. Regul. Integr. Comp. Physiol., 1994, 266, R228-R236.
68. Sermasi, E., Coote, J.H. Oxytocin acts at v-1 receptors to excite sympathetic preganglionic neurons in neonate rat spinal-cord invitro. Brain Res., 1994, 647, 323-332.
69. Pittman, Q., Riphagen, C., Lederis, K. Release of immunoassayable neurohypophyseal peptides from rat spinal cord, in vivo. Brain Res., 1984, 300, 321-326.
70. Yang, Z., Han, D.D., Coote, J.H. Cardiac sympatho-excitatory action of pvn-spinal oxytocin neurones. Auton. Neurosci-Basic Clin., 2009, 147, 80-85.
71. Gladwell, S.J., Coote, J.H. Inhibitory and indirect excitatory effects of dopamine on sympathetic preganglionic neurones in the neonatal rat spinal cord in vitro. Brain Res., 1999, 818, 397-407.
72. Gladwell, S.J., Coote, J.H. Fast excitatory post synaptic potentials and their response to catecholaminergic antagonists in rat sympathetic preganglionic neurones in vitro. Neurosci. Lett., 1999, 268, 89-92.
73. Gladwell, S.J., Pyner, S., Barnes, N.M., Coote, J.H. D-1-like dopamine receptors on retrogradely labelled sympathoadrenal neurones in the thoracic spinal cord of the rat. Exp. Brain Res., 1999, 128, 377-382.
74. Lahlou, S. Mechanisms underlying the cardiovascular responses to spinal dopamine receptor stimulation by apomorphine in anesthetized rats. Neurosci. Lett., 2003, 335, 187-191.
75. Yang, Z., Wheatley, M., Coote, J.H. Neuropeptides, amines and amino acids as mediators of the sympathetic effects of paraventricular nucleus activation in the rat. Exp. Physiol., 2002, 87, 663-674.
76. Gwyn, P., Logan, S.D. Direct actions of l-enkephalin on neonatal rat sympathetic preganglionic neurones via delta opioid receptors in vitro. Br. J. Pharmacol., 1997, 122, 350P.
77. Lewis, D.I., Coote, J.H. Angiotensin-ii in the spinal-cord of the rat and its sympathoexcitatory effects. Brain Res., 1993, 614, 1-9.
78. Suter, C., Coote, J.H. Intrathecally administered angiotensin-ii increases sympathetic activity in the rat. J. Auton. Nervous Syst., 1987, 19, 31-37.
79. Llewellyn-Smith, I.J., DiCarlo, S.E., Collins, H.L., Keast, J.R. Enkephalin-immunoreactive interneurons extensively innervate sympathetic preganglionic neurons regulating the pelvic viscera. J. Comp. Neurol., 2005, 488, 278-289.
80. Macdonald, R.L., Olsen, R.W. Gaba(a) receptor channels. Ann. Rev. Neurosci., 1994, 17, 569-602.
81. Watkins, N.D., Cork, S.C., Pyner, S. An immunohistochemical investigation of the relationship between neuronal nitric oxide synthase, gaba and presympathetic paraventricular neurons in the hypothalamus. Neuroscience, 2009, 159, 1079-1088.
82. Kalsbeek, A., Fliers, E., Franke, A.N., Wortel, J., Buijs, R.M. Functional connections between the suprachiasmatic nucleus and the thyroid gland as revealed by lesioning and viral tracing techniques in the rat. Endocrinology, 2000, 141, 3832-3841.
83. Kalsbeek, A., La Fleur, S., Van Heijningen, C., Buijs, R.M. Suprachiasmatic gabaergic inputs to the paraventricular nucleus control plasma glucose concentrations in the rat via sympathetic innervation of the liver. J. Neurosci., 2004, 24, 7604-7613.
84. la Fleur, S.E., Kalsbeek, A., Wortel, J., Buijs, R.M. Polysynaptic neural pathways between the hypothalamus, including the suprachiasmatic nucleus, and the liver. Brain Res., 2000, 871, 50-56.
85. Yamashita, H., Inenaga, K., Koizumi, K. Possible projections from regions of paraventricular and supraoptic nuclei to the spinal-cord-electrophysiological studies. Brain Res., 1984, 296, 373-378.
86. Kannan, H., Hayashida, Y., Yamashita, H. Increase in sympathetic outflow by paraventricular nucleus stimulation in awake rats. Am. J. Physiol., 1989, 256, R1325-R1330.
87. Li, Y.F., Jackson, K.L., Stern, J.E., Rabeler, B., Patel, K.P. Interaction between glutamate and gaba systems in the integration of sympathetic outflow by the paraventricular nucleus of the hypothalamus. Am. J. Physiol. Heart Circ. Physiol., 2006, 291, H2847-H2856.
