Multifocal gastric gastrointestinal stromal tumors (GISTs) with lymph node metastases in children and young adults: A comparative clinical and histomorphological study of three cases including a new case of Carney triad

Diagnostic Pathology

Volumn 6, Issue 1, 2011, Pages

  Otto, Claudia ^a   Agaimy, Abbas ^b   Braun, Alexander ^a   Rädecke, Jochen ^a   Hoeppner, Jens ^a   Illerhaus, Gerald ^a   Werner, Martin ^a   Kontny, Udo ^a   Haller, Florian ^a  

^a UNIVERSITY OF FREIBURG   (Germany)

^b UNIVERSITY HOSPITAL ERLANGEN   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

DNA; TUMOR MARKER;

ADOLESCENT; ADULT; ARTICLE; CASE REPORT; CHEMODECTOMA; CHONDROMA; COMPARATIVE STUDY; FEMALE; GASTROINTESTINAL STROMAL TUMOR; GENETICS; HUMAN; LUNG TUMOR; LYMPH NODE; LYMPH NODE METASTASIS; METABOLISM; METASTASIS; MULTIPLE CANCER; MUTATION; NUCLEOTIDE SEQUENCE; PATHOLOGY; SINGLE NUCLEOTIDE POLYMORPHISM; STOMACH TUMOR;

ADOLESCENT; ADULT; CHONDROMA; DNA MUTATIONAL ANALYSIS; DNA, NEOPLASM; FEMALE; GASTROINTESTINAL STROMAL TUMORS; HUMANS; LUNG NEOPLASMS; LYMPH NODES; LYMPHATIC METASTASIS; MUTATION; NEOPLASMS, MULTIPLE PRIMARY; PARAGANGLIOMA, EXTRA-ADRENAL; POLYMORPHISM, SINGLE NUCLEOTIDE; STOMACH NEOPLASMS; TUMOR MARKERS, BIOLOGICAL;

EID: 79958097421     PISSN: None     EISSN: 17461596     Source Type: Journal    
DOI: 10.1186/1746-1596-6-52     Document Type: Article

References (27)