88. Brickley, S.G., CullCandy, S.G., Farrant, M. Development of a tonic form of synaptic inhibition in rat cerebellar granule cells resulting from persistent activation of gaba(a) receptors. J. Physiol-Lond, 1996, 497, 753-759.
89. Farrant, M., Nusser, Z. Variations on an inhibitory theme: Phasic and tonic activation of gaba(a) receptors. Nat. Rev. Neurosci., 2005, 6, 215-229.
90. Glykys, J., Mann, E.O., Mody, I. Which gaba(a) receptor subunits are necessary for tonic inhibition in the hippocampus? J. Neurosci., 2008, 28, 1421-1426.
91. Semyanov, A., Walker, M.C., Kullmann, D.M., Silver, R.A. Tonically active gaba(a) receptors: Modulating gain and maintaining the tone. Trends Neurosci., 2004, 27, 262-269.
92. Jia, F., Yue, M., Chandra, D., Keramidas, A., Goldstein, P.A., Homanics, G.E., Harrison, N.L. Taurine is a potent activator of extrasynaptic gaba(a) receptors in the thalamus. J. Neurosci., 2008, 28, 106-115.
93. Mody, I., Glykys, J., Wei, W.Z. A new meaning for "Gin & tonic": Tonic inhibition as the target for ethanol action in the brain. Alcohol, 2007, 41, 145-153.
94. Park, J.B., Jo, J.Y., Zheng, H., Patel, K.P., Stern, J.E. Regulation of tonic gaba inhibitory function, presympathetic neuronal activity and sympathetic outflow from the paraventricular nucleus by astroglial gaba transporters. J. Physiol. London, 2009, 587, 4645-4660.
95. Schlenker, E., Barnes, L., Hansen, S., Martin, D. Cardiorespiratory and metabolic responses to injection of bicuculline into the hypothalamic paraventricular nucleus (pvn) of conscious rats. Brain Res., 2001, 895, 33-40.
96. Barrett-Jolley, R. Nipecotic acid directly activates gaba(a)-like ion channels. Br. J. Pharmacol., 2001, 133, 673-678.
97. Boudaba, C., Szabo, K., Tasker, J.G. Physiological mapping of local inhibitory inputs to the hypothalamic paraventricular nucleus. J. Neurosci., 1996, 16, 7151-7160.
98. Fenelon, V.S., Sieghart, W., Herbison, A.E. Cellular localization and differential distribution of gabaa receptor subunit proteins and messenger rnas within hypothalamic magnocellular neurons. Neurosci., 1995, 64, 1129-1143.
99. Hermes, M.L., Coderre, E.M., Buijs, R.M., Renaud, L.P. (Gaba and glutamate mediate rapid neurotransmission from suprachiasmatic nucleus to hypothalamic paraventricular nucleus in rat. J. Physiol.(Lond), 1996, 496(Pt 3), 749-757.
100. Zaki, A., Barrett-Jolley, R. Rapid neuromodulation by cortisol in the rat paraventricular nucleus: An in vitro study. Br. J. Pharmacol., 2002, 137, 87-97.
101. Fritschy, J.M., Mohler, H. Gaba(a)-receptor heterogeneity in the adult-rat brain-differential regional and cellular-distribution of 7 major subunits. J. Comp. Neurol., 1995, 359, 154-194.
102. Barrett-Jolley, R., Pyner, S. Inhibition of rat spinally projecting pvn neurones by the neurosteroid tetrahydroxycorticosterone. J. Physiol. London, 2003, 548 P.
103. Womack, M.D., Pyner, S., Barrett-Jolley, R. Inhibition by [alpha]-tetrahydrodeoxycorticosterone (thdoc) of pre-sympathetic parvocellular neurones in the paraventricular nucleus of rat hypothalamus. Br. J. Pharmacol., 2006, 149, 600-607.
104. Li, D.P., Chen, S.R., Pan, H.L. Nitric oxide inhibits spinally projecting paraventricular neurons through potentiation of presynaptic gaba release. J. Neurophysiol., 2002, 88, 2664-2674.
105. Chen, Q., Pan, H.L. Regulation of synaptic input to hypothalamic presympathetic neurons by gaba(b) receptors. Neuroscience, 2006, 142, 595-606.
106. Khawaled, R., Bruening-Wright, A., Adelman, J., Maylie, J. Bicuculline block of small-conductance calcium-activated potassium channels. Pflügers Archiv. Eur. J. Physiol., 1999, 438, 314-321.
107. Strobaek, D., Jorgensen, T.D., Christophersen, P., Ahring, P.K., Olesen, S.P. Pharmacological characterization of smallconductance ca2+-activated k+ channels stably expressed in hek 293 cells. Br. J. Pharmacol., 2000, 129, 991-999.
108. Druzin, M., Haage, D., Johansson, S. Bicuculline free base blocks voltage-activated k+ currents in rat medial preoptic neurons. Neuropharmacology, 2004, 46, 285-295.
109. Stern, J.E., Li, Y.J., Sonner, P. Nitric oxide modulates firing activity of preautonomic neurons in the paraventricular nucleus (pvn) of the hypothalamus. FASEB J., 2002, 16, A501-A501.
110. Stern, J.E., Zhang, W. Preautonomic neurons in the paraventricular nucleus of the hypothalamus contain estrogen receptor beta. Brain Res., 2003, 975, 99-109.
111. Zhang, W.F., Stern, J.E. Preautonomic neurons in the paraventricular nucleus (pvn) of the hypothalamus express estrogen receptor-b immunoreactivity. FASEB J., 2002, 16, A501-A501.
112. Badoer, E., Ryan, A. Effects of leptin on spinally projecting neurons in the pvn of the hypothalamus. Brain Res., 1999, 844, 210-215.
113. Oldfield, B.J., Davern, P.J., Giles, M.E., Allen, A.M., Badoer, E., McKinley, M.J. Efferent neural projections of angiotensin receptor (at1) expressing neurones in the hypothalamic paraventricular nucleus of the rat. J. Neuroendocrinol., 2001, 13, 139-146.
114. Li, D.P., Chen, S.R., Pan, H.L. Angiotensin ii stimulates spinally projecting paraventricular neurons through presynaptic disinhibition. J. Neurosci., 2003, 23, 5041-5049.
115. Price, C.J., Samson, W.K., Ferguson, A.V. Neuropeptide w has cell phenotype-specific effects on the excitability of different subpopulations of paraventricular nucleus neurones. J. Neuroendocrinol., 2009, 21, 850-857.
116. Lind, R.W., Swanson, L.W., Bruhn, T.O., Ganten, D. The distribution of angiotensin-ii-immunoreactive cells and fibers in the paraventriculo-hypophysial system of the rat. Brain Res., 1985, 338, 81-89.
117. Alexander, S.P.H., Mathie, A., Peters, J.A. Guide to receptors and channels (grac), 3rd edition. Br. J. Pharmacol., 2008, 153, S1-S209.
118. Allen, A.M., MacGregor, D.P., McKinley, M.J., Mendelsohn, F.A.O. Angiotensin ii receptors in the human brain. Regul. Peptides, 1999, 79, 1-7.
119. de Gasparo, M., Catt, K.J., Inagami, T., Wright, J.W., Unger, T. International union of pharmacology. Xxiii. The angiotensin II receptors. Pharmacol. Rev., 2000, 52, 415-472.
120. Oliverio, M.I., Best, C.F., Kim, H.S., Arendshorst, W.J., Smithies, O., Coffman, T.M. Angiotensin II responses in at(1a) receptordeficient mice: A role for at(1b) receptors in blood pressure regulation. Am. J. Physiol. Renal. Physiol., 1997, 41, F515-F520.
121. Lenkei, Z., Palkovits, M., Corvol, P., LlorensCortes, C. Expression of angiotensin type-1 (at1) and type-2 (at2) receptor mrnas in the adult rat brain: A functional neuroanatomical review. Front. Neuroendocrinol., 1997, 18, 383-439.
122. Bains, J.S., Potyok, A., Ferguson, A.V. Angiotensin-ii actions in paraventricular nucleus-functional evidence for neurotransmitter role in efferents originating in subfornical organ. Brain Res., 1992, 599, 223-229.
123. Bains, J.S., Ferguson, A.V. Paraventricular nucleus neurons projecting to the spinal-cord receive excitatory input from the subfornical organ. Am. J. Physiol. Regul. Integr. Comp. Physiol., 1995, 268, R625-R633.
124. Li, Z., Ferguson, A.V. Electrophysiological properties of paraventricular magnocellular neurons in rat brain slices: Modulation of I-A by angiotensin II. Neuroscience, 1996, 71, 133-145.
125. Cato, M.J., Toney, G.M. Angiotensin ii excites paraventricular nucleus neurons that innervate the rostral ventrolateral medulla: An in vitro patch-clamp study in brain slices. J. Neurophysiol., 2005, 93, 403-413.
126. Culman, J., Itoi, K., Unger, T. Hypothalamic tachykinins. Mediators of stress responses? Ann. N.Y. Acad. Sci., 1995, 771, 204-218.
127. Ding, Y.Q., Shigemoto, R., Takada, M., Ohishi, H., Nakanishi, S., Mizuno, N. Localization of the neuromedin k receptor (nk3) in the central nervous system of the rat. J. Comp. Neurol., 1996, 364, 290-310.