1. Miettinen M, Sobin LH, Sarlomo-Rikala M. Immunohistochemical spectrum of GISTs at different sites and their differential diagnosis with a reference to CD117 (KIT). Mod Pathol 2000, 10:1134-1142.
2. Miettinen M, Lasota J. Gastrointestinal stromal tumors-definition, clinical, histological, immunohistochemical, and molecular genetic features and differential diagnosis. Virchows Arch 2001, 438(1):1-12. 10.1007/s004280000338, 11213830.
3. Fletcher CD, Berman JJ, Corless C, Gorstein F, Lasota J, Longley BJ, Miettinen M, O'Leary TJ, Remotti H, Rubin BP, Shmookler B, Sobin LH, Weiss SW. Diagnosis of gastrointestinal stromal tumors: A consensus approach. Hum Pathol 2002, 33:459-465. 10.1053/hupa.2002.123545, 12094370.
4. Yamaguchi U, Hasegawa T, Masuda T, Sekine S, Kawai A, Chuman H, Shimoda T. Differential diagnosis of gastrointestinal stromal tumor and other spindle cell tumors in the gastrointestinal tract based on immunohistochemical analysis. Virchows Arch 2004, 445:142-50.
5. Miettinen M, Sobin LH, Lasota J. Gastrointestinal stromal tumors of the stomach. A clinicopathologic, immunohistochemical and molecular genetic study of 1765 cases with long-term follow-up. Am Surg Pathol 2005, 29:52-68.
6. Nilsson B, Bümming P, Meis-Kindblom J, Oden A, Dortok A, Gustavsson B, Sablinska K, Kindblom LG. Gastrointestinal stromal tumors: The incidence, prevalence, clinical course and prognostication in the preimatinib mesylate era. A population-based study in western Sweden. Cancer 2005, 103(4):821-9. 10.1002/cncr.20862, 15648083.
7. Tran T, Davila JA, El-Serag HB. The epidemiology of malignant gastrointestinal stromal tumors: an analysis of 1,458 cases from 1992 to 2000. Am J Gastroenterol 2005, 100(1):162-8. 10.1111/j.1572-0241.2005.40709.x, 15654796.
8. Tryggvason G, Gíslason HG, Magnússon MK, Jónasson JG. Gastrointestinal stromal tumors in Iceland, 1990-2003: the icelandic GIST study, a population-based incidence and pathologic risk stratification study. Int J Cancer 2005, 117(2):289-93. 10.1002/ijc.21167, 15900576.
9. Prakash S, Sarran L, Socci N. Gastrointestinal stromal tumors in children and young adults: a clinicopathologic, molecular, and genomic study of 15 cases and review of the literature. J Pediatr Hematol Oncol 2005, 27:179-187. 10.1097/01.mph.0000157790.81329.47, 15838387.
10. Agaram NP, Laquaglia MP, Ustun B, Guo T, Wong GC, Socci ND, Maki RG, DeMatteo RP, Besmer P. Molecular characterization of pediatric gastrointestinal stromal tumors. Clin Cancer Res 2008, 14(10):3204-3215. 10.1158/1078-0432.CCR-07-1984, 18483389.
11. Wang JH, Lasota J, Miettinen M. Succinate Dehydrogenase Subunit B (SDHB) Is Expressed in Neurofibromatosis 1-Associated Gastrointestinal Stromal Tumors (Gists): Implications for the SDHB Expression Based Classification of Gists. J Cancer 2011, 16(2):90-3.
12. Carney JA, Sheps SG, Go VL, Gordon H. The triad of gastric leiomyosarcoma, functioning extra-adrenal paraganglioma and pulmonary chondroma. N Engl Med 1977, 296:1517-8.
13. Online Mendelian Inheritance in Man, OMIM (TM) Center for Medical Genetics, John Hopkins University, Baltimore, MD and National Center for Biomedical Information, National Library of Medicine, Bethesda, MD. 1999, Updated 11-8-99, Online Mendelian Inheritance in Man, OMIM (TM).
14. Stratakis CA, Carney JA. The triad of paragangliomas, gastric stromal tumours and pulmonary chondromas (Carney triad), and the dyad of paragangliomas and gastric stromal sarcomas (Carney-Stratakis syndrome): molecular genetics and clinical implications. J Intern Med 2009, 266(1):43-52. 10.1111/j.1365-2796.2009.02110.x, 19522824.
15. Zhang L, Smyrk TC, Young WF, Stratakis CA, Carney JA. Gastric stromal tumors in Carney triad are different clinically, pathologically and behaviourally from sporadic gastric gastrointestinal stromal tumors: findings in 104 cases. Am J Surg Pathol 2010, 34:53-64. 10.1097/PAS.0b013e3181c20f4f, 19935059.
16. Carney JA. Gastric stromal sarcoma, pulmonary chondroma and extra-adrenal paraganglioma (Carney-Triad): Natural history, adrenocortical component and possible familial occurrence. Mayo Clin Proc 1999, 74:543-52. 10.4065/74.6.543, 10377927.
17. Agaimy A, Pelz AF, Corless CL, Wünsch PH, Heinrich MC, Hofstaedter F, Dietmaier W, Blanke CD, Wieacker P, Roessner A, Hartmann A, Schneider-Stock R. Epithelioid gastric stromal tumours of the antrum in young females with the Carney triad: a report of three new cases with mutational analysis and comparative genomic hybridization. Oncol Rep 2007, 18:9-15.
18. Matyakhina L, Bei TA, McWhinney SR, Pasini B, Cameron S, Gunawan B, Stergiopoulos SG, Boikos S, Muchow M, Dutra A, Pak E, Campo E, Cid MC, Gomez F, Gaillard RC, Assie G, Füzesi L, Baysal BE, Eng C, Carney JA, Stratakis CA. Genetics of Carney triad: recurrent losses at chromosome 1 but lack of germline mutations in genes associated with paragangliomas and gastrointestinal stromal tumors. J Clin Endocrinol Metab 2007, 92:2938-43. 10.1210/jc.2007-0797, 17535989.
19. Agaimy A, Wünsch PH. Lymph node metastasis in gastrointestinal stromal tumours (GIST) occurs preferentially in young patients ≤ 40 yrs: An overview based on our case material and the literature. Langenbecks Arch Surg 2009, 394:375-81. 10.1007/s00423-008-0449-5, 19104826.
20. Agaimy A, Carney JA. Lymphatics and D2-40/podoplanin expression in gastrointestinal stromal tumours of the stomach with and without lymph node metastasis: an immunohistochemical study with special reference to the Carney triad. J Clin Pathol 2010, 63(3):229-34. 10.1136/jcp.2009.074062, 20203222.
21. De Matteo RP, Lewis JJ, Leung D, Mudan SS, Woodruff JM, Brennan MF. Two hundred gastrointestinal stromal tumors. Recurrence patterns and prognostic factors for survival. Ann Surg 2000, 231:51-8. 10.1097/00000658-200001000-00008, 1420965, 10636102.
22. Rubin BP. Gastrointestinal stromal tumours: an update. Histopathology 2006, 48(1):83-96. 10.1111/j.1365-2559.2005.02291.x, 16359540.
23. Casali PG, Jost L, Reichardt P, Schlemmer M, Blay JY, . ESMO Guidelines Working Group Gastrointestinal stromal tumors: ESMO clinical recommendations for diagnosis, treatment and follow-up. Ann Oncol 2008, 19(Suppl 2):ii35-8. ESMO Guidelines Working Group.
24. Benesch M, Leuschner I, Wardelmann E, Thielen M, Schmid I, Kontny U, Ebetsberger G, Frey E, Graf N, Schneider DT, Kremens B, Amann G, Urban C, Schlemmer M, Quehenberger F, Klingebiel T, Dantonello T, Koscielniak E. Gastrointestinal stromal tumours in children and young adults: A clinicopathologic series with long-term follow-up from the database of the Cooperative Weichteilsarkom Studiengruppe (CWS). Eur J Cancer 2011,
25. Fetscher S, Brugger W, Bertz H, Krieger G, Kanz L, Mertelsmann R, Lange W. High-dose chemotherapy with autologous peripheral blood stem cell transplantation for metastatic gastric leiomyosarcoma. Bone Marrow Transplantation 1997, 20:787-788. 10.1038/sj.bmt.1700970, 9384483.
26. Benesch M, Wardelmann E, Ferrari A, Brennan B, Verschuur A. Gastrointestinal stromal tumors (GIST) in children and adolescents: A comprehensive review of the current literature. Pediatr Blood Cancer 2009, 53(7):1171-9. 10.1002/pbc.22123, 19499582.
27. Carney JA. Carney triad: A syndrome featuring paraganglionic, adrenocortical and possibly other endocrine tumours. J Clin Endocrinol Metab 2009, 94:3656-3662. 10.1210/jc.2009-1156, 19723753.