128. Koutcherov, Y., Ashwell, K.W.S., Paxinos, G. The distribution of the neurokinin b receptor in the human and rat hypothalamus. Neuroreport, 2000, 11, 3127-3131.
129. Shults, C.W., Buck, S.H., Burcher, E., Chase, T.N., O'Donohue, T.L. Distinct binding sites for substance p and neurokinin a (substance k): Co-transmitters in rat brain. Peptides, 1985, 6, 343-345.
130. Nakajima, Y., Tsuchida, K., Negishi, M., Ito, S., Nakanishi, S. Direct linkage of three tachykinin receptors to stimulation of both phosphatidylinositol hydrolysis and cyclic amp cascades in transfected chinese hamster ovary cells. J. Biol. Chem., 1992, 267, 2437-2442.
131. Quartara, L., Maggi, C.A. The tachykinin nk1 receptor. Part i: Ligands and mechanisms of cellular activation. Neuropeptides, 1997, 31, 537-563.
132. Connolly, C.N., Kittler, J.T., Thomas, P., Uren, J.M., Brandon, N.J., Smart, T.G., Moss, S.J. Cell surface stability of gammaaminobutyric acid type a receptors-dependence on protein kinase c activity and subunit composition. J. Biol. Chem., 1999, 274, 36565-36572.
133. Bittencourt, J.C., Benoit, R., Sawchenko, P.E. Distribution and origins of substance-p-immunoreactive projections to the paraventricular and supraoptic nuclei-partial overlap with ascending catecholaminergic projections. J. Chem. Neuroanat., 1991, 4, 63-78.
134. Womack, M.D., Barrett-Jolley, R. Activation of paraventricular nucleus neurones by the dorsomedial hypothalamus via a tachykinin pathway in rats. Exp. Physiol., 2007, 92, 671-676.
135. DiMicco, J.A., Samuels, B.C., Zaretskaia, M.V., Zaretsky, D.V. The dorsomedial hypothalamus and the response to stress part renaissance, part revolution. Pharmacol. Biochem. Behav., 2002, 71, 469-480.
136. Yi, C.-X., la Fleur, S.E., Fliers, E., Kalsbeek, A. The role of the autonomic nervous liver innervation in the control of energy metabolism. Biochim. Biophys. Acta-Mol. Basis Dis., 2010, 1802, 416-431.
137. Klieverik, L.P., Janssen, S.F., van Riel, A., Foppen, E., Bisschop, P.H., Serlie, M.J., Boelen, A., Ackermans, M.T., Sauerwein, H.P., Fliers, E., Kalsbeek, A. Thyroid hormone modulates glucose production via a sympathetic pathway from the hypothalamic paraventricular nucleus to the liver. Proc. Natl. Acad. Sci. U. S. A., 2009, 106, 5966-5971.
138. Fredholm, B.B., Abbracchio, M.P., Burnstock, G., Daly, J.W., Harden, T.K., Jacobson, K.A., Leff, P., Williams, M. Nomenclature and classification of purinoceptors. Pharmacol. Rev., 1994, 46, 143-156.
139. Ralevic, V., Burnstock, G. Receptors for purines and pyrimidines. Pharmacol. Rev., 1998, 50, 413-492.
140. Cham, J.L., Owens, N.C., Barden, J.A., Lawrence, A.J., Badoer, E. P2x purinoceptor subtypes on paraventricular nucleus neurones projecting to the rostral ventrolateral medulla in the rat. Exp. Physiol., 2006, 91, 403-411.
141. Kirsch, G.E., Codina, J., Birnbaumer, L., Brown, A.M. Coupling of atp-sensitive k+ channels to a1-receptors by g-proteins in rat ventricular myocytes. Am. J. Physiol., 1990, 259, H820-H826.
142. Dart, C., Standen, N.B. Adenosine-activated potassium current in smooth-muscle cells isolated from the pig coronary-artery. J. Physiol-London, 1993, 471, 767-786.
143. Barrett-Jolley, R., Comtois, A., Davies, N.W., Stanfield, P.R., Standen, N.B. Effect of adenosine and intracellular gtp on k-atp channels of mammalian skeletal muscle. J. Membr. Biol, 1996, 152, 111-116.
144. Mondal, M.S., Yamaguchi, H., Date, Y., Shimbara, T., Toshinai, K., Shimomura, Y., Mori, M., Nakazato, M. A role for neuropeptide w in the regulation of feeding behavior. Endocrinology, 2003, 144, 4729-4733.
145. Jhamandas, J.H., MacTavish, D., Harris, K.H. Neuropeptide ff (npff) control of magnocellular neurosecretory cells of the rat hypothalamic paraventricular nucleus (pvn). Peptides, 2006, 27, 973-979.
146. Jhamandas, J.H., Simonin, F., Bourguignon, J.J., Harris, K.H. Neuropeptide ff and neuropeptide vf inhibit gabaergic neurotransmission in parvocellular neurons of the rat hypothalamic paraventricular nucleus. Am. J. Physiol-Regul. Integr. Compar. Physiol, 2007, 292, R1872-R1880.
147. Jhamandas, J.H., MacTavish, D. Central administration of neuropeptide ff causes activation of oxytocin paraventricular hypothalamic neurones that project to the brainstem. J. Neuroendocrinol., 2003, 15, 24-32.
148. Maratos-Flier, E. The long reach of leptin. Nat. Med., 2008, 14, 604-606.
149. Morton, G.J., Cummings, D.E., Baskin, D.G., Barsh, G.S., Schwartz, M.W. Central nervous system control of food intake and body weight. Nature, 2006, 443, 289-295.
150. Cone, R.D. Anatomy and regulation of the central melanocortin system. Nat. Neurosci., 2005, 8, 571-578.
151. Meister, B., Hakansson, M.L. Leptin receptors in hypothalamus and circumventricular organs. Clin. Exp. Pharmacol. Physiol., 2001, 28, 610-617.
152. Powis, J.E., Bains, J.S., Ferguson, A.V. (1998) Leptin depolarizes rat hypothalamic paraventricular nucleus neurons. Am. J. Physiol-Regul. Integrat. Comp. Physiol., 274, R1468-R1472.
153. Shirasaka, T., Miyahara, S., Kunitake, T., Jin, Q.H., Kato, K., Takasaki, M., Kannan, H. Orexin depolarizes rat hypothalamic paraventricular nucleus neurons. Am. J. Physiol-Regul. Integr. Comp. Physiol., 2001, 281, R1114-R1118.
154. Shan, J., Krukoff, T.L. Intracerebroventricular adrenomedullin stimulates the hypothalamic-pituitary-adrenal axis, the sympathetic nervous system and production of hypothalamic nitric oxide. J. Neuroendocrinol., 2001, 13, 975-984.
155. Badoer, E. Hypothalamic paraventricular nucleus and cardiovascular regulation. Clin. Exp. Pharmacol. Physiol., 2001, 28, 95-99.
156. Herd, J.A. Cardiovascular response to stress in man. Annu. Rev. Physiol., 1984, 46, 177-185.
157. Everson, S.A., Kaplan, G.A., Goldberg, D.E., Salonen, J.T. Anticipatory blood pressure response to exercise predicts future high blood pressure in middle-aged men. Hypertension, 1996, 27, 1059-1064.
158. Berdina, N.A., Kolenko, O.L., Kotz, I.M., Kuznetzov, A.P., Rodionov, I.M., Savtchenko, A.P., Thorevsky, V.I. Increase in skeletal muscle performance during emotional stress in man. Circ. Res., 1972, 30, 642-650.
159. Gillespie, R.D. The relative influence of mental and muscular work on the pulse-rate and blood-pressure. J. Physiol-London, 1924, 58, 425-432.
160. Herd, J.A. Cardiovascular response to stress. Physiol. Rev., 1991, 71, 305-330.
161. Folkow, B. Mental stress and its importance for cardiovascular disorders; physiological aspects, "From-mice-to-man". Scand. Cardiovasc. J., 2001, 35, 163-172.
162. Rozanski, A., Blumenthal, J.A., Kaplan, J. Impact of psychological factors on the pathogenesis of cardiovascular disease and implications for therapy. Circulation, 1999, 99, 2192-2217.
163. Duan, Y.F., Winters, R., McCabe, P.M., Green, E.J., Huang, Y., Schneiderman, N. Cardiorespiratory components of defense reaction elicited from paraventricular nucleus. Physiol. Behav., 1997, 61, 325-330.
164. Busnardo, C., Tavares, R.F., Resstel, L.B.M., Elias, L.L.K., Correa, F.M.A. Paraventricular nucleus modulates autonomic and neuroendocrine responses to acute restraint stress in rats. Autonomic Neurosci., In Press.
165. Li, Y.F., Wang, W., Mayhan, W.G., Patel, K.P. Angiotensinmediated increase in renal sympathetic nerve discharge within the pvn: Role of nitric oxide. Am. J. Physiol.-Regul. Integr. Comp. Physiol., 2006, 290, R1035-R1043.
166. Martin, D.S., Haywood, J.R. Sympathetic nervous-system activation by glutamate injections into the paraventricular nucleus. Brain Res., 1992, 577, 261-267.
167. Martin, D.S., Haywood, J.R., Thornhill, J.A. Stimulation of the hypothalamic paraventricular nucleus causes systemic venoconstriction. Brain Res., 1993, 604, 318-324.
168. Jessop, D.S., Chowdrey, H.S., Biswas, S., Lightman, S.L. Substance-p and substance-k in the rat hypothalamus following monosodium glutamate lesions of the arcuate nucleus. Neuropeptides, 1991, 18, 165-170.
169. Unger, T., Becker, H., Petty, M., Demmert, G., Schneider, B., Ganten, D., Lang, R.E. Differential-effects of central angiotensin-ii and substance-p on sympathetic-nerve activity in conscious rats-implications for cardiovascular adaptation to behavioral-responses. Circ. Res., 1985, 56, 563-575.
170. Itoi, K., Jost, N., Badoer, E., Tschope, C., Culman, J., Unger, T. Localization of the substance p-induced cardiovascular responses in the rat hypothalamus. Brain Res., 1991, 558, 123-126.
171. Nakayama, Y., Takano, Y., Saito, R., Kamiya, H. Central pressor actions of tachykinin nk-3 receptor in the paraventricular nucleus of the rat hypothalamus. Brain Res., 1992, 595, 339-342.
172. Takano, Y., Nakayama, Y., Matsumoto, T., Saito, R., Kamiya, H. The mechanism of central pressor actions of tachykinin nk-3 receptor in the paraventricular nucleus of the hypothalamus in rats. Regul. Peptides, 1993, 46, 360-363.
173. Culman, J., Klee, S., Ohlendorf, C., Unger, T. Effect of tachykinin receptor inhibition in the brain on cardiovascular and behavioral responses to stress. J. Pharmacol. Exp. Ther., 1997, 280, 238-246.
174. Cannon, W.B. Bodily changes in pain hunger, fear and rage-an account of recent researches into the function of emotional excitement. New York & London, D. Appleton & Company 1927.
175. Stotz-Potter, E.H., Morin, S.M., DiMicco, J.A. Effect of microinjection of muscimol into the dorsomedial or paraventricular hypothalamic nucleus on air stress-induced neuroendocrine and cardiovascular changes in rats. Brain Res., 1996, 742, 219-224.
176. Pyner, S., Deering, J., Coote, J.H. Right atrial stretch induces renal nerve inhibition and c-fos expression in parvocellular neurones of the paraventricular nucleus in rats. Exp. Physiol., 2002, 87, 25-32.
177. Deering, J., Coote, J.H. Paraventricular neurones elicit a volume expansion-like change of activity in sympathetic nerves to the heart and kidney in the rabbit. Exp. Physiol., 2000, 85, 177-186.
178. Greenway, C.V., Lister, G.E. Capacitance effects and blood reservoir function in splanchnic vascular bed during nonhypotensive hemorrhage and blood-volume expansion in anesthetized cats. J. Physiol-London, 1974, 237, 279-294.
179. Fater, D.C., Schultz, H.D., Sundet, W.D., Mapes, J.S., Goetz, K.L. Effects of left atrial stretch in cardiac-denervated and intact conscious dogs. Am. J. Physiol-Heart Cir. Physiol., 1982, 242, H1056-1064.
180. Badoer, E., McKinley, M.J., Oldfield, B.J., McAllen, R.M. A comparison of hypotensive and nonhypotensive hemorrhage on fos expression in spinally projecting neurons of the paraventricular nucleus and rostral ventrolateral medulla. Brain Res., 1993, 610, 216-223.
181. Stocker, S.D., Cunningham, J.T., Toney, G.M. Water deprivation increases fos immunoreactivity in pvn autonomic neurons with projections to the spinal cord and rostral ventrolateral medulla. Am. J. Physiol-Regul. Integrat. Comp. Physiol., 2004, 287, R1172-R1183.
182. Stocker, S.D., Keith, K.J., Toney, G.M. Acute inhibition of the hypothalamic paraventricular nucleus decreases renal sympathetic nerve activity and arterial blood pressure in water-deprived rats. Am. J. Physiol-Regul. Integr. Compar. Physiol., 2004, 286, R719-R725.
183. Millar-Craig, M.W., Bishop, C.N., Raftery, E.B. Circadian variation of blood-pressure. Lancet, 1978, 1, 795-797.
184. Degaute, J.P., Vandeborne, P., Linkowski, P., Vancauter, E. Quantitative-analysis of the 24-hour blood-pressure and heart-rate patterns in young men. Hypertension, 1991, 18, 199-210.
185. Verdecchia, P., Schillaci, G., Guerrieri, M., Gatteschi, C., Benemio, G., Boldrini, F., Porcellati, C. Circadian blood pressure changes and left ventricular hypertrophy in essential hypertension. Circulation, 1990, 81, 528-536.
186. Pickering, T.G. The clinical significance of diurnal blood pressure variations. Dippers and nondippers. Circulation, 1990, 81, 700-702.
187. Boari, B., Salmi, R., Gallerani, M., Malagoni, A.M., Manfredini, F., Manfredini, R. Acute myocardial infarction: Circadian, weekly, and seasonal patterns of occurrence. Biol. Rhythm. Res., 2007, 38, 155-167.
188. Muller, J.E., Tofler, G.H., Stone, P.H. Circadian variation and triggers of onset of acute cardiovascular-disease. Circulation, 1989, 79, 733-743.
189. Brown, T.M., Piggins, H.D. Electrophysiology of the suprachiasmatic circadian clock. Prog. Neurobiol., 2007, 82, 229-255.
190. Tei, H., Okamura, H., Shigeyoshi, Y., Fukuhara, C., Ozawa, R., Hirose, M., Sakaki, Y. Circadian oscillation of a mammalian homologue of the drosophila period gene. Nature, 1997, 389, 512-516.
191. Reppert, S.M., Weaver, D.R. Coordination of circadian timing in mammals. Nature, 2002, 418, 935-941.
192. Hermes, M.L., Buijs, R.M., Renaud, L.P. Electrophysiology of suprachiasmatic nucleus projections to hypothalamic paraventricular nucleus neurons. Prog. Brain Res., 1996, 111, 241-252.
193. Chen, K.K., Chan, S.H.H., Chang, L.S., Chan, J.Y.H. Participation of paraventricular nucleus of hypothalamus in central regulation of penile erection in the rat. J. Urol., 1997, 158, 238-244.
194. Argiolas, A., Melis, M.R. Neuromodulation of penile erection: An overview of the role of neurotransmitters and neuropeptides. Prog. Neurobiol., 1995, 47, 235-255.
195. Andersson, K.E., Wagner, G. Physiology of penile erection. Physiol. Rev., 1995, 75, 191-236.
196. Argiolas, A., Melis, M.R. Central control of penile erection: Role of the paraventricular nucleus of the hypothalamus. Prog. Neurobiol., 2005, 76, 1-21.
197. Marson, L., Platt, K.B., Mckenna, K.E. Central-nervous-system innervation of the penis as revealed by the transneuronal transport of pseudorabies virus. Neuroscience, 1993, 55, 263-280.
198. Stafford, S.A., Tang, K., Coote, J.H. Activation of lumbosacral 5-ht2c receptors induces bursts of rhythmic activity in sympathetic nerves to the vas deferens in male rats. Br. J. Pharmacol., 2006, 148, 1083-1090.
199. Stafford, S.A., Bowery, N.G., Tang, K., Coote, J.H. Activation by p-chloroamphetamine of the spinal ejaculatory pattern generator in anaesthetized male rats. Neuroscience, 2006, 140, 1031-1040.
200. Levin, B.E. Metabolic sensing neurons and the control of energy homeostasis. Physiol. Behav., 2006, 89, 486-489.
201. Sakaguchi, T., Bray, G.A. Sympathetic activity following paraventricular injections of glucose and insulin. Brain Res Bull., 1988, 21, 25-29.
202. Carrasco, M., Portillo, F., Larsen, P.J., Vallo, J.J. Insulin and glucose administration stimulates fos expression in neurones of the paraventricular nucleus that project to autonomic preganglionic structures. J. Neuroendocrinol., 2001, 13, 339-346.
203. Dunn-Meynell, A.A., Govek, E., Levin, B.E. Intracarotid glucose selectively increases fos-like immunoreactivity in paraventricular, ventromedial and dorsomedial nuclei neurons. Brain Res., 1997, 748, 100-106.
204. Stanley, S., Pinto, S., Segal, J., Perez, C.A., Viale, A., DeFalco, J., Cai, X.L., Heisler, L.K., Friedman, J.M. Identification of neuronal subpopulations that project from hypothalamus to both liver and adipose tissue polysynaptically. Proc. Natl. Acad. Sci USA, 2010, 107, 7024-7029.
205. Oldfield, B.J., Giles, M.E., Watson, A., Anderson, C., Colvill, L.M., McKinley, M.J. The neurochemical characterisation of hypothalamic pathways projecting polysynaptically to brown adipose tissue in the rat. Neuroscience, 2002, 110, 515-526.
206. Bamshad, M., Song, C.K., Bartness, T.J. Cns origins of the sympathetic nervous system outflow to brown adipose tissue. Am. J. Physiol-Regul Integr. Compar. Physiol., 1999, 276, R1569-R1578.
207. Amir, S. Stimulation of the paraventricular nucleus with glutamate activates interscapular brown adipose-tissue thermogenesis in rats. Brain Res., 1990, 508, 152-155.
208. Yoshimatsu, H., Egawa, M., Bray, G.A. Effects of cholecystokinin on sympathetic activity to interscapular brown adipose-tissue. Brain Res., 1992, 597, 298-303.
209. Yoshimatsu, H., Egawa, M., Bray, G.A. Sympathetic-nerve activity after discrete hypothalamic injections of l-glutamate. Brain Res., 1993, 601, 121-128.
210. Madden, C.J., Morrison, S.F. Neurons in the paraventricular nucleus of the hypothalamus inhibit sympathetic outflow to brown adipose tissue. Am. J. Physiol-Regul. Integr. Comp. Physiol., 2009, 96, R831-R843.
211. Inenaga, K., Osaka, T., Yamashita, H. Thermosensitivity of neurons in the paraventricular nucleus of the rat slice preparation. Brain Res., 1987, 424, 126-132.
212. Smith, J.E., Jansen, A.S.P., Gilbey, M.P., Loewy, A.D. Cns cell groups projecting to sympathetic outflow of tail artery: Neural circuits involved in heat loss in the rat. Brain Res., 1998, 786, 153-164.
213. Cham, J.L., Badoer, E. Hypothalamic paraventricular nucleus is critical for renal vasoconstriction elicited by elevations in body temperature. Am. J. Physiol-Renal. Physiol., 2008, 294, F309-F315.
214. Chen, F., Dworak, M., Wang, Y., Cham, J.L., Badoer, E. Role of the hypothalamic pvn in the reflex reduction in mesenteric blood flow elicited by hyperthermia. Am. J. Physiol. Regul. Integr. Comp. Physiol., 2008, 295, R1874-1881.
215. Cham, J.L., Badoer, E. Exposure to a hot environment can activate rostral ventrolateral medulla-projecting neurones in the hypothalamic paraventricular nucleus in conscious rats. Exp. Physiol., 2008, 93, 64-74.
216. Cham, J.L., Klein, R., Owens, N.C., Mathai, M., McKinley, M., Badoer, E. Activation of spinally projecting and nitrergic neurons in the pvn following heat exposure. Am. J. Physiol-Regul. Integr. Comp. Physiol., 2006, 291, R91-R101.
217. Roddie, I.C., Shepherd, J.T., Whelan, R.F. The contribution of constrictor and dilator nerves to the skin vasodilation during body heating. J. Physiol-London, 1957, 136, 489-497.
218. Patel, K.P., Zhang, K., Kenney, M.J., Weiss, M., Mayhan, W.G. Neuronal expression of fos protein in the hypothalamus of rats with heart failure. Brain Res., 2000, 865, 27-34.
219. Calabrese, V., Mancuso, C., Calvani, M., Rizzarelli, E., Butterfield, D.A., Stella, A.M.G. Nitric oxide in the central nervous system: Neuroprotection versus neurotoxicity. Nat. Rev. Neurosci., 2007, 8, 766-775.
220. Garthwaite, J. Neural nitric-oxide signaling. Trends Neurosci., 1995, 18, 51-52.
221. Yamaguchi, N., Okada, S., Usui, D., Yokotani, K. Nitric oxide synthase isozymes in spinally projecting pvn neurons are involved in crf-induced sympathetic activation. Auton. Neurosci-Basic Clin., 2009, 148, 83-89.
222. Kantzides, A., Badoer, E. Nnos-containing neurons in the hypothalamus and medulla project to the rvlm. Brain Res., 2005, 1037, 25-34.
223. Li, Y., Zhang, W., Stern, J.E. Nitric oxide inhibits the firing activity of hypothalamic paraventricular neurons that innervate the medulla oblongata: Role of gaba. Neuroscience, 2003, 118, 585-601.
224. Bains, J.S., Ferguson, A.V. Nitric oxide regulates nmda-driven gabaergic inputs to type i neurones of the rat paraventricular nucleus. J. Physiol-London, 1997, 499, 733-746.
225. Zhang, K., Zucker, I.H., Patel, K.P. Altered number of diaphorase (nos) positive neurons in the hypothalamus of rats with heart failure. Brain Res, 1998, 786, 219-225.
226. Zheng, H., Li, Y.F., Wang, W., Patel, K.P. Enhanced angiotensinmediated excitation of renal sympathetic nerve activity within the paraventricular nucleus of anesthetized rats with heart failure. Am. J. Physiol-Regul. Integr. Comp. Physiol., 2009, 297, R1364-R1374.
227. Strack, A.M., Sawyer, W.B., Hughes, J.H., Platt, K.B., Loewy, A.D. A general pattern of cns innervation of the sympathetic outflow demonstrated by trans-neuronal pseudorabies viralinfections. Brain Res., 1989, 491, 156-162